{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:52:14Z","timestamp":1791035534785,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Microbiol"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1038\/nrmicro1048","type":"journal-article","created":{"date-parts":[[2004,11,19]],"date-time":"2004-11-19T05:36:16Z","timestamp":1100842576000},"page":"984-989","source":"Crossref","is-referenced-by-count":239,"title":["The life and times of ivermectin \u2014 a success story"],"prefix":"10.1038","volume":"2","author":[{"given":"Satoshi","family":"\u00d5mura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Crump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrmicro1048_CR1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1128\/MMBR.50.3.259-279.1986","volume":"50","author":"S \u00d5mura","year":"1986","unstructured":"\u00d5mura, S. Philosophy of new drug discovery. Microbiol. Rev. 50, 259\u2013279 (1986).","journal-title":"Microbiol. Rev."},{"key":"BFnrmicro1048_CR2","first-page":"192","volume-title":"Inventive Minds","author":"WC Campbell","year":"1992","unstructured":"Campbell, W. C. in Inventive Minds (eds Weber, R. J. & Perkins, D. N.) Chapter 11, 192\u2013214 (Oxford Univ. Press, New York, 1992)."},{"key":"BFnrmicro1048_CR3","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/978-1-4612-3626-9_2","volume-title":"Ivermectin and Abamectin","author":"RW Burg","year":"1989","unstructured":"Burg, R. W. & Stapley, E. O. in Ivermectin and Abamectin (ed. Campbell, W. C.) 24\u201332 (Springer, New York, 1989)."},{"key":"BFnrmicro1048_CR4","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1099\/00207713-52-6-2163","volume":"52","author":"Y Takahashi","year":"2002","unstructured":"Takahashi, Y. et al. Streptomyces avermectinius sp. nov., an avermectin-producing strain. Int. J. Syst. Evol. Microbiol. 52, 2163\u20132168 (2002).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"BFnrmicro1048_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1128\/AAC.15.3.361","volume":"15","author":"RW Burg","year":"1979","unstructured":"Burg, R. W. et al. Avermectins, new family of potent anthelmintic agents: producing organisms and fermentation. Antimicrob. Agents Chemother. 15, 361\u2013367 (1979).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnrmicro1048_CR6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1128\/AAC.15.3.368","volume":"15","author":"TW Miller","year":"1979","unstructured":"Miller, T. W. Avermectins, new family of potent anthelmintic agents: isolation and chromatographic properties. Antimicrob. Agents Chemother. 15, 368\u2013371 (1979).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnrmicro1048_CR7","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1128\/AAC.15.3.372","volume":"15","author":"JR Egerton","year":"1979","unstructured":"Egerton, J. R. et al. Avermectins, new family of potent anthelmintic agents: efficacy of the B1A component. Antimicrob. Agents Chemother. 15, 372\u2013378 (1979).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnrmicro1048_CR8","first-page":"99","volume-title":"Macrolide Antibiotics \u2014 Chemistry, Biology and Practice","author":"T Sunazuka","year":"2002","unstructured":"Sunazuka, T. et al. in Macrolide Antibiotics \u2014 Chemistry, Biology and Practice 2nd ed. (ed. S. \u00d5mura) 99\u2013180 (Academic Press, 2002)."},{"key":"BFnrmicro1048_CR9","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1021\/jm00184a014","volume":"23","author":"JC Chabala","year":"1980","unstructured":"Chabala, J. C. et al. Ivermectin, a new broad-spectrum antiparasitic agent. J. Med. Chem. 23, 1134\u20131136 (1980).","journal-title":"J. Med. Chem."},{"key":"BFnrmicro1048_CR10","doi-asserted-by":"publisher","first-page":"460","DOI":"10.4269\/ajtmh.1989.41.460","volume":"41","author":"HR Taylor","year":"1989","unstructured":"Taylor, H. R. & Greene, B. M. The status of ivermectin in the treatment of human onchocerciasis. Am. J. Trop. Med. Hyg. 41, 460\u2013466 (1989).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR11","doi-asserted-by":"publisher","first-page":"12215","DOI":"10.1073\/pnas.211433198","volume":"98","author":"S \u00d5mura","year":"2001","unstructured":"\u00d5mura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl Acad. Sci. USA 98, 12215\u201312220 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1048_CR12","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/nbt820","volume":"21","author":"H Ikeda","year":"2003","unstructured":"Ikeda, H. et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nature Biotechnol. 21, 526\u2013531 (2003).","journal-title":"Nature Biotechnol."},{"key":"BFnrmicro1048_CR13","first-page":"571","volume-title":"Macrolide Antibiotics \u2014 Chemistry, Biology and Practice","author":"S \u00d5mura","year":"2002","unstructured":"\u00d5mura, S. in Macrolide Antibiotics \u2014 Chemistry, Biology and Practice 2nd edn (ed. Omura, S.) 571\u2013576 (Academic Press, 2002)."},{"key":"BFnrmicro1048_CR14","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/j.1476-5381.1985.tb08874.x","volume":"85","author":"R Duce","year":"1985","unstructured":"Duce, R. & Scott, R. H. Actions of dihydroavermectin B1a on insect muscle. Br. J. Pharmacol. 85, 395\u2013401 (1985).","journal-title":"Br. J. Pharmacol."},{"key":"BFnrmicro1048_CR15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1006\/expr.1993.1064","volume":"77","author":"TG Geary","year":"1993","unstructured":"Geary, T. G. et al. Haemonchus contortus: ivermectin-induced paralysis of the pharynx. Exp. Parasitol. 77, 88\u201396 (1993).","journal-title":"Exp. Parasitol."},{"key":"BFnrmicro1048_CR16","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1073\/pnas.76.4.2062","volume":"76","author":"LC Fritz","year":"1979","unstructured":"Fritz, L. C. et al. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Proc. Natl Acad. Sci. USA 76, 2062\u20132066 (1979).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1048_CR17","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0028-3908(83)90265-4","volume":"22","author":"TN Mellin","year":"1983","unstructured":"Mellin, T. N. et al. Postsynaptic inhibition of invertebrate neuromuscular transmission by avermectin B1a . Neuropharmacology 22, 89\u201396 (1983).","journal-title":"Neuropharmacology"},{"key":"BFnrmicro1048_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/978-1-4612-3626-9_5","volume-title":"Ivermectin and Abamectinn","author":"M Turner","year":"1989","unstructured":"Turner, M. & Schaeffer J. M. in Ivermectin and Abamectinn (ed. Campbell, W. C.) 73\u201388 (Springer, New York, 1989)."},{"key":"BFnrmicro1048_CR19","unstructured":"TDR. Twelfth Programme Report. Tropical Disease Research: progress 1975\u201394, highlights 1993\u201394. (WHO, Geneva, 1995)."},{"key":"BFnrmicro1048_CR20","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1111\/j.1365-3156.2004.01226.x","volume":"9","author":"B Thylefors","year":"2004","unstructured":"Thylefors, B. Eliminating onchocerciasis as a public health problem. Trop. Med. Int. Health 9, A1\u2013A3 (2004).","journal-title":"Trop. Med. Int. Health"},{"key":"BFnrmicro1048_CR21","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0140-6736(82)91026-1","volume":"2","author":"MA Aziz","year":"1982","unstructured":"Aziz, M. A. et al. Efficacy and tolerance of ivermectin in human onchocerciasis. Lancet 2, 171\u2013173 (1982).","journal-title":"Lancet"},{"key":"BFnrmicro1048_CR22","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1016\/S0140-6736(82)91350-2","volume":"2","author":"MA Aziz","year":"1982","unstructured":"Aziz, M. A. et al. Ivermectin in onchocerciasis. Lancet 2, 1456\u20131457 (1982).","journal-title":"Lancet"},{"key":"BFnrmicro1048_CR23","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/infdis\/156.3.463","volume":"156","author":"AT White","year":"1987","unstructured":"White, A. T. et al. Controlled trial and dose-finding study of ivermectin for treatment of infectious diseases. J. Infect. Dis. 156, 463\u2013470 (1987).","journal-title":"J. Infect. Dis."},{"key":"BFnrmicro1048_CR24","first-page":"131","volume":"100","author":"BM Greene","year":"1987","unstructured":"Greene, B. M. et al. Single dose therapy with ivermectin for onchocerciasis. Trans. Assoc. Am. Physicians 100, 131\u2013138 (1987).","journal-title":"Trans. Assoc. Am. Physicians"},{"key":"BFnrmicro1048_CR25","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1136\/bjo.72.8.561","volume":"72","author":"HS Newland","year":"1988","unstructured":"Newland, H. S. et al. Effect of single-dose ivermectin therapy on human Onchocerca volvulus infection with onchocercal ocular involvement. Br. J. Opthalmol. 72, 561\u2013569 (1988).","journal-title":"Br. J. Opthalmol."},{"key":"BFnrmicro1048_CR26","first-page":"177","volume":"59","author":"JHF Remme","year":"1990","unstructured":"Remme, J. H. F. et al. Large-scale ivermectin distribution and its epidemiological consequences. Acta Leiden. 59, 177\u2013191 (1990).","journal-title":"Acta Leiden."},{"key":"BFnrmicro1048_CR27","doi-asserted-by":"publisher","first-page":"657","DOI":"10.4269\/ajtmh.1990.43.657","volume":"43","author":"BOL Duke","year":"1990","unstructured":"Duke, B. O. L. et al. Effects of multiple monthly doses of ivermectin on adult Onchocerca volvulus. Am. J. Trop. Med. Hyg. 43, 657\u2013664 (1990).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR28","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1126\/science.6308762","volume":"221","author":"WC Campbell","year":"1983","unstructured":"Campbell, W. C. et al. Ivermectin: a potent new antiparasitic agent. Science 221, 823\u2013828 (1983).","journal-title":"Science"},{"key":"BFnrmicro1048_CR29","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1111\/j.1365-3156.1996.tb00111.x","volume":"1","author":"JAG Whitworth","year":"1992","unstructured":"Whitworth, J. A. G. et al. Clinical and parasitological response after up to 6.5 years of ivermectin treatment for onchocerciasis. Trop. Med. Int. Health 1, 786\u2013793 (1992).","journal-title":"Trop. Med. Int. Health"},{"key":"BFnrmicro1048_CR30","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/0035-9203(94)90172-4","volume":"88","author":"ES Alley","year":"1994","unstructured":"Alley, E. S. et al. The impact of five years of annual ivermectin treatment on microfilarial loads in the onchocerciasis focus of Asubende, Ghana. Trans. R. Soc. Trop. Med. Hyg. 88, 581\u2013584 (1994).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR31","first-page":"804","volume":"49","author":"MH Kennedy","year":"2002","unstructured":"Kennedy, M. H. et al. The effect of five years of annual treatment with ivermectin (Mectizan\u00ae) on the prevalence and morbidity of onchocerciasis in the village of Gami in the Central African Republic. Ann. Trop. Med. Parasitol. 49, 804\u2013811 (2002).","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"BFnrmicro1048_CR32","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0035-9203(92)90308-Y","volume":"86","author":"JAG Whitworth","year":"1996","unstructured":"Whitworth, J. A. G. et al. A community trial of ivermectin for onchocerciasis in Sierra Leone; clinical and parasitological response to four doses given at six-monthly intervals. Trans. R. Soc. Trop. Med. Hyg. 86, 277\u2013280 (1996).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR33","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4269\/ajtmh.1992.46.189","volume":"46","author":"BOL Duke","year":"1992","unstructured":"Duke, B. O. L. et al. Effects of three-month doses of ivermectin on adult Onchocerca volvulus. Am. J. Trop. Med. Hyg. 46, 189\u2013194 (1992).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR34","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/archopht.1986.01050180097039","volume":"104","author":"HR Taylor","year":"1986","unstructured":"Taylor, H. R. et al. Comparison of the treatment of ocular onchocerciaisis with ivermectin and diethylcarbamazine. Arch. Opthalmol. 104, 863\u2013870 (1986).","journal-title":"Arch. Opthalmol."},{"key":"BFnrmicro1048_CR35","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/infdis\/163.2.381","volume":"163","author":"M Pacqu\u00e9","year":"1991","unstructured":"Pacqu\u00e9, M. et al. Community-based treatment of onchocerciasis with ivermectin: safety, efficacy and acceptability of yearly treatment. J. Infect. Dis. 163, 381\u2013385 (1991).","journal-title":"J. Infect. Dis."},{"key":"BFnrmicro1048_CR36","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/0035-9203(92)90310-9","volume":"86","author":"CP Chijioke","year":"1992","unstructured":"Chijioke, C. P. & Okonkwo, P. Adverse events following mass ivermectin therapy for onchocerciasis. Trans. R. Soc. Trop. Med. Hyg. 86, 284\u2013286 (1992).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR37","first-page":"707","volume":"67","author":"G De Sole","year":"1989","unstructured":"De Sole, G. et al. Adverse reactions after large-scale treatment of onchocerciasis with ivermectin: combined results from eight community trials. Bull. World Health Organ. 67, 707\u2013719 (1989).","journal-title":"Bull. World Health Organ."},{"key":"BFnrmicro1048_CR38","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","volume":"350","author":"J Gardon","year":"1997","unstructured":"Gardon, J. et al. Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection. Lancet 350, 18\u201322 (1997).","journal-title":"Lancet"},{"issue":"Suppl.","key":"BFnrmicro1048_CR39","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1186\/1475-2883-2-S1-S3","volume":"2","author":"NAY Twum-Danso","year":"2003","unstructured":"Twum-Danso, N. A. Y. Serious adverse events following treatment with ivermectin for onchocerciais control: a review of reported cases. Filaria J. 2 (Suppl.), S3\u2013S13 (2003).","journal-title":"Filaria J."},{"key":"BFnrmicro1048_CR40","unstructured":"WHO. Strategies for ivermectin distribution through primary health care systems. WHO\/PBL\/91. 24. (WHO, Geneva, 1991)."},{"key":"BFnrmicro1048_CR41","unstructured":"Mectizan Donation Programme. Newsletter of the Mectizan Donation Programme. [online], < http:\/\/www.mectizan.org\/mpn33\/mpnhtml336.htm > (2004)."},{"key":"BFnrmicro1048_CR42","doi-asserted-by":"publisher","first-page":"A16","DOI":"10.1111\/j.1365-3156.2004.01210.x","volume":"9","author":"HR Waters","year":"2004","unstructured":"Waters, H. R. et al. Economic evaluation of Mectizan distribution. Trop. Med. Int. Health 9, A16\u2013A25 (2004).","journal-title":"Trop. Med. Int. Health"},{"key":"BFnrmicro1048_CR43","doi-asserted-by":"publisher","first-page":"A26","DOI":"10.1111\/j.1365-3156.2004.01211.x","volume":"9","author":"G Burnham","year":"2004","unstructured":"Burnham, G. & Mebrahtu, T. The delivery of ivermectin (Mectizan). Trop. Med. Int. Health 9, A26\u2013A44 (2004).","journal-title":"Trop. Med. Int. Health"},{"key":"BFnrmicro1048_CR44","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1046\/j.1365-3156.1998.00304.x","volume":"3","author":"O Onwujekwe","year":"1998","unstructured":"Onwujekwe, O. et al. Willingness to pay for community-based ivermectin distribution: a study of three onchocerciasis endemic communities in Nigeria. Trop. Med. Int. Health 3, 802\u2013808 (1998).","journal-title":"Trop. Med. Int. Health"},{"key":"BFnrmicro1048_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0168-8510(01)00226-3","volume":"62","author":"O Onwujekwe","year":"2002","unstructured":"Onwujekwe, O. et al. Community-directed treatment with ivermectin in two Nigerian communities: an analysis of first year start-up processes, costs and consequences. Health Policy 62, 31\u201351 (2002).","journal-title":"Health Policy"},{"key":"BFnrmicro1048_CR46","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(97)02231-9","volume":"350","author":"DG Addis","year":"1997","unstructured":"Addis, D. G. et al. Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children. Lancet 350, 480\u2013484 (1997).","journal-title":"Lancet"},{"key":"BFnrmicro1048_CR47","doi-asserted-by":"publisher","first-page":"652","DOI":"10.4269\/ajtmh.1993.48.652","volume":"48","author":"FL Njoo","year":"1993","unstructured":"Njoo, FL. et al. Concurrent parastic infections in onchocerciasis and the occurrence of adverse reactions after ivermectin treatment. Am. J. Trop. Med. Hyg. 48, 652\u2013657 (1993).","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR48","doi-asserted-by":"publisher","first-page":"495","DOI":"10.2165\/00128072-200103070-00002","volume":"3","author":"LS Stephenson","year":"2001","unstructured":"Stephenson, L. S. Optimising the benefits of anthelmintic treatment in children. Paediatr. Drugs 3, 495\u2013508 (2001).","journal-title":"Paediatr. Drugs"},{"key":"BFnrmicro1048_CR49","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/0035-9203(91)90255-W","volume":"85","author":"CL Dunne","year":"1991","unstructured":"Dunne, C. L. et al. A field study of the effects of ivermectin on ectoparasites of man. Trans. R. Soc. Trop. Med. Hyg. 85, 550\u2013551 (1991).","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"BFnrmicro1048_CR50","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0166-6851(98)00087-5","volume":"95","author":"WJ Blackhall","year":"1998","unstructured":"Blackhall, W. J. et al. Selection at a P-glycoprotein gene in ivermectin and moxidectin-selected strains of Haemonchus contortus. Mol. Biochem. Parasitol. 95, 193\u2013201 (1998).","journal-title":"Mol. Biochem. Parasitol."},{"key":"BFnrmicro1048_CR51","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/S0020-7519(98)00071-X","volume":"28","author":"MS Kwa","year":"1998","unstructured":"Kwa, M. S. et al. Use of P-glycoprotein gene probes to investigate anthelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus. Int. J. Parasitol. 28, 1235\u20131240 (1998).","journal-title":"Int. J. Parasitol."},{"key":"BFnrmicro1048_CR52","unstructured":"Eckholm, E. Conquering an ancient scourge; river blindness. New York Times Magazine, 20\u201327 (Jan 8, 1989)."},{"key":"BFnrmicro1048_CR53","first-page":"287","volume-title":"Macrolide Antibiotics","author":"H Ikeda","year":"2002","unstructured":"Ikeda, H. & \u00d5mura, S. in Macrolide Antibiotics (ed. \u00d5mura, S.) 287\u2013326 (Academic Press, San Diego, 2002)."}],"container-title":["Nature Reviews Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1048","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T04:51:48Z","timestamp":1734670308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrmicro1048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["BFnrmicro1048"],"URL":"https:\/\/doi.org\/10.1038\/nrmicro1048","relation":{},"ISSN":["1740-1526","1740-1534"],"issn-type":[{"value":"1740-1526","type":"print"},{"value":"1740-1534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}