{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:22:12Z","timestamp":1792156932525,"version":"4.4.0"},"reference-count":116,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Microbiol"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1038\/nrmicro1286","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T14:35:01Z","timestamp":1133447701000},"page":"937-947","source":"Crossref","is-referenced-by-count":1522,"title":["Fungal secondary metabolism \u2014 from biochemistry to genomics"],"prefix":"10.1038","volume":"3","author":[{"given":"Nancy P.","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan W.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrmicro1286_CR1","volume-title":"Fungal Metabolites","author":"WB Turner","year":"1971","unstructured":"Turner, W. B. Fungal Metabolites (Academic Press, London, 1971)."},{"key":"BFnrmicro1286_CR2","volume-title":"Fungal Metabolites II","author":"WB Turner","year":"1983","unstructured":"Turner, W. B. & Aldridge, D. C. Fungal Metabolites II (Academic Press, London, 1983)."},{"key":"BFnrmicro1286_CR3","volume-title":"Handbook of Secondary Fungal Metabolites Volumes 1\u20133","author":"R Cole","year":"2003","unstructured":"Cole, R. & Schweikert, M. Handbook of Secondary Fungal Metabolites Volumes 1\u20133 (Elsevier, Amsterdam, 2003)."},{"key":"BFnrmicro1286_CR4","volume-title":"Recombinant DNA and the Production of Small Molecules","author":"J Davies","year":"1985","unstructured":"Davies, J. Recombinant DNA and the Production of Small Molecules (ASM Press, Washington DC, 1985)."},{"key":"BFnrmicro1286_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2164(08)70316-2","volume":"34","author":"JW Bennett","year":"1989","unstructured":"Bennett, J. W. & Bentley, R. What's in a name? Microbial secondary metabolism. Adv. Appl. Microbiol. 34, 1\u201328 (1989).","journal-title":"Adv. Appl. Microbiol."},{"key":"BFnrmicro1286_CR6","unstructured":"Ciba Foundation Symposium 171. Secondary Metabolites: Their Function and Evolution (John Wiley & Sons, Chicester, 1992)."},{"key":"BFnrmicro1286_CR7","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1098\/rspb.1950.0001","volume":"136","author":"H Raistrick","year":"1950","unstructured":"Raistrick, H. A region of biosynthesis. Proc. R. Soc. Lond. B Biol. Sci. 136, 481\u2013508 (1950).","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"BFnrmicro1286_CR8","first-page":"49","volume-title":"Handbook of Industrial Mycology","author":"F Pelaez","year":"2005","unstructured":"Pelaez, F. Biological activities of fungal metabolites. in Handbook of Industrial Mycology (ed. An, Z.) 49\u201392 (Marcel Dekker, New York, 2005)."},{"key":"BFnrmicro1286_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1074-5521(00)90068-1","volume":"8","author":"I Fujii","year":"2001","unstructured":"Fujii, I., Watanabe, A., Sankawa, U. & Ebizuka, Y. Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans. Chem. Biol. 8, 189\u2013197 (2001).","journal-title":"Chem. Biol."},{"key":"BFnrmicro1286_CR10","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1126\/science.284.5418.1368","volume":"284","author":"J Kennedy","year":"1999","unstructured":"Kennedy, J. et al. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284, 1368\u20131372 (1999). The first biochemical dissection of fungal polyketide synthase and use of the model system A. nidulans to help decipher lovastatin assembly in A. terreus.","journal-title":"Science"},{"key":"BFnrmicro1286_CR11","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev.micro.53.1.411","volume":"53","author":"R Bentley","year":"1999","unstructured":"Bentley, R. & Bennett, J. W. Constructing polyketides: from Collie to combinatorial biosynthesis. Annu. Rev. Microbiol. 53, 411\u2013446 (1999).","journal-title":"Annu. Rev. Microbiol."},{"key":"BFnrmicro1286_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1126\/science.2024119","volume":"252","author":"S Donadio","year":"1991","unstructured":"Donadio S., Staver, M. J., McAlpine, J. B., Swanson, S. J. & Katz, L. Modular organization of gene required for complex polyketide biosynthesis. Science 252, 675\u2013679 (1991).","journal-title":"Science"},{"key":"BFnrmicro1286_CR13","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1073\/pnas.93.4.1418","volume":"93","author":"D Brown","year":"1996","unstructured":"Brown, D. et al. Twenty-five co-regulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl Acad. Sci. USA 93, 1418\u20131422 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1286_CR14","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1128\/AEM.70.3.1253-1262.2004","volume":"70","author":"J Yu","year":"2004","unstructured":"Yu, J. et al. Clustered pathway genes in aflatoxin biosynthesis. Appl. Environ. Microbiol. 70, 1253\u20131262 (2004).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR15","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/S0014-5793(04)00327-8","volume":"564","author":"J,D Yu","year":"2004","unstructured":"Yu, J., D. Bhatnagar, D. & Cleveland, T. D. Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus. FEBS Lett. 564, 126\u2013130 (2004).","journal-title":"FEBS Lett."},{"key":"BFnrmicro1286_CR16","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1146\/annurev.micro.58.030603.123615","volume":"58","author":"R Finking","year":"2004","unstructured":"Finking, R. & Marahiel, M. Biosynthesis of nonribosomal peptides. Annu. Rev. Microbiol. 58, 453\u2013488 (2004).","journal-title":"Annu. Rev. Microbiol."},{"key":"BFnrmicro1286_CR17","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1002\/j.1460-2075.1990.tb07461.x","volume":"9","author":"DJ Smith","year":"1990","unstructured":"Smith, D. J., Earl, A. J., Turner, G. The multifunctional peptide synthetase performing the first step of penicillin biosynthesis in Penicillium chrysogenum is a 421073 dalton protein similar to Bacillus brevis peptide antibiotic synthetases. EMBO J. 9, 2743\u20132750 (1990). First indication of the multimodular structure of peptide synthetases: three modules were detected in this tripeptide synthetase.","journal-title":"EMBO J."},{"key":"BFnrmicro1286_CR18","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1006\/jmbi.2000.3566","volume":"297","author":"W Kallow","year":"2000","unstructured":"Kallow, W., Kennedy, J., Arezi, B., Turner, G. & von Doehren, H. Thioesterase domain of \u03b4-(L-a-aminoadipyl)-L-cysteinyl-D-valine synthetase: alteration of stereospecificity by site-directed mutagenesis. J. Mol. Biol. 297, 395\u2013408 (2000).","journal-title":"J. Mol. Biol."},{"key":"BFnrmicro1286_CR19","doi-asserted-by":"publisher","first-page":"20862","DOI":"10.1074\/jbc.M201654200","volume":"277","author":"A Wiest","year":"2002","unstructured":"Wiest, A. et al. Identification of peptaibols from Trichoderma virens and cloning of a peptaibol synthetase. J. Biol. Chem. 277, 20862\u201320868 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnrmicro1286_CR20","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/BF00313798","volume":"26","author":"G Weber","year":"1994","unstructured":"Weber, G., Schorgendorfer, K., Schneider-Scherzer, E. & Leitner, E. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26, 120\u2013125 (1994).","journal-title":"Curr. Genet."},{"key":"BFnrmicro1286_CR21","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1046\/j.1365-2958.2003.03586.x","volume":"49","author":"M Eisendle","year":"2003","unstructured":"Eisendle, M., Oberegger, H., Zadra, I. & Haas, H. The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding L-ornithine N5-monooxygenase (sidA) and a nonribosomal peptide synthetase (sidC). Mol. Microbiol. 49, 359\u2013375 (2003).","journal-title":"Mol. Microbiol."},{"key":"BFnrmicro1286_CR22","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1128\/AEM.67.8.3514-3522.2001","volume":"67","author":"B Tudzynski","year":"2001","unstructured":"Tudzynski, B., Hedden, P. Carrera, E. & Gaskin, P. The 450\u20134 gene of Gibberella fujikuroi encodes ent-kaurine oxidase in the gibberellin biosynthesis pathway. Appl. Environ. Microbiol. 67, 3514\u20133522 (2001).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR23","doi-asserted-by":"publisher","first-page":"13543","DOI":"10.1073\/pnas.231313098","volume":"98","author":"MJ Rynkiewicz","year":"2001","unstructured":"Rynkiewicz, M. J., Cane, D. E. & Christianson, D. W. Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade. Proc. Natl Acad. Sci. USA 98, 13543\u201313548 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1286_CR24","doi-asserted-by":"publisher","first-page":"25533","DOI":"10.1074\/jbc.M000433200","volume":"275","author":"J Carruthers","year":"2000","unstructured":"Carruthers, J., Kang, I., Rynkiewicz, M., Cane, D. & Christianson, D. Crystal structure determination of aristolochene synthase from the cheese mold, Penicillium roquefortii. J. Biol. Chem. 275, 25533\u201325539 (2000). Structural determination of a fungal terpenecyclase, showing that whereas the primary sequences of terpene cyclases are not well conserved between plants and fungi, the tertiary structure is conserved. Also, terpene cyclases might all be derived from a common ancestor.","journal-title":"J. Biol. Chem."},{"key":"BFnrmicro1286_CR25","doi-asserted-by":"publisher","first-page":"5064","DOI":"10.1128\/MCB.10.10.5064","volume":"10","author":"T Schmidhauser","year":"1990","unstructured":"Schmidhauser, T., Lauter, F., Russo, V. & Yanofsky, C. Cloning, sequence, and photoregulation of al-1, a carotenoid biosynthetic gene of Neurospora crassa. Mol. Cell. Biol. 10, 5064\u20135070 (1990).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrmicro1286_CR26","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1046\/j.1365-2958.2001.02265.x","volume":"39","author":"C Young","year":"2001","unstructured":"Young, C., McMillan, L., Telfer, E. & Scott, B. Molecular cloning and genetic analysis of an indole-diterpene gene cluster from Penicillium paxilli. Mol. Microbiol. 39, 754\u2013764 (2001)","journal-title":"Mol. Microbiol."},{"key":"BFnrmicro1286_CR27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s004380050950","volume":"261","author":"P Tudzynski","year":"1999","unstructured":"Tudzynski, P. et al. Evidence for an ergot alkaloid gene cluster in Claviceps purpurea. Mol. Gen. Genet. 261, 133\u2013141 (1999). Identification of the ergot alkaloid gene cluster, which includes an NRPS required for ergotamine biosynthesis.","journal-title":"Mol. Gen. Genet."},{"key":"BFnrmicro1286_CR28","doi-asserted-by":"publisher","first-page":"3068","DOI":"10.1002\/anie.200301646","volume":"42","author":"F von Nussbaum","year":"2003","unstructured":"von Nussbaum, F. Stephacidin B \u2014 a new stage of complexity within prenylated indole alkaloids from fungi. Angew. Chem. Int. Ed. Engl. 42, 3068\u20133071 (2003).","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"BFnrmicro1286_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2164(08)70260-0","volume":"45","author":"JW Bennett","year":"1997","unstructured":"Bennett, J. W., Chang, P. -K. & Bhatnagar, D. One gene to whole pathway: the role of norsolorinic acid in aflatoxin research. Adv. Appl. Microbiol. 45, 1\u201315 (1997).","journal-title":"Adv. Appl. Microbiol."},{"key":"BFnrmicro1286_CR30","first-page":"603","volume-title":"Penicillin Biosynthesis in Aspergillus: 50 Years On","author":"JM Luengo","year":"1994","unstructured":"Luengo, J. M. & Penalva, M. A. Penicillin Biosynthesis in Aspergillus: 50 Years On (eds Martinelli, S. D & Kinghorn, J. R.) 603\u2013638 (Elsevier, Amsterdam,1994)."},{"key":"BFnrmicro1286_CR31","volume-title":"Ergot Alkaloids: Chemistry, Biological Effects, Biotechnology","author":"Z Rehacek","year":"1990","unstructured":"Rehacek, Z. & Sajdl, P. Ergot Alkaloids: Chemistry, Biological Effects, Biotechnology (Academia, Prague, 1990)"},{"key":"BFnrmicro1286_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/fgbi.1997.0970","volume":"21","author":"N Keller","year":"1997","unstructured":"Keller, N. & Hohn, T. Metabolic pathway gene clusters in filamentous fungi. Fungal Genet. Biol. 21, 17\u201329 (1997).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR33","first-page":"355","volume-title":"Handbook of Industrial Microbiology","author":"Y-Q Zhang","year":"2005","unstructured":"Zhang, Y. -Q., Wilkinson, H., Keller, N. P. & Tsitsigiannis, D. Secondary metabolite gene clusters. in Handbook of Industrial Microbiology (ed. An, Z.) 355\u2013386 (Marcel Dekker, New York, 2005)."},{"key":"BFnrmicro1286_CR34","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1128\/jb.174.9.3056-3064.1992","volume":"174","author":"S Gutierrez","year":"1992","unstructured":"Gutierrez, S., Velasco, J., Fernandez, F. J. & Martin, J. F. The cefG gene of Cephalosporium acremonium is linked to the cefEF gene and encodes a deacetylcephalosporin C acetyltransferase closely related to homoserine O-acetyltransferase. J. Bacteriol. 174, 3056\u20133064 (1992).","journal-title":"J. Bacteriol."},{"key":"BFnrmicro1286_CR35","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s00438-002-0736-8","volume":"268","author":"Y Abe","year":"2002","unstructured":"Abe, Y. et al. Effect of increased dosage of the ML-236B (compactin) biosynthetic gene cluster on ML-236B production in Penicillium citrinum. Mol. Gen. Genet. 268, 130\u2013137 (2002).","journal-title":"Mol. Gen. Genet."},{"key":"BFnrmicro1286_CR36","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/s00438-002-0755-5","volume":"268","author":"Y Abe","year":"2002","unstructured":"Abe, Y., Ono, C., Hosobuchi, M. & Yoshikawa, H. Functional analysis of mlcR, a regulatory gene for ML-236B (compactin) biosynthesis in Penicillium citrinum. Mol. Genet. Genomics 268, 352\u2013361 (2002).","journal-title":"Mol. Genet. Genomics"},{"key":"BFnrmicro1286_CR37","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1087-1845(02)00525-X","volume":"38","author":"RH Proctor","year":"2003","unstructured":"Proctor, R. H., Brown, D. W., Plattner, R. D. & Desjardins, A. E. Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis. Fungal Genet. Biol. 38, 237\u2013249 (2003).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR38","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s003440010037","volume":"20","author":"P Hedden","year":"2002","unstructured":"Hedden, P., Phillips, A., Rojas, M., Carrera, C. & Tudzynski, B. Gibberellin biosynthesis in plants and fungi: a case of convergent evolution? J. Plant Growth Regul. 20, 319\u2013331 (2002).","journal-title":"J. Plant Growth Regul."},{"key":"BFnrmicro1286_CR39","first-page":"298","volume":"52","author":"B Tudzynski","year":"1999","unstructured":"Tudzynski, B. Biosynthesis of gibberellins in Gibberella fujikuroi: biomolecular aspects. Appl. Environ. Microbiol. 52, 298\u2013310 (1999).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1006\/fgbi.2001.1305","volume":"35","author":"J Ahn","year":"2002","unstructured":"Ahn, J., Cheng, Y. & Walton, J. An extended physical map of the TOX2 locus of Cochliobolus carbonum required for biosynthesis of HC-toxin. Fungal Genet. Biol. 35, 31\u201338 (2002).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR41","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1128\/jb.175.14.4427-4435.1993","volume":"175","author":"N Kimura","year":"1993","unstructured":"Kimura, N. & Tsuge, T. Gene cluster involved in melanin biosynthesis of the filamentous fungus Alternaria alternata. J. Bacteriol. 175, 4427\u20134435 (1993).","journal-title":"J. Bacteriol."},{"key":"BFnrmicro1286_CR42","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1128\/JB.181.20.6469-6477.1999","volume":"181","author":"H Tsai","year":"1999","unstructured":"Tsai, H., Wheeler, M., Chang, Y. & Kwon-Chung, K. A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus. J. Bacteriol. 181, 6469\u20136477 (1999).","journal-title":"J. Bacteriol."},{"key":"BFnrmicro1286_CR43","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/j.1460-2075.1990.tb08168.x","volume":"9","author":"DJ Smith","year":"1990","unstructured":"Smith, D. J. et al. \u03b2-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes. EMBO J. 9, 741\u2013747 (1990). Showed that secondary metabolic genes were clustered in filamentous fungi, and revealed the close relationship between the \u03b2-lactam biosynthetic genes of bacteria and fungi.","journal-title":"EMBO J."},{"key":"BFnrmicro1286_CR44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/MMBR.62.3.547-585.1998","volume":"62","author":"AA Brakhaage","year":"1998","unstructured":"Brakhaage, A. A. Molecular regulation of \u03b2-lactam biosynthesis in filamentous fungi. Microbiol. Mol. Biol. Rev. 62, 547\u2013585 (1998).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"BFnrmicro1286_CR45","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/j.1365-2958.2004.04215.x","volume":"53","author":"D Gardiner","year":"2004","unstructured":"Gardiner, D., Cozijnsen, A., Wilson, L., Pedras, M. & Howlett, B. The sirodesmin biosynthetic gene cluster of the plant pathogenic fungus Leptosphaeria maculans. Mol. Microbiol. 53, 1307\u20131318 (2004).","journal-title":"Mol. Microbiol."},{"key":"BFnrmicro1286_CR46","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s004380050666","volume":"257","author":"S Trapp","year":"1998","unstructured":"Trapp, S., Hohn T., McCormick, S. & Jarvis, B. Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum. Mol. Gen. Genet. 257, 421\u2013432 (1998).","journal-title":"Mol. Gen. Genet."},{"key":"BFnrmicro1286_CR47","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1006\/fgbi.2001.1256","volume":"32","author":"D Brown","year":"2001","unstructured":"Brown, D., McCormick, S., Alexander, N., Proctor, R. & Desjardins, A. A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. Fungal Genet. Biol. 32, 121\u2013133 (2001).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR48","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1128\/AEM.61.5.1923-1930.1995","volume":"61","author":"R Proctor","year":"1995","unstructured":"Proctor, R, Hohn, T., McCormick, S. & Desjardins, A. Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides. Appl. Environ. Microbiol. 61, 1923\u20131930 (1995).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR49","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1128\/AEM.60.7.2408-2414.1994","volume":"60","author":"C Woloshuk","year":"1994","unstructured":"Woloshuk, C. et al. Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis. Appl. Environ. Microbiol. 60, 2408\u20132414 (1994). Identification of the first Zn(II) 2 Cys 6 that regulates a secondary metabolite gene cluster.","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR50","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1046\/j.1365-2958.1998.00907.x","volume":"28","author":"M Fernandes","year":"1998","unstructured":"Fernandes, M., Keller, N. & Adams, T. Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol. Microbiol. 28, 1355\u20131365 (1998).","journal-title":"Mol. Microbiol."},{"key":"BFnrmicro1286_CR51","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1128\/AEM.61.6.2372-2377.1995","volume":"61","author":"P Chang","year":"1995","unstructured":"Chang, P., Ehrlich, K., Yu, J., Bhatnagar, D. & Cleveland, T. Increased expression of Aspergillus parasiticus aflR, encoding a sequence-specific DNA-binding protein, relieves nitrate inhibition of aflatoxin biosynthesis. Appl. Environ. Microbiol. 61, 2372\u20132377 (1995).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFnrmicro1286_CR52","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/BF02426959","volume":"29","author":"J Yu","year":"1996","unstructured":"Yu, J. et al. Conservation of structure and function of the aflatoxin regulatory gene aflR from Aspergillus nidulans and A. flavus. Curr. Genet. 29, 549\u2013555 (1996).","journal-title":"Curr. Genet."},{"key":"BFnrmicro1286_CR53","doi-asserted-by":"publisher","first-page":"14174","DOI":"10.1073\/pnas.231491298","volume":"98","author":"K Pedley","year":"2001","unstructured":"Pedley, K. & Walton, J. Regulation of cyclic peptide biosynthesis in a plant pathogenic fungus by a novel transcription factor. Proc. Natl Acad. Sci. USA 98, 14174\u201314179 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1286_CR54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.gene.2004.08.002","volume":"342","author":"EK Schmitt","year":"2004","unstructured":"Schmitt, E. K., Hoff, B. & Kuck, U. AcFKH1, a novel member of the forkhead family, associates with the RFX transcription factor CPCR1 in the cephalosporin C-producing fungus Acremonium chrysogenum. Gene 342, 269\u2013281 (2004). In contrast to penicillin regulation in A. nidulans , cephalosporin regulation is by a forkhead transcription factor in Acremonium.","journal-title":"Gene"},{"key":"BFnrmicro1286_CR55","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1046\/j.1432-1327.1998.2510758.x","volume":"251","author":"O Litzka","year":"1998","unstructured":"Litzka, O., Papagiannopolus, P., Davis, M., Hynes, M. & Brakhage, A. The penicillin regulator PENR1 of Aspergillus nidulans is a HAP-like transcriptional complex. Eur. J. Biochem. 251, 758\u2013767 (1998). A HAP-like CCAAT-binding complex regulates penicillin biosynthesis.","journal-title":"Eur. J. Biochem."},{"key":"BFnrmicro1286_CR56","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/fgbi.1999.1136","volume":"27","author":"A Brakhage","year":"1999","unstructured":"Brakhage, A. et al. HAP-like CCAAT-binding complexes in filamentous fungi: implications for biotechnology. Fungal Genet. Biol. 27, 243\u2013252 (1999).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR57","volume-title":"Secondary Metabolism and Differentiation in Fungi","author":"J Bennett","year":"1983","unstructured":"Bennett, J. & Ciegler, A. (eds) Secondary Metabolism and Differentiation in Fungi. (Marcel Dekker, New York, 1983)."},{"key":"BFnrmicro1286_CR58","volume-title":"Physiology of Industrial Fungi","author":"DR Berry","year":"1988","unstructured":"Berry, D. R. (ed.) Physiology of Industrial Fungi (Blackwell Scientific Publishing, Oxford, 1988)."},{"key":"BFnrmicro1286_CR59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S1087-1845(02)00509-1","volume":"38","author":"K Ehrlich","year":"2003","unstructured":"Ehrlich, K., Montalbano, B. & Cotty, P. Sequence comparison of aflR from different Aspergillus species provides evidence for variability in regulation of aflatoxin production. Fungal Genet. Biol. 38, 63\u201374 (2003).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR60","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s004380050950","volume":"261","author":"B Tudzynski","year":"1999","unstructured":"Tudzynski, B., Homann, V., Feng, B. & Marzluf, G. Isolation, characterization and disruption of the areA nitrogen regulatory gene of Gibberella fujikuroi. Mol. Gen. Genet. 261, 106\u2013114 (1999).","journal-title":"Mol. Gen. Genet."},{"key":"BFnrmicro1286_CR61","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/BF00376804","volume":"15","author":"C Dowzer","year":"1989","unstructured":"Dowzer, C. & Kelly, J. Cloning of the creA gene from Aspergillus nidulans: a gene involved in carbon catabolite repression. Curr. Genet. 15, 457\u2013459 (1989).","journal-title":"Curr. Genet."},{"key":"BFnrmicro1286_CR62","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1002\/j.1460-2075.1990.tb08250.x","volume":"9","author":"B Kudla","year":"1990","unstructured":"Kudla, B. et al. The regulatory gene areA mediation nitrogen metabolite repression in Aspergillus nidulans. Mutations affecting specificity of gene activation alter a loop residue of a putative zinc finger. EMBO J. 9, 1355\u20131364 (1990).","journal-title":"EMBO J."},{"key":"BFnrmicro1286_CR63","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1002\/j.1460-2075.1995.tb07056.x","volume":"14","author":"J Tilburn","year":"1995","unstructured":"Tilburn, J. et al. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J. 14, 779\u2013790 (1995). Important contribution that showed that pH regulates the penicillin gene cluster through a global transcription factor, PacC.","journal-title":"EMBO J."},{"key":"BFnrmicro1286_CR64","doi-asserted-by":"publisher","first-page":"2355","DOI":"10.1128\/JB.182.9.2355-2362.2000","volume":"182","author":"J Martin","year":"2000","unstructured":"Martin, J. Molecular control of expression of penicillin biosynthesis genes in fungi: regulatory proteins interact with a bidirectional promoter region. J. Bacteriol. 182, 2355\u20132362 (2000).","journal-title":"J. Bacteriol."},{"key":"BFnrmicro1286_CR65","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-09838-7","volume-title":"Secondary Metabolism in Microorganisms, Plants and Animals","author":"M Luckner","year":"1990","unstructured":"Luckner, M. Secondary Metabolism in Microorganisms, Plants and Animals (Springer\u2013Verlag, Berlin, 1990)."},{"key":"BFnrmicro1286_CR66","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0953-7562(09)80411-5","volume":"98","author":"S Kale","year":"1994","unstructured":"Kale, S., Bhatnagar D. & Bennett, J. Isolation and characterization of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production. Mycol. Res. 98, 645\u2013652 (1994).","journal-title":"Mycol. Res."},{"key":"BFnrmicro1286_CR67","first-page":"3999","volume":"62","author":"S Kale","year":"1996","unstructured":"Kale, S., Cary, J., Bhatnagar, D. & Bennett, J. Characterization of an experimentally induced, nonaflatoxigenic variant strains of Aspergillus parasiticus. Appl. Environ. Microbiol. 62, 3999\u20133404 (1996).","journal-title":"Microbiol."},{"key":"BFnrmicro1286_CR68","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1017\/S0953756203007998","volume":"107","author":"S Kale","year":"2003","unstructured":"Kale, S. et al. Genetic analysis of morphological variants of Aspergillus parasiticus deficient in secondary metabolite production. Mycol. Res. 107, 831\u2013840 (2003).","journal-title":"Mycol. Res."},{"key":"BFnrmicro1286_CR69","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s004380000335","volume":"264","author":"R Zhou","year":"2000","unstructured":"Zhou, R., Rasooly, R. & Linz, J. Isolation and analysis of fluP, a gene associated with hyphal grown and sporulation in Aspergillus parasiticus. Mol. Gen. Genet. 264, 514\u2013520 (2000).","journal-title":"Mol. Gen. Genet."},{"key":"BFnrmicro1286_CR70","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1128\/MMBR.66.3.447-459.2002","volume":"66","author":"A Calvo","year":"2002","unstructured":"Calvo, A., Wilson, R., Bok, J. & Keller, N. Relationship between secondary metabolism and fungal development. Mol. Microbiol. Rev. 66, 447\u2013459 (2002).","journal-title":"Mol. Microbiol. Rev."},{"key":"BFnrmicro1286_CR71","doi-asserted-by":"publisher","first-page":"4916","DOI":"10.1093\/emboj\/16.16.4916","volume":"16","author":"J Hicks","year":"1997","unstructured":"Hicks, J., Yu, J., Keller, N. & Adams, T. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G \u03b1 protein-dependent signaling pathway. EMBO J. 16, 4916\u20134923 (1997). This paper reported the genetic connection of sporulation and secondary metabolism through a G-protein signalling pathway.","journal-title":"EMBO J."},{"key":"BFnrmicro1286_CR72","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/genetics\/157.2.591","volume":"157","author":"K Shimizu","year":"2001","unstructured":"Shimizu, K. & Keller, N. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157, 591\u2013600 (2001).","journal-title":"Genetics"},{"key":"BFnrmicro1286_CR73","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1023\/B:MYCO.0000041841.71648.6e","volume":"158","author":"L Roze","year":"2004","unstructured":"Roze, L., Beaudry, R., Keller, N. & Linz, J. Regulation of aflatoxin synthesis by FadA\/cAMP\/protein kinase A signaling in Aspergillus parasiticus. Mycopathologia 158, 219\u2013232 (2004).","journal-title":"Mycopathologia"},{"key":"BFnrmicro1286_CR74","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/genetics\/165.3.1095","volume":"165","author":"K Shimizu","year":"2003","unstructured":"Shimizu, K., Hicks, J., Huang T. -P. & Keller, N. P. Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans. Genetics 165, 1095\u20131104 (2003).","journal-title":"Genetics"},{"key":"BFnrmicro1286_CR75","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1128\/EC.3.2.527-535.2004","volume":"3","author":"J Bok","year":"2004","unstructured":"Bok, J. & Keller, N. LaeA, a regulator of secondary metabolism in Aspergillus. Euk. Cell 3, 527\u2013535 (2004). Discovery of novel global regulator of several Aspergillus secondary metabolites.","journal-title":"Euk. Cell"},{"key":"BFnrmicro1286_CR76","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1046\/j.1365-2958.2000.02166.x","volume":"38","author":"A Tag","year":"2000","unstructured":"Tag, A. et al. G-protein signalling mediates differential production of toxic secondary metabolites. Mol. Microbiol. 38, 658\u2013665 (2000).","journal-title":"Mol. Microbiol."},{"key":"BFnrmicro1286_CR77","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1094\/MPMI.2004.17.5.537","volume":"17","author":"C Schulze Gronover","year":"2004","unstructured":"Schulze Gronover, C., Schorn, C. & Tydzynski, B. Identification of Botrytis cinerea genes up-regulated during infection and controlled by the G \u03b1 subunit BCG1 using suppression subtractive hybridization (SSH). Mol. Plant Microbe Interact. 17, 537\u2013546 (2004).","journal-title":"Mol. Plant Microbe Interact."},{"key":"BFnrmicro1286_CR78","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.fgb.2005.04.009","volume":"42","author":"B Reithner","year":"2005","unstructured":"Reithner, B. et al. The G protein \u03b1 subunit Tga1 of Trichoderma atroviride is involved in chitinase formation and differential production of antifungal metabolites. Fungal Genet. Biol. 42, 749\u2013760 (2005).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR79","doi-asserted-by":"publisher","first-page":"14122","DOI":"10.1073\/pnas.93.24.14122","volume":"93","author":"S Gao","year":"1996","unstructured":"Gao, S. & Nuss, D. Distinct roles for two G protein \u03b1 subunits in fungal virulence, morphology, and reproduction revealed by targeted gene disruption. Proc. Natl Acad. Sci. USA 93, 14122\u201314127 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1286_CR80","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1093\/genetics\/143.4.1843","volume":"143","author":"JG Lawrence","year":"1996","unstructured":"Lawrence, J. G. & Roth, J. R. Selfish operons: horizontal transfer may drive the evolution of gene clusters. Genetics 143, 1843\u20131860 (1996).","journal-title":"Genetics"},{"key":"BFnrmicro1286_CR81","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0966-842X(97)01110-4","volume":"5","author":"JG Lawrence","year":"1997","unstructured":"Lawrence, J. G. Selfish operons and speciation by gene transfer. Trends Microbiol. 5, 355\u2013359 (1997).","journal-title":"Trends Microbiol."},{"key":"BFnrmicro1286_CR82","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S1369-5274(99)00010-7","volume":"2","author":"JG Lawrence","year":"1999","unstructured":"Lawrence, J. G. Gene transfer, speciation, and the evolution of bacterial genomes. Curr. Opin. Microbiol. 2, 519\u2013523 (1999).","journal-title":"Curr. Opin. Microbiol."},{"key":"BFnrmicro1286_CR83","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev.phyto.38.1.325","volume":"38","author":"U Rosewich","year":"2000","unstructured":"Rosewich, U. & Kistler, H. Role of horizontal gene transfer in the evolution of fungi. Annu. Rev. Phytopathol. 38, 325\u2013363 (2000).","journal-title":"Annu. Rev. Phytopathol."},{"key":"BFnrmicro1286_CR84","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1006\/fgbi.2000.1224","volume":"30","author":"JJ Walton","year":"2000","unstructured":"Walton, J. J. Horizontal gene transfer and the evolution of secondary metabolite gene clusters in fungi: an hypothesis. Fungal Genet. Biol. 30, 167\u2013171 (2000).","journal-title":"Fungal Genet. Biol."},{"key":"BFnrmicro1286_CR85","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0968-0004(92)90335-7","volume":"17","author":"MW Smith","year":"1992","unstructured":"Smith, M. W., Feng, D. -F. & Doolittle, R. F. Evolution by acquisition: the case for horizontal gene transfers. Trends Biochem. Sci. 17, 489\u2013493 (1992).","journal-title":"Trends Biochem. Sci."},{"key":"BFnrmicro1286_CR86","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1126\/science.1064413","volume":"293","author":"M Litt","year":"2001","unstructured":"Litt, M., Simpson, M., Gaszner, M., Allis, D. & Felsenfeld, G. Correlation between histone lysine methylation and developmental changes at the chicken \u03b2-globin locus. Science 293, 2453\u20132455 (2001).","journal-title":"Science"},{"key":"BFnrmicro1286_CR87","doi-asserted-by":"publisher","first-page":"6883","DOI":"10.1073\/pnas.102179399","volume":"99","author":"F Recillas-Targa","year":"2002","unstructured":"Recillas-Targa, F. et al. Position-effect protection and enhancer blocking by the chicken \u03b2-globin insulator are separable activities. Proc. Natl Acad. Sci. USA 99, 6883\u20136888 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrmicro1286_CR88","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1126\/science.1064150","volume":"293","author":"K Noma","year":"2001","unstructured":"Noma, K., Allis, C. & Grewal, S. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Science 293, 1150\u20131155 (2001).","journal-title":"Science"},{"key":"BFnrmicro1286_CR89","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1210\/er.2004-0008","volume":"26","author":"DY Lee","year":"2005","unstructured":"Lee, D. Y., Teyssier, C., Strahl, B. D. & Stallcup, M. R. Role of protein methylation I regulation of transcription. Endocr. Rev. 26, 147\u2013170 (2005).","journal-title":"Endocr. Rev."},{"key":"BFnrmicro1286_CR90","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1039\/jr9610002085","volume":"5","author":"JF Spilsbury","year":"1961","unstructured":"Spilsbury, J. F. & Wilkinson, S. The isolation of festuclavine and two new clavine alkaloids from Aspergillus fumigatus Fres. J. Chem. Soc. 5, 2085\u20132091 (1961).","journal-title":"J. Chem. Soc."},{"key":"BFnrmicro1286_CR91","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1021\/jf60212a015","volume":"25","author":"RJ Cole","year":"1977","unstructured":"Cole, R. J. et al. Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage. J. Agric. Food Chem. 25, 826\u2013830 (1977).","journal-title":"J. Agric. Food Chem."},{"key":"BFnrmicro1286_CR92","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S1074-5521(00)00091-0","volume":"7","author":"GL Challis","year":"2000","unstructured":"Challis, G. L, Ravel, J. & Townsend, C. A. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem. Biol. 7, 211\u2013224 (2000).","journal-title":"Chem. Biol."},{"key":"BFnrmicro1286_CR93","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1002\/cbic.200400138","volume":"5","author":"Z Song","year":"2004","unstructured":"Song, Z., Cox, R. J., Lazarus, C. M. & Simpson, T. J. Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. ChembioChem. 5, 1196\u20131203 (2004).","journal-title":"ChembioChem."},{"key":"BFnrmicro1286_CR94","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1105\/tpc.104.022715","volume":"16","author":"HU Bohnert","year":"2004","unstructured":"Bohnert, H. U. et al. A putative polyketide synthase\/peptide synthetase from Magnaporthe grisea signals pathogen attack to resistant rice. Plant Cell 16, 2499\u20132513 (2004).","journal-title":"Plant Cell"},{"key":"BFnrmicro1286_CR95","doi-asserted-by":"publisher","DOI":"10.2307\/j.ctt1xp3smj","volume-title":"Penicillin: Meeting the Challenge","author":"G Hobby","year":"1985","unstructured":"Hobby, G. Penicillin: Meeting the Challenge (Yale University Press, New Haven, 1985)."},{"key":"BFnrmicro1286_CR96","volume-title":"Miracle Cure: the Story of Penicillin and the Golden Age of Antibiotics","author":"M Wainwright","year":"1990","unstructured":"Wainwright, M. Miracle Cure: the Story of Penicillin and the Golden Age of Antibiotics (Blackwell Publishing, Oxford, 1990)."},{"key":"BFnrmicro1286_CR97","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0065-2164(01)49013-7","volume":"49","author":"J Bennett","year":"2001","unstructured":"Bennett, J. & Chung, K. Alexander Fleming and the discovery of penicillin. Adv. Appl. Microbiol. 49, 163\u2013184 (2001).","journal-title":"Adv. Appl. Microbiol."},{"key":"BFnrmicro1286_CR98","volume-title":"The Mold in Dr Florey's Coat. The Story of the Penicillin Miracle","author":"A Lax","year":"2004","unstructured":"Lax, A. The Mold in Dr Florey's Coat. The Story of the Penicillin Miracle (Henry Holt & Company, New York, 2004)"},{"key":"BFnrmicro1286_CR99","first-page":"175","volume":"38","author":"M Scoutaris","year":"1996","unstructured":"Scoutaris, M. \u201cMoldy Mary\u201d and the Illinois Fruit and Vegetable Company. Pharm. Hist. 38, 175\u2013177 (1996).","journal-title":"Pharm. Hist."},{"key":"BFnrmicro1286_CR100","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1021\/ed081p1462","volume":"81","author":"R Bentley","year":"2004","unstructured":"Bentley, R. The molecular structure of penicillin. J. Chem. Ed. 81, 1462\u20131470 (2004).","journal-title":"J. Chem. Ed."},{"key":"BFnrmicro1286_CR101","first-page":"25","volume-title":"Mycotoxins and Phycotoxins \u2014 Developments in Chemistry, Toxicology and Food Safety","author":"T Kuiper-Goodman","year":"1998","unstructured":"Kuiper-Goodman, T. Food safety: mycotoxins and phycotoxins in perspective. In Mycotoxins and Phycotoxins \u2014 Developments in Chemistry, Toxicology and Food Safety. (eds Miraglia, M., van Edmond, H., Brera, C. & Gilbert, J.) 25\u201348 (Alaken Inc., Fort Collins, 1998)"},{"key":"BFnrmicro1286_CR102","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1126\/science.7302565","volume":"214","author":"RA Squire","year":"1981","unstructured":"Squire, R. A. Ranking animal carcinogens. A proposed regulatory approach. Science 214, 877\u2013880 (1981).","journal-title":"Science"},{"key":"BFnrmicro1286_CR103","volume-title":"The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance","author":"D Eaton","year":"1998","unstructured":"Eaton, D. & Groopman, J. (eds) The Toxicology of Aflatoxins: Human Health, Veterinary, and Agricultural Significance (Academic Press, San Diego, 1998)."},{"key":"BFnrmicro1286_CR104","first-page":"329","volume":"36","author":"G Payne","year":"1998","unstructured":"Payne, G. & Brown, M. Genetics and physiology of aflatoxin biosynthesis. Annu. Rev. Plant Path. 36, 329\u2013362 (1998).","journal-title":"Annu. Rev. Plant Path."},{"key":"BFnrmicro1286_CR105","first-page":"55","volume-title":"The Mycota. Volume XI. Agricultural Applications","author":"J Hicks","year":"2002","unstructured":"Hicks, J., Shimizu, K. & Keller, N. Genetics and biosynthesis of aflatoxins and sterigmatocystin. in The Mycota. Volume XI. Agricultural Applications, (ed. Kempken, F.) 55\u201369 (Springer\u2013Verlag, Berlin, 2002)."},{"key":"BFnrmicro1286_CR106","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1001\/jama.1997.03550050080037","volume":"278","author":"RA Zilinskas","year":"1997","unstructured":"Zilinskas, R. A. Iraq's biological weapons. The past as future? J. Amer. Med. Assoc. 278, 418\u2013424 (1997).","journal-title":"J. Amer. Med. Assoc."},{"key":"BFnrmicro1286_CR107","volume-title":"The Human Factor","author":"G Green","year":"1979","unstructured":"Green, G. The Human Factor (Everyman's Library, London, 1979)."},{"key":"BFnrmicro1286_CR108","unstructured":"Centers for Disease Control and Prevention (CDC). Outbreak of aflatoxin poisoning \u2014 eastern and central provinces, Kenya. January\u2013July 2004. Morb. Mortal. Wkly Rep. 53, 790\u2013793 (2004)."},{"key":"BFnrmicro1286_CR109","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1353\/pbm.1999.0026","volume":"42","author":"JW Bennett","year":"1999","unstructured":"Bennett, J. W. & Bentley, R. Pride and prejudice: the story of ergot. Persp. Biol. Med. 42, 333\u2013355 (1999).","journal-title":"Persp. Biol. Med."},{"key":"BFnrmicro1286_CR110","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1353\/pbm.1991.0062","volume":"34","author":"RF Ulrich","year":"1991","unstructured":"Ulrich, R. F. & Paten, B. M. The rise, decline and fall of LSD. Persp. Biol. Med. 34, 561\u2013578 (1991).","journal-title":"Persp. Biol. Med."},{"key":"BFnrmicro1286_CR111","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1126\/science.769159","volume":"192","author":"L Caporeal","year":"1976","unstructured":"Caporeal, L. Ergotism: the Satan loosed in Salem? Science 192, 21\u201326 (1976).","journal-title":"Science"},{"key":"BFnrmicro1286_CR112","first-page":"355","volume":"70","author":"M Matossian","year":"1982","unstructured":"Matossian, M. Ergot and the Salem witchcraft affair. Am. Scientist 70, 355\u2013357 (1982).","journal-title":"Am. Scientist"},{"key":"BFnrmicro1286_CR113","volume-title":"Acceptable Risk","author":"R Cook","year":"1996","unstructured":"Cook, R. Acceptable Risk (Barkley, New York, 1996)."},{"key":"BFnrmicro1286_CR114","unstructured":"Nierman, W. C. et al. Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature (in the press)."},{"key":"BFnrmicro1286_CR115","doi-asserted-by":"crossref","unstructured":"Galagan, J. et al. Sequencing and comparative analysis of Aspergillus nidulans. Nature (in the press).","DOI":"10.1038\/nature04341"},{"key":"BFnrmicro1286_CR116","doi-asserted-by":"crossref","unstructured":"Machida, M. et al. Genome sequencing and analysis of Aspergillus oryzae. Nature (in the press).","DOI":"10.1038\/nature04300"}],"container-title":["Nature Reviews Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1286","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrmicro1286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:18:59Z","timestamp":1684455539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrmicro1286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":116,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["BFnrmicro1286"],"URL":"https:\/\/doi.org\/10.1038\/nrmicro1286","relation":{},"ISSN":["1740-1526","1740-1534"],"issn-type":[{"value":"1740-1526","type":"print"},{"value":"1740-1534","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}