{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:23Z","timestamp":1791295583081,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1038\/nrneph.2009.43","type":"journal-article","created":{"date-parts":[[2009,4,22]],"date-time":"2009-04-22T07:14:05Z","timestamp":1240384445000},"page":"270-276","source":"Crossref","is-referenced-by-count":268,"title":["Lithium nephrotoxicity revisited"],"prefix":"10.1038","volume":"5","author":[{"given":"Jean-Pierre","family":"Gr\u00fcnfeld","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard C.","family":"Rossier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrneph200943_CR1","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1056\/NEJMra035354","volume":"351","author":"RH Belmaker","year":"2004","unstructured":"Belmaker, R. H. Bipolar disorder. N. Engl. J. Med. 351, 476\u2013486 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph200943_CR2","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/S0140-6736(02)07450-0","volume":"359","author":"B Muller-Oerlinghausen","year":"2002","unstructured":"Muller-Oerlinghausen, B., Berghofer, A. & Bauer, M. Bipolar disorder. Lancet 359, 241\u2013247 (2002).","journal-title":"Lancet"},{"key":"BFnrneph200943_CR3","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.amjmed.2005.11.003","volume":"119","author":"MP Freeman","year":"2006","unstructured":"Freeman, M. P. & Freeman, S. A. Lithium: clinical considerations in internal medicine. Am. J. Med. 119, 478\u2013481 (2006).","journal-title":"Am. J. Med."},{"key":"BFnrneph200943_CR4","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1073\/pnas.0708022105","volume":"105","author":"F Fornai","year":"2008","unstructured":"Fornai, F. et al. Lithium delays progression of amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA 105, 2052\u20132057 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph200943_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3233\/JAD-2008-15204","volume":"15","author":"A Martinez","year":"2008","unstructured":"Martinez, A. & Perez, D. I. GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? J. Alzheimers Dis. 15, 181\u2013191 (2008).","journal-title":"J. Alzheimers Dis."},{"key":"BFnrneph200943_CR6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0272-6386(87)80098-7","volume":"10","author":"R Boton","year":"1987","unstructured":"Boton, R., Gaviria, M. & Batlle, D. C. Prevalence, pathogenesis, and treatment of renal dysfunction associated with chronic lithium therapy. Am. J. Kidney Dis. 10, 329\u2013345 (1987).","journal-title":"Am. J. Kidney Dis."},{"key":"BFnrneph200943_CR7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/ndt\/11.3.457","volume":"11","author":"H Bendz","year":"1996","unstructured":"Bendz, H., Sjodin, I. & Aurell, M. Renal function on and off lithium in patients treated with lithium for 15 years or more. A controlled, prospective lithium-withdrawal study. Nephrol. Dial. Transplant. 11, 457\u2013460 (1996).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph200943_CR8","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1046\/j.1523-1755.2003.00096.x","volume":"64","author":"C Presne","year":"2003","unstructured":"Presne, C. et al. Lithium-induced nephropathy: rate of progression and prognostic factors. Kidney Int. 64, 585\u2013592 (2003).","journal-title":"Kidney Int."},{"key":"BFnrneph200943_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3122\/15572625-12-1-43","volume":"12","author":"KA Stone","year":"1999","unstructured":"Stone, K. A. Lithium-induced nephrogenic diabetes insipidus. J. Am. Board Fam. Pract. 12, 43\u201347 (1999).","journal-title":"J. Am. Board Fam. Pract."},{"key":"BFnrneph200943_CR10","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1172\/JCI117863","volume":"95","author":"D Marples","year":"1995","unstructured":"Marples, D., Christensen, S., Christensen, E. I., Ottosen, P. D. & Nielsen, S. Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J. Clin. Invest. 95, 1838\u20131845 (1995).","journal-title":"J. Clin. Invest."},{"key":"BFnrneph200943_CR11","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1159\/000077593","volume":"97","author":"UH Laursen","year":"2004","unstructured":"Laursen, U. H. et al. Changes of rat kidney AQP2 and Na, K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus. Nephron Exp. Nephrol. 97, e1\u2013e16 (2004).","journal-title":"Nephron Exp. Nephrol."},{"key":"BFnrneph200943_CR12","doi-asserted-by":"publisher","first-page":"F1244","DOI":"10.1152\/ajprenal.00176.2003","volume":"285","author":"YH Kim","year":"2003","unstructured":"Kim, Y. H. et al. Altered expression of renal acid\u2013base transporters in rats with lithium-induced NDI. Am. J. Physiol. Renal Physiol. 285, F1244\u2013F1257 (2003).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR13","doi-asserted-by":"publisher","first-page":"C952","DOI":"10.1152\/ajpcell.00266.2003","volume":"286","author":"BM Christensen","year":"2004","unstructured":"Christensen, B. M. et al. Changes in cellular composition of kidney collecting duct cells in rats with lithium-induced NDI. Am. J. Physiol. Cell Physiol. 286, C952\u2013C964 (2004).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFnrneph200943_CR14","doi-asserted-by":"publisher","first-page":"F39","DOI":"10.1152\/ajprenal.00383.2005","volume":"291","author":"BM Christensen","year":"2006","unstructured":"Christensen, B. M., Kim, Y. H., Kwon, T. H. & Nielsen, S. Lithium treatment induces a marked proliferation of primarily principal cells in rat kidney inner medullary collecting duct. Am. J. Physiol. Renal Physiol. 291, F39\u2013F48 (2006).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR15","doi-asserted-by":"publisher","first-page":"F1198","DOI":"10.1152\/ajprenal.00118.2003","volume":"285","author":"J Nielsen","year":"2003","unstructured":"Nielsen, J. et al. Segment-specific ENaC downregulation in kidney of rats with lithium-induced NDI. Am. J. Physiol. Renal Physiol. 285, F1198\u2013F1209 (2003).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR16","doi-asserted-by":"publisher","first-page":"F1222","DOI":"10.1152\/ajprenal.00321.2005","volume":"290","author":"J Nielsen","year":"2006","unstructured":"Nielsen, J., Kwon, T. H., Frokiaer, J., Knepper, M. A. & Nielsen, S. Lithium-induced NDI in rats is associated with loss of \u03b1-ENaC regulation by aldosterone in CCD. Am. J. Physiol. Renal Physiol. 290, F1222\u2013F1233 (2006).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR17","doi-asserted-by":"publisher","first-page":"F1276","DOI":"10.1152\/ajprenal.00305.2004","volume":"288","author":"A Rojek","year":"2005","unstructured":"Rojek, A. et al. Altered expression of selected genes in kidney of rats with lithium-induced NDI. Am. J. Physiol. Renal Physiol. 288, F1276\u2013F1289 (2005).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR18","doi-asserted-by":"publisher","first-page":"F642","DOI":"10.1152\/ajprenal.00287.2004","volume":"288","author":"R Rao","year":"2005","unstructured":"Rao, R. et al. Lithium treatment inhibits renal GSK-3 activity and promotes cyclooxygenase 2-dependent polyuria. Am. J. Physiol. Renal Physiol. 288, F642\u2013F649 (2005).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR19","doi-asserted-by":"publisher","first-page":"F1053","DOI":"10.1152\/ajprenal.00114.2004","volume":"288","author":"P Kotnik","year":"2005","unstructured":"Kotnik, P. et al. Altered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus. Am. J. Physiol. Renal Physiol. 288, F1053\u2013F1068 (2005).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR20","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1681\/ASN.2005080884","volume":"17","author":"Y Li","year":"2006","unstructured":"Li, Y., Shaw, S., Kamsteeg, E. J., Vandewalle, A. & Deen, P. M. Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylyl cyclase activity. J. Am. Soc. Nephrol. 17, 1063\u20131072 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph200943_CR21","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1681\/ASN.2006020135","volume":"17","author":"DG Bichet","year":"2006","unstructured":"Bichet, D. G. Lithium, cyclic AMP signaling, A-kinase anchoring proteins, and aquaporin-2. J. Am. Soc. Nephrol. 17, 920\u2013922 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph200943_CR22","doi-asserted-by":"publisher","first-page":"3634","DOI":"10.1073\/pnas.0800001105","volume":"105","author":"J Nielsen","year":"2008","unstructured":"Nielsen, J. et al. Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Proc. Natl Acad. Sci. USA 105, 3634\u20133639 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph200943_CR23","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/35096075","volume":"2","author":"P Cohen","year":"2001","unstructured":"Cohen, P. & Frame, S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2, 769\u2013776 (2001).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnrneph200943_CR24","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/sj.npp.1300731","volume":"30","author":"TD Gould","year":"2005","unstructured":"Gould, T. D. & Manji, H. K. Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology 30, 1223\u20131237 (2005).","journal-title":"Neuropsychopharmacology"},{"key":"BFnrneph200943_CR25","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.1523\/JNEUROSCI.4753-03.2004","volume":"24","author":"WT O'Brien","year":"2004","unstructured":"O'Brien, W. T. et al. Glycogen synthase kinase-3\u03b2 haploinsufficiency mimics the behavioral and molecular effects of lithium. J. Neurosci. 24, 6791\u20136798 (2004).","journal-title":"J. Neurosci."},{"key":"BFnrneph200943_CR26","first-page":"295A","volume":"17","author":"BM Christensen","year":"2006","unstructured":"Christensen, B. M., Loffing, J., Hummler, E. & Rossier, B. C. Collecting duct-specific gene inactivation of \u03b1 ENaC protects mice against lithium-induced nephrogenic diabetes insipidus. J. Am. Soc. Nephrol. 17, 295A (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph200943_CR27","doi-asserted-by":"publisher","first-page":"F812","DOI":"10.1152\/ajprenal.00554.2007","volume":"294","author":"JJ Bedford","year":"2008","unstructured":"Bedford, J. J. et al. Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. Am. J. Physiol. Renal Physiol. 294, F812\u2013F820 (2008).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph200943_CR28","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.2215\/CJN.01640408","volume":"3","author":"JJ Bedford","year":"2008","unstructured":"Bedford, J. J. et al. Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride. Clin. J. Am. Soc. Nephrol. 3, 1324\u20131331 (2008).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"BFnrneph200943_CR29","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1056\/NEJM198502143120705","volume":"312","author":"DC Batlle","year":"1985","unstructured":"Batlle, D. C., von Riotte, A. B., Gaviria, M. & Grupp, M. Amelioration of polyuria by amiloride in patients receiving long-term lithium therapy. N. Engl. J. Med. 312, 408\u2013414 (1985).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph200943_CR30","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.jpeds.2006.10.070","volume":"150","author":"GS Leverich","year":"2007","unstructured":"Leverich, G. S. et al. The poor prognosis of childhood-onset bipolar disorder. J. Pediatr. 150, 485\u2013490 (2007).","journal-title":"J. Pediatr."},{"key":"BFnrneph200943_CR31","first-page":"1250","volume":"9","author":"H Bendz","year":"1994","unstructured":"Bendz, H., Aurell, M., Balldin, J., Mathe, A. A. & Sjodin, I. Kidney damage in long-term lithium patients: a cross-sectional study of patients with 15 years or more on lithium. Nephrol. Dial. Transplant. 9, 1250\u20131254 (1994).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph200943_CR32","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1600-0447.1983.tb07013.x","volume":"68","author":"H Bendz","year":"1983","unstructured":"Bendz, H., Andersch, S. & Aurell, M. Kidney function in an unselected lithium population. A cross-sectional study. Acta Psychiatr. Scand. 68, 325\u2013334 (1983).","journal-title":"Acta Psychiatr. Scand."},{"key":"BFnrneph200943_CR33","doi-asserted-by":"publisher","first-page":"850","DOI":"10.4088\/JCP.v65n0618","volume":"65","author":"E Lepkifker","year":"2004","unstructured":"Lepkifker, E. et al. Renal insufficiency in long-term lithium treatment. J. Clin. Psychiatry 65, 850\u2013856 (2004).","journal-title":"J. Clin. Psychiatry"},{"key":"BFnrneph200943_CR34","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1093\/ndt\/gfm567","volume":"23","author":"N Bassilios","year":"2008","unstructured":"Bassilios, N. et al. Monitoring of glomerular filtration rate in lithium-treated outpatients\u2014an ambulatory laboratory database surveillance. Nephrol. Dial. Transplant. 23, 562\u2013565 (2008).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph200943_CR35","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/ki.1977.102","volume":"12","author":"J Hestbech","year":"1977","unstructured":"Hestbech, J., Hansen, H. E., Amdisen, A. & Olsen, S. Chronic renal lesions following long-term treatment with lithium. Kidney Int. 12, 205\u2013213 (1977).","journal-title":"Kidney Int."},{"key":"BFnrneph200943_CR36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1681\/ASN.V1181439","volume":"11","author":"GS Markowitz","year":"2000","unstructured":"Markowitz, G. S. et al. Lithium nephrotoxicity: a progressive combined glomerular and tubulointerstitial nephropathy. J. Am. Soc. Nephrol. 11, 1439\u20131448 (2000).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph200943_CR37","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1148\/radiol.2292020758","volume":"229","author":"MT Farres","year":"2003","unstructured":"Farres, M. T. et al. Chronic lithium nephropathy: MR imaging for diagnosis. Radiology 229, 570\u2013574 (2003).","journal-title":"Radiology"},{"key":"BFnrneph200943_CR38","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.4161\/cc.6.15.4518","volume":"6","author":"CR Thoma","year":"2007","unstructured":"Thoma, C. R., Frew, I. J. & Krek, W. The VHL tumor suppressor: riding tandem with GSK3\u03b2 in primary cilium maintenance. Cell Cycle 6, 1809\u20131813 (2007).","journal-title":"Cell Cycle"},{"key":"BFnrneph200943_CR39","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1124\/mi.4.5.6","volume":"4","author":"JA Quiroz","year":"2004","unstructured":"Quiroz, J. A., Gould, T. D. & Manji, H. K. Molecular effects of lithium. Mol. Interv. 4, 259\u2013272 (2004).","journal-title":"Mol. Interv."},{"key":"BFnrneph200943_CR40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/sj.ki.5002578","volume":"73","author":"MP Alexander","year":"2008","unstructured":"Alexander, M. P., Farag, Y. M., Mittal, B. V., Rennke, H. G. & Singh, A. K. Lithium toxicity: a double-edged sword. Kidney Int. 73, 233\u2013237 (2008).","journal-title":"Kidney Int."},{"key":"BFnrneph200943_CR41","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1136\/ebmh.7.3.72","volume":"7","author":"M Bauer","year":"2004","unstructured":"Bauer, M. Review: lithium reduces relapse rates in people with bipolar disorder. Evid. Based Ment. Health 7, 72 (2004).","journal-title":"Evid. Based Ment. Health"},{"key":"BFnrneph200943_CR42","doi-asserted-by":"publisher","first-page":"611","DOI":"10.2165\/00023210-200721080-00001","volume":"21","author":"A Gonzalez-Pinto","year":"2007","unstructured":"Gonzalez-Pinto, A., Aldama, A., Mosquera, F. & Gonzalez Gomez, C. Epidemiology, diagnosis and management of mixed mania. CNS Drugs 21, 611\u2013626 (2007).","journal-title":"CNS Drugs"},{"key":"BFnrneph200943_CR43","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0140-6736(73)90846-5","volume":"2","author":"PE Garfinkel","year":"1973","unstructured":"Garfinkel, P. E., Ezrin, C. & Stancer, H. C. Hypothyroidism and hyperparathyroidism associated with lithium. Lancet 2, 331\u2013332 (1973).","journal-title":"Lancet"},{"key":"BFnrneph200943_CR44","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1530\/acta.0.0880528","volume":"88","author":"C Christiansen","year":"1978","unstructured":"Christiansen, C., Baastrup, P. C., Lindgreen, P. & Transbol, I. Endocrine effects of lithium: II. 'Primary' hyperparathyroidism. Acta Endocrinol. (Copenh.) 88, 528\u2013534 (1978).","journal-title":"Acta Endocrinol. (Copenh.)"},{"key":"BFnrneph200943_CR45","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1046\/j.1365-2796.1996.28864000.x","volume":"240","author":"H Bendz","year":"1996","unstructured":"Bendz, H., Sjodin, I., Toss, G. & Berglund, K. Hyperparathyroidism and long-term lithium therapy\u2014a cross-sectional study and the effect of lithium withdrawal. J. Intern. Med. 240, 357\u2013365 (1996).","journal-title":"J. Intern. Med."},{"key":"BFnrneph200943_CR46","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.surg.2005.09.028","volume":"138","author":"JC Hundley","year":"2005","unstructured":"Hundley, J. C., Woodrum, D. T., Saunders, B. D., Doherty, G. M. & Gauger, P. G. Revisiting lithium-associated hyperparathyroidism in the era of intraoperative parathyroid hormone monitoring. Surgery 138, 1027\u20131031 (2005).","journal-title":"Surgery"},{"key":"BFnrneph200943_CR47","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1053\/j.ajkd.2006.07.019","volume":"48","author":"JA Sloand","year":"2006","unstructured":"Sloand, J. A. & Shelly, M. A. Normalization of lithium-induced hypercalcemia and hyperparathyroidism with cinacalcet hydrochloride. Am. J. Kidney Dis. 48, 832\u2013837 (2006).","journal-title":"Am. J. Kidney Dis."},{"key":"BFnrneph200943_CR48","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/sj.ki.5002065","volume":"71","author":"PS Gregoor","year":"2007","unstructured":"Gregoor, P. S. & de Jong, G. M. Lithium hypercalcemia, hyperparathyroidism, and cinacalcet. Kidney Int. 71, 470 (2007).","journal-title":"Kidney Int."},{"key":"BFnrneph200943_CR49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.metabol.2007.11.014","volume":"57","author":"S Sajid-Crockett","year":"2008","unstructured":"Sajid-Crockett, S., Singer, F. R. & Hershman, J. M. Cinacalcet for the treatment of primary hyperparathyroidism. Metabolism 57, 517\u2013521 (2008).","journal-title":"Metabolism"},{"key":"BFnrneph200943_CR50","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1253\/circj.72.847","volume":"72","author":"T Shiraki","year":"2008","unstructured":"Shiraki, T., Kohno, K., Saito, D., Takayama, H. & Fujimoto, A. Complete atrioventricular block secondary to lithium therapy. Circ. J. 72, 847\u2013849 (2008).","journal-title":"Circ. J."},{"key":"BFnrneph200943_CR51","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.105.548487","volume":"112","author":"D Darbar","year":"2005","unstructured":"Darbar, D., Yang, T., Churchwell, K., Wilde, A. A. & Roden, D. M. Unmasking of Brugada syndrome by lithium. Circulation 112, 1527\u20131531 (2005).","journal-title":"Circulation"}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2009.43.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2009.43","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2009.43.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:32:33Z","timestamp":1684470753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrneph.2009.43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["BFnrneph200943"],"URL":"https:\/\/doi.org\/10.1038\/nrneph.2009.43","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}