{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:37:47Z","timestamp":1787510267833,"version":"build-2736575974"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T00:00:00Z","timestamp":1286236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1038\/nrneph.2010.121","type":"journal-article","created":{"date-parts":[[2010,10,6]],"date-time":"2010-10-06T06:10:22Z","timestamp":1286345422000},"page":"657-665","source":"Crossref","is-referenced-by-count":83,"title":["Hereditary disorders of renal phosphate wasting"],"prefix":"10.1038","volume":"6","author":[{"given":"Amir S.","family":"Alizadeh Naderi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,5]]},"reference":[{"key":"BFnrneph2010121_CR1","volume-title":"Nephrology in 30 Days","author":"RF Reilly","year":"2005","unstructured":"Reilly, R. F. & Perazella, M. A. Nephrology in 30 Days (McGraw-Hill Medical Pub. Division, New York, 2005)."},{"key":"BFnrneph2010121_CR2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ncpneph0124","volume":"2","author":"J Amanzadeh","year":"2006","unstructured":"Amanzadeh, J. & Reilly, R. F. Jr. Hypophosphatemia: an evidence-based approach to its clinical consequences and management. Nat. Clin. Pract. Nephrol. 2, 136\u2013148 (2006).","journal-title":"Nat. Clin. Pract. Nephrol."},{"key":"BFnrneph2010121_CR3","doi-asserted-by":"publisher","first-page":"14564","DOI":"10.1073\/pnas.95.24.14564","volume":"95","author":"H Hilfiker","year":"1998","unstructured":"Hilfiker, H. et al. Characterization of a murine type II sodium-phosphate cotransporter expressed in mammalian small intestine. Proc. Natl Acad. Sci. USA 95, 14564\u201314569 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph2010121_CR4","doi-asserted-by":"publisher","first-page":"F1466","DOI":"10.1152\/ajprenal.00279.2009","volume":"297","author":"H Giral","year":"2009","unstructured":"Giral, H. et al. Regulation of rat intestinal Na-dependent phosphate transporters by dietary phosphate. Am. J. Physiol. Renal Physiol. 297, F1466\u2013F1475 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/BF00658486","volume":"388","author":"G Danisi","year":"1980","unstructured":"Danisi, G., Bonjour, J. P. & Straub, R. W. Regulation of Na-dependent phosphate influx across the mucosal border of duodenum by 1,25-dihydroxycholecalciferol. Pflugers Arch. 388, 227\u2013232 (1980).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR6","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1080\/00365521.1990.12067093","volume":"25","author":"G Danisi","year":"1990","unstructured":"Danisi, G., Caverzasio, J., Trechsel, U., Bonjour, J. P. & Straub, R. W. Phosphate transport adaptation in rat jejunum and plasma level of 1,25-dihydroxyvitamin D3. Scand. J. Gastroenterol. 25, 210\u2013215 (1990).","journal-title":"Scand. J. Gastroenterol."},{"key":"BFnrneph2010121_CR7","first-page":"G533","volume":"242","author":"B Hildmann","year":"1982","unstructured":"Hildmann, B., Storelli, C., Danisi, G. & Murer, H. Regulation of Na+-Pi cotransport by 1,25-dihydroxyvitamin D3 in rabbit duodenal brush-border membrane. Am. J. Physiol. 242, G533\u2013G539 (1982).","journal-title":"Am. J. Physiol."},{"key":"BFnrneph2010121_CR8","doi-asserted-by":"publisher","first-page":"G496","DOI":"10.1152\/ajpgi.00167.2004","volume":"288","author":"T Radanovic","year":"2005","unstructured":"Radanovic, T., Wagner, C. A., Murer, H. & Biber, J. Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G496\u2013G500 (2005).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"BFnrneph2010121_CR9","doi-asserted-by":"publisher","first-page":"C487","DOI":"10.1152\/ajpcell.00412.2001","volume":"282","author":"H Xu","year":"2002","unstructured":"Xu, H., Bai, L., Collins, J. F. & Ghishan, F. K. Age-dependent regulation of rat intestinal type IIb sodium-phosphate cotransporter by 1,25-(OH)2 vitamin D3 . Am. J. Physiol. Cell Physiol. 282, C487\u2013C493 (2002).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFnrneph2010121_CR10","volume-title":"Disorders of Bone and Mineral Metabolism","author":"FL Coe","year":"2002","unstructured":"Coe, F. L. & Favus, M. J. Disorders of Bone and Mineral Metabolism, 2nd edn (Lippincott Williams & Wilkins, Philadelphia, 2002)."},{"key":"BFnrneph2010121_CR11","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/BF01063453","volume":"368","author":"F Lang","year":"1977","unstructured":"Lang, F., Greger, R., Marchand, G. R. & Knox, F. G. Stationary microperfusion study of phosphate reabsorption in proximal and distal nephron segments. Pflugers Arch. 368, 45\u201348 (1977).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR12","doi-asserted-by":"publisher","first-page":"F691","DOI":"10.1152\/ajprenal.90623.2008","volume":"296","author":"R Villa-Bellosta","year":"2009","unstructured":"Villa-Bellosta, R. et al. The Na+-Pi cotransporter PiT-2 (SLC20A2) is expressed in the apical membrane of rat renal proximal tubules and regulated by dietary Pi. Am. J. Physiol. Renal Physiol. 296, F691\u2013F699 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR13","doi-asserted-by":"publisher","first-page":"F671","DOI":"10.1152\/ajprenal.00156.2009","volume":"297","author":"H Segawa","year":"2009","unstructured":"Segawa, H. et al. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am. J. Physiol. Renal Physiol. 297, F671\u2013F678 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR14","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1007\/s00424-003-1072-5","volume":"447","author":"H Murer","year":"2004","unstructured":"Murer, H., Forster, I. & Biber, J. The sodium phosphate cotransporter family SLC34. Pflugers Arch. 447, 763\u2013767 (2004).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR15","doi-asserted-by":"publisher","first-page":"9608","DOI":"10.1073\/pnas.88.21.9608","volume":"88","author":"A Werner","year":"1991","unstructured":"Werner, A. et al. Cloning and expression of cDNA for a Na\/Pi cotransport system of kidney cortex. Proc. Natl Acad. Sci. USA 88, 9608\u20139612 (1991).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph2010121_CR16","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1073\/pnas.93.11.5347","volume":"93","author":"AE Busch","year":"1996","unstructured":"Busch, A. E. et al. Expression of a renal type I sodium\/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc. Natl Acad. Sci. USA 93, 5347\u20135351 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph2010121_CR17","doi-asserted-by":"publisher","first-page":"F643","DOI":"10.1152\/ajprenal.00228.2007","volume":"293","author":"LV Virkki","year":"2007","unstructured":"Virkki, L. V., Biber, J., Murer, H. & Forster, I. C. Phosphate transporters: a tale of two solute carrier families. Am. J. Physiol. Renal Physiol. 293, F643\u2013F654 (2007).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR18","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00424-003-1087-y","volume":"447","author":"RJ Reimer","year":"2004","unstructured":"Reimer, R. J. & Edwards, R. H. Organic anion transport is the primary function of the SLC17\/type I phosphate transporter family. Pflugers Arch. 447, 629\u2013635 (2004).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR19","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1073\/pnas.95.9.5372","volume":"95","author":"L Beck","year":"1998","unstructured":"Beck, L. et al. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Proc. Natl Acad. Sci. USA 95, 5372\u20135377 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph2010121_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1056\/NEJMoa020028","volume":"347","author":"D Prie","year":"2002","unstructured":"Prie, D. et al. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter. N. Engl. J. Med. 347, 983\u2013991 (2002).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR21","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1359\/jbmr.2003.18.12.2135","volume":"18","author":"LV Virkki","year":"2003","unstructured":"Virkki, L. V., Forster, I. C., Hernando, N., Biber, J. & Murer, H. Functional characterization of two naturally occurring mutations in the human sodium-phosphate cotransporter type IIa. J. Bone Miner. Res. 18, 2135\u20132141 (2003).","journal-title":"J. Bone Miner. Res."},{"key":"BFnrneph2010121_CR22","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1038\/sj.ki.5000437","volume":"69","author":"JY Lapointe","year":"2006","unstructured":"Lapointe, J. Y. et al. NPT2a gene variation in calcium nephrolithiasis with renal phosphate leak. Kidney Int. 69, 2261\u20132267 (2006).","journal-title":"Kidney Int."},{"key":"BFnrneph2010121_CR23","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1056\/NEJMoa0905647","volume":"362","author":"D Magen","year":"2010","unstructured":"Magen, D. et al. A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome. N. Engl. J. Med. 362, 1102\u20131109 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR24","doi-asserted-by":"crossref","unstructured":"Kavanaugh, M. P. et al. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters. Proc. Natl Acad. Sci. USA 91, 7071\u2013-7075 (1994).","DOI":"10.1073\/pnas.91.15.7071"},{"key":"BFnrneph2010121_CR25","doi-asserted-by":"crossref","first-page":"8270","DOI":"10.1128\/JVI.68.12.8270-8276.1994","volume":"68","author":"DG Miller","year":"1994","unstructured":"Miller, D. G. & Miller, A. D. A family of retroviruses that utilize related phosphate transporters for cell entry. J. Virol. 68, 8270\u20138276 (1994).","journal-title":"J. Virol."},{"key":"BFnrneph2010121_CR26","doi-asserted-by":"publisher","first-page":"F527","DOI":"10.1152\/ajpcell.1998.275.2.C527","volume":"275","author":"HS Tenenhouse","year":"1998","unstructured":"Tenenhouse, H. S., Roy, S., Martel, J. & Gauthier, C. Differential expression, abundance, and regulation of Na+-phosphate cotransporter genes in murine kidney. Am. J. Physiol. 275, F527\u2013F534 (1998).","journal-title":"Am. J. Physiol."},{"key":"BFnrneph2010121_CR27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-2005-870096","volume":"37","author":"JC Leung","year":"2005","unstructured":"Leung, J. C., Barac-Nieto, M., Hering-Smith, K. & Silverstein, D. M. Expression of the rat renal PiT-2 phosphate transporter. Horm. Metab. Res. 37, 265\u2013269 (2005).","journal-title":"Horm. Metab. Res."},{"key":"BFnrneph2010121_CR28","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00424-008-0530-5","volume":"457","author":"M Nowik","year":"2008","unstructured":"Nowik, M. et al. Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Pflugers Arch. 457, 539\u2013549 (2008).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR29","doi-asserted-by":"publisher","first-page":"F350","DOI":"10.1152\/ajprenal.90765.2008","volume":"297","author":"SY Breusegem","year":"2009","unstructured":"Breusegem, S. Y. et al. Differential regulation of the renal sodium-phosphate cotransporters NaPi-IIa, NaPi-IIc, and PiT-2 in dietary potassium deficiency. Am. J. Physiol. Renal Physiol. 297, F350\u2013F361 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00424-009-0746-z","volume":"459","author":"R Villa-Bellosta","year":"2010","unstructured":"Villa-Bellosta, R. & Sorribas, V. Compensatory regulation of the sodium\/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis. Pflugers Arch. 459, 499\u2013508 (2010).","journal-title":"Pflugers Arch."},{"key":"BFnrneph2010121_CR31","doi-asserted-by":"publisher","first-page":"F689","DOI":"10.1152\/ajprenal.00007.2009","volume":"296","author":"OW Moe","year":"2009","unstructured":"Moe, O. W. PiT-2 coming out of the pits. Am. J. Physiol. Renal Physiol. 296, F689\u2013F690 (2009).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR32","first-page":"F644","volume":"276","author":"IC Forster","year":"1999","unstructured":"Forster, I. C., Loo, D. D. & Eskandari, S. Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Am. J. Physiol. 276, F644\u2013F649 (1999).","journal-title":"Am. J. Physiol."},{"key":"BFnrneph2010121_CR33","doi-asserted-by":"publisher","first-page":"19665","DOI":"10.1074\/jbc.M200943200","volume":"277","author":"H Segawa","year":"2002","unstructured":"Segawa, H. et al. Growth-related renal type II Na\/Pi cotransporter. J. Biol. Chem. 277, 19665\u201319672 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnrneph2010121_CR34","doi-asserted-by":"publisher","first-page":"C606","DOI":"10.1152\/ajpcell.00064.2007","volume":"293","author":"S Ravera","year":"2007","unstructured":"Ravera, S., Virkki, L. V., Murer, H. & Forster, I. C. Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements. Am. J. Physiol. Cell Physiol. 293, C606\u2013C620 (2007).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"BFnrneph2010121_CR35","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1146\/annurev.physiol.69.040705.141729","volume":"69","author":"T Berndt","year":"2007","unstructured":"Berndt, T. & Kumar, R. Phosphatonins and the regulation of phosphate homeostasis. Annu. Rev. Physiol. 69, 341\u2013359 (2007).","journal-title":"Annu. Rev. Physiol."},{"key":"BFnrneph2010121_CR36","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1159\/000107069","volume":"27","author":"K Miyamoto","year":"2007","unstructured":"Miyamoto, K., Ito, M., Tatsumi, S., Kuwahata, M. & Segawa, H. New aspect of renal phosphate reabsorption: the type IIc sodium-dependent phosphate transporter. Am. J. Nephrol. 27, 503\u2013515 (2007).","journal-title":"Am. J. Nephrol."},{"key":"BFnrneph2010121_CR37","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1152\/physrev.2000.80.4.1373","volume":"80","author":"H Murer","year":"2000","unstructured":"Murer, H., Hernando, N., Forster, I. & Biber, J. Proximal tubular phosphate reabsorption: molecular mechanisms. Physiol. Rev. 80, 1373\u20131409 (2000).","journal-title":"Physiol. Rev."},{"key":"BFnrneph2010121_CR38","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1056\/NEJM199406093302304","volume":"330","author":"Q Cai","year":"1994","unstructured":"Cai, Q. et al. Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N. Engl. J. Med. 330, 1645\u20131649 (1994).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR39","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1056\/NEJM199406093302310","volume":"330","author":"MJ Econs","year":"1994","unstructured":"Econs, M. J. & Drezner, M. K. Tumor-induced osteomalacia\u2014unveiling a new hormone. N. Engl. J. Med. 330, 1679\u20131681 (1994).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR40","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1002\/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-Q","volume":"59","author":"N Weidner","year":"1987","unstructured":"Weidner, N. & Santa Cruz, D. Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer 59, 1442\u20131454 (1987).","journal-title":"Cancer"},{"key":"BFnrneph2010121_CR41","doi-asserted-by":"crossref","unstructured":"ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat. Genet. 26, 345\u2013348 (2000).","DOI":"10.1038\/81664"},{"key":"BFnrneph2010121_CR42","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1210\/jc.2004-0357","volume":"90","author":"TO Carpenter","year":"2005","unstructured":"Carpenter, T. O. et al. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J. Clin. Endocrinol. Metab. 90, 1012\u20131020 (2005).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrneph2010121_CR43","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1093\/ndt\/gfm535","volume":"23","author":"H Dobbie","year":"2008","unstructured":"Dobbie, H., Unwin, R. J., Faria, N. J. & Shirley, D. G. Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Nephrol. Dial. Transplant. 23, 730\u2013733 (2008).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph2010121_CR44","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1172\/JCI18563","volume":"112","author":"T Berndt","year":"2003","unstructured":"Berndt, T. et al. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J. Clin. Invest. 112, 785\u2013794 (2003).","journal-title":"J. Clin. Invest."},{"key":"BFnrneph2010121_CR45","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s00467-008-0751-z","volume":"23","author":"A Shaikh","year":"2008","unstructured":"Shaikh, A., Berndt, T. & Kumar, R. Regulation of phosphate homeostasis by the phosphatonins and other novel mediators. Pediatr. Nephrol. 23, 1203\u20131210 (2008).","journal-title":"Pediatr. Nephrol."},{"key":"BFnrneph2010121_CR46","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1359\/JBMR.0301264","volume":"19","author":"T Shimada","year":"2004","unstructured":"Shimada, T. et al. FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J. Bone Miner. Res. 19, 429\u2013435 (2004).","journal-title":"J. Bone Miner. Res."},{"key":"BFnrneph2010121_CR47","doi-asserted-by":"publisher","first-page":"F1577","DOI":"10.1152\/ajprenal.00463.2006","volume":"293","author":"F Perwad","year":"2007","unstructured":"Perwad, F., Zhang, M. Y., Tenenhouse, H. S. & Portale, A. A. Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1-alpha-hydroxylase expression in vitro. Am. J. Physiol. Renal Physiol. 293, F1577\u2013F1583 (2007).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR48","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.1210\/en.2005-0777","volume":"146","author":"F Perwad","year":"2005","unstructured":"Perwad, F. et al. Dietary and serum phosphorus regulate fibroblast growth factor 23 expression and 1,25-dihydroxyvitamin D metabolism in mice. Endocrinology 146, 5358\u20135364 (2005).","journal-title":"Endocrinology"},{"key":"BFnrneph2010121_CR49","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1210\/jc.2006-0021","volume":"91","author":"DM Antoniucci","year":"2006","unstructured":"Antoniucci, D. M., Yamashita, T. & Portale, A. A. Dietary phosphorus regulates serum fibroblast growth factor-23 concentrations in healthy men. J. Clin. Endocrinol. Metab. 91, 3144\u20133149 (2006).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrneph2010121_CR50","doi-asserted-by":"publisher","first-page":"2141","DOI":"10.1038\/sj.ki.5002000","volume":"70","author":"Y Nishida","year":"2006","unstructured":"Nishida, Y. et al. Acute effect of oral phosphate loading on serum fibroblast growth factor 23 levels in healthy men. Kidney Int. 70, 2141\u20132147 (2006).","journal-title":"Kidney Int."},{"key":"BFnrneph2010121_CR51","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.bbrc.2003.12.102","volume":"314","author":"T Shimada","year":"2004","unstructured":"Shimada, T. et al. FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem. Biophys. Res. Commun. 314, 409\u2013414 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrneph2010121_CR52","doi-asserted-by":"publisher","first-page":"6500","DOI":"10.1073\/pnas.101545198","volume":"98","author":"T Shimada","year":"2001","unstructured":"Shimada, T. et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc. Natl Acad. Sci. USA 98, 6500\u20136505 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneph2010121_CR53","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/nature05315","volume":"444","author":"I Urakawa","year":"2006","unstructured":"Urakawa, I. et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444, 770\u2013774 (2006).","journal-title":"Nature"},{"key":"BFnrneph2010121_CR54","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrneph.2010.17","volume":"6","author":"EG Farrow","year":"2010","unstructured":"Farrow, E. G. & White, K. E. Recent advances in renal phosphate handling. Nat. Rev. Nephrol. 6, 207\u2013217 (2010).","journal-title":"Nat. Rev. Nephrol."},{"key":"BFnrneph2010121_CR55","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1038\/ki.2008.643","volume":"75","author":"D Prie","year":"2009","unstructured":"Prie, D., Urena Torres, P. & Friedlander, G. Latest findings in phosphate homeostasis. Kidney Int. 75, 882\u2013889 (2009).","journal-title":"Kidney Int."},{"key":"BFnrneph2010121_CR56","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.amjmed.2005.02.014","volume":"118","author":"A Gaasbeek","year":"2005","unstructured":"Gaasbeek, A. & Meinders, A. E. Hypophosphatemia: an update on its etiology and treatment. Am. J. Med. 118, 1094\u20131101 (2005).","journal-title":"Am. J. Med."},{"key":"BFnrneph2010121_CR57","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1161\/01.CIR.47.6.1313","volume":"47","author":"JA Young","year":"1973","unstructured":"Young, J. A., Lichtman, M. A. & Cohen, J. Reduced red cell 2,3-diphosphoglycerate and adenosine triphosphate, hypophosphatemia, and increased hemoglobin-oxygen affinity after cardiac surgery. Circulation 47, 1313\u20131318 (1973).","journal-title":"Circulation"},{"key":"BFnrneph2010121_CR58","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1172\/JCI111006","volume":"72","author":"BD Hettleman","year":"1983","unstructured":"Hettleman, B. D., Sabina, R. L., Drezner, M. K., Holmes, E. W. & Swain, J. L. Defective adenosine triphosphate synthesis. An explanation for skeletal muscle dysfunction in phosphate-deficient mice. J. Clin. Invest. 72, 582\u2013589 (1983).","journal-title":"J. Clin. Invest."},{"key":"BFnrneph2010121_CR59","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1590\/S0004-27302006000400025","volume":"50","author":"H de Menezes Filho","year":"2006","unstructured":"de Menezes Filho, H., de Castro, L. C. & Damiani, D. Hypophosphatemic rickets and osteomalacia. Arq. Bras. Endocrinol. Metabol. 50, 802\u2013813 (2006).","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"BFnrneph2010121_CR60","unstructured":"Hypophosphatemic rickets, X-linked dominant Online Mendelian Inheritance in Man [online] ."},{"key":"BFnrneph2010121_CR61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00005792-195805000-00001","volume":"37","author":"RW Winters","year":"1958","unstructured":"Winters, R. W., Graham, J. B., Williams, T. F., McFalls, V. W. & Burnett, C. H. A genetic study of familial hypophosphatemia and vitamin D resistant rickets with a review of the literature. Medicine (Baltimore) 37, 97\u2013142 (1958).","journal-title":"Medicine (Baltimore)"},{"key":"BFnrneph2010121_CR62","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1001\/archinte.1974.00320210159025","volume":"134","author":"JM Morgan","year":"1974","unstructured":"Morgan, J. M., Hawley, W. L, Chenoweth, A. I., Retan, W. J. & Diethelm, A. G. Renal transplantation in hypophosphatemia with vitamin D-resistant rickets. Arch. Intern. Med. 134, 549\u2013552 (1974).","journal-title":"Arch. Intern. Med."},{"key":"BFnrneph2010121_CR63","unstructured":"Phosphate-regulating endopeptidase homolog, X-linked; PHEX Online Mendelian Inheritance in Man [online] ."},{"key":"BFnrneph2010121_CR64","doi-asserted-by":"crossref","unstructured":"HYP Consortium. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nat. Genet. 11, 130\u2013136 (1995).","DOI":"10.1038\/ng1095-130"},{"key":"BFnrneph2010121_CR65","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1359\/jbmr.1997.12.7.1009","volume":"12","author":"R Guo","year":"1997","unstructured":"Guo, R. & Quarles, L. D. Cloning and sequencing of human PEX from a bone cDNA library: evidence for its developmental stage-specific regulation in osteoblasts. J. Bone Miner. Res. 12, 1009\u20131017 (1997).","journal-title":"J. Bone Miner. Res."},{"key":"BFnrneph2010121_CR66","first-page":"790","volume":"60","author":"IA Holm","year":"1997","unstructured":"Holm, I. A., Huang, X. & Kunkel, L. M. Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Am. J. Hum. Genet. 60, 790\u2013797 (1997).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrneph2010121_CR67","first-page":"3615","volume":"83","author":"PH Dixon","year":"1998","unstructured":"Dixon, P. H. et al. Mutational analysis of PHEX gene in X-linked hypophosphatemia. J. Clin. Endocrinol. Metab. 83, 3615\u20133623 (1998).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrneph2010121_CR68","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/sj.ejhg.5200341","volume":"7","author":"D Filisetti","year":"1999","unstructured":"Filisetti, D. et al. Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues. Eur. J. Hum. Genet. 7, 615\u2013619 (1999).","journal-title":"Eur. J. Hum. Genet."},{"key":"BFnrneph2010121_CR69","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1006\/bbrc.2001.5084","volume":"284","author":"AE Bowe","year":"2001","unstructured":"Bowe, A. E. et al. FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate. Biochem. Biophys. Res. Commun. 284, 977\u2013981 (2001).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrneph2010121_CR70","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.bone.2004.04.002","volume":"35","author":"A Benet-Pages","year":"2004","unstructured":"Benet-Pages, A. et al. FGF23 is processed by proprotein convertases but not by PHEX. Bone 35, 455\u2013462 (2004).","journal-title":"Bone"},{"key":"BFnrneph2010121_CR71","doi-asserted-by":"publisher","first-page":"37419","DOI":"10.1074\/jbc.M304544200","volume":"278","author":"S Liu","year":"2003","unstructured":"Liu, S. et al. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J. Biol. Chem. 278, 37419\u201337426 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnrneph2010121_CR72","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/MNH.0b013e3282fd6e5b","volume":"17","author":"TM Strom","year":"2008","unstructured":"Strom, T. M. & Juppner, H. PHEX, FGF23, DMP1 and beyond. Curr. Opin. Nephrol. Hypertens. 17, 357\u2013362 (2008).","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"BFnrneph2010121_CR73","unstructured":"Hypophosphatemic rickets, Autosomal dominant; ADHR Online Mendelian Inheritance in Man [online] ."},{"key":"BFnrneph2010121_CR74","first-page":"287","volume":"7","author":"JW Bianchine","year":"1971","unstructured":"Bianchine, J. W., Stambler, A. A. & Harrison, H. E. Familial hypophosphatemic rickets showing autosomal dominant inheritance. Birth Defects Orig. Artic. Ser. 7, 287\u2013295 (1971).","journal-title":"Birth Defects Orig. Artic. Ser."},{"key":"BFnrneph2010121_CR75","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1172\/JCI18399","volume":"112","author":"M Riminucci","year":"2003","unstructured":"Riminucci, M. et al. FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. J. Clin. Invest. 112, 683\u2013692 (2003).","journal-title":"J. Clin. Invest."},{"key":"BFnrneph2010121_CR76","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.bone.2004.06.014","volume":"35","author":"M Mirams","year":"2004","unstructured":"Mirams, M., Robinson, B. G., Mason, R. S. & Nelson, A. E. Bone as a source of FGF23: regulation by phosphate? Bone 35, 1192\u20131199 (2004).","journal-title":"Bone"},{"key":"BFnrneph2010121_CR77","doi-asserted-by":"publisher","first-page":"F1088","DOI":"10.1152\/ajprenal.00474.2004","volume":"289","author":"T Shimada","year":"2005","unstructured":"Shimada, T. et al. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am. J. Physiol. Renal Physiol. 289, F1088\u2013F1095 (2005).","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrneph2010121_CR78","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1210\/en.2003-1768","volume":"145","author":"T Larsson","year":"2004","unstructured":"Larsson, T. et al. Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145, 3087\u20133094 (2004).","journal-title":"Endocrinology"},{"key":"BFnrneph2010121_CR79","unstructured":"Fibroblast growth factor 23; FGF23 Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR80","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00774-009-0111-5","volume":"28","author":"M Gribaa","year":"2009","unstructured":"Gribaa, M. et al. An autosomal dominant hypophosphatemic rickets phenotype in a Tunisian family caused by a new FGF23 missense mutation. J. Bone Miner. Metab. 28, 111\u2013115 (2009).","journal-title":"J. Bone Miner. Metab."},{"key":"BFnrneph2010121_CR81","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1210\/jcem.82.2.3765","volume":"82","author":"MJ Econs","year":"1997","unstructured":"Econs, M. J. & McEnery, P. T. Autosomal dominant hypophosphatemic rickets\/osteomalacia: clinical characterization of a novel renal phosphate-wasting disorder. J. Clin. Endocrinol. Metab. 82, 674\u2013681 (1997).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrneph2010121_CR82","unstructured":"Hypophosphatemic rickets, autosomal recessive, 1; ARHR1 Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR83","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/ng1905","volume":"38","author":"JQ Feng","year":"2006","unstructured":"Feng, J. Q. et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 38, 1310\u20131315 (2006).","journal-title":"Nat. Genet."},{"key":"BFnrneph2010121_CR84","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/ng1868","volume":"38","author":"B Lorenz-Depiereux","year":"2006","unstructured":"Lorenz-Depiereux, B. et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat. Genet. 38, 1248\u20131250 (2006).","journal-title":"Nat. Genet."},{"key":"BFnrneph2010121_CR85","unstructured":"Dentin matrix acidic phosphoprotein 1; DMP1 Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR86","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1016\/S0021-9258(18)31434-0","volume":"268","author":"A George","year":"1993","unstructured":"George, A., Sabsay, B., Simonian, P. A. & Veis, A. Characterization of a novel dentin matrix acidic phosphoprotein. Implications for induction of biomineralization. J. Biol. Chem. 268, 12624\u201312630 (1993).","journal-title":"J. Biol. Chem."},{"key":"BFnrneph2010121_CR87","first-page":"308","volume":"7","author":"A George","year":"2007","unstructured":"George, A., Ramachandran, A., Albazzaz, M. & Ravindran, S. DMP1-a key regulator in mineralized matrix formation. J. Musculoskelet. Neuronal Interact. 7, 308 (2007).","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"BFnrneph2010121_CR88","doi-asserted-by":"publisher","first-page":"17500","DOI":"10.1074\/jbc.M212700200","volume":"278","author":"K Narayanan","year":"2003","unstructured":"Narayanan, K. et al. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J. Biol. Chem. 278, 17500\u201317508 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFnrneph2010121_CR89","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ajhg.2010.01.010","volume":"86","author":"V Levy-Litan","year":"2010","unstructured":"Levy-Litan, V. et al. Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Am. J. Hum. Genet. 86, 273\u2013278 (2010).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrneph2010121_CR90","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/ng1221","volume":"34","author":"F Rutsch","year":"2003","unstructured":"Rutsch, F. et al. Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat. Genet. 34, 379\u2013381 (2003).","journal-title":"Nat. Genet."},{"key":"BFnrneph2010121_CR91","unstructured":"Hypophosphatemic rickets with hypercalciuria, hereditary; HHRH Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR92","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1086\/499410","volume":"78","author":"B Lorenz-Depiereux","year":"2006","unstructured":"Lorenz-Depiereux, B. et al. Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Am. J. Hum. Genet. 78, 193\u2013201 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrneph2010121_CR93","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1086\/499409","volume":"78","author":"C Bergwitz","year":"2006","unstructured":"Bergwitz, C. et al. SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis. Am. J. Hum. Genet. 78, 179\u2013192 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrneph2010121_CR94","unstructured":"Solute carrier family 34 (sodium\/phosphate cotransporter), member 3; SLC34A3 Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR95","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1056\/NEJM198503073121003","volume":"312","author":"M Tieder","year":"1985","unstructured":"Tieder, M. et al. Hereditary hypophosphatemic rickets with hypercalciuria. N. Engl. J. Med. 312, 611\u2013617 (1985).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR96","doi-asserted-by":"publisher","first-page":"4433","DOI":"10.1210\/jc.2009-1535","volume":"94","author":"AL Tencza","year":"2009","unstructured":"Tencza, A. L. et al. Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3\/type IIc sodium-phosphate cotransporter: presentation as hypercalciuria and nephrolithiasis. J. Clin. Endocrinol. Metab. 94, 4433\u20134438 (2009).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrneph2010121_CR97","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1055\/s-2008-1076716","volume":"117","author":"B Kremke","year":"2009","unstructured":"Kremke, B. et al. Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3\/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications. Exp. Clin. Endocrinol. Diabetes 117, 49\u201356 (2009).","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"BFnrneph2010121_CR98","doi-asserted-by":"publisher","first-page":"869","DOI":"10.4158\/EP.14.7.869","volume":"14","author":"K Page","year":"2008","unstructured":"Page, K., Bergwitz, C., Jaureguiberry, G., Harinarayan, C. V. & Insogna, K. A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3. Endocr. Pract. 14, 869\u2013874 (2008).","journal-title":"Endocr. Pract."},{"key":"BFnrneph2010121_CR99","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1056\/NEJM198809293191307","volume":"319","author":"M Tieder","year":"1988","unstructured":"Tieder, M. et al. Elevated serum 1,25-dihydroxyvitamin D concentrations in siblings with primary Fanconi's syndrome. N. Engl. J. Med. 319, 845\u2013849 (1988).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR100","unstructured":"McCune-albright syndrome; MAS Online Mendelian Inheritance in Man, [online] ."},{"key":"BFnrneph2010121_CR101","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1056\/NEJM199112123252403","volume":"325","author":"LS Weinstein","year":"1991","unstructured":"Weinstein, L. S. et al. Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N. Engl. J. Med. 325, 1688\u20131695 (1991).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph2010121_CR102","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.berh.2007.11.004","volume":"22","author":"RD Chapurlat","year":"2008","unstructured":"Chapurlat, R. D. & Orcel, P. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Pract. Res. Clin. Rheumatol. 22, 55\u201369 (2008).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"BFnrneph2010121_CR103","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00774-004-0589-9","volume":"23","author":"T Yamamoto","year":"2005","unstructured":"Yamamoto, T. et al. The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome. J. Bone Miner. Metab. 23, 231\u2013237 (2005).","journal-title":"J. Bone Miner. Metab."},{"key":"BFnrneph2010121_CR104","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1359\/jbmr.2001.16.5.806","volume":"16","author":"MT Collins","year":"2001","unstructured":"Collins, M. T. et al. Renal phosphate wasting in fibrous dysplasia of bone is part of a generalized renal tubular dysfunction similar to that seen in tumor-induced osteomalacia. J. Bone Miner. Res. 16, 806\u2013813 (2001).","journal-title":"J. Bone Miner. Res."},{"key":"BFnrneph2010121_CR105","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1016\/j.lfs.2005.09.052","volume":"78","author":"K Kobayashi","year":"2006","unstructured":"Kobayashi, K. et al. Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. Life Sci. 78, 2295\u20132301 (2006).","journal-title":"Life Sci."},{"key":"BFnrneph2010121_CR106","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1038\/ki.2008.33","volume":"73","author":"S Faroqui","year":"2008","unstructured":"Faroqui, S., Levi, M., Soleimani, M. & Amlal, H. Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Kidney Int. 73, 1141\u20131150 (2008).","journal-title":"Kidney Int."},{"key":"BFnrneph2010121_CR107","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1042\/BJ20090671","volume":"427","author":"M Ishiguro","year":"2010","unstructured":"Ishiguro, M. et al. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent phosphate co-transporter (Npt2a) gene. Biochem. J. 427, 161\u2013169 (2010).","journal-title":"Biochem. J."}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2010.121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2010.121","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2010.121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:33:10Z","timestamp":1684456390000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrneph.2010.121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,5]]},"references-count":107,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["BFnrneph2010121"],"URL":"https:\/\/doi.org\/10.1038\/nrneph.2010.121","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,5]]}}}