{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:48:22Z","timestamp":1791848902111,"version":"4.3.4"},"reference-count":112,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Nephrol"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1038\/nrneph.2017.17","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T04:33:35Z","timestamp":1488170015000},"page":"285-296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Cardiovascular disease in haemodialysis: role of the intravascular innate immune system"],"prefix":"10.1038","volume":"13","author":[{"given":"Kristina N.","family":"Ekdahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Soveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6ns","family":"Hilborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Fellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"BFnrneph201717_CR1","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1093\/ndt\/gfv349","volume":"31","author":"SA Peters","year":"2016","unstructured":"Peters, S. A. et al. Haemodiafiltration and mortality in end-stage kidney disease patients: a pooled individual participant data analysis from four randomized controlled trials. Nephrol. Dial. Transplant. 31, 978\u2013984 (2016).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph201717_CR2","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1681\/ASN.2005101085","volume":"17","author":"M Tonelli","year":"2006","unstructured":"Tonelli, M. et al. Chronic kidney disease and mortality risk: a systematic review. J. Am. Soc. Nephrol. 17, 2034\u20132047 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR3","doi-asserted-by":"publisher","first-page":"3480","DOI":"10.1093\/ndt\/gfp287","volume":"24","author":"KS Rogacev","year":"2009","unstructured":"Rogacev, K. S. et al. Haemodialysis-induced transient CD16+ monocytopenia and cardiovascular outcome. Nephrol. Dial. Transplant. 24, 3480\u20133486 (2009).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph201717_CR4","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/prca.201000031","volume":"4","author":"J Mares","year":"2010","unstructured":"Mares, J. et al. Proteomic profiling of blood-dialyzer interactome reveals involvement of lectin complement pathway in hemodialysis-induced inflammatory response. Proteomics Clin. Appl. 4, 829\u2013838 (2010).","journal-title":"Proteomics Clin. Appl."},{"key":"BFnrneph201717_CR5","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/ki.2012.130","volume":"82","author":"JT Daugirdas","year":"2012","unstructured":"Daugirdas, J. T. & Bernardo, A. A. Hemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia. Kidney Int. 82, 147\u2013157 (2012).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR6","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3109\/00365513.2011.558106","volume":"71","author":"M Schoorl","year":"2011","unstructured":"Schoorl, M., Schoorl, M., Nub\u00e9, M. J. & Bartels, P. C. M. Platelet depletion, platelet activation and coagulation during treatment with hemodialysis. Scand. J. Clin. Lab. Invest. 71, 240\u2013247 (2011).","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"BFnrneph201717_CR7","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1056\/NEJMoa041031","volume":"351","author":"AS Go","year":"2004","unstructured":"Go, A. S., Chertow, G. M., Fan, D., McCulloch, C. E. & Hsu, C. Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Engl. J. Med. 351, 1296\u20131305 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph201717_CR8","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1681\/ASN.V92267","volume":"9","author":"RN Foley","year":"1998","unstructured":"Foley, R. N., Parfrey, P. S. & Sarnak, M. J. Epidemiology of cardiovascular disease in chronic renal disease. J. Am. Soc. Nephrol. 9, S16\u2013S23 (1998).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","volume":"382","author":"V Jha","year":"2013","unstructured":"Jha, V. et al. Chronic kidney disease: global dimension and perspectives. Lancet 382, 260\u2013272 (2013).","journal-title":"Lancet"},{"key":"BFnrneph201717_CR10","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/S0140-6736(11)61334-2","volume":"378","author":"AG Jardine","year":"2011","unstructured":"Jardine, A. G., Gaston, R. S., Fellstrom, B. C. & Holdaas, H. Prevention of cardiovascular disease in adult recipients of kidney transplants. Lancet 378, 1419\u20131427 (2011).","journal-title":"Lancet"},{"key":"BFnrneph201717_CR11","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1056\/NEJMoa0810177","volume":"360","author":"BC Fellstrom","year":"2009","unstructured":"Fellstrom, B. C. et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N. Engl. J. Med. 360, 1395\u20131407 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph201717_CR12","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/S0140-6736(11)60739-3","volume":"377","author":"C Baigent","year":"2011","unstructured":"Baigent, C. et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 377, 2181\u20132192 (2011).","journal-title":"Lancet"},{"key":"BFnrneph201717_CR13","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/S0140-6736(03)13638-0","volume":"361","author":"H Holdaas","year":"2003","unstructured":"Holdaas, H. et al. Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial. Lancet 361, 2024\u20132031 (2003).","journal-title":"Lancet"},{"key":"BFnrneph201717_CR14","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1056\/NEJMoa043545","volume":"353","author":"C Wanner","year":"2005","unstructured":"Wanner, C. et al. Atorvastatin in patients with type 2 diabetes mellitus undergoing hemodialysis. N. Engl. J. Med. 353, 238\u2013248 (2005).","journal-title":"N. Engl. J. Med."},{"key":"BFnrneph201717_CR15","doi-asserted-by":"publisher","first-page":"243","DOI":"10.5301\/jn.5000169","volume":"26","author":"W Zhang","year":"2013","unstructured":"Zhang, W. et al. Prognostic role of C-reactive protein and interleukin-6 in dialysis patients: a systematic review and meta-analysis. J. Nephrol. 26, 243\u2013253 (2013).","journal-title":"J. Nephrol."},{"key":"BFnrneph201717_CR16","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.2215\/CJN.10441015","volume":"11","author":"J Sun","year":"2016","unstructured":"Sun, J. et al. Biomarkers of cardiovascular disease and mortality risk in patients with advanced CKD. Clin. J. Am. Soc. Nephrol. 11, 1163\u20131172 (2016).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"Suppl. 1","key":"BFnrneph201717_CR17","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1681\/ASN.2004110972","volume":"16","author":"G Tripepi","year":"2005","unstructured":"Tripepi, G., Mallamaci, F. & Zoccali, C. Inflammation markers, adhesion molecules, and all-cause and cardiovascular mortality in patients with ESRD: searching for the best risk marker by multivariate modeling. J. Am. Soc. Nephrol. 16 (Suppl. 1), S83\u2013S88 (2005).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR18","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1093\/ndt\/gfp625","volume":"25","author":"SD Cohen","year":"2010","unstructured":"Cohen, S. D., Phillips, T. M., Khetpal, P. & Kimmel, P. L. Cytokine patterns and survival in haemodialysis patients. Nephrol. Dial. Transplant. 25, 1239\u20131243 (2010).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph201717_CR19","doi-asserted-by":"publisher","first-page":"S169","DOI":"10.1681\/ASN.2006080910","volume":"17","author":"C Zoccali","year":"2006","unstructured":"Zoccali, C., Tripepi, G. & Mallamaci, F. Dissecting inflammation in ESRD: do cytokines and C-reactive protein have a complementary prognostic value for mortality in dialysis patients? J. Am. Soc. Nephrol. 17, S169\u2013S173 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR20","doi-asserted-by":"publisher","first-page":"S274","DOI":"10.1681\/ASN.2006080926","volume":"17","author":"R Jofre","year":"2006","unstructured":"Jofre, R., Rodriguez-Benitez, P., Lopez-Gomez, J. M. & Perez-Garcia, R. Inflammatory syndrome in patients on hemodialysis. J. Am. Soc. Nephrol. 17, S274\u2013S280 (2006).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000368940","volume":"39","author":"OM Akchurin","year":"2015","unstructured":"Akchurin, O. M. & Kaskel, F. Update on inflammation in chronic kidney disease. Blood Purif. 39, 84\u201392 (2015).","journal-title":"Blood Purif."},{"key":"BFnrneph201717_CR22","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/sdi.12440","volume":"29","author":"G Cobo","year":"2016","unstructured":"Cobo, G., Qureshi, A. R., Lindholm, B. & Stenvinkel, P. C-reactive protein: repeated measurements will improve dialysis patient care. Semin. Dial. 29, 7\u201314 (2016).","journal-title":"Semin. Dial."},{"key":"BFnrneph201717_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrneph.2013.44","volume":"9","author":"MG Betjes","year":"2013","unstructured":"Betjes, M. G. Immune cell dysfunction and inflammation in end-stage renal disease. Nat. Rev. Nephrol. 9, 255\u2013265 (2013).","journal-title":"Nat. Rev. Nephrol."},{"key":"BFnrneph201717_CR24","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jvs.2016.01.053","volume":"64","author":"J Almasri","year":"2016","unstructured":"Almasri, J. et al. Outcomes of vascular access for hemodialysis: a systematic review and meta-analysis. J. Vasc. Surg. 64, 236\u2013243 (2016).","journal-title":"J. Vasc. Surg."},{"issue":"Suppl. 1","key":"BFnrneph201717_CR25","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.2215\/CJN.02720409","volume":"4","author":"JJ Carrero","year":"2009","unstructured":"Carrero, J. J. & Stenvinkel, P. Persistent inflammation as a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal. Clin. J. Am. Soc. Nephrol. 4 (Suppl. 1), S49\u2013S55 (2009).","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR26","doi-asserted-by":"publisher","first-page":"515796","DOI":"10.1155\/2013\/515796","volume":"2013","author":"G Ismail","year":"2013","unstructured":"Ismail, G., Dumitriu, H. T., Dumitriu, A. S. & Ismail, F. B. Periodontal disease: a covert source of inflammation in chronic kidney disease patients. Int. J. Nephrol. 2013, 515796 (2013).","journal-title":"Int. J. Nephrol."},{"key":"BFnrneph201717_CR27","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1002\/pds.3755","volume":"24","author":"IA Gillespie","year":"2015","unstructured":"Gillespie, I. A. et al. Factors precipitating erythropoiesis-stimulating agent responsiveness in a European haemodialysis cohort: case-crossover study. Pharmacoepidemiol. Drug Saf. 24, 414\u2013426 (2015).","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"BFnrneph201717_CR28","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1046\/j.1523-1755.2001.00009.x","volume":"60","author":"RD Frank","year":"2001","unstructured":"Frank, R. D. et al. Role of contact system activation in hemodialyzer-induced thrombogenicity. Kidney Int. 60, 1972\u20131981 (2001).","journal-title":"Kidney Int."},{"issue":"Suppl. 1","key":"BFnrneph201717_CR29","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1681\/ASN.V13suppl_1s62","volume":"13","author":"WH Horl","year":"2002","unstructured":"Horl, W. H. Hemodialysis membranes: interleukins, biocompatibility, and middle molecules. J. Am. Soc. Nephrol. 13 (Suppl. 1), S62\u2013S71 (2002).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR30","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/ki.2015.117","volume":"88","author":"KU Eckardt","year":"2015","unstructured":"Eckardt, K. U. et al. High cardiovascular event rates occur within the first weeks of starting hemodialysis. Kidney Int. 88, 1117\u20131125 (2015).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR31","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1038\/sj.ki.5001865","volume":"70","author":"B Friedrich","year":"2006","unstructured":"Friedrich, B. et al. Acute effects of hemodialysis on cytokine transcription profiles: evidence for C-reactive protein-dependency of mediator induction. Kidney Int. 70, 2124\u20132130 (2006).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR32","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1038\/nrneph.2012.36","volume":"8","author":"MZ Molnar","year":"2012","unstructured":"Molnar, M. Z., Ojo, A. O., Bunnapradist, S., Kovesdy, C. P. & Kalantar-Zadeh, K. Timing of dialysis initiation in transplant-naive and failed transplant patients. Nat. Rev. Nephrol. 8, 284\u2013292 (2012).","journal-title":"Nat. Rev. Nephrol."},{"key":"BFnrneph201717_CR33","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/MNH.0000000000000114","volume":"24","author":"AA Merchant","year":"2015","unstructured":"Merchant, A. A., Quinn, R. R. & Perl, J. Dialysis modality and survival: does the controversy live on? Curr. Opin. Nephrol. Hypertens. 24, 276\u2013283 (2015).","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"BFnrneph201717_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-3083.2006.01729.x","volume":"63","author":"ES Reis","year":"2006","unstructured":"Reis, E. S., Falcao, D. A. & Isaac, L. Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H. Scand. J. Immunol. 63, 155\u2013168 (2006).","journal-title":"Scand. J. Immunol."},{"key":"BFnrneph201717_CR35","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1159\/000321753","volume":"168","author":"Y Takemoto","year":"2011","unstructured":"Takemoto, Y., Naganuma, T. & Yoshimura, R. Biocompatibility of the dialysis membrane. Contrib. Nephrol. 168, 139\u2013145 (2011).","journal-title":"Contrib. Nephrol."},{"key":"BFnrneph201717_CR36","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.biomaterials.2014.09.011","volume":"36","author":"AE Engberg","year":"2015","unstructured":"Engberg, A. E. et al. Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma. Biomaterials 36, 55\u201365 (2015).","journal-title":"Biomaterials"},{"key":"BFnrneph201717_CR37","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.biomaterials.2015.10.067","volume":"77","author":"S Huang","year":"2016","unstructured":"Huang, S. et al. Reciprocal relationship between the contact and the complement system activation on artificial polymers exposed to whole human blood. Biomaterials 77, 111\u2013119 (2016).","journal-title":"Biomaterials"},{"key":"BFnrneph201717_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/S0140-6736(16)30508-6","volume":"388","author":"C Wanner","year":"2016","unstructured":"Wanner, C., Amann, K. & Shoji, T. The heart and vascular system in dialysis. Lancet 388, 276\u2013284 (2016).","journal-title":"Lancet"},{"key":"BFnrneph201717_CR39","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1177\/0003319713483000","volume":"65","author":"S Ghanavatian","year":"2014","unstructured":"Ghanavatian, S. et al. Subclinical atherosclerosis, endothelial function, and serum inflammatory markers in chronic kidney disease stages 3 to 4. Angiology 65, 443\u2013449 (2014).","journal-title":"Angiology"},{"key":"BFnrneph201717_CR40","first-page":"308","volume":"56","author":"M Annuk","year":"2001","unstructured":"Annuk, M. et al. Oxidative stress markers in pre-uremic patients. Clin. Nephrol. 56, 308\u2013314 (2001).","journal-title":"Clin. Nephrol."},{"key":"BFnrneph201717_CR41","first-page":"721","volume":"18","author":"M Annuk","year":"2005","unstructured":"Annuk, M. et al. Endothelial function, CRP and oxidative stress in chronic kidney disease. J. Nephrol. 18, 721\u2013726 (2005).","journal-title":"J. Nephrol."},{"key":"BFnrneph201717_CR42","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1001\/jama.291.4.451","volume":"291","author":"Y Liu","year":"2004","unstructured":"Liu, Y. et al. Association between cholesterol level and mortality in dialysis patients: role of inflammation and malnutrition. JAMA 291, 451\u2013459 (2004).","journal-title":"JAMA"},{"key":"BFnrneph201717_CR43","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/j.1523-1755.2005.00200.x","volume":"67","author":"P Stenvinkel","year":"2005","unstructured":"Stenvinkel, P. et al. IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia \u2014 the good, the bad, and the ugly. Kidney Int. 67, 1216\u20131233 (2005).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR44","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1046\/j.1523-1755.2001.059002407.x","volume":"59","author":"M Arici","year":"2001","unstructured":"Arici, M. & Walls, J. End-stage renal disease, atherosclerosis, and cardiovascular mortality: is C-reactive protein the missing link? Kidney Int. 59, 407\u2013414 (2001).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR45","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1053\/j.ajkd.2005.09.014","volume":"47","author":"H Honda","year":"2006","unstructured":"Honda, H. et al. Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD. Am. J. Kidney Dis. 47, 139\u2013148 (2006).","journal-title":"Am. J. Kidney Dis."},{"key":"BFnrneph201717_CR46","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1681\/ASN.V12122747","volume":"12","author":"M Annuk","year":"2001","unstructured":"Annuk, M., Zilmer, M., Lind, L., Linde, T. & Fellstrom, B. Oxidative stress and endothelial function in chronic renal failure. J. Am. Soc. Nephrol. 12, 2747\u20132752 (2001).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR47","doi-asserted-by":"publisher","first-page":"c180","DOI":"10.1159\/000104429","volume":"106","author":"I Soveri","year":"2007","unstructured":"Soveri, I. et al. Improvement in central arterial pressure waveform during hemodialysis is related to a reduction in asymmetric dimethylarginine (ADMA) levels. Nephron. Clin. Pract. 106, c180\u2013c186 (2007).","journal-title":"Nephron. Clin. Pract."},{"key":"BFnrneph201717_CR48","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/01.mnh.0000441153.40072.e0","volume":"23","author":"MW Taal","year":"2014","unstructured":"Taal, M. W. Arterial stiffness in chronic kidney disease: an update. Curr. Opin. Nephrol. Hypertens. 23, 169\u2013173 (2014).","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"BFnrneph201717_CR49","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/ajh\/hpu225","volume":"28","author":"M Agharazii","year":"2015","unstructured":"Agharazii, M. et al. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am. J. Hypertens. 28, 746\u2013755 (2015).","journal-title":"Am. J. Hypertens."},{"key":"BFnrneph201717_CR50","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1681\/ASN.2010070760","volume":"22","author":"AM Hung","year":"2011","unstructured":"Hung, A. M., Ellis, C. D., Shintani, A., Booker, C. & Ikizler, T. A. IL-1beta receptor antagonist reduces inflammation in hemodialysis patients. J. Am. Soc. Nephrol. 22, 437\u2013442 (2011).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR51","doi-asserted-by":"crossref","unstructured":"The Cholesterol Treatment Trialists' (CTT) Collaboration et al. Impact of renal function on the effects of reducing LDL cholesterol with statin-based regimens: meta-analysis of individual data from 28 randomised trials. Lancet Diabetes Endocrinol. 4, 829\u2013839 (2016).","DOI":"10.1016\/S2213-8587(16)30156-5"},{"key":"BFnrneph201717_CR52","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.molimm.2011.04.014","volume":"48","author":"TM Woodruff","year":"2011","unstructured":"Woodruff, T. M., Nandakumar, K. S. & Tedesco, F. Inhibiting the C5-C5a receptor axis. Mol. Immunol. 48, 1631\u20131642 (2011).","journal-title":"Mol. Immunol."},{"key":"BFnrneph201717_CR53","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/BF00918247","volume":"5","author":"CA Dinarello","year":"1985","unstructured":"Dinarello, C. A. An update on human interleukin-1: from molecular biology to clinical relevance. J. Clin. Immunol. 5, 287\u2013297 (1985).","journal-title":"J. Clin. Immunol."},{"key":"BFnrneph201717_CR54","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1159\/000046967","volume":"19","author":"MP Varela","year":"2001","unstructured":"Varela, M. P. et al. Biocompatibility of hemodialysis membranes: interrelations between plasma complement and cytokine levels. Blood Purif. 19, 370\u2013379 (2001).","journal-title":"Blood Purif."},{"key":"BFnrneph201717_CR55","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1111\/j.1523-1755.1998.00836.x","volume":"53","author":"K Lhotta","year":"1998","unstructured":"Lhotta, K., Wurzner, R., Kronenberg, F., Oppermann, M. & Konig, P. Rapid activation of the complement system by cuprophane depends on complement component C4. Kidney Int. 53, 1044\u20131051 (1998).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR56","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1111\/j.1525-139X.2009.00658.x","volume":"22","author":"Z Huang","year":"2009","unstructured":"Huang, Z., Gao, D., Letteri, J. J. & Clark, W. R. Blood-membrane interactions during dialysis. Semin. Dial. 22, 623\u2013628 (2009).","journal-title":"Semin. Dial."},{"key":"BFnrneph201717_CR57","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.molimm.2006.06.020","volume":"44","author":"B Nilsson","year":"2007","unstructured":"Nilsson, B., Ekdahl, K. N., Mollnes, T. E. & Lambris, J. D. The role of complement in biomaterial-induced inflammation. Mol. Immunol. 44, 82\u201394 (2007).","journal-title":"Mol. Immunol."},{"key":"BFnrneph201717_CR58","doi-asserted-by":"publisher","first-page":"5786","DOI":"10.4049\/jimmunol.168.11.5786","volume":"168","author":"J Andersson","year":"2002","unstructured":"Andersson, J., Ekdahl, K. N., Larsson, R., Nilsson, U. R. & Nilsson, B. C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase. J. Immunol. 168, 5786\u20135791 (2002).","journal-title":"J. Immunol."},{"key":"BFnrneph201717_CR59","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1002\/(SICI)1097-4636(199607)31:3<305::AID-JBM3>3.0.CO;2-Q","volume":"31","author":"P Tengvall","year":"1996","unstructured":"Tengvall, P., Askendal, A. & Lundstr\u00f6m, I. Complement activation by IgG immobilized on methylated silicon. J. Biomed. Mater. Res. 31, 305\u2013312 (1996).","journal-title":"J. Biomed. Mater. Res."},{"key":"BFnrneph201717_CR60","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.colsurfb.2013.04.010","volume":"110","author":"M Hulander","year":"2013","unstructured":"Hulander, M. et al. Gradients in surface nanotopography used to study platelet adhesion and activation. Colloids Surf. B Biointerfaces 110, 261\u2013269 (2013).","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"BFnrneph201717_CR61","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.biomaterials.2004.05.011","volume":"26","author":"J Andersson","year":"2005","unstructured":"Andersson, J., Ekdahl, K. N., Lambris, J. D. & Nilsson, B. Binding of C3 fragments on top of adsorbed plasma proteins during complement activation on a model biomaterial surface. Biomaterials 26, 1477\u20131485 (2005).","journal-title":"Biomaterials"},{"key":"BFnrneph201717_CR62","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/ki.1983.225","volume":"24","author":"DE Chenoweth","year":"1983","unstructured":"Chenoweth, D. E., Cheung, A. K. & Henderson, L. W. Anaphylatoxin formation during hemodialysis: effects of different dialyzer membranes. Kidney Int. 24, 764\u2013769 (1983).","journal-title":"Kidney Int."},{"key":"BFnrneph201717_CR63","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1365-3083.1992.tb02837.x","volume":"35","author":"KN Ekdahl","year":"1992","unstructured":"Ekdahl, K. N., Nilsson, B., Pekna, M. & Nilsson, U. R. Generation of iC3 at the interface between blood and gas. Scand. J. Immunol. 35, 85\u201391 (1992).","journal-title":"Scand. J. Immunol."},{"key":"BFnrneph201717_CR64","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1525-139X.2008.00455.x","volume":"21","author":"CA Herzog","year":"2008","unstructured":"Herzog, C. A., Mangrum, J. M. & Passman, R. Sudden cardiac death and dialysis patients. Semin. Dial. 21, 300\u2013307 (2008).","journal-title":"Semin. Dial."},{"key":"BFnrneph201717_CR65","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/j.1365-3083.2006.01724.x","volume":"63","author":"M Furebring","year":"2006","unstructured":"Furebring, M., Hakansson, L., Venge, P. & Sjolin, J. C5a, interleukin-8 and tumour necrosis factor-alpha-induced changes in granulocyte and monocyte expression of complement receptors in whole blood and on isolated leukocytes. Scand. J. Immunol. 63, 208\u2013216 (2006).","journal-title":"Scand. J. Immunol."},{"key":"BFnrneph201717_CR66","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000317194","volume":"2","author":"PA Ward","year":"2010","unstructured":"Ward, P. A. The harmful role of c5a on innate immunity in sepsis. J. Innate Immun. 2, 439\u2013445 (2010).","journal-title":"J. Innate Immun."},{"key":"BFnrneph201717_CR67","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/imr.12473","volume":"274","author":"A Verschoor","year":"2016","unstructured":"Verschoor, A., Karsten, C. M., Broadley, S. P., Laumonnier, Y. & Kohl, J. Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments. Immunol. Rev. 274, 112\u2013126 (2016).","journal-title":"Immunol. Rev."},{"key":"BFnrneph201717_CR68","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1182\/blood-2010-01-264051","volume":"116","author":"I Kourtzelis","year":"2010","unstructured":"Kourtzelis, I. et al. Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood 116, 631\u2013639 (2010).","journal-title":"Blood"},{"key":"BFnrneph201717_CR69","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.imbio.2014.10.026","volume":"220","author":"ES Reis","year":"2015","unstructured":"Reis, E. S. et al. Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters. Immunobiology 220, 476\u2013482 (2015).","journal-title":"Immunobiology"},{"key":"BFnrneph201717_CR70","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1084\/jem.20051207","volume":"203","author":"AD Niederbichler","year":"2006","unstructured":"Niederbichler, A. D. et al. An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J. Exp. Med. 203, 53\u201361 (2006).","journal-title":"J. Exp. Med."},{"key":"BFnrneph201717_CR71","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1096\/fj.10-174284","volume":"25","author":"HD Manthey","year":"2011","unstructured":"Manthey, H. D. et al. Complement C5a inhibition reduces atherosclerosis in ApoE\u2212\/\u2212 mice. FASEB J. 25, 2447\u20132455 (2011).","journal-title":"FASEB J."},{"key":"BFnrneph201717_CR72","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1111\/jcmm.12357","volume":"18","author":"A Wezel","year":"2014","unstructured":"Wezel, A. et al. Complement factor C5a induces atherosclerotic plaque disruptions. J. Cell. Mol. Med. 18, 2020\u20132030 (2014).","journal-title":"J. Cell. Mol. Med."},{"key":"BFnrneph201717_CR73","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1002\/iub.1333","volume":"66","author":"M Koch","year":"2014","unstructured":"Koch, M. & Zernecke, A. The hemostatic system as a regulator of inflammation in atherosclerosis. IUBMB Life 66, 735\u2013744 (2014).","journal-title":"IUBMB Life"},{"key":"BFnrneph201717_CR74","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.thromres.2015.02.013","volume":"135","author":"S Giri","year":"2015","unstructured":"Giri, S. & Jennings, L. K. The spectrum of thrombin in acute coronary syndromes. Thromb. Res. 135, 782\u2013787 (2015).","journal-title":"Thromb. Res."},{"key":"BFnrneph201717_CR75","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/35025229","volume":"407","author":"SR Coughlin","year":"2000","unstructured":"Coughlin, S. R. Thrombin signalling and protease-activated receptors. Nature 407, 258\u2013264 (2000).","journal-title":"Nature"},{"key":"BFnrneph201717_CR76","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1160\/TH13-09-0730","volume":"111","author":"CT Esmon","year":"2014","unstructured":"Esmon, C. T. Targeting factor Xa and thrombin: impact on coagulation and beyond. Thromb. Haemost. 111, 625\u2013633 (2014).","journal-title":"Thromb. Haemost."},{"key":"BFnrneph201717_CR77","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-1-4614-0106-3_11","volume":"946","author":"OA Hamad","year":"2012","unstructured":"Hamad, O. A., B\u00e4ck, J., Nilsson, P. H., Nilsson, B. & Ekdahl, K. N. Platelets, complement, and contact activation: partners in inflammation and thrombosis. Adv. Exp. Med. Biol. 946, 185\u2013205 (2012).","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFnrneph201717_CR78","doi-asserted-by":"publisher","first-page":"e84358","DOI":"10.1371\/journal.pone.0084358","volume":"9","author":"E Terzuoli","year":"2014","unstructured":"Terzuoli, E. et al. Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation. PLoS ONE 9, e84358 (2014).","journal-title":"PLoS ONE"},{"key":"BFnrneph201717_CR79","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1681\/ASN.2009050505","volume":"20","author":"AM Marney","year":"2009","unstructured":"Marney, A. M., Ma, J., Luther, J. M., Ikizler, T. A. & Brown, N. J. Endogenous bradykinin contributes to increased plasminogen activator inhibitor 1 antigen following hemodialysis. J. Am. Soc. Nephrol. 20, 2246\u20132252 (2009).","journal-title":"J. Am. Soc. Nephrol."},{"key":"BFnrneph201717_CR80","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1517\/13543784.12.5.759","volume":"12","author":"H Heitsch","year":"2003","unstructured":"Heitsch, H. The therapeutic potential of bradykinin B2 receptor agonists in the treatment of cardiovascular disease. Expert Opin. Investig. Drugs 12, 759\u2013770 (2003).","journal-title":"Expert Opin. Investig. Drugs"},{"key":"BFnrneph201717_CR81","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/gerona\/glu210","volume":"71","author":"W Feng","year":"2016","unstructured":"Feng, W. et al. Increased age-related cardiac dysfunction in bradykinin B2 receptor-deficient mice. J. Gerontol. A Biol. Sci. Med. Sci. 71, 178\u2013187 (2016).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"BFnrneph201717_CR82","doi-asserted-by":"publisher","first-page":"8785","DOI":"10.1074\/jbc.M007396200","volume":"276","author":"LM Leeb-Lundberg","year":"2001","unstructured":"Leeb-Lundberg, L. M., Kang, D. S., Lamb, M. E. & Fathy, D. B. The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domains. J. Biol. Chem. 276, 8785\u20138792 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnrneph201717_CR83","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.coph.2008.11.011","volume":"9","author":"J Duchene","year":"2009","unstructured":"Duchene, J. & Ahluwalia, A. The kinin B1 receptor and inflammation: new therapeutic target for cardiovascular disease. Curr. Opin. Pharmacol. 9, 125\u2013131 (2009).","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFnrneph201717_CR84","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1177\/1753425914566083","volume":"21","author":"AJ Lizama","year":"2015","unstructured":"Lizama, A. J. et al. Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil. Innate Immun. 21, 575\u2013586 (2015).","journal-title":"Innate Immun."},{"key":"BFnrneph201717_CR85","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/1753425914529169","volume":"21","author":"CD Figueroa","year":"2015","unstructured":"Figueroa, C. D. et al. Kinin B1 receptor regulates interactions between neutrophils and endothelial cells by modulating the levels of Mac-1, LFA-1 and intercellular adhesion molecule-1. Innate Immun. 21, 289\u2013304 (2015).","journal-title":"Innate Immun."},{"key":"BFnrneph201717_CR86","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1097\/HJH.0000000000000192","volume":"32","author":"PC Papageorgiou","year":"2014","unstructured":"Papageorgiou, P. C., Chan, C. T., Yeo, E. L., Backx, P. H. & Floras, J. S. Coagulation factor XIIa-kinin-mediated contribution to hypertension of chronic kidney disease. J. Hypertens. 32, 1523\u20131533 (2014).","journal-title":"J. Hypertens."},{"key":"BFnrneph201717_CR87","doi-asserted-by":"publisher","first-page":"e111117","DOI":"10.1371\/journal.pone.0111117","volume":"9","author":"GS Ceravolo","year":"2014","unstructured":"Ceravolo, G. S. et al. An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. PLoS ONE 9, e111117 (2014).","journal-title":"PLoS ONE"},{"key":"BFnrneph201717_CR88","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/imr.12469","volume":"274","author":"B Ghebrehiwet","year":"2016","unstructured":"Ghebrehiwet, B., Kaplan, A. P., Joseph, K. & Peerschke, E. I. The complement and contact activation systems: partnership in pathogenesis beyond angioedema. Immunol. Rev. 274, 281\u2013289 (2016).","journal-title":"Immunol. Rev."},{"key":"BFnrneph201717_CR89","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/BF00421226","volume":"48","author":"I Bjork","year":"1982","unstructured":"Bjork, I. & Lindahl, U. Mechanism of the anticoagulant action of heparin. Mol. Cell. Biochem. 48, 161\u2013182 (1982).","journal-title":"Mol. Cell. Biochem."},{"key":"BFnrneph201717_CR90","doi-asserted-by":"publisher","first-page":"e0128634","DOI":"10.1371\/journal.pone.0128634","volume":"10","author":"A Dhondt","year":"2015","unstructured":"Dhondt, A. et al. Where and when to inject low molecular weight heparin in hemodiafiltration? A cross over randomised trial. PLoS ONE 10, e0128634 (2015).","journal-title":"PLoS ONE"},{"key":"BFnrneph201717_CR91","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1111\/jth.13555","volume":"14","author":"HC Hemker","year":"2016","unstructured":"Hemker, H. C. A century of heparin: past, present and future. J. Thromb. Haemost. 14, 2329\u20132338 (2016).","journal-title":"J. Thromb. Haemost."},{"key":"BFnrneph201717_CR92","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/BF01541228","volume":"16","author":"J Gong","year":"1996","unstructured":"Gong, J. et al. Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas phase interfaces induce complement activation in an in vitro model. J. Clin. Immunol. 16, 222\u2013229 (1996).","journal-title":"J. Clin. Immunol."},{"key":"BFnrneph201717_CR93","doi-asserted-by":"publisher","first-page":"222ra17","DOI":"10.1126\/scitranslmed.3006804","volume":"6","author":"M Larsson","year":"2014","unstructured":"Larsson, M. et al. A factor XIIa inhibitory antibody provides thromboprotection in extracorporeal circulation without increasing bleeding risk. Sci. Transl Med. 6, 222ra17 (2014).","journal-title":"Sci. Transl Med."},{"key":"BFnrneph201717_CR94","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/14017430050142378","volume":"34","author":"C Olsson","year":"2000","unstructured":"Olsson, C. et al. Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery. Scand. Cardiovasc. J. 34, 33\u201340 (2000).","journal-title":"Scand. Cardiovasc. J."},{"key":"BFnrneph201717_CR95","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/1471-2369-15-104","volume":"15","author":"K Fran\u00e7ois","year":"2014","unstructured":"Fran\u00e7ois, K. et al. Avoidance of systemic anticoagulation during intermittent haemodialysis with heparin-grafted polyacrilonitrile membrane and citrate-enriched dialysate: a retrospective cohort study. BMC Nephrol. 15, 104 (2014).","journal-title":"BMC Nephrol."},{"key":"BFnrneph201717_CR96","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1542-4758.2012.00733.x","volume":"17","author":"M Kessler","year":"2013","unstructured":"Kessler, M. et al. Heparin-grafted dialysis membrane allows minimal systemic anticoagulation in regular hemodialysis patients: a prospective proof-of-concept study. Hemodial. Int. 17, 282\u2013293 (2013).","journal-title":"Hemodial. Int."},{"key":"BFnrneph201717_CR97","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1093\/ndt\/gfq396","volume":"26","author":"Y-L Cheng","year":"2011","unstructured":"Cheng, Y.-L. et al. Anticoagulation during haemodialysis using a citrate-enriched dialysate: a feasibility study. Nephrol. Dial. Transplant. 26, 641\u2013646 (2011).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrneph201717_CR98","doi-asserted-by":"publisher","first-page":"343","DOI":"10.5301\/ijao.5000421","volume":"38","author":"P Persona","year":"2015","unstructured":"Persona, P. et al. Anticoagulation with citrate for hemodiafiltration in an acute bleeding trauma. Int. J. Artif. Organs 38, 343\u2013344 (2015).","journal-title":"Int. J. Artif. Organs"},{"issue":"Suppl. 3","key":"BFnrneph201717_CR99","first-page":"S279","volume":"6","author":"K Ishihara","year":"2009","unstructured":"Ishihara, K. & Takai, M. Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry. J. R. Soc. Interface 6 (Suppl. 3), S279\u2013S291 (2009).","journal-title":"J. R. Soc. Interface"},{"key":"BFnrneph201717_CR100","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000328940","volume-title":"High-Performance Membrane Dialyzers. Contributions to Nephrology","author":"K Sakai","year":"2011","unstructured":"Sakai, K. & Matsuda, M. in High-Performance Membrane Dialyzers. Contributions to Nephrology (eds Saito, A., Kawanishi, H., Yamashita, A. & Mineshima, M.) 11\u201322 (Karger, 2011)."},{"key":"BFnrneph201717_CR101","first-page":"351","volume-title":"Comprehensive Membrane Science and Engineering","author":"C Zweigert","year":"2013","unstructured":"Zweigert, C., Neubauer, M. & Storr, M. in Comprehensive Membrane Science and Engineering (eds Drioli, E. & Giorno, L.) 351\u2013387 (Elsevier, 2013)."},{"issue":"Suppl. 2","key":"BFnrneph201717_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000350835","volume":"35","author":"T Krummel","year":"2013","unstructured":"Krummel, T. & Hannedouche, T. Clinical potentials of adsorptive dialysis membranes. Blood Purif. 35 (Suppl. 2), 1\u20134 (2013).","journal-title":"Blood Purif."},{"key":"BFnrneph201717_CR103","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1159\/isbn.978-3-8055-9813-2","volume-title":"High-Performance Membrane Dialyzers. Contributions to Nephrology","author":"A Saito","year":"2011","unstructured":"Saito, A., Kawanishi, H., Yamashita, A. & Mineshima, M. (eds) in High-Performance Membrane Dialyzers. Contributions to Nephrology 137\u2013147 (Karger, 2011)."},{"key":"BFnrneph201717_CR104","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1159\/000329056","volume-title":"High-Performance Membrane Dialyzers. Contributions to Nephrology","author":"A Nakano","year":"2011","unstructured":"Nakano, A. in High-Performance Membrane Dialyzers. Contributions to Nephrology (eds Saito, A., Kawanishi, H., Yamashita, A. & Mineshima, M) 164\u2013171 (Karger, 2011)."},{"key":"BFnrneph201717_CR105","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.1021\/pr060150u","volume":"5","author":"M Bonomini","year":"2006","unstructured":"Bonomini, M. et al. Proteomics characterization of protein adsorption onto hemodialysis membranes. J. Proteome Res. 5, 2666\u20132674 (2006).","journal-title":"J. Proteome Res."},{"key":"BFnrneph201717_CR106","first-page":"694312","volume":"2014","author":"H Kol\u00e1r\u02d8ov\u00e1","year":"2014","unstructured":"Kol\u00e1r\u02d8ov\u00e1, H., Ambruzov\u00e1, B., Svih\u00e1lkov\u00e1 \u0160indlerov\u00e1, L., Klinke, A. & Kubala, L. Modulation of endothelial glycocalyx structure under inflammatory conditions. Mediators Inflamm. 2014, 694312 (2014).","journal-title":"Mediators Inflamm."},{"key":"BFnrneph201717_CR107","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/0975-3583.64432","volume":"1","author":"G Yang","year":"2010","unstructured":"Yang, G. et al. Novel mechanisms of endothelial dysfunction in diabetes. J. Cardiovasc. Dis. Res. 1, 59\u201363 (2010).","journal-title":"J. Cardiovasc. Dis. Res."},{"key":"BFnrneph201717_CR108","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/imr.12471","volume":"274","author":"KN Ekdahl","year":"2016","unstructured":"Ekdahl, K. N. et al. Dangerous liaisons: complement, coagulation, and kallikrein\/kinin cross-talk act as a linchpin in the events leading to thromboinflammation. Immunol. Rev. 274, 245\u2013269 (2016).","journal-title":"Immunol. Rev."},{"key":"BFnrneph201717_CR109","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/ni.1923","volume":"11","author":"D Ricklin","year":"2010","unstructured":"Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, J. D. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785\u2013797 (2010).","journal-title":"Nat. Immunol."},{"key":"BFnrneph201717_CR110","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.imlet.2011.02.014","volume":"138","author":"LA Trouw","year":"2011","unstructured":"Trouw, L. A. & Daha, M. R. Role of complement in innate immunity and host defense. Immunol. Lett. 138, 35\u201337 (2011).","journal-title":"Immunol. Lett."},{"key":"BFnrneph201717_CR111","doi-asserted-by":"publisher","first-page":"6573","DOI":"10.1016\/j.biomaterials.2009.07.052","volume":"30","author":"J B\u00e4ck","year":"2009","unstructured":"B\u00e4ck, J. et al. Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces. Biomaterials 30, 6573\u20136580 (2009).","journal-title":"Biomaterials"},{"key":"BFnrneph201717_CR112","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nature04005","volume":"437","author":"BJ Janssen","year":"2005","unstructured":"Janssen, B. J. et al. Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 437, 505\u2013511 (2005).","journal-title":"Nature"}],"container-title":["Nature Reviews Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2017.17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2017.17","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneph.2017.17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:50:28Z","timestamp":1684471828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrneph.2017.17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,27]]},"references-count":112,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["BFnrneph201717"],"URL":"https:\/\/doi.org\/10.1038\/nrneph.2017.17","relation":{},"ISSN":["1759-5061","1759-507X"],"issn-type":[{"value":"1759-5061","type":"print"},{"value":"1759-507X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,27]]},"assertion":[{"value":"27 February 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}