{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:50:44Z","timestamp":1793904644105,"version":"4.8.0"},"reference-count":118,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Neurol"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1038\/nrneurol.2009.54","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T04:12:59Z","timestamp":1244175179000},"page":"311-322","source":"Crossref","is-referenced-by-count":841,"title":["Brain-derived neurotrophic factor in neurodegenerative diseases"],"prefix":"10.1038","volume":"5","author":[{"given":"Chiara","family":"Zuccato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnrneurol200954_CR1","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1101\/gad.841400","volume":"14","author":"M Bibel","year":"2000","unstructured":"Bibel, M. & Barde, Y. A. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 14, 2919\u20132937 (2000).","journal-title":"Genes Dev."},{"key":"BFnrneurol200954_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/08977190410001723308","volume":"22","author":"DK Binder","year":"2004","unstructured":"Binder, D. K. & Scharfman, H. E. Brain-derived neurotrophic factor. Growth Factors 22, 123\u2013131 (2004).","journal-title":"Growth Factors"},{"key":"BFnrneurol200954_CR3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0896-6273(91)90273-3","volume":"7","author":"HS Phillips","year":"1991","unstructured":"Phillips, H. S.  et al. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7, 695\u2013702 (1991).","journal-title":"Neuron"},{"key":"BFnrneurol200954_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0301-0082(00)00014-9","volume":"3","author":"MG Murer","year":"2001","unstructured":"Murer, M. G., Yan, Q. & Raisman-Vozari, R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog. Neurobiol. 3, 71\u2013124 (2001).","journal-title":"Prog. Neurobiol."},{"key":"BFnrneurol200954_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.brainresrev.2008.07.007","volume":"59","author":"L Tapia-Arancibia","year":"2008","unstructured":"Tapia-Arancibia, L., Aliaga, E., Silhol, M. & Arancibia, S. New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res. Rev. 59, 201\u2013220 (2008).","journal-title":"Brain Res. Rev."},{"key":"BFnrneurol200954_CR6","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0306-4522(98)00219-X","volume":"88","author":"MG Murer","year":"1999","unstructured":"Murer, M. G.  et al. An immunohistochemical study of the distribution of brain-derived neurotrophic factor in the adult human brain, with particular reference to Alzheimer's disease. Neuroscience 88, 1015\u20131032 (1999).","journal-title":"Neuroscience"},{"key":"BFnrneurol200954_CR7","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1097\/00001756-199611250-00024","volume":"7","author":"M Narisawa-Saito","year":"1996","unstructured":"Narisawa-Saito, M., Wakabayashi, K., Tsuji, S., Takahashi, H. & Nawa, H. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 7, 2925\u20132928 (1996).","journal-title":"Neuroreport"},{"key":"BFnrneurol200954_CR8","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1111\/j.1471-4159.2005.03135.x","volume":"93","author":"S Peng","year":"2005","unstructured":"Peng, S., Wuu, J., Mufson, E. J. & Fahnestock, M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem. 93, 1412\u20131421 (2005).","journal-title":"J. Neurochem."},{"key":"BFnrneurol200954_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.expneurol.2005.01.026","volume":"194","author":"J Lee","year":"2005","unstructured":"Lee, J.  et al. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp. Neurol. 194, 91\u201396 (2005).","journal-title":"Exp. Neurol."},{"key":"BFnrneurol200954_CR10","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1523\/JNEUROSCI.5599-03.2004","volume":"24","author":"GJ Burbach","year":"2004","unstructured":"Burbach, G. J.  et al. Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. J. Neurosci. 24, 2421\u20132430 (2004).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR11","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/jnr.10443","volume":"70","author":"S Ando","year":"2002","unstructured":"Ando, S.  et al. Animal model of dementia induced by entorhinal synaptic damage and partial restoration of cognitive deficits by BDNF and carnitine. J. Neurosci. Res. 70, 519\u2013527 (2002).","journal-title":"J. Neurosci. Res."},{"key":"BFnrneurol200954_CR12","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/0092-8674(94)90377-8","volume":"76","author":"KR Jones","year":"1994","unstructured":"Jones, K. R., Fari\u00f1as, I., Backus, C. & Reichardt, L. F. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, 989\u2013999 (1994).","journal-title":"Cell"},{"key":"BFnrneurol200954_CR13","first-page":"799","volume":"39","author":"P Ernfors","year":"1995","unstructured":"Ernfors, P., Kucera, J., Lee, K. F., Loring, J. & Jaenisch, R. Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice. Int. J. Dev. Biol. 39, 799\u2013807 (1995).","journal-title":"Int. J. Dev. Biol."},{"key":"BFnrneurol200954_CR14","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/S0896-6273(00)81109-5","volume":"24","author":"MM Mesulam","year":"1999","unstructured":"Mesulam, M. M. Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles. Neuron 24, 521\u2013529 (1999).","journal-title":"Neuron"},{"key":"BFnrneurol200954_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0166-2236(00)01682-9","volume":"24","author":"DK Binder","year":"2001","unstructured":"Binder, D. K., Croll, S. D., Gall, C. M. & Scharfman, H. E. BDNF and epilepsy: too much of a good thing? Trends Neurosci. 24, 47\u201353 (2001).","journal-title":"Trends Neurosci."},{"key":"BFnrneurol200954_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.bbrc.2004.04.012","volume":"318","author":"R Kohno","year":"2004","unstructured":"Kohno, R.  et al. BDNF is induced by wild-type \u03b1-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem. Biophys. Res. Commun. 318, 113\u2013118 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrneurol200954_CR17","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.expneurol.2004.11.030","volume":"192","author":"MJ Porritt","year":"2005","unstructured":"Porritt, M. J., Batchelor, P. E. & Howells, D. W. Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons. Exp. Neurol. 192, 226\u2013234 (2005).","journal-title":"Exp. Neurol."},{"key":"BFnrneurol200954_CR18","doi-asserted-by":"publisher","first-page":"6251","DOI":"10.1523\/JNEUROSCI.4601-04.2005","volume":"25","author":"ZC Baquet","year":"2005","unstructured":"Baquet, Z. C., Bickford, P. C. & Jones, K. R. Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta. J. Neurosci. 25, 6251\u20136259 (2005).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR19","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/sj.mp.4001370","volume":"8","author":"F Fumagalli","year":"2003","unstructured":"Fumagalli, F., Racagni, G., Colombo, E. & Riva, M. A. BDNF gene expression is reduced in the frontal cortex of dopamine transporter knockout mice. Mol. Psychiatry 8, 898\u2013899 (2003).","journal-title":"Mol. Psychiatry"},{"key":"BFnrneurol200954_CR20","doi-asserted-by":"crossref","unstructured":"The Huntington's disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971\u2013983 (1993).","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"BFnrneurol200954_CR21","doi-asserted-by":"publisher","first-page":"5733","DOI":"10.1073\/pnas.85.15.5733","volume":"85","author":"A Reiner","year":"1988","unstructured":"Reiner, A.  et al. Differential loss of striatal projection neurons in Huntington disease. Proc. Natl Acad. Sci. USA 85, 5733\u20135737 (1988).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneurol200954_CR22","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","volume":"65","author":"HD Rosas","year":"2005","unstructured":"Rosas, H. D.  et al. Regional cortical thinning in preclinical Huntington disease and its relationship to cognition. Neurology 65, 745\u2013747 (2005).","journal-title":"Neurology"},{"key":"BFnrneurol200954_CR23","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1038\/39885","volume":"389","author":"CA Altar","year":"1997","unstructured":"Altar, C. A.  et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 389, 856\u2013860 (1997).","journal-title":"Nature"},{"key":"BFnrneurol200954_CR24","doi-asserted-by":"publisher","first-page":"4250","DOI":"10.1523\/JNEUROSCI.3920-03.2004","volume":"24","author":"ZC Baquet","year":"2004","unstructured":"Baquet, Z. C., Gorski, J. A. & Jones, K. R. Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor. J. Neurosci. 24, 4250\u20134258 (2004).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0006-8993(00)02237-X","volume":"866","author":"I Ferrer","year":"2000","unstructured":"Ferrer, I., Goutan, E., Mar\u00edn, C., Rey, M. J. & Ribalta, T. Brain-derived neurotrophic factor in Huntington disease. Brain Res. 866, 257\u2013261 (2000).","journal-title":"Brain Res."},{"key":"BFnrneurol200954_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","volume":"293","author":"C Zuccato","year":"2001","unstructured":"Zuccato, C.  et al. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 293, 493\u2013498 (2001).","journal-title":"Science"},{"key":"BFnrneurol200954_CR27","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","volume":"81","author":"C Zuccato","year":"2007","unstructured":"Zuccato, C. & Cattaneo, E. Role of brain-derived neurotrophic factor in Huntington's disease. Prog. Neurobiol. 81, 294\u2013330 (2007).","journal-title":"Prog. Neurobiol."},{"key":"BFnrneurol200954_CR28","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1750-3639.2007.00111.x","volume":"18","author":"C Zuccato","year":"2008","unstructured":"Zuccato, C.  et al. Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease. Brain Pathol. 18, 225\u2013238 (2008).","journal-title":"Brain Pathol."},{"key":"BFnrneurol200954_CR29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ng1219","volume":"35","author":"C Zuccato","year":"2003","unstructured":"Zuccato, C.  et al. Huntingtin interacts with REST\/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature Genet. 35, 76\u201383 (2003).","journal-title":"Nature Genet."},{"key":"BFnrneurol200954_CR30","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.1523\/JNEUROSCI.4278-06.2007","volume":"27","author":"C Zuccato","year":"2007","unstructured":"Zuccato, C.  et al. Widespread disruption of repressor element-1 silencing transcription factor\/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J. Neurosci. 27, 6972\u20136983 (2007).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","volume":"90","author":"P Pruunsild","year":"2007","unstructured":"Pruunsild, P., Kazantseva, A., Aid, T., Palm, K. & Timmusk, T. Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90, 397\u2013406 (2007).","journal-title":"Genomics"},{"key":"BFnrneurol200954_CR32","doi-asserted-by":"publisher","first-page":"34880","DOI":"10.1074\/jbc.M804183200","volume":"283","author":"M Shimojo","year":"2008","unstructured":"Shimojo, M. Huntingtin regulates RE1-silencing transcription factor (REST\/NRSF) nuclear trafficking indirectly through a complex with REST\/NRSF-interacting LIM domain protein (RILP) and dynactin p150Glued. J. Biol. Chem. 283, 34880\u201334886 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnrneurol200954_CR33","doi-asserted-by":"crossref","unstructured":"Marullo, M.  et al. Analysis of the repressor element-1 silencing transcription factor\/neuronal-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's Disease. Brain Pathol. doi:10.1111\/j.1750-3639.2008.00249.x","DOI":"10.1111\/j.1750-3639.2008.00249.x"},{"key":"BFnrneurol200954_CR34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","volume":"118","author":"LR Gauthier","year":"2004","unstructured":"Gauthier, L. R.  et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118, 127\u2013138 (2004).","journal-title":"Cell"},{"key":"BFnrneurol200954_CR35","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.1038\/emboj.2008.133","volume":"27","author":"E Colin","year":"2008","unstructured":"Colin, E.  et al. Huntingtin phosphorylation acts as a molecular switch for anterograde\/retrograde transport in neurons. EMBO J. 27, 2124\u20132134 (2008).","journal-title":"EMBO J."},{"key":"BFnrneurol200954_CR36","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1093\/hmg\/ddn281","volume":"17","author":"D Zala","year":"2008","unstructured":"Zala, D.  et al. Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum. Mol. Genet. 17, 3837\u20133846 (2008).","journal-title":"Hum. Mol. Genet."},{"key":"BFnrneurol200954_CR37","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.1523\/JNEUROSCI.4144-08.2008","volume":"28","author":"LS Her","year":"2008","unstructured":"Her, L. S. & Goldstein, L. S. Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin. J. Neurosci. 28, 13662\u201313672 (2008).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR38","doi-asserted-by":"publisher","first-page":"11758","DOI":"10.1523\/JNEUROSCI.2461-07.2007","volume":"27","author":"AD Strand","year":"2007","unstructured":"Strand, A. D.  et al. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J. Neurosci. 27, 11758\u201311768 (2007).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR39","doi-asserted-by":"publisher","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","volume":"24","author":"JM Canals","year":"2004","unstructured":"Canals, J. M.  et al. Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with encephalinergic neuronal degeneration in Huntington's disease. J. Neurosci. 24, 7727\u20137739 (2004).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR40","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1212\/01.wnl.0000175977.57661.b1","volume":"65","author":"J Alberch","year":"2005","unstructured":"Alberch, J.  et al. Association between BDNF Val66Met polymorphism and age at onset in Huntington disease. Neurology 65, 964\u2013965 (2005).","journal-title":"Neurology"},{"key":"BFnrneurol200954_CR41","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.nbd.2006.07.002","volume":"24","author":"E Di Maria","year":"2006","unstructured":"Di Maria, E.  et al. No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease. Neurobiol. Dis. 24, 274\u2013279 (2006).","journal-title":"Neurobiol. Dis."},{"key":"BFnrneurol200954_CR42","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.nbd.2006.07.008","volume":"24","author":"S Kishikawa","year":"2006","unstructured":"Kishikawa, S.  et al. Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease. Neurobiol. Dis. 24, 280\u2013285 (2006).","journal-title":"Neurobiol. Dis."},{"key":"BFnrneurol200954_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2350-7-79","volume":"7","author":"M Mai","year":"2006","unstructured":"Mai, M.  et al. No association between polymorphisms in the BDNF gene and age at onset in Huntington disease. BMC Med. Genet. 7, 79 (2006).","journal-title":"BMC Med. Genet."},{"key":"BFnrneurol200954_CR44","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00439-006-0221-2","volume":"120","author":"S Metzger","year":"2006","unstructured":"Metzger, S.  et al. Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease. Hum. Genet. 120, 285\u2013292 (2006).","journal-title":"Hum. Genet."},{"key":"BFnrneurol200954_CR45","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/S0306-4522(99)00296-1","volume":"93","author":"SD Croll","year":"1999","unstructured":"Croll, S. D.  et al. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93, 1491\u20131506 (1999).","journal-title":"Neuroscience"},{"key":"BFnrneurol200954_CR46","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.nbd.2008.05.012","volume":"31","author":"S Arancibia","year":"2008","unstructured":"Arancibia, S.  et al. Protective effect of BDNF against \u03b2-amyloid induced neurotoxicity in vitro and in vivo in rats. Neurobiol. Dis. 31, 316\u2013326 (2008).","journal-title":"Neurobiol. Dis."},{"key":"BFnrneurol200954_CR47","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JAD-2001-3111","volume":"3","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe, D. J. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid \u03b2-protein. J. Alzheimers Dis. 3, 75\u201380 (2001).","journal-title":"J. Alzheimers Dis."},{"key":"BFnrneurol200954_CR48","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nm.1912","volume":"15","author":"AH Nagahara","year":"2009","unstructured":"Nagahara, A. H.  et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat. Med. 15, 331\u2013337 (2009).","journal-title":"Nat. Med."},{"key":"BFnrneurol200954_CR49","doi-asserted-by":"publisher","first-page":"7810","DOI":"10.1523\/JNEUROSCI.15-12-07810.1995","volume":"15","author":"M Levivier","year":"1995","unstructured":"Levivier, M., Przedborski, S., Bencsics, C. & Kang, U. J. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 15, 7810\u20137820 (1995).","journal-title":"J. Neurosci."},{"key":"BFnrneurol200954_CR50","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1038\/nm1195-1189","volume":"1","author":"O Isacson","year":"1995","unstructured":"Isacson, O.  et al. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nat. Med. 1, 1189\u20131194 (1995).","journal-title":"Nat. Med."},{"key":"BFnrneurol200954_CR51","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/0169-328X(96)00062-9","volume":"41","author":"HC Hung","year":"1996","unstructured":"Hung, H. C. & Lee, E. H. The mesolimbic dopaminergic pathway is more resistant than the nigrostriatal dopaminergic pathway to MPTP and MPP+ toxicity: role of BDNF gene expression. Brain Res. Mol. Brain Res. 41, 14\u201326 (1996).","journal-title":"Brain Res. Mol. Brain Res."},{"key":"BFnrneurol200954_CR52","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1227\/00006123-199510000-00018","volume":"37","author":"T Tsukahara","year":"1995","unstructured":"Tsukahara, T., Takeda, M., Shimohama, S., Ohara, O. & Hashimoto, N. Effects of brain-derived neurotrophic factor on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in monkeys. Neurosurgery 37, 733\u2013741 (1995).","journal-title":"Neurosurgery"},{"key":"BFnrneurol200954_CR53","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.pneurobio.2008.05.001","volume":"85","author":"T Deierborg","year":"2008","unstructured":"Deierborg, T., Soulet, D., Roybon, L., Hall, V. & Brundin, P. Emerging restorative treatments for Parkinson's disease. Prog. Neurobiol. 85, 407\u2013432 (2008).","journal-title":"Prog. Neurobiol."},{"key":"BFnrneurol200954_CR54","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/321168a0","volume":"321","author":"MF Beal","year":"1986","unstructured":"Beal, M. F.  et al. Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321, 168\u2013171 (1986).","journal-title":"Nature"},{"key":"BFnrneurol200954_CR55","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/gt.2008.23","volume":"15","author":"AP Kells","year":"2008","unstructured":"Kells, A. P., Henry, R. A. & Connor, B. AAV-BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment. Gene Ther. 15, 966\u2013977 (2008).","journal-title":"Gene Ther."},{"key":"BFnrneurol200954_CR56","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0092-8674(00)80513-9","volume":"90","author":"SW Davies","year":"1997","unstructured":"Davies, S. W.  et al. Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90, 537\u2013548 (1997).","journal-title":"Cell"},{"key":"BFnrneurol200954_CR57","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0092-8674(00)81782-1","volume":"95","author":"F Saudou","year":"1998","unstructured":"Saudou, F., Finkbeiner, S., Devys, D. & Greenberg, M. E. Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell 95, 55\u201366 (1998).","journal-title":"Cell"},{"key":"BFnrneurol200954_CR58","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.nbd.2005.05.017","volume":"20","author":"D Zala","year":"2005","unstructured":"Zala, D.  et al. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiol. Dis. 20, 785\u2013798 (2005).","journal-title":"Neurobiol. Dis."},{"key":"BFnrneurol200954_CR59","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1471-4159.2007.05137.x","volume":"105","author":"K Gharami","year":"2008","unstructured":"Gharami, K., Xie, Y., An, J. J., Tonegawa, S. & Xu, B. Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice. J. Neurochem. 105, 369\u2013379 (2008).","journal-title":"J. Neurochem."},{"key":"BFnrneurol200954_CR60","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1172\/JCI31778","volume":"117","author":"SR Cho","year":"2007","unstructured":"Cho, S. R.  et al. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J. Clin. Invest. 117, 2889\u20132902 (2007).","journal-title":"J. Clin. Invest."},{"key":"BFnrneurol200954_CR61","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/j.1460-9568.2006.04590.x","volume":"23","author":"S Gines","year":"2006","unstructured":"Gines, S.  et al. Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. Eur. J. Neurosci. 23, 649\u2013658 (2006).","journal-title":"Eur. J. Neurosci."},{"key":"BFnrneurol200954_CR62","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/j.1471-4159.2006.03764.x","volume":"97","author":"SD Ginsberg","year":"2006","unstructured":"Ginsberg, S. D., Che, S., Wuu, J., Counts, S. E. & Mufson, E. J. Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease. J. Neurochem. 97, 475\u2013487 (2006).","journal-title":"J. Neurochem."},{"key":"BFnrneurol200954_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0169-328X(96)00040-X","volume":"42","author":"B Connor","year":"1996","unstructured":"Connor, B.  et al. Trk receptor alterations in Alzheimer's disease. Brain Res. Mol. Brain Res. 42, 1\u201317 (1996).","journal-title":"Brain Res. Mol. Brain Res."},{"key":"BFnrneurol200954_CR64","doi-asserted-by":"crossref","unstructured":"The BDNF Study Group Phase III. A controlled trial of recombinant methionyl human BDNF in ALS. Neurology 52, 1427\u20131433 (1999).","DOI":"10.1212\/WNL.52.7.1427"},{"key":"BFnrneurol200954_CR65","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1080\/14660820050515197","volume":"1","author":"G Ochs","year":"2000","unstructured":"Ochs, G.  et al. A phase I\/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1, 201\u2013206 (2000).","journal-title":"Amyotroph. Lateral Scler. Other Motor Neuron Disord."},{"key":"BFnrneurol200954_CR66","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nm850","volume":"9","author":"SS Gill","year":"2003","unstructured":"Gill, S. S.  et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat. Med. 9, 589\u2013595 (2003).","journal-title":"Nat. Med."},{"key":"BFnrneurol200954_CR67","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1172\/JCI35700","volume":"118","author":"S Hacein-Bey-Abina","year":"2008","unstructured":"Hacein-Bey-Abina, S.  et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J. Clin. Invest. 118, 3132\u20133142 (2008).","journal-title":"J. Clin. Invest."},{"key":"BFnrneurol200954_CR68","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1089\/hum.2005.16.1133","volume":"16","author":"A Biffi","year":"2005","unstructured":"Biffi, A. & Naldini, L. Gene therapy of storage disorders by retroviral and lentiviral vectors. Hum. Gene Ther. 16, 1133\u20131142 (2005).","journal-title":"Hum. Gene Ther."},{"key":"BFnrneurol200954_CR69","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/nm1365","volume":"12","author":"RJ Y\u00e1\u00f1ez-Mu\u00f1oz","year":"2006","unstructured":"Y\u00e1\u00f1ez-Mu\u00f1oz, R. J.  et al. Effective gene therapy with nonintegrating lentiviral vectors. Nat. Med. 12, 348\u2013353 (2006).","journal-title":"Nat. Med."},{"key":"BFnrneurol200954_CR70","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/386395a0","volume":"386","author":"DF Emerich","year":"1997","unstructured":"Emerich, D. F.  et al. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386, 395\u2013399 (1997).","journal-title":"Nature"},{"key":"BFnrneurol200954_CR71","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrn809","volume":"3","author":"F Rossi","year":"2002","unstructured":"Rossi, F. & Cattaneo, E. Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat. Rev. Neurosci. 3, 401\u2013409 (2002).","journal-title":"Nat. Rev. Neurosci."},{"key":"BFnrneurol200954_CR72","first-page":"139","volume":"6","author":"WM Pardridge","year":"2006","unstructured":"Pardridge, W. M. Molecular trojan horses for blood-brain barrier drug delivery. Discov. Med. 6, 139\u2013143 (2006).","journal-title":"Discov. Med."},{"key":"BFnrneurol200954_CR73","doi-asserted-by":"publisher","first-page":"503","DOI":"10.2174\/156720507783018316","volume":"4","author":"FM Longo","year":"2007","unstructured":"Longo, F. M.  et al. Small molecule neurotrophin receptor ligands: novel strategies for for targeting Alzheimer's disease mechanisms. Curr. Alzheimer Res. 4, 503\u2013506 (2007).","journal-title":"Curr. Alzheimer Res."},{"key":"BFnrneurol200954_CR74","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1152\/physrev.00004.2002","volume":"82","author":"MP Mattson","year":"2002","unstructured":"Mattson, M. P., Chan, S. L. & Duan, W. Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol. Rev. 82, 637\u2013672 (2002).","journal-title":"Physiol. Rev."},{"key":"BFnrneurol200954_CR75","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1111\/j.1742-4658.2005.04677.x","volume":"272","author":"TL Spires","year":"2005","unstructured":"Spires, T. L. & Hannan, A. J. Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw. FEBS J. 272, 2347\u20132361 (2005).","journal-title":"FEBS J."},{"key":"BFnrneurol200954_CR76","doi-asserted-by":"publisher","first-page":"18171","DOI":"10.1073\/pnas.0405831102","volume":"101","author":"N Maswood","year":"2004","unstructured":"Maswood, N.  et al. Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease. Proc. Natl Acad. Sci. USA 101, 18171\u201318176 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneurol200954_CR77","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/sj.tpj.6500337","volume":"6","author":"F Fumagalli","year":"2006","unstructured":"Fumagalli, F., Racagni, G. & Riva, M. A. The expanding role of BDNF: a therapeutic target for Alzheimer's disease? Pharmacogenomics J. 6, 8\u201315 (2006).","journal-title":"Pharmacogenomics J."},{"key":"BFnrneurol200954_CR78","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/sj.tpj.6500360","volume":"6","author":"F Fumagalli","year":"2006","unstructured":"Fumagalli, F., Racagni, G. & Riva, M. A. Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. Pharmacogenomics J. 6, 95\u2013104 (2006).","journal-title":"Pharmacogenomics J."},{"key":"BFnrneurol200954_CR79","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.nbd.2008.01.015","volume":"30","author":"W Duan","year":"2008","unstructured":"Duan, W.  et al. Sertraline slows disease progression and increases neurogenesis in N171\u201382Q mouse model of Huntington's disease. Neurobiol. Dis. 30, 312\u2013322 (2008).","journal-title":"Neurobiol. Dis."},{"key":"BFnrneurol200954_CR80","doi-asserted-by":"publisher","first-page":"24554","DOI":"10.1074\/jbc.M609885200","volume":"282","author":"D Rigamonti","year":"2007","unstructured":"Rigamonti, D.  et al. Loss of huntingtin function complemented by small molecules acting as repressor element 1\/neuron restrictive silencer element silencer modulators. J. Biol. Chem. 282, 24554\u201324562 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnrneurol200954_CR81","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1172\/JCI27607","volume":"116","author":"M Borrell-Pag\u00e8s","year":"2006","unstructured":"Borrell-Pag\u00e8s, M.  et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J. Clin. Invest. 116, 1410\u20131424 (2006).","journal-title":"J. Clin. Invest."},{"key":"BFnrneurol200954_CR82","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nm1239","volume":"11","author":"MH Tuszynski","year":"2005","unstructured":"Tuszynski, M. H.  et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat. Med. 11, 551\u2013555 (2005).","journal-title":"Nat. Med."},{"key":"BFnrneurol200954_CR83","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","volume":"49","author":"Q Chang","year":"2006","unstructured":"Chang, Q., Khare, G., Dani, V., Nelson, S. & Jaenisch, R. The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron 49, 341\u2013348 (2006).","journal-title":"Neuron"},{"key":"BFnrneurol200954_CR84","doi-asserted-by":"publisher","first-page":"3225","DOI":"10.1073\/pnas.0808387106","volume":"106","author":"P Koch","year":"2009","unstructured":"Koch, P., Opitz, T., Steinbeck, J. A., Ladewig, J. & Br\u00fcstle, O. A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration. Proc. Natl Acad. Sci. USA 106, 3225\u20133230 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneurol200954_CR85","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.mcn.2008.02.014","volume":"38","author":"Y Sun","year":"2008","unstructured":"Sun, Y.  et al. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Mol. Cell Neurosci. 38, 245\u2013258 (2008).","journal-title":"Mol. Cell Neurosci."},{"key":"BFnrneurol200954_CR86","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/ana.10842","volume":"55","author":"S Bagnoli","year":"2004","unstructured":"Bagnoli, S.  et al. Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy. Ann. Neurol. 55, 447\u2013448 (2004).","journal-title":"Ann. Neurol."},{"key":"BFnrneurol200954_CR87","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1385\/JMN:22:3:257","volume":"22","author":"AL Nishimura","year":"2004","unstructured":"Nishimura, A. L.  et al. Lack of association between the brain-derived neurotrophin factor (C-270T) polymorphism and late-onset Alzheimer's disease (LOAD) in Brazilian patients. J. Mol. Neurosci. 22, 257\u2013260 (2004).","journal-title":"J. Mol. Neurosci."},{"key":"BFnrneurol200954_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajmg.b.30154","volume":"134B","author":"SM Bodner","year":"2005","unstructured":"Bodner, S. M.  et al. Genetic variation in the brain derived neurotrophic factor gene in Alzheimer's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 134B, 1\u20135 (2005).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFnrneurol200954_CR89","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s00415-005-0667-5","volume":"252","author":"S Veps\u00e4l\u00e4inen","year":"2005","unstructured":"Veps\u00e4l\u00e4inen, S.  et al. Genetic analysis of BDNF and TrkB gene polymorphisms in Alzheimer's disease. J. Neurol. 252, 423\u2013428 (2005).","journal-title":"J. Neurol."},{"key":"BFnrneurol200954_CR90","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3233\/JAD-2006-9104","volume":"9","author":"JY Chuu","year":"2006","unstructured":"Chuu, J. Y.  et al. The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. J. Alzheimers Dis. 9, 43\u201349 (2006).","journal-title":"J. Alzheimers Dis."},{"key":"BFnrneurol200954_CR91","first-page":"12","volume":"44","author":"MS Saarela","year":"2006","unstructured":"Saarela, M. S.  et al. No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease. Folia Neuropathol. 44, 12\u201316 (2006).","journal-title":"Folia Neuropathol."},{"key":"BFnrneurol200954_CR92","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1136\/jmg.2006.044883","volume":"44","author":"R Huang","year":"2007","unstructured":"Huang, R., Huang, J., Cathcart, H., Smith, S. & Poduslo, S. E. Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J. Med. Genet. 44, e66 (2007).","journal-title":"J. Med. Genet."},{"key":"BFnrneurol200954_CR93","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10048-008-0151-3","volume":"10","author":"BM Schjeide","year":"2008","unstructured":"Schjeide, B. M.  et al. Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics 10, 19\u201325 (2008).","journal-title":"Neurogenetics"},{"key":"BFnrneurol200954_CR94","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/sj.mp.4000792","volume":"6","author":"H Kunugi","year":"2001","unstructured":"Kunugi, H.  et al. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol. Psychiatry 6, 83\u201386 (2001).","journal-title":"Mol. Psychiatry"},{"key":"BFnrneurol200954_CR95","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/sj.mp.4001073","volume":"7","author":"M Riemenschneider","year":"2002","unstructured":"Riemenschneider, M.  et al. A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E \u03b54 allele. Mol. Psychiatry 7, 782\u2013785 (2002).","journal-title":"Mol. Psychiatry"},{"key":"BFnrneurol200954_CR96","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000075332","volume":"49","author":"SJ Tsai","year":"2004","unstructured":"Tsai, S. J.  et al. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 49, 10\u201312 (2004).","journal-title":"Neuropsychobiology"},{"key":"BFnrneurol200954_CR97","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.neulet.2005.01.008","volume":"379","author":"P Desai","year":"2005","unstructured":"Desai, P., Nebes, R., DeKosky, S. T. & Kamboh, M. I. Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci. Lett. 379, 229\u2013234 (2005).","journal-title":"Neurosci. Lett."},{"key":"BFnrneurol200954_CR98","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1159\/000094933","volume":"22","author":"H Akatsu","year":"2006","unstructured":"Akatsu, H.  et al. Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan. Dement. Geriatr. Cogn. Disord. 22, 216\u2013222 (2006).","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"BFnrneurol200954_CR99","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1007\/s00702-004-0210-3","volume":"112","author":"S Matsushita","year":"2005","unstructured":"Matsushita, S.  et al. Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. J. Neural Transm. 112, 703\u2013711 (2005).","journal-title":"J. Neural Transm."},{"key":"BFnrneurol200954_CR100","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1002\/mds.20491","volume":"20","author":"M Nishimura","year":"2005","unstructured":"Nishimura, M., Kuno, S., Kaji, R. & Kawakami, H. Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Mov. Disord. 20, 1031\u20131033 (2005).","journal-title":"Mov. Disord."},{"key":"BFnrneurol200954_CR101","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.neulet.2005.02.017","volume":"381","author":"D Olin","year":"2005","unstructured":"Olin, D., MacMurray, J. & Comings, D. E. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci. Lett. 381, 275\u2013278 (2005).","journal-title":"Neurosci. Lett."},{"key":"BFnrneurol200954_CR102","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3233\/JAD-2008-15105","volume":"15","author":"A Cozza","year":"2008","unstructured":"Cozza, A.  et al. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. J. Alzheimers Dis. 15, 61\u201370 (2008).","journal-title":"J. Alzheimers Dis."},{"key":"BFnrneurol200954_CR103","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1601-183X.2008.00440.x","volume":"8","author":"R Hashimoto","year":"2008","unstructured":"Hashimoto, R.  et al. Effect of the BDNF and the ApoE polymorphisms on disease progression in preclinical Alzheimer's disease. Genes Brain Behav. 8, 43\u201352 (2008).","journal-title":"Genes Brain Behav."},{"key":"BFnrneurol200954_CR104","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/ana.10585","volume":"53","author":"A H\u00e5kansson","year":"2003","unstructured":"H\u00e5kansson, A.  et al. Lack of association between the BDNF Val66Met polymorphism and Parkinson's disease in a Swedish population. Ann. Neurol. 53, 823 (2003).","journal-title":"Ann. Neurol."},{"key":"BFnrneurol200954_CR105","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neulet.2003.09.009","volume":"353","author":"CJ Hong","year":"2003","unstructured":"Hong, C. J.  et al. Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset. Neurosci. Lett. 353, 75\u201377 (2003).","journal-title":"Neurosci. Lett."},{"key":"BFnrneurol200954_CR106","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ajmg.b.30109","volume":"134B","author":"QR Liu","year":"2005","unstructured":"Liu, Q. R.  et al. Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 134B, 93\u2013103 (2005).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFnrneurol200954_CR107","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.neulet.2006.12.038","volume":"415","author":"G Xiromerisiou","year":"2007","unstructured":"Xiromerisiou, G.  et al. BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neurosci. Lett. 415, 59\u201363 (2007).","journal-title":"Neurosci. Lett."},{"key":"BFnrneurol200954_CR108","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/ajmg.b.30476","volume":"144B","author":"CM Chen","year":"2007","unstructured":"Chen, C. M.  et al. Nuclear receptor NR4A2 IVS6 +18insG and brain derived neurotrophic factor (BDNF) V66M polymorphisms and risk of Taiwanese Parkinson's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 458\u2013462 (2007).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"BFnrneurol200954_CR109","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/ana.10079","volume":"51","author":"Y Momose","year":"2002","unstructured":"Momose, Y.  et al. Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms. Ann. Neurol. 51, 133\u2013136 (2002).","journal-title":"Ann. Neurol."},{"issue":"Suppl. 3","key":"BFnrneurol200954_CR110","first-page":"iii40","volume":"250","author":"T Toda","year":"2003","unstructured":"Toda, T.  et al. Toward identification of susceptibility genes for sporadic Parkinson's disease. J. Neurol. 250 (Suppl. 3), iii40\u2013iii43 (2003).","journal-title":"J. Neurol."},{"key":"BFnrneurol200954_CR111","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.parkreldis.2003.12.003","volume":"10","author":"A Parsian","year":"2004","unstructured":"Parsian, A., Sinha, R., Racette, B., Zhao, J. H. & Perlmutter, J. S. Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease. Parkinsonism Relat. Disord. 10, 213\u2013219 (2004).","journal-title":"Parkinsonism Relat. Disord."},{"key":"BFnrneurol200954_CR112","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1212\/01.wnl.0000187075.81589.fd","volume":"65","author":"S Karamohamed","year":"2005","unstructured":"Karamohamed, S.  et al. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study. Neurology 65, 1823\u20131825 (2005).","journal-title":"Neurology"},{"key":"BFnrneurol200954_CR113","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1160\/TH06-03-0173","volume":"96","author":"C Laske","year":"2006","unstructured":"Laske, C.  et al. Decreased brain-derived neurotrophic factor (BDNF)- and \u03b2-thromboglobulin (\u03b2-TG)- blood levels in Alzheimer's disease. Thromb. Haemost. 96, 102\u2013103 (2006).","journal-title":"Thromb. Haemost."},{"key":"BFnrneurol200954_CR114","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s00702-005-0397-y","volume":"113","author":"C Laske","year":"2006","unstructured":"Laske, C.  et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J. Neural Transm. 113, 1217\u20131224 (2006).","journal-title":"J. Neural Transm."},{"key":"BFnrneurol200954_CR115","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jpsychires.2006.01.014","volume":"41","author":"C Laske","year":"2007","unstructured":"Laske, C.  et al. BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls. J. Psychiatr. Res. 41, 387\u2013394 (2007).","journal-title":"J. Psychiatr. Res."},{"key":"BFnrneurol200954_CR116","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/s00406-007-0764-9","volume":"258","author":"T Leyhe","year":"2008","unstructured":"Leyhe, T.  et al. Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease. Eur. Arch. Psychiatry Clin. Neurosci. 258, 124\u2013128 (2008).","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"BFnrneurol200954_CR117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcn.2008.04.012","volume":"39","author":"P Conforti","year":"2008","unstructured":"Conforti, P.  et al. Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347. Mol. Cell Neurosci. 39, 1\u20137 (2008).","journal-title":"Mol. Cell Neurosci."},{"key":"BFnrneurol200954_CR118","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/ajmg.b.30501","volume":"144B","author":"A Ciammola","year":"2007","unstructured":"Ciammola, A.  et al. Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 574\u2013577 (2007).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["Nature Reviews Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2009.54.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2009.54","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2009.54.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:55:24Z","timestamp":1684457724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrneurol.2009.54"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":118,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["BFnrneurol200954"],"URL":"https:\/\/doi.org\/10.1038\/nrneurol.2009.54","relation":{},"ISSN":["1759-4758","1759-4766"],"issn-type":[{"value":"1759-4758","type":"print"},{"value":"1759-4766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}