{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:06Z","timestamp":1791302526428,"version":"4.1.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T00:00:00Z","timestamp":1372118400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Neurol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1038\/nrneurol.2013.128","type":"journal-article","created":{"date-parts":[[2013,6,25]],"date-time":"2013-06-25T10:19:19Z","timestamp":1372155559000},"page":"421-422","source":"Crossref","is-referenced-by-count":15,"title":["'Fifty shades of grey' in the Huntington disease gene"],"prefix":"10.1038","volume":"9","author":[{"given":"Ferdinando","family":"Squitieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,25]]},"reference":[{"key":"BFnrneurol2013128_CR1","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1212\/WNL.0b013e318294b304","volume":"80","author":"A Killoran","year":"2013","unstructured":"Killoran, A.  et al. Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS. Neurology 80, 2022\u20132027 (2013).","journal-title":"Neurology"},{"key":"BFnrneurol2013128_CR2","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1073\/pnas.0800048105","volume":"105","author":"R Gonitel","year":"2008","unstructured":"Gonitel, R.  et al. DNA instability in postmitotic neurons. Proc. Natl Acad. Sci. USA 105, 3467\u20133472 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneurol2013128_CR3","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1073\/pnas.0308679101","volume":"101","author":"NS Wexler","year":"2004","unstructured":"Wexler, N. S.  et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc. Natl Acad. Sci. USA 101, 3498\u20133503 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrneurol2013128_CR4","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1093\/hmg\/ddi319","volume":"14","author":"IS Seong","year":"2005","unstructured":"Seong, I. S.  et al. HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Hum. Mol. Genet. 14, 2871\u20132880 (2005).","journal-title":"Hum. Mol. Genet."},{"key":"BFnrneurol2013128_CR5","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.biopsych.2006.11.034","volume":"62","author":"K Duff","year":"2007","unstructured":"Duff, K., Paulsen, J. S., Beglinger, L. J., Langbehn, D. R. & Stout, J. C. Psychiatric symptoms in Huntington's disease before diagnosis: the Predict-HD study. Biol. Psychiatry 62, 1341\u20131346 (2007).","journal-title":"Biol. Psychiatry"},{"key":"BFnrneurol2013128_CR6","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1212\/WNL.0b013e3182648b65","volume":"79","author":"JK Lee","year":"2012","unstructured":"Lee, J. K.  et al. Measures of growth in children at risk for Huntington disease. Neurology 79, 668\u2013674 (2012).","journal-title":"Neurology"},{"key":"BFnrneurol2013128_CR7","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.cell.2006.09.036","volume":"127","author":"HG Serra","year":"2006","unstructured":"Serra, H. G.  et al. ROR\u03b1-mediated Purkinje cell development determines disease severity in adult SCA1 mice. Cell 127, 697\u2013708 (2006).","journal-title":"Cell"},{"key":"BFnrneurol2013128_CR8","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1007\/s00415-012-6415-8","volume":"259","author":"JA Byars","year":"2012","unstructured":"Byars, J. A., Beglinger, L. J., Moser, D. J., Gonzalez-Alegre, P. & Nopoulos, P. Substance abuse may be a risk factor for earlier onset of Huntington disease. J. Neurol. 259, 1824\u20131831 (2012).","journal-title":"J. Neurol."},{"key":"BFnrneurol2013128_CR9","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1126\/science.1111427","volume":"308","author":"EA Hammock","year":"2005","unstructured":"Hammock, E. A. & Young, L. J. Microsatellite instability generates diversity in brain and sociobehavioral traits. Science 308, 1630\u20131634 (2005).","journal-title":"Science"},{"key":"BFnrneurol2013128_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/ajmg.b.20010","volume":"120B","author":"GH Nguyen","year":"2003","unstructured":"Nguyen, G. H.  et al. DNA stability and schizophrenia in twins. Am. J. Med. Genet. B Neuropsychiatr. Genet. 120B, 1\u201310 (2003).","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."}],"container-title":["Nature Reviews Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2013.128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2013.128","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrneurol.2013.128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:10:27Z","timestamp":1684469427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrneurol.2013.128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,25]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["BFnrneurol2013128"],"URL":"https:\/\/doi.org\/10.1038\/nrneurol.2013.128","relation":{},"ISSN":["1759-4758","1759-4766"],"issn-type":[{"value":"1759-4758","type":"print"},{"value":"1759-4766","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,25]]}}}