{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:11:53Z","timestamp":1793247113766,"version":"4.5.0"},"reference-count":123,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/nrrheum.2011.205","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T08:39:59Z","timestamp":1327999199000},"page":"153-162","source":"Crossref","is-referenced-by-count":296,"title":["Hypoxia\u2014a key regulator of angiogenesis and inflammation in rheumatoid arthritis"],"prefix":"10.1038","volume":"8","author":[{"given":"Sofia","family":"Konisti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serafim","family":"Kiriakidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa M.","family":"Paleolog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,31]]},"reference":[{"key":"BFnrrheum2011205_CR1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/978-1-4615-3428-0_61","volume":"317","author":"H Pagel","year":"1992","unstructured":"Pagel, H., Engel, A. & Jelkmann, W. Erythropoietin induction by hypoxia. A comparison of in vitro and in vivo experiments. Adv. Exp. Med. Biol. 317, 515\u2013519 (1992).","journal-title":"Adv. Exp. Med. Biol."},{"key":"BFnrrheum2011205_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.vph.2009.02.002","volume":"51","author":"Z Szekanecz","year":"2009","unstructured":"Szekanecz, Z. & Koch, A. E. Angiogenesis and its targeting in rheumatoid arthritis. Vascul. Pharmacol. 51, 1\u20137 (2009).","journal-title":"Vascul. Pharmacol."},{"key":"BFnrrheum2011205_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/ar2568","volume":"11","author":"B Muz","year":"2009","unstructured":"Muz, B., Khan, M. N., Kiriakidis, S. & Paleolog, E. M. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. Arthritis Res. Ther. 11, 201 (2009).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2011205_CR4","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jbspin.2009.05.011","volume":"77","author":"Z Szekanecz","year":"2010","unstructured":"Szekanecz, Z., Besenyei, T., Paragh, G. & Koch, A. E. New insights in synovial angiogenesis. Joint Bone Spine 77, 13\u201319 (2010).","journal-title":"Joint Bone Spine"},{"key":"BFnrrheum2011205_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10456-011-9208-2","volume":"14","author":"N Thairu","year":"2011","unstructured":"Thairu, N., Kiriakidis, S., Dawson, P. & Paleolog, E. Angiogenesis as a therapeutic target in arthritis in learning the lessons of the colorectal cancer experience. Angiogenesis 14, 223\u2013234 (2011).","journal-title":"Angiogenesis"},{"key":"BFnrrheum2011205_CR6","first-page":"97","volume":"24","author":"GL Semenza","year":"2009","unstructured":"Semenza, G. L. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 24, 97\u2013106 (2009).","journal-title":"Physiology (Bethesda)"},{"key":"BFnrrheum2011205_CR7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","volume":"473","author":"P Carmeliet","year":"2011","unstructured":"Carmeliet, P. & Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298\u2013307 (2011).","journal-title":"Nature"},{"key":"BFnrrheum2011205_CR8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1093\/cvr\/cvq045","volume":"86","author":"S Rey","year":"2010","unstructured":"Rey, S. & Semenza, G. L. Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling. Cardiovasc. Res. 86, 236\u2013242 (2010).","journal-title":"Cardiovasc. Res."},{"key":"BFnrrheum2011205_CR9","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/onc.2009.441","volume":"29","author":"GL Semenza","year":"2010","unstructured":"Semenza, G. L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625\u2013634 (2010).","journal-title":"Oncogene"},{"key":"BFnrrheum2011205_CR10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/20459","volume":"399","author":"PH Maxwell","year":"1999","unstructured":"Maxwell, P. H. et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271\u2013275 (1999).","journal-title":"Nature"},{"key":"BFnrrheum2011205_CR11","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1093\/emboj\/18.7.1905","volume":"18","author":"M Ema","year":"1999","unstructured":"Ema, M. et al. Molecular mechanisms of transcription activation by HLF and HIF1\u03b1 in response to hypoxia: their stabilization and redox signal-induced interaction with CBP\/p300. EMBO J. 18, 1905\u20131914 (1999).","journal-title":"EMBO J."},{"key":"BFnrrheum2011205_CR12","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1074\/jbc.270.3.1230","volume":"270","author":"GL Wang","year":"1995","unstructured":"Wang, G. L. & Semenza, G. L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270, 1230\u20131237 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2011205_CR13","doi-asserted-by":"publisher","first-page":"9361","DOI":"10.1128\/MCB.23.24.9361-9374.2003","volume":"23","author":"CJ Hu","year":"2003","unstructured":"Hu, C. J., Wang, L. Y., Chodosh, L. A., Keith, B. & Simon, M. C. Differential roles of hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and HIF-2\u03b1 in hypoxic gene regulation. Mol. Cell. Biol. 23, 9361\u20139374 (2003).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrrheum2011205_CR14","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1096\/fj.04-1640fje","volume":"18","author":"C Warnecke","year":"2004","unstructured":"Warnecke, C. et al. Differentiating the functional role of hypoxia-inducible factor (HIF)-1\u03b1 and HIF-2\u03b1 (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2\u03b1 target gene in Hep3B and Kelly cells. FASEB J. 18, 1462\u20131464 (2004).","journal-title":"FASEB J."},{"key":"BFnrrheum2011205_CR15","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1128\/MCB.25.13.5675-5686.2005","volume":"25","author":"RR Raval","year":"2005","unstructured":"Raval, R. R. et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 25, 5675\u20135686 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrrheum2011205_CR16","doi-asserted-by":"publisher","first-page":"4273","DOI":"10.1073\/pnas.94.9.4273","volume":"94","author":"M Ema","year":"1997","unstructured":"Ema, M. et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1\u03b1 regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl Acad. Sci. USA 94, 4273\u20134278 (1997).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2011205_CR17","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1101\/gad.11.1.72","volume":"11","author":"H Tian","year":"1997","unstructured":"Tian, H., McKnight, S. L. & Russell, D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72\u201382 (1997).","journal-title":"Genes Dev."},{"key":"BFnrrheum2011205_CR18","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1016\/j.yexcr.2008.03.003","volume":"314","author":"C Warnecke","year":"2008","unstructured":"Warnecke, C. et al. The specific contribution of hypoxia-inducible factor-2\u03b1 to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors. Exp. Cell. Res. 314, 2016\u20132027 (2008).","journal-title":"Exp. Cell. Res."},{"key":"BFnrrheum2011205_CR19","doi-asserted-by":"publisher","first-page":"5641","DOI":"10.1158\/0008-5472.CAN-05-3345","volume":"66","author":"O Aprelikova","year":"2006","unstructured":"Aprelikova, O., Wood, M., Tackett, S., Chandramouli, G. V. & Barrett, J. C. Role of ETS transcription factors in the hypoxia-inducible factor-2 target gene selection. Cancer Res. 66, 5641\u20135647 (2006).","journal-title":"Cancer Res."},{"key":"BFnrrheum2011205_CR20","first-page":"6130","volume":"63","author":"HM Sowter","year":"2003","unstructured":"Sowter, H. M., Raval, R. R., Moore, J. W., Ratcliffe, P. J. & Harris, A. L. Predominant role of hypoxia-inducible transcription factor (Hif)-1\u03b1 versus Hif-2\u03b1 in regulation of the transcriptional response to hypoxia. Cancer Res. 63, 6130\u20136134 (2003).","journal-title":"Cancer Res."},{"key":"BFnrrheum2011205_CR21","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1093\/emboj\/17.11.3005","volume":"17","author":"HE Ryan","year":"1998","unstructured":"Ryan, H. E., Lo, J. & Johnson, R. S. HIF-1\u03b1 is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005\u20133015 (1998).","journal-title":"EMBO J."},{"key":"BFnrrheum2011205_CR22","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nri802","volume":"2","author":"M Feldmann","year":"2002","unstructured":"Feldmann, M. Development of anti-TNF therapy for rheumatoid arthritis. Nat. Rev. Immunol. 2, 364\u2013371 (2002).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnrrheum2011205_CR23","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.1007\/s10067-007-0605-2","volume":"26","author":"YA Lee","year":"2007","unstructured":"Lee, Y. A. et al. Synovial proliferation differentially affects hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients. Clin. Rheumatol. 26, 2023\u20132029 (2007).","journal-title":"Clin. Rheumatol."},{"key":"BFnrrheum2011205_CR24","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1002\/art.1780130606","volume":"13","author":"K Lund-Olesen","year":"1970","unstructured":"Lund-Olesen, K. Oxygen tension in synovial fluids. Arthritis Rheum. 13, 769\u2013776 (1970).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR25","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s00296-009-0865-z","volume":"29","author":"CA Hitchon","year":"2009","unstructured":"Hitchon, C. A., El-Gabalawy, H. S. & Bezabeh, T. Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation. Rheumatol. Int. 29, 1205\u20131211 (2009).","journal-title":"Rheumatol. Int."},{"key":"BFnrrheum2011205_CR26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jhsa.2007.09.002","volume":"33","author":"B Sivakumar","year":"2008","unstructured":"Sivakumar, B. et al. Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis. J. Hand Surg. Am. 33, 49\u201358 (2008).","journal-title":"J. Hand Surg. Am."},{"key":"BFnrrheum2011205_CR27","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1136\/ard.2009.111211","volume":"69","author":"M Biniecka","year":"2010","unstructured":"Biniecka, M. et al. Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Ann. Rheum. Dis. 69, 1172\u20131178 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum2011205_CR28","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1136\/ard.2009.119776","volume":"69","author":"CT Ng","year":"2010","unstructured":"Ng, C. T. et al. Synovial tissue hypoxia and inflammation in vivo. Ann. Rheum. Dis. 69, 1389\u20131395 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum2011205_CR29","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1002\/art.10520","volume":"46","author":"C Hitchon","year":"2002","unstructured":"Hitchon, C. et al. Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum. 46, 2587\u20132597 (2002).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR30","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1002\/1529-0131(200107)44:7<1540::AID-ART277>3.0.CO;2-7","volume":"44","author":"AP Hollander","year":"2001","unstructured":"Hollander, A. P., Corke, K. P., Freemont, A. J. & Lewis, C. E. Expression of hypoxia-inducible factor 1\u03b1 by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum. 44, 1540\u20131544 (2001).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR31","doi-asserted-by":"publisher","first-page":"R193","DOI":"10.1186\/ar756","volume":"5","author":"A Giatromanolaki","year":"2003","unstructured":"Giatromanolaki, A. et al. Upregulated hypoxia inducible factor-1\u03b1 and -2\u03b1 pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res. Ther. 5, R193\u2013R201 (2003).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2011205_CR32","first-page":"945","volume":"27","author":"E Brouwer","year":"2009","unstructured":"Brouwer, E. et al. Hypoxia inducible factor-1-\u03b1 (HIF-1\u03b1) is related to both angiogenesis and inflammation in rheumatoid arthritis. Clin. Exp. Rheumatol. 27, 945\u2013951 (2009).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum2011205_CR33","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.4049\/jimmunol.152.8.4149","volume":"152","author":"AE Koch","year":"1994","unstructured":"Koch, A. E. et al. Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol. 152, 4149\u20134156 (1994).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR34","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1084\/jem.180.1.341","volume":"180","author":"RA Fava","year":"1994","unstructured":"Fava, R. A. et al. Vascular permeability factor\/endothelial growth factor (VPF\/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J. Exp. Med. 180, 341\u2013346 (1994).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum2011205_CR35","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1002\/1529-0131(199807)41:7<1258::AID-ART17>3.0.CO;2-1","volume":"41","author":"EM Paleolog","year":"1998","unstructured":"Paleolog, E. M. et al. Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor \u03b1 and interleukin-1 in rheumatoid arthritis. Arthritis Rheum. 41, 1258\u20131265 (1998).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR36","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.1002\/1529-0131(200109)44:9<2055::AID-ART355>3.0.CO;2-2","volume":"44","author":"SC Ballara","year":"2001","unstructured":"Ballara, S. C. et al. Raised serum vascular endothelial growth factor levels are associated with destructive change in inflammatory arthritis. Arthritis Rheum. 44, 2055\u20132064 (2001).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR37","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3899\/jrheum.090941","volume":"37","author":"D Kurosaka","year":"2010","unstructured":"Kurosaka, D. et al. Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis. J. Rheumatol. 37, 1121\u20131128 (2010).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum2011205_CR38","doi-asserted-by":"publisher","first-page":"R64","DOI":"10.1186\/ar2689","volume":"11","author":"MA Akhavani","year":"2009","unstructured":"Akhavani, M. A. et al. Hypoxia upregulates angiogenesis and synovial cell migration in rheumatoid arthritis. Arthritis Res. Ther. 11, R64 (2009).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2011205_CR39","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/rheumatology\/ken086","volume":"47","author":"JK Ahn","year":"2008","unstructured":"Ahn, J. K. et al. Role of hypoxia-inducible factor-1\u03b1 in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes. Rheumatology (Oxford) 47, 834\u2013839 (2008).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum2011205_CR40","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1002\/art.23516","volume":"58","author":"MC Bosco","year":"2008","unstructured":"Bosco, M. C. et al. Hypoxic synovial environment and expression of macrophage inflammatory protein 3\u03b3\/CCL20 in juvenile idiopathic arthritis. Arthritis Rheum. 58, 1833\u20131838 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR41","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1002\/art.24844","volume":"60","author":"MJ Del Rey","year":"2009","unstructured":"Del Rey, M. J. et al. Human inflammatory synovial fibroblasts induce enhanced myeloid cell recruitment and angiogenesis through a hypoxia-inducible transcription factor 1\u03b1\/vascular endothelial growth factor-mediated pathway in immunodeficient mice. Arthritis Rheum. 60, 2926\u20132934 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR42","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.cyto.2010.06.006","volume":"53","author":"B Santiago","year":"2011","unstructured":"Santiago, B. et al. CXCL12 gene expression is upregulated by hypoxia and growth arrest but not by inflammatory cytokines in rheumatoid synovial fibroblasts. Cytokine 53, 184\u2013190 (2011).","journal-title":"Cytokine"},{"key":"BFnrrheum2011205_CR43","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1002\/art.27287","volume":"62","author":"A Kennedy","year":"2010","unstructured":"Kennedy, A. et al. Angiogenesis and blood vessel stability in inflammatory arthritis. Arthritis Rheum. 62, 711\u2013721 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR44","doi-asserted-by":"publisher","first-page":"e8131","DOI":"10.1371\/journal.pone.0008131","volume":"4","author":"E Izquierdo","year":"2009","unstructured":"Izquierdo, E. et al. Immature blood vessels in rheumatoid synovium are selectively depleted in response to anti-TNF therapy. PLoS ONE 4, e8131 (2009).","journal-title":"PLoS ONE"},{"key":"BFnrrheum2011205_CR45","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1002\/art.30221","volume":"63","author":"A Kennedy","year":"2011","unstructured":"Kennedy, A. et al. Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia. Arthritis Rheum. 63, 923\u2013932 (2011).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR46","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1002\/art.30395","volume":"63","author":"M Biniecka","year":"2011","unstructured":"Biniecka, M. et al. Hypoxia induces mitochondrial mutagenesis and dysfunction in inflammatory arthritis. Arthritis Rheum. 63, 2172\u20132182 (2011).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR47","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1056\/NEJMra0910283","volume":"364","author":"HK Eltzschig","year":"2011","unstructured":"Eltzschig, H. K. & Carmeliet, P. Hypoxia and inflammation. N. Engl. J. Med. 364, 656\u2013665 (2011).","journal-title":"N. Engl. J. Med."},{"key":"BFnrrheum2011205_CR48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3171\/JNS\/2008\/109\/7\/0083","volume":"109","author":"T Higashida","year":"2008","unstructured":"Higashida, T., Kanno, H., Nakano, M., Funakoshi, K. & Yamamoto, I. Expression of hypoxia-inducible angiogenic proteins (hypoxia-inducible factor-1\u03b1, vascular endothelial growth factor, and E26 transformation-specific-1) and plaque hemorrhage in human carotid atherosclerosis. J. Neurosurg. 109, 83\u201391 (2008).","journal-title":"J. Neurosurg."},{"key":"BFnrrheum2011205_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/jcp.56.3.209","volume":"56","author":"A Giatromanolaki","year":"2003","unstructured":"Giatromanolaki, A. et al. Hypoxia inducible factor 1\u03b1 and 2\u03b1 overexpression in inflammatory bowel disease. J. Clin. Pathol. 56, 209\u2013213 (2003).","journal-title":"J. Clin. Pathol."},{"key":"BFnrrheum2011205_CR50","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/S1081-1206(10)60971-4","volume":"97","author":"SY Lee","year":"2006","unstructured":"Lee, S. Y. et al. Expression of vascular endothelial growth factor and hypoxia-inducible factor in the airway of asthmatic patients. Ann. Allergy Asthma Immunol. 97, 794\u2013799 (2006).","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"BFnrrheum2011205_CR51","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1365-4632.2006.02962.x","volume":"46","author":"LE Tovar-Castillo","year":"2007","unstructured":"Tovar-Castillo, L. E. et al. Under-expression of VHL and over-expression of HDAC-1, HIF-1\u03b1, LL-37, and IAP-2 in affected skin biopsies of patients with psoriasis. Int. J. Dermatol. 46, 239\u2013246 (2007).","journal-title":"Int. J. Dermatol."},{"key":"BFnrrheum2011205_CR52","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","volume":"112","author":"T Cramer","year":"2003","unstructured":"Cramer, T. et al. HIF-1\u03b1 is essential for myeloid cell-mediated inflammation. Cell 112, 645\u2013657 (2003).","journal-title":"Cell"},{"key":"BFnrrheum2011205_CR53","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1172\/JCI23865","volume":"115","author":"C Peyssonnaux","year":"2005","unstructured":"Peyssonnaux, C. et al. HIF-1\u03b1 expression regulates the bactericidal capacity of phagocytes. J. Clin. Invest. 115, 1806\u20131815 (2005).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum2011205_CR54","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1042\/bj3500307","volume":"350","author":"RD Thornton","year":"2000","unstructured":"Thornton, R. D. et al. Interleukin 1 induces hypoxia-inducible factor 1 in human gingival and synovial fibroblasts. Biochem. J. 350, 307\u2013312 (2000).","journal-title":"Biochem. J."},{"key":"BFnrrheum2011205_CR55","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1196\/annals.1422.035","volume":"1108","author":"J Westra","year":"2007","unstructured":"Westra, J. et al. Regulation of cytokine-induced HIF-1\u03b1 expression in rheumatoid synovial fibroblasts. Ann. NY Acad. Sci. 1108, 340\u2013348 (2007).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnrrheum2011205_CR56","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1042\/BJ20051839","volume":"396","author":"S Frede","year":"2006","unstructured":"Frede, S., Stockmann, C., Freitag, P. & Fandrey, J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44\/42 MAPK and NF-\u03baB. Biochem. J. 396, 517\u2013527 (2006).","journal-title":"Biochem. J."},{"key":"BFnrrheum2011205_CR57","doi-asserted-by":"publisher","first-page":"e2215","DOI":"10.1371\/journal.pone.0002215","volume":"3","author":"S Oda","year":"2008","unstructured":"Oda, S. et al. Macrophage migration inhibitory factor activates hypoxia-inducible factor in a p53-dependent manner. PLoS ONE 3, e2215 (2008).","journal-title":"PLoS ONE"},{"key":"BFnrrheum2011205_CR58","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/rheumatology\/kem298","volume":"47","author":"RE Simmonds","year":"2008","unstructured":"Simmonds, R. E. & Foxwell, B. M. Signalling, inflammation and arthritis: NF-\u03baB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 47, 584\u2013590 (2008).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum2011205_CR59","doi-asserted-by":"publisher","first-page":"4055","DOI":"10.1113\/jphysiol.2008.157669","volume":"586","author":"CT Taylor","year":"2008","unstructured":"Taylor, C. T. Interdependent roles for hypoxia inducible factor and nuclear factor-\u03baB in hypoxic inflammation. J. Physiol. 586, 4055\u20134059 (2008).","journal-title":"J. Physiol."},{"key":"BFnrrheum2011205_CR60","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/ar2575","volume":"11","author":"KM Oliver","year":"2009","unstructured":"Oliver, K. M., Taylor, C. T. & Cummins, E. P. Hypoxia. Regulation of NF\u03baB signalling during inflammation: the role of hydroxylases. Arthritis Res. Ther. 11, 215 (2009).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2011205_CR61","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.20040624","volume":"201","author":"SR Walmsley","year":"2005","unstructured":"Walmsley, S. R. et al. Hypoxia-induced neutrophil survival is mediated by HIF-1\u03b1-dependent NF-\u03baB activity. J. Exp. Med. 201, 105\u2013115 (2005).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum2011205_CR62","first-page":"1425","volume":"54","author":"AC Koong","year":"1994","unstructured":"Koong, A. C., Chen, E. Y. & Giaccia, A. J. Hypoxia causes the activation of nuclear factor \u03baB through the phosphorylation of I\u03baB\u03b1 on tyrosine residues. Cancer Res. 54, 1425\u20131430 (1994).","journal-title":"Cancer Res."},{"key":"BFnrrheum2011205_CR63","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1128\/MCB.00409-10","volume":"30","author":"C Culver","year":"2010","unstructured":"Culver, C. et al. Mechanism of hypoxia-induced NF-\u03baB. Mol. Cell. Biol. 30, 4901\u20134921 (2010).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrrheum2011205_CR64","doi-asserted-by":"publisher","first-page":"18154","DOI":"10.1073\/pnas.0602235103","volume":"103","author":"EP Cummins","year":"2006","unstructured":"Cummins, E. P. et al. Prolyl hydroxylase-1 negatively regulates I\u03baB kinase-\u03b2, giving insight into hypoxia-induced NF\u03baB activity. Proc. Natl Acad. Sci. USA 103, 18154\u201318159 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2011205_CR65","doi-asserted-by":"publisher","first-page":"8927","DOI":"10.1074\/jbc.M109.078600","volume":"285","author":"J Fu","year":"2010","unstructured":"Fu, J. & Taubman, M. B. Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-\u03baB-dependent pathway. J. Biol. Chem. 285, 8927\u20138935 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2011205_CR66","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","volume":"138","author":"J Xue","year":"2010","unstructured":"Xue, J. et al. Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKK\u03b2 independent of hydroxylase activity. Gastroenterology 138, 606\u2013615 (2010).","journal-title":"Gastroenterology"},{"key":"BFnrrheum2011205_CR67","doi-asserted-by":"publisher","first-page":"6407","DOI":"10.1128\/MCB.00511-07","volume":"27","author":"JE Ferguson 3rd","year":"2007","unstructured":"Ferguson, J. E. 3rd et al. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol. Cell. Biol. 27, 6407\u20136419 (2007).","journal-title":"Mol. Cell. Biol."},{"key":"BFnrrheum2011205_CR68","doi-asserted-by":"publisher","first-page":"14767","DOI":"10.1073\/pnas.0606877103","volume":"103","author":"ME Cockman","year":"2006","unstructured":"Cockman, M. E. et al. Posttranslational hydroxylation of ankyrin repeats in I\u03baB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl Acad. Sci. USA 103, 14767\u201314772 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2011205_CR69","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1161\/01.ATV.0000258979.92828.bc","volume":"27","author":"S Bonello","year":"2007","unstructured":"Bonello, S. et al. Reactive oxygen species activate the HIF-1alpha promoter via a functional NF\u03baB site. Arterioscler. Thromb. Vasc. Biol. 27, 755\u2013761 (2007).","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"BFnrrheum2011205_CR70","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/nature06905","volume":"453","author":"J Rius","year":"2008","unstructured":"Rius, J. et al. NF-\u03baB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1\u03b1. Nature 453, 807\u2013811 (2008).","journal-title":"Nature"},{"key":"BFnrrheum2011205_CR71","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1038\/cr.2009.44","volume":"19","author":"SA Nicholas","year":"2009","unstructured":"Nicholas, S. A. & Sumbayev, V. V. The involvement of hypoxia-inducible factor 1\u03b1 in Toll-like receptor 7\/8-mediated inflammatory response. Cell. Res. 19, 973\u2013983 (2009).","journal-title":"Cell. Res."},{"key":"BFnrrheum2011205_CR72","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1189\/jlb.1210683","volume":"90","author":"J Jantsch","year":"2011","unstructured":"Jantsch, J. et al. Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1\u03b1 (HIF1A) and result in differential HIF1A-dependent gene expression. J. Leukoc. Biol. 90, 551\u2013562 (2011).","journal-title":"J. Leukoc. Biol."},{"key":"BFnrrheum2011205_CR73","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.4049\/jimmunol.178.12.7516","volume":"178","author":"C Peyssonnaux","year":"2007","unstructured":"Peyssonnaux, C. et al. Cutting edge: Essential role of hypoxia inducible factor-1\u03b1 in development of lipopolysaccharide-induced sepsis. J. Immunol. 178, 7516\u20137519 (2007).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR74","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/icb.2009.76","volume":"88","author":"SA Nicholas","year":"2010","unstructured":"Nicholas, S. A. & Sumbayev, V. V. The role of redox-dependent mechanisms in the downregulation of ligand-induced Toll-like receptors 7, 8 and 4-mediated HIF-1\u03b1 prolyl hydroxylation. Immunol. Cell. Biol. 88, 180\u2013186 (2010).","journal-title":"Immunol. Cell. Biol."},{"key":"BFnrrheum2011205_CR75","doi-asserted-by":"publisher","first-page":"6140","DOI":"10.4049\/jimmunol.167.11.6140","volume":"167","author":"CC Caldwell","year":"2001","unstructured":"Caldwell, C. C. et al. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J. Immunol. 167, 6140\u20136149 (2001).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR76","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/(SICI)1097-4652(199712)173:3<335::AID-JCP5>3.0.CO;2-O","volume":"173","author":"A Naldini","year":"1997","unstructured":"Naldini, A., Carraro, F., Silvestri, S. & Bocci, V. Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells. J. Cell. Physiol. 173, 335\u2013342 (1997).","journal-title":"J. Cell. Physiol."},{"key":"BFnrrheum2011205_CR77","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/S0192-0561(96)00057-4","volume":"18","author":"JA Krieger","year":"1996","unstructured":"Krieger, J. A., Landsiedel, J. C. & Lawrence, D. A. Differential in vitro effects of physiological and atmospheric oxygen tension on normal human peripheral blood mononuclear cell proliferation, cytokine and immunoglobulin production. Int. J. Immunopharmacol. 18, 545\u2013552 (1996).","journal-title":"Int. J. Immunopharmacol."},{"key":"BFnrrheum2011205_CR78","doi-asserted-by":"publisher","first-page":"6534","DOI":"10.4049\/jimmunol.171.12.6534","volume":"171","author":"Y Makino","year":"2003","unstructured":"Makino, Y. et al. Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells. J. Immunol. 171, 6534\u20136540 (2003).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR79","doi-asserted-by":"publisher","first-page":"7592","DOI":"10.4049\/jimmunol.174.12.7592","volume":"174","author":"H Nakamura","year":"2005","unstructured":"Nakamura, H. et al. TCR engagement increases hypoxia-inducible factor-1\u03b1 protein synthesis via rapamycin-sensitive pathway under hypoxic conditions in human peripheral T cells. J. Immunol. 174, 7592\u20137599 (2005).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR80","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","volume":"146","author":"EV Dang","year":"2011","unstructured":"Dang, E. V. et al. Control of TH17\/TREG balance by hypoxia-inducible factor 1. Cell 146, 772\u2013784 (2011).","journal-title":"Cell"},{"key":"BFnrrheum2011205_CR81","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1084\/jem.20110278","volume":"208","author":"LZ Shi","year":"2011","unstructured":"Shi, L. Z. et al. HIF1\u03b1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and TREG cells. J. Exp. Med. 208, 1367\u20131376 (2011).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum2011205_CR82","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ejca.2006.01.003","volume":"42","author":"A Sica","year":"2006","unstructured":"Sica, A., Schioppa, T., Mantovani, A., Allavena, P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur. J. Cancer 42, 717\u2013727 (2006).","journal-title":"Eur. J. Cancer"},{"key":"BFnrrheum2011205_CR83","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","volume":"25","author":"A Mantovani","year":"2004","unstructured":"Mantovani, A. et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 25, 677\u2013686 (2004).","journal-title":"Trends Immunol."},{"key":"BFnrrheum2011205_CR84","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1093\/carcin\/bgq088","volume":"31","author":"C Werno","year":"2010","unstructured":"Werno, C. et al. Knockout of HIF-1\u03b1 in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses. Carcinogenesis 31, 1863\u20131872 (2010).","journal-title":"Carcinogenesis"},{"key":"BFnrrheum2011205_CR85","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/S0002-9440(10)64554-3","volume":"157","author":"KL Talks","year":"2000","unstructured":"Talks, K. L. et al. The expression and distribution of the hypoxia-inducible factors HIF-1\u03b1 and HIF-2\u03b1 in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157, 411\u2013421 (2000).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum2011205_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0888-7543(03)00215-5","volume":"83","author":"JR White","year":"2004","unstructured":"White, J. R. et al. Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83, 1\u20138 (2004).","journal-title":"Genomics"},{"key":"BFnrrheum2011205_CR87","doi-asserted-by":"publisher","first-page":"2699","DOI":"10.1172\/JCI39506","volume":"120","author":"HZ Imtiyaz","year":"2010","unstructured":"Imtiyaz, H. Z. et al. Hypoxia-inducible factor 2\u03b1 regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120, 2699\u20132714 (2010).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum2011205_CR88","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1101\/gad.1881410","volume":"24","author":"N Takeda","year":"2010","unstructured":"Takeda, N. et al. Differential activation and antagonistic function of HIF-\u03b1 isoforms in macrophages are essential for NO homeostasis. Genes Dev. 24, 491\u2013501 (2010).","journal-title":"Genes Dev."},{"key":"BFnrrheum2011205_CR89","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/path.1029","volume":"196","author":"B Burke","year":"2002","unstructured":"Burke, B. et al. Expression of HIF-1\u03b1 by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol. 196, 204\u2013212 (2002).","journal-title":"J. Pathol."},{"key":"BFnrrheum2011205_CR90","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.imbio.2008.07.016","volume":"213","author":"L Elbarghati","year":"2008","unstructured":"Elbarghati, L., Murdoch, C. & Lewis, C. E. Effects of hypoxia on transcription factor expression in human monocytes and macrophages. Immunobiology 213, 899\u2013908 (2008).","journal-title":"Immunobiology"},{"key":"BFnrrheum2011205_CR91","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1182\/blood-2008-12-195941","volume":"114","author":"HY Fang","year":"2009","unstructured":"Fang, H. Y. et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114, 844\u2013859 (2009).","journal-title":"Blood"},{"key":"BFnrrheum2011205_CR92","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1084\/jem.20100587","volume":"207","author":"CA Corzo","year":"2010","unstructured":"Corzo, C. A. et al. HIF-1\u03b1 regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207, 2439\u20132453 (2010).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum2011205_CR93","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1182\/blood-2010-01-261792","volume":"117","author":"TD Eubank","year":"2011","unstructured":"Eubank, T. D., Roda, J. M., Liu, H., O'Neil, T. & Marsh, C. B. Opposing roles for HIF-1\u03b1 and HIF-2\u03b1 in the regulation of angiogenesis by mononuclear phagocytes. Blood 117, 323\u2013332 (2011).","journal-title":"Blood"},{"key":"BFnrrheum2011205_CR94","doi-asserted-by":"publisher","first-page":"7465","DOI":"10.1158\/0008-5472.CAN-10-1439","volume":"70","author":"AL Doedens","year":"2010","unstructured":"Doedens, A. L. et al. Macrophage expression of hypoxia-inducible factor-1\u03b1 suppresses T-cell function and promotes tumor progression. Cancer Res. 70, 7465\u20137475 (2010).","journal-title":"Cancer Res."},{"key":"BFnrrheum2011205_CR95","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1002\/art.23956","volume":"58","author":"N Takahashi","year":"2008","unstructured":"Takahashi, N. et al. The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40. Arthritis Rheum. 58, 3471\u20133484 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR96","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1182\/blood-2002-02-0454","volume":"100","author":"KI Mecklenburgh","year":"2002","unstructured":"Mecklenburgh, K. I. et al. Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis. Blood 100, 3008\u20133016 (2002).","journal-title":"Blood"},{"key":"BFnrrheum2011205_CR97","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1189\/jlb.0806541","volume":"81","author":"MC Vissers","year":"2007","unstructured":"Vissers, M. C. & Wilkie, R. P. Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1\u03b1. J. Leukoc. Biol. 81, 1236\u20131244 (2007).","journal-title":"J. Leukoc. Biol."},{"key":"BFnrrheum2011205_CR98","doi-asserted-by":"publisher","first-page":"3723","DOI":"10.1182\/blood-2008-02-142091","volume":"112","author":"A Mancino","year":"2008","unstructured":"Mancino, A. et al. Divergent effects of hypoxia on dendritic cell functions. Blood 112, 3723\u20133734 (2008).","journal-title":"Blood"},{"key":"BFnrrheum2011205_CR99","doi-asserted-by":"publisher","first-page":"e1364","DOI":"10.1371\/journal.pone.0001364","volume":"2","author":"J Kuhlicke","year":"2007","unstructured":"Kuhlicke, J., Frick, J. S., Morote-Garcia, J. C., Rosenberger, P. & Eltzschig, H. K. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE 2, e1364 (2007).","journal-title":"PLoS ONE"},{"key":"BFnrrheum2011205_CR100","doi-asserted-by":"publisher","first-page":"4697","DOI":"10.4049\/jimmunol.180.7.4697","volume":"180","author":"J Jantsch","year":"2008","unstructured":"Jantsch, J. et al. Hypoxia and hypoxia-inducible factor-1\u03b1 modulate lipopolysaccharide-induced dendritic cell activation and function. J. Immunol. 180, 4697\u20134705 (2008).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR101","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1056\/NEJMoa032691","volume":"350","author":"H Hurwitz","year":"2004","unstructured":"Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335\u20132342 (2004).","journal-title":"N. Engl. J. Med."},{"key":"BFnrrheum2011205_CR102","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1159\/000163850","volume":"75","author":"F Kabbinavar","year":"2008","unstructured":"Kabbinavar, F., Irl, C., Zurlo, A. & Hurwitz, H. Bevacizumab improves the overall and progression-free survival of patients with metastatic colorectal cancer treated with 5-fluorouracil-based regimens irrespective of baseline risk. Oncology 75, 215\u2013223 (2008).","journal-title":"Oncology"},{"key":"BFnrrheum2011205_CR103","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.4049\/jimmunol.164.11.5922","volume":"164","author":"J Lu","year":"2000","unstructured":"Lu, J. et al. Vascular endothelial growth factor expression and regulation of murine collagen-induced arthritis. J. Immunol. 164, 5922\u20135927 (2000).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR104","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1006\/bbrc.2001.4395","volume":"281","author":"H Sone","year":"2001","unstructured":"Sone, H. et al. Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice. Biochem. Biophys. Res. Commun. 281, 562\u2013568 (2001).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrrheum2011205_CR105","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/nm731","volume":"8","author":"A Luttun","year":"2002","unstructured":"Luttun, A. et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8, 831\u2013840 (2002).","journal-title":"Nat. Med."},{"key":"BFnrrheum2011205_CR106","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.1038\/sj.gt.3302104","volume":"10","author":"AO Afuwape","year":"2003","unstructured":"Afuwape, A. O., Feldmann, M. & Paleolog, E. M. Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis. Gene Ther. 10, 1950\u20131960 (2003).","journal-title":"Gene Ther."},{"key":"BFnrrheum2011205_CR107","doi-asserted-by":"publisher","first-page":"4853","DOI":"10.4049\/jimmunol.171.9.4853","volume":"171","author":"M de Bandt","year":"2003","unstructured":"de Bandt, M. et al. Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGF-RII, suppresses joint destruction in the K\/BxN model of rheumatoid arthritis. J. Immunol. 171, 4853\u20134859 (2003).","journal-title":"J. Immunol."},{"key":"BFnrrheum2011205_CR108","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1093\/jnci\/djm086","volume":"99","author":"FA Scappaticci","year":"2007","unstructured":"Scappaticci, F. A. et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J. Natl Cancer Inst. 99, 1232\u20131239 (2007).","journal-title":"J. Natl Cancer Inst."},{"key":"BFnrrheum2011205_CR109","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1002\/art.23935","volume":"59","author":"Z Nadareishvili","year":"2008","unstructured":"Nadareishvili, Z., Michaud, K., Hallenbeck, J. M. & Wolfe, F. Cardiovascular, rheumatologic, and pharmacologic predictors of stroke in patients with rheumatoid arthritis: a nested, case\u2013control study. Arthritis Rheum. 59, 1090\u20131096 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2011205_CR110","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1161\/01.CIR.0000054612.26458.B2","volume":"107","author":"DH Solomon","year":"2003","unstructured":"Solomon, D. H. et al. Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 107, 1303\u20131307 (2003).","journal-title":"Circulation"},{"key":"BFnrrheum2011205_CR111","first-page":"4316","volume":"62","author":"A Rapisarda","year":"2002","unstructured":"Rapisarda, A. et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62, 4316\u20134324 (2002).","journal-title":"Cancer Res."},{"key":"BFnrrheum2011205_CR112","doi-asserted-by":"publisher","first-page":"5123","DOI":"10.1158\/1078-0432.CCR-11-0682","volume":"17","author":"S Kummar","year":"2011","unstructured":"Kummar, S. et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) in advanced solid tumors. Clin. Cancer Res. 17, 5123\u20135131 (2011).","journal-title":"Clin. Cancer Res."},{"key":"BFnrrheum2011205_CR113","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1124\/mol.109.061366","volume":"77","author":"M DeNiro","year":"2010","unstructured":"DeNiro, M., Al-Halafi, A., Al-Mohanna, F. H., Alsmadi, O. & Al-Mohanna, F. A. Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. Mol. Pharmacol. 77, 348\u2013367 (2010).","journal-title":"Mol. Pharmacol."},{"key":"BFnrrheum2011205_CR114","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s00011-007-7036-z","volume":"57","author":"H Manabe","year":"2008","unstructured":"Manabe, H. et al. Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts. Inflamm. Res. 57, 4\u201310 (2008).","journal-title":"Inflamm. Res."},{"key":"BFnrrheum2011205_CR115","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbrc.2009.01.086","volume":"387","author":"J Shankar","year":"2009","unstructured":"Shankar, J., Thippegowda, P. B. & Kanum, S. A. Inhibition of HIF-1\u03b1 activity by BP-1 ameliorates adjuvant induced arthritis in rats. Biochem. Biophys. Res. Commun. 387, 223\u2013228 (2009).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrrheum2011205_CR116","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.cell.2009.01.020","volume":"136","author":"M Mazzone","year":"2009","unstructured":"Mazzone, M. et al. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136, 839\u2013851 (2009).","journal-title":"Cell"},{"key":"BFnrrheum2011205_CR117","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1172\/JCI200421086","volume":"114","author":"J Karhausen","year":"2004","unstructured":"Karhausen, J. et al. Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. J. Clin. Invest. 114, 1098\u20131106 (2004).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum2011205_CR118","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1053\/j.gastro.2007.10.012","volume":"134","author":"EP Cummins","year":"2008","unstructured":"Cummins, E. P. et al. The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. Gastroenterology 134, 156\u2013165 (2008).","journal-title":"Gastroenterology"},{"key":"BFnrrheum2011205_CR119","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/j.gastro.2007.09.033","volume":"134","author":"A Robinson","year":"2008","unstructured":"Robinson, A. et al. Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134, 145\u2013155 (2008).","journal-title":"Gastroenterology"},{"key":"BFnrrheum2011205_CR120","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1053\/j.gastro.2010.06.068","volume":"139","author":"MM Tambuwala","year":"2010","unstructured":"Tambuwala, M. M. et al. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology 139, 2093\u20132101 (2010).","journal-title":"Gastroenterology"},{"key":"BFnrrheum2011205_CR121","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1089\/ars.2009.2711","volume":"12","author":"S Nagel","year":"2010","unstructured":"Nagel, S. et al. Therapeutic manipulation of the HIF hydroxylases. Antioxid. Redox Signal 12, 481\u2013501 (2010).","journal-title":"Antioxid. Redox Signal"},{"key":"BFnrrheum2011205_CR122","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1073\/pnas.0509459103","volume":"103","author":"M Safran","year":"2006","unstructured":"Safran, M. et al. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc. Natl Acad. Sci. USA 103, 105\u2013110 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2011205_CR123","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1001\/jama.2011.51","volume":"305","author":"V Ranpura","year":"2011","unstructured":"Ranpura, V., Hapani, S. & Wu, S. Treatment-related mortality with bevacizumab in cancer patients: a meta-analysis. JAMA 305, 487\u2013494 (2011).","journal-title":"JAMA"}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2011.205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2011.205","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2011.205.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T01:18:23Z","timestamp":1686705503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2011.205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,31]]},"references-count":123,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFnrrheum2011205"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2011.205","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,31]]}}}