{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:11:51Z","timestamp":1791079911859,"version":"4.1.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T00:00:00Z","timestamp":1344902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1038\/nrrheum.2012.128","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T11:40:11Z","timestamp":1344944411000},"page":"543-552","source":"Crossref","is-referenced-by-count":210,"title":["Macro view of microRNA function in osteoarthritis"],"prefix":"10.1038","volume":"8","author":[{"given":"Shigeru","family":"Miyaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Asahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"BFnrrheum2012128_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/art.23177","volume":"58","author":"CG Helmick","year":"2008","unstructured":"Helmick, C. G. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 58, 15\u201325 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"RC Lawrence","year":"2008","unstructured":"Lawrence, R. C. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26\u201335 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/ar3046","volume":"12","author":"MK Lotz","year":"2010","unstructured":"Lotz, M. K. & Kraus, V. B. New developments in osteoarthritis. Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options. Arthritis Res. Ther. 12, 211 (2010).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2012128_CR4","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/med.20113","volume":"28","author":"M Hashimoto","year":"2008","unstructured":"Hashimoto, M., Nakasa, T., Hikata, T. & Asahara, H. Molecular network of cartilage homeostasis and osteoarthritis. Med. Res. Rev. 28, 464\u2013481 (2008).","journal-title":"Med. Res. Rev."},{"key":"BFnrrheum2012128_CR5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/ar2592","volume":"11","author":"MB Goldring","year":"2009","unstructured":"Goldring, M. B. & Marcu, K. B. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res. Ther. 11, 224 (2009).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2012128_CR6","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrrheum.2011.109","volume":"7","author":"MK Lotz","year":"2011","unstructured":"Lotz, M. K. & Caram\u00e9s, B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat. Rev. Rheumatol. 7, 579\u2013587 (2011).","journal-title":"Nat. Rev. Rheumatol."},{"key":"BFnrrheum2012128_CR7","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1126\/science.1121158","volume":"310","author":"KK Farh","year":"2005","unstructured":"Farh, K. K. et al. The widespread impact of mammalian microRNAs on mRNA repression and evolution. Science 310, 1817\u20131821 (2005).","journal-title":"Science"},{"key":"BFnrrheum2012128_CR8","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"DP Bartel","year":"2004","unstructured":"Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281\u2013297 (2004).","journal-title":"Cell"},{"key":"BFnrrheum2012128_CR9","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nrc1997","volume":"6","author":"GA Calin","year":"2006","unstructured":"Calin, G. A. & Croce, C. M. MicroRNA signatures in human cancers. Nat. Rev. Cancer 6, 857\u2013866 (2006).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnrrheum2012128_CR10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cell.2010.03.009","volume":"141","author":"M Hafner","year":"2010","unstructured":"Hafner, M. et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141, 129\u2013141 (2010).","journal-title":"Cell"},{"key":"BFnrrheum2012128_CR11","doi-asserted-by":"publisher","first-page":"8721","DOI":"10.1073\/pnas.0602831103","volume":"103","author":"PK Rao","year":"2006","unstructured":"Rao, P. K., Kumar, R. M., Farkhondeh, M., Baskerville, S. & Lodish, H. F. Myogenic factors that regulate expression of muscle-specific microRNAs. Proc. Natl Acad. Sci. USA 103, 8721\u20138726 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR12","doi-asserted-by":"publisher","first-page":"12481","DOI":"10.1073\/pnas.0605298103","volume":"103","author":"KD Taganov","year":"2006","unstructured":"Taganov, K. D., Boldin, M. P., Chang, K. J. & Baltimore, D. NF-\u03baB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl Acad. Sci. USA 103, 12481\u201312486 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR13","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1038\/nature03868","volume":"436","author":"TP Chendrimada","year":"2005","unstructured":"Chendrimada, T. P. et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 436, 740\u2013744 (2005).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR14","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nature01957","volume":"425","author":"Y Lee","year":"2003","unstructured":"Lee, Y. et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425, 415\u2013419 (2003).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR15","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature03120","volume":"432","author":"RI Gregory","year":"2004","unstructured":"Gregory, R. I. et al. The Microprocessor complex mediates the genesis of microRNAs. Nature 432, 235\u2013240 (2004).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature03049","volume":"432","author":"AM Denli","year":"2004","unstructured":"Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F. & Hannon, G. J. Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231\u2013235 (2004).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR17","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nrg3074","volume":"12","author":"M Esteller","year":"2011","unstructured":"Esteller, M. Non-coding RNAs in human disease. Nat. Rev. Genet. 12, 861\u2013874 (2011).","journal-title":"Nat. Rev. Genet."},{"key":"BFnrrheum2012128_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"BP Lewis","year":"2005","unstructured":"Lewis, B. P., Burge, C. B. & Bartel, D. P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15\u201320 (2005).","journal-title":"Cell"},{"key":"BFnrrheum2012128_CR19","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/ng1253","volume":"35","author":"E Bernstein","year":"2003","unstructured":"Bernstein, E. et al. Dicer is essential for mouse development. Nat. Genet. 35, 215\u2013217 (2003).","journal-title":"Nat. Genet."},{"key":"BFnrrheum2012128_CR20","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1101\/gad.1248505","volume":"19","author":"C Kanellopoulou","year":"2005","unstructured":"Kanellopoulou, C. et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 19, 489\u2013501 (2005).","journal-title":"Genes Dev."},{"key":"BFnrrheum2012128_CR21","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/ng1969","volume":"39","author":"Y Wang","year":"2007","unstructured":"Wang, Y., Medvid, R., Melton, C., Jaenisch, R. & Blelloch, R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39, 380\u2013385 (2007).","journal-title":"Nat. Genet."},{"key":"BFnrrheum2012128_CR22","doi-asserted-by":"publisher","first-page":"10898","DOI":"10.1073\/pnas.0504834102","volume":"102","author":"BD Harfe","year":"2005","unstructured":"Harfe, B. D., McManus, M. T., Mansfield, J. H., Hornstein, E. & Tabin, C. J. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc. Natl Acad. Sci. USA 102, 10898\u201310903 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR23","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1073\/pnas.0707900105","volume":"105","author":"T Kobayashi","year":"2008","unstructured":"Kobayashi, T. et al. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc. Natl Acad. Sci. USA 105, 1949\u20131954 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR24","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/jcb.22228","volume":"109","author":"F Mizoguchi","year":"2010","unstructured":"Mizoguchi, F. et al. Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J. Cell. Biochem. 109, 866\u2013875 (2010).","journal-title":"J. Cell. Biochem."},{"key":"BFnrrheum2012128_CR25","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1073\/pnas.0510565103","volume":"103","author":"S Volinia","year":"2006","unstructured":"Volinia, S. et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl Acad. Sci. USA 103, 2257\u20132261 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR26","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature09783","volume":"469","author":"EM Small","year":"2011","unstructured":"Small, E. M. & Olson, E. N. Pervasive roles of microRNAs in cardiovascular biology. Nature 469, 336\u2013342 (2011).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR27","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddq367","volume":"19","author":"CY Park","year":"2010","unstructured":"Park, C. Y., Choi, Y. S. & McManus, M. T. Analysis of microRNA knockouts in mice. Hum. Mol. Genet. 19, R169\u2013R175 (2010).","journal-title":"Hum. Mol. Genet."},{"key":"BFnrrheum2012128_CR28","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1126\/science.1178178","volume":"327","author":"RE Lanford","year":"2010","unstructured":"Lanford, R. E. et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327, 198\u2013201 (2010).","journal-title":"Science"},{"key":"BFnrrheum2012128_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1126\/science.1114519","volume":"309","author":"E Wienholds","year":"2005","unstructured":"Wienholds, E. et al. MicroRNA expression in zebrafish embryonic development. Science 309, 310\u2013311 (2005).","journal-title":"Science"},{"key":"BFnrrheum2012128_CR30","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/ng.82","volume":"40","author":"JK Eberhart","year":"2008","unstructured":"Eberhart, J. K. et al. MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat. Genet. 40, 290\u2013298 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum2012128_CR31","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.1016\/j.febslet.2006.06.080","volume":"580","author":"L Tuddenham","year":"2006","unstructured":"Tuddenham, L. et al. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett. 580, 4214\u20134217 (2006).","journal-title":"FEBS Lett."},{"key":"BFnrrheum2012128_CR32","doi-asserted-by":"publisher","first-page":"2723","DOI":"10.1002\/art.24745","volume":"60","author":"S Miyaki","year":"2009","unstructured":"Miyaki, S. et al. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum. 60, 2723\u20132730 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR33","doi-asserted-by":"publisher","first-page":"22206","DOI":"10.1074\/jbc.M112.343194","volume":"287","author":"S Yamashita","year":"2012","unstructured":"Yamashita, S. et al. L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. J. Biol. Chem. 287, 22206\u201322215 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR34","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/jor.21423","volume":"29","author":"L Lin","year":"2011","unstructured":"Lin, L., Shen, Q., Zhang, C., Chen, L., & Yu, C. Assessment of the profiling microRNA expression of differentiated and dedifferentiated human adult articular chondrocytes. J. Orthop. Res. 29, 1578\u20131584 (2011).","journal-title":"J. Orthop. Res."},{"key":"BFnrrheum2012128_CR35","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1101\/gad.1915510","volume":"24","author":"S Miyaki","year":"2010","unstructured":"Miyaki, S. et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 24, 1173\u20131185 (2010).","journal-title":"Genes Dev."},{"key":"BFnrrheum2012128_CR36","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.1128\/MCB.05178-11","volume":"31","author":"Y Nakamura","year":"2011","unstructured":"Nakamura, Y., Inloes, J. B., Katagiri, T. & Kobayashi, T. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol. Cell Biol. 31, 3019\u20133028 (2011).","journal-title":"Mol. Cell Biol."},{"key":"BFnrrheum2012128_CR37","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1016\/j.febslet.2011.08.013","volume":"585","author":"J Yang","year":"2011","unstructured":"Yang, J. et al. MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 585, 2992\u20132997 (2011).","journal-title":"FEBS Lett."},{"key":"BFnrrheum2012128_CR38","doi-asserted-by":"publisher","first-page":"607","DOI":"10.4161\/rna.8.4.15390","volume":"8","author":"FE Nicolas","year":"2011","unstructured":"Nicolas, F. E. et al. mRNA expression profiling reveals conserved and non-conserved miR-140 targets. RNA Biol. 8, 607\u2013615 (2011).","journal-title":"RNA Biol."},{"key":"BFnrrheum2012128_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12010-011-9404-y","volume":"166","author":"Y Nakamura","year":"2012","unstructured":"Nakamura, Y. et al. Sox9 is upstream of microRNA-140 in cartilage. Appl. Biochem. Biotechnol. 166, 64\u201371 (2012).","journal-title":"Appl. Biochem. Biotechnol."},{"key":"BFnrrheum2012128_CR40","doi-asserted-by":"publisher","first-page":"24381","DOI":"10.1074\/jbc.M110.111328","volume":"285","author":"KA Dudek","year":"2010","unstructured":"Dudek, K. A., Lafont, J. E., Martinez-Sanchez, A. & Murphy, C. L. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J. Biol. Chem. 285, 24381\u201324387 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR41","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1002\/art.34314","volume":"64","author":"TE Swingler","year":"2012","unstructured":"Swingler, T. E. et al. The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis Rheum. 64, 1909\u20131919 (2012).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR42","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1074\/jbc.M111.302430","volume":"287","author":"A Martinez-Sanchez","year":"2012","unstructured":"Martinez-Sanchez, A., Dudek, K. A., & Murphy, C. L. Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145). J. Biol. Chem. 287, 916\u2013924 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR43","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1101\/gad.1842409","volume":"23","author":"M Xin","year":"2009","unstructured":"Xin, M. et al. MicroRNA miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev. 23, 2166\u20132178 (2009).","journal-title":"Genes Dev."},{"key":"BFnrrheum2012128_CR44","doi-asserted-by":"publisher","first-page":"e3740","DOI":"10.1371\/journal.pone.0003740","volume":"3","author":"D Iliopoulos","year":"2008","unstructured":"Iliopoulos, D., Malizos, K. N., Oikonomou, P. & Tsezou, A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One 3, e3740 (2008).","journal-title":"PLoS One"},{"key":"BFnrrheum2012128_CR45","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.joca.2008.09.012","volume":"17","author":"SW Jones","year":"2009","unstructured":"Jones, S. W. et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-\u03b1 and MMP13. Osteoarthritis Cartilage 17, 464\u2013472 (2009).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum2012128_CR46","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/1471-2474-10-148","volume":"10","author":"G Tardif","year":"2009","unstructured":"Tardif, G., Hum, D., Pelletier, J. P., Duval, N. & Martel-Pelletier, J. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord. 10, 148 (2009).","journal-title":"BMC Musculoskelet Disord."},{"issue":"Suppl. 1","key":"BFnrrheum2012128_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.arr.2010.08.002","volume":"9","author":"LH Chen","year":"2010","unstructured":"Chen, L. H., Chiou, G. Y., Chen, Y. W., Li, H. Y. & Chiou, S. H. MicroRNA and aging: a novel modulator in regulating the aging network. Ageing Res. Rev. 9 (Suppl. 1), 59\u201366 (2010).","journal-title":"Ageing Res. Rev."},{"key":"BFnrrheum2012128_CR48","doi-asserted-by":"publisher","first-page":"184","DOI":"10.2174\/138920209788185225","volume":"10","author":"R Liang","year":"2009","unstructured":"Liang, R., Bates, D. J. & Wang, E. Epigenetic control of microRNA expression and aging. Curr. Genomics 10, 184\u2013193 (2009).","journal-title":"Curr. Genomics"},{"key":"BFnrrheum2012128_CR49","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1002\/art.27369","volume":"62","author":"V Gagarina","year":"2010","unstructured":"Gagarina, V. et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum. 62, 1383\u20131392 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR50","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1074\/jbc.M109.058628","volume":"285","author":"EH Hong","year":"2010","unstructured":"Hong, E. H. et al. Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J. Biol. Chem. 285, 1283\u20131295 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR51","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1002\/art.24864","volume":"60","author":"K Takayama","year":"2009","unstructured":"Takayama, K. et al. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis Rheum. 60, 2731\u20132740 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR52","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1002\/jor.21284","volume":"29","author":"N Fujita","year":"2011","unstructured":"Fujita, N. et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J. Orthop. Res. 29, 511\u2013515 (2011).","journal-title":"J. Orthop. Res."},{"key":"BFnrrheum2012128_CR53","doi-asserted-by":"publisher","first-page":"36300","DOI":"10.1074\/jbc.M803196200","volume":"283","author":"M Dvir-Ginzberg","year":"2008","unstructured":"Dvir-Ginzberg, M., Gagarina, V., Lee, E. J. & Hall, D. J. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J. Biol. Chem. 283, 36300\u201336310 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR54","doi-asserted-by":"publisher","first-page":"415","DOI":"10.18632\/aging.100176","volume":"2","author":"LR Saunders","year":"2010","unstructured":"Saunders, L. R. et al. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2, 415\u2013431 (2010).","journal-title":"Aging (Albany NY)"},{"key":"BFnrrheum2012128_CR55","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s12031-011-9587-2","volume":"46","author":"N Schonrock","year":"2012","unstructured":"Schonrock, N., Humphreys, D. T., Preiss, T. & G\u00f6tz, J. Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-\u03b2. J. Mol. Neurosci. 46, 324\u2013335 (2012).","journal-title":"J. Mol. Neurosci."},{"key":"BFnrrheum2012128_CR56","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1083\/jcb.201010100","volume":"193","author":"D Xu","year":"2011","unstructured":"Xu, D. et al. miR-22 represses cancer progression by inducing cellular senescence. J. Cell. Biol. 193, 409\u2013424 (2011).","journal-title":"J. Cell. Biol."},{"key":"BFnrrheum2012128_CR57","unstructured":"Jazbutyte, V. et al. MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart. Age (Dordr.) (in press)."},{"key":"BFnrrheum2012128_CR58","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1093\/rheumatology\/keq247","volume":"49","author":"MM Abouheif","year":"2010","unstructured":"Abouheif, M. M. et al. Silencing microRNA-34a inhibits chondrocytes apoptosis in a rat osteoarthritis model in vitro. Rheumatology (Oxford) 49, 2054\u20132060 (2010).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum2012128_CR59","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1002\/art.24678","volume":"60","author":"W Dunn","year":"2009","unstructured":"Dunn, W., DuRaine, G. & Reddi, A. H. Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction. Arthritis Rheum. 60, 2333\u20132339 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR60","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1016\/j.febslet.2011.05.020","volume":"585","author":"A Ceribelli","year":"2011","unstructured":"Ceribelli, A., Nahid, M. A., Satoh, M. & Chan, E. K. MicroRNAs in rheumatoid arthritis. FEBS Lett. 585, 3667\u20133674 (2011).","journal-title":"FEBS Lett."},{"key":"BFnrrheum2012128_CR61","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1002\/art.23386","volume":"58","author":"J Stanczyk","year":"2008","unstructured":"Stanczyk, J. et al. Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 58, 1001\u20131009 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR62","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1002\/art.23429","volume":"58","author":"T Nakasa","year":"2008","unstructured":"Nakasa, T. et al. Expression of microRNA-146 in rheumatoid arthritis synovial tissue. Arthritis Rheum. 58, 1284\u20131292 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR63","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1002\/art.24404","volume":"60","author":"K Yamasaki","year":"2009","unstructured":"Yamasaki, K. et al. Expression of microRNA-146a in osteoarthritis cartilage. Arthritis Rheum. 60, 1035\u20131041 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR64","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1002\/art.27329","volume":"62","author":"N Akhtar","year":"2010","unstructured":"Akhtar, N. et al. MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum. 62, 1361\u20131371 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR65","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.gene.2011.03.003","volume":"480","author":"X Li","year":"2011","unstructured":"Li, X. et al. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene 480, 34\u201341 (2011).","journal-title":"Gene"},{"key":"BFnrrheum2012128_CR66","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.bone.2011.10.010","volume":"51","author":"S Suri","year":"2012","unstructured":"Suri, S. & Walsh, D. A. Osteochondral alterations in osteoarthritis. Bone 51, 204\u2013211 (2012).","journal-title":"Bone"},{"key":"BFnrrheum2012128_CR67","doi-asserted-by":"publisher","first-page":"R101","DOI":"10.1186\/ar2493","volume":"10","author":"KM Pauley","year":"2008","unstructured":"Pauley, K. M. et al. Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res. Ther. 10, R101 (2008).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2012128_CR68","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3109\/s10165-011-0536-2","volume":"22","author":"A Okuhara","year":"2012","unstructured":"Okuhara, A. et al. Change in microRNA expression in peripheral mononuclear cells according to the progression of osteoarthritis. Mod. Rheumatol. 22, 446\u2013457 (2012).","journal-title":"Mod. Rheumatol."},{"key":"BFnrrheum2012128_CR69","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1002\/art.30321","volume":"63","author":"T Nakasa","year":"2011","unstructured":"Nakasa, T., Shibuya, H., Nagata, Y., Niimoto, T. & Ochi, M. The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum. 63, 1582\u20131590 (2011).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR70","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1002\/jcb.21335","volume":"101","author":"T Sugatani","year":"2007","unstructured":"Sugatani, T. & Hruska, K. A. MicroRNA-223 is a key factor in osteoclast differentiation. J. Cell Biochem. 101, 996\u2013999 (2007).","journal-title":"J. Cell Biochem."},{"key":"BFnrrheum2012128_CR71","doi-asserted-by":"publisher","first-page":"4667","DOI":"10.1074\/jbc.M805777200","volume":"284","author":"T Sugatani","year":"2009","unstructured":"Sugatani, T. & Hruska, K. A. Impaired micro-RNA pathways diminish osteoclast differentiation and function. J. Biol. Chem. 284, 4667\u20134678 (2009).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR72","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1016\/j.febslet.2009.06.006","volume":"583","author":"Y Mizuno","year":"2009","unstructured":"Mizuno, Y. et al. miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett. 583, 2263\u20132268 (2009).","journal-title":"FEBS Lett."},{"key":"BFnrrheum2012128_CR73","doi-asserted-by":"publisher","first-page":"15878","DOI":"10.1074\/jbc.M800731200","volume":"283","author":"P Fasanaro","year":"2008","unstructured":"Fasanaro, P. et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J. Biol. Chem. 283, 15878\u201315883 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR74","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1172\/JCI39832","volume":"119","author":"H Li","year":"2009","unstructured":"Li, H. et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J. Clin. Invest. 119, 3666\u20133677 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum2012128_CR75","doi-asserted-by":"publisher","first-page":"12328","DOI":"10.1074\/jbc.M110.176099","volume":"286","author":"R Hu","year":"2011","unstructured":"Hu, R. et al. A Runx\/miR-3960\/miR-2861 regulatory feedback loop during mouse osteoblast differentiation. J. Biol. Chem. 286, 12328\u201312339 (2011).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum2012128_CR76","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nm.1998","volume":"15","author":"F Echtermeyer","year":"2009","unstructured":"Echtermeyer, F. et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat. Med. 15, 1072\u20131076 (2009).","journal-title":"Nat. Med."},{"key":"BFnrrheum2012128_CR77","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/nature03369","volume":"434","author":"SS Glasson","year":"2005","unstructured":"Glasson, S. S. et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 434, 644\u2013648 (2005).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR78","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nature03417","volume":"434","author":"H Stanton","year":"2005","unstructured":"Stanton, H. et al. ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature 434, 648\u2013652 (2005).","journal-title":"Nature"},{"key":"BFnrrheum2012128_CR79","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/nm.2146","volume":"16","author":"T Saito","year":"2010","unstructured":"Saito, T. et al. Transcriptional regulation of endochondral ossification by HIF-2\u03b1 during skeletal growth and osteoarthritis development. Nat. Med. 16, 678\u2013686 (2010).","journal-title":"Nat. Med."},{"key":"BFnrrheum2012128_CR80","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/nm.2153","volume":"16","author":"S Yang","year":"2010","unstructured":"Yang, S. et al. Hypoxia-inducible factor-2\u03b1 is a catabolic regulator of osteoarthritic cartilage destruction. Nat. Med. 16, 687\u2013693 (2010).","journal-title":"Nat. Med."},{"key":"BFnrrheum2012128_CR81","doi-asserted-by":"publisher","first-page":"10202","DOI":"10.1073\/pnas.0913897107","volume":"107","author":"S Otsuki","year":"2010","unstructured":"Otsuki, S. et al. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc. Natl Acad. Sci. USA 107, 10202\u201310207 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR82","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1073\/pnas.0806062106","volume":"106","author":"N Taniguchi","year":"2009","unstructured":"Taniguchi, N. et al. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc. Natl Acad. Sci. USA 106, 1181\u20131186 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR83","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/j.joca.2009.04.009","volume":"17","author":"MP Hellio Le Graverand-Gastineau","year":"2009","unstructured":"Hellio Le Graverand-Gastineau, M. P. OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed? Osteoarthritis Cartilage 17, 1393\u20131401 (2009).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum2012128_CR84","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s11033-006-9037-3","volume":"34","author":"K Thirunavukkarasu","year":"2007","unstructured":"Thirunavukkarasu, K., Pei, Y. & Wei, T. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. Mol. Biol. Rep. 34, 225\u2013231 (2007).","journal-title":"Mol. Biol. Rep."},{"key":"BFnrrheum2012128_CR85","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1038\/nm.2055","volume":"15","author":"AC Lin","year":"2009","unstructured":"Lin, A. C. et al. Modulating hedgehog signaling can attenuate the severity of osteoarthritis. Nat. Med. 15, 1421\u20131425 (2009).","journal-title":"Nat. Med."},{"key":"BFnrrheum2012128_CR86","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.joca.2010.10.006","volume":"18","author":"T Saito","year":"2010","unstructured":"Saito, T. & Kawaguchi, H. HIF-2\u03b1 as a possible therapeutic target of osteoarthritis. Osteoarthritis Cartilage 18, 1552\u20131556 (2010).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum2012128_CR87","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.bcp.2010.02.017","volume":"80","author":"MJ Alcaraz","year":"2010","unstructured":"Alcaraz, M. J., Meg\u00edas, J., Garc\u00eda-Arnandis, I., Cl\u00e9rigues V & Guill\u00e9n, M. I. New molecular targets for the treatment of osteoarthritis. Biochem. Pharmacol. 80, 13\u201321 (2010).","journal-title":"Biochem. Pharmacol."},{"key":"BFnrrheum2012128_CR88","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1038\/nbt.1541","volume":"27","author":"A Eguchi","year":"2009","unstructured":"Eguchi, A. et al. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat. Biotechnol. 27, 567\u2013571 (2009).","journal-title":"Nat. Biotechnol."},{"key":"BFnrrheum2012128_CR89","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.24762","volume":"60","author":"Y Nagata","year":"2009","unstructured":"Nagata, Y. et al. Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded microRNA-15a. Arthritis Rheum. 60, 2677\u20132683 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum2012128_CR90","doi-asserted-by":"publisher","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"PS Mitchell","year":"2008","unstructured":"Mitchell, P. S. et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl Acad. Sci. USA 105, 10513\u201310518 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum2012128_CR91","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1111\/j.1349-7006.2010.01650.x","volume":"101","author":"N Kosaka","year":"2010","unstructured":"Kosaka, N., Iguchi, H. & Ochiya, T. Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101, 2087\u20132092 (2010).","journal-title":"Cancer Sci."},{"key":"BFnrrheum2012128_CR92","first-page":"200","volume":"1806","author":"J Wittmann","year":"2010","unstructured":"Wittmann, J. & J\u00e4ck, H. M. Serum microRNAs as powerful cancer biomarkers. Biochim. Biophys. Acta 1806, 200\u2013207 (2010).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnrrheum2012128_CR93","doi-asserted-by":"publisher","first-page":"R86","DOI":"10.1186\/ar3013","volume":"12","author":"K Murata","year":"2010","unstructured":"Murata, K. et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res. Ther. 12, R86 (2010).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum2012128_CR94","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1758-907X-1-7","volume":"1","author":"N Kosaka","year":"2010","unstructured":"Kosaka, N., Izumi, H., Sekine, K. & Ochiya, T. MicroRNA as a new immune-regulatory agent in breast milk. Silence 1, 7 (2010).","journal-title":"Silence"},{"key":"BFnrrheum2012128_CR95","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nbt.1807","volume":"29","author":"L Alvarez-Erviti","year":"2011","unstructured":"Alvarez-Erviti, L. et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29, 341\u2013345 (2011).","journal-title":"Nat. Biotechnol."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.128","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T11:43:59Z","timestamp":1714304639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2012.128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,14]]},"references-count":95,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["BFnrrheum2012128"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2012.128","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,14]]}}}