{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:52:43Z","timestamp":1791103963443,"version":"4.1.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T00:00:00Z","timestamp":1334016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1038\/nrrheum.2012.41","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T10:38:06Z","timestamp":1334054286000},"page":"296-304","source":"Crossref","is-referenced-by-count":178,"title":["Genetics of spondyloarthritis\u2014beyond the MHC"],"prefix":"10.1038","volume":"8","author":[{"given":"John D.","family":"Reveille","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,10]]},"reference":[{"key":"BFnrrheum201241_CR1","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1056\/NEJM197304052881403","volume":"288","author":"L Schlosstein","year":"1973","unstructured":"Schlosstein, L., Terasaki, P. I., Bluestone, R., Pearson, C. M. High association of an HLA antigen, W27, with ankylosing spondylitis. N. Engl. J. Med. 288, 704\u2013706 (1973).","journal-title":"N. Engl. J. Med."},{"key":"BFnrrheum201241_CR2","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1172\/JCI109903","volume":"66","author":"C Murray","year":"1980","unstructured":"Murray, C.  et al. Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex. J. Clin. Invest. 66, 670\u2013675 (1980).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum201241_CR3","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/35079107","volume":"411","author":"JP Hugot","year":"2001","unstructured":"Hugot, J. P.  et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599\u2013603 (2001).","journal-title":"Nature"},{"key":"BFnrrheum201241_CR4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/35079114","volume":"411","author":"Y Ogura","year":"2001","unstructured":"Ogura, Y.  et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603\u2013606 (2001).","journal-title":"Nature"},{"key":"BFnrrheum201241_CR5","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1002\/art.1780401015","volume":"40","author":"MA Brown","year":"1997","unstructured":"Brown, M. A.  et al. Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum. 40, 1823\u20131828 (1997).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1136\/ard.59.11.883","volume":"59","author":"MA Brown","year":"2000","unstructured":"Brown, M. A., Laval, S. H., Brophy, S. & Calin, A. Recurrence risk modeling of the genetic susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 59, 883\u2013886 (2000).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR7","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/bfgp\/elr023","volume":"10","author":"MA Brown","year":"2011","unstructured":"Brown, M. A. Progress in the genetics of ankylosing spondylitis. Brief Funct. Genomics 10, 249\u2013257 (2011).","journal-title":"Brief Funct. Genomics"},{"key":"BFnrrheum201241_CR8","doi-asserted-by":"publisher","first-page":"23459","DOI":"10.1074\/jbc.M110336200","volume":"277","author":"NS Dangoria","year":"2002","unstructured":"Dangoria, N. S.  et al. HLA-B27 misfolding is associated with aberrant intermolecular disulfide bond formation (dimerization) in the endoplasmic reticulum. J. Biol. Chem. 277, 23459\u201323468 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum201241_CR9","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1002\/art.24763","volume":"60","author":"ML Delay","year":"2009","unstructured":"Delay, M. L.  et al. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with TH17 activation in transgenic rats. Arthritis Rheum. 60, 2633\u20132643 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR10","doi-asserted-by":"publisher","first-page":"2972","DOI":"10.1002\/art.10605","volume":"46","author":"S Kollnberger","year":"2002","unstructured":"Kollnberger, S.  et al. Cell-surface expression and immune receptor recognition of HLA-B27 homodimers. Arthritis Rheum. 46, 2972\u20132982 (2002).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1365-2567.2011.03453.x","volume":"133","author":"EC Campbell","year":"2011","unstructured":"Campbell, E. C., Fettke, F., Bhat, S., Morley, K. D. & Powis, S. J. Expression of MHC class I dimers and ERAP1 in an ankylosing spondylitis patient cohort. Immunology 133, 379\u2013385 (2011).","journal-title":"Immunology"},{"key":"BFnrrheum201241_CR12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.autrev.2009.01.003","volume":"8","author":"A Mathieu","year":"2009","unstructured":"Mathieu, A.  et al. The interplay between the geographic distribution of HLA-B27 alleles and their role in infectious and autoimmune diseases: a unifying hypothesis. Autoimmun. Rev. 8, 420\u2013425 (2009).","journal-title":"Autoimmun. Rev."},{"key":"BFnrrheum201241_CR13","first-page":"734","volume":"25","author":"HC Gerard","year":"1998","unstructured":"Gerard, H. C., Branigan, P. J., Schumacher, H. R. & Hudson, A. P. Synovial Chlamydia trachomatis in patients with reactive arthritis\/Reiter's syndrome are viable but show aberrant gene expression. J. Rheumatol. 25, 734\u2013742 (1998).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201241_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/art.1780270301","volume":"27","author":"SM van der Linden","year":"1984","unstructured":"van der Linden, S. M., Valkenburg, H. A., de Jongh, B. M. & Cats, A. The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. A comparison of relatives of spondylitis patients with the general population. Arthritis Rheum. 27, 241\u2013249 (1984).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR15","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/anr.1780320912","volume":"32","author":"WP Robinson","year":"1989","unstructured":"Robinson, W. P.  et al. HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum. 32, 1135\u20131141 (1989).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1136\/ard.55.4.268","volume":"55","author":"MA Brown","year":"1996","unstructured":"Brown, M. A.  et al. HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann. Rheum. Dis. 55, 268\u2013270 (1996).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR17","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/rheumatology\/keh193","volume":"43","author":"JC Wei","year":"2004","unstructured":"Wei, J. C., Tsai, W. C., Lin, H. S., Tsai, C. Y. & Chou, C. T. HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients. Rheumatology (Oxford) 43, 839\u2013842 (2004).","journal-title":"Rheumatology (Oxford)"},{"issue":"Suppl. 1","key":"BFnrrheum201241_CR18","doi-asserted-by":"publisher","first-page":"i44","DOI":"10.1136\/ard.2010.140574","volume":"70","author":"JD Reveille","year":"2011","unstructured":"Reveille, J. D. The genetic basis of spondyloarthritis. Ann. Rheum. Dis. 70 (Suppl. 1), i44\u2013i50 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR19","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/ng.873","volume":"43","author":"DM Evans","year":"2011","unstructured":"Evans, D. M.  et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat. Genet. 43, 761\u2013767 (2011).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR20","doi-asserted-by":"crossref","unstructured":"Wellcome Trust Case Control Consortium  et al. Association scan of 14,500 nsSNPs in four common diseases identifies variants involved in autoimmunity. Nat. Genet. 39, 1329\u20131337 (2007).","DOI":"10.1038\/ng.2007.17"},{"key":"BFnrrheum201241_CR21","doi-asserted-by":"crossref","unstructured":"Australo-Anglo-American Spondyloarthritis Consortium  et al. Genomewide association study of ankylosing spondylitis identifies multiple non-MHC susceptibility loci. Nat. Genet. 42, 123\u2013127 (2010).","DOI":"10.1038\/ng.513"},{"key":"BFnrrheum201241_CR22","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/art.24467","volume":"60","author":"WP Maksymowych","year":"2009","unstructured":"Maksymowych, W. P.  et al. Association of a specific ERAP1\/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. Arthritis Rheum. 60, 1317\u20131323 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR23","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1136\/ard.2008.103804","volume":"69","author":"FW Tsui","year":"2010","unstructured":"Tsui, F. W.  et al. Association of an ERAP1\/ ERAP2 haplotype with familial ankylosing spondylitis. Ann. Rheum. Dis. 69, 733\u2013736 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR24","first-page":"800","volume":"27","author":"FM Pimentel-Santos","year":"2009","unstructured":"Pimentel-Santos, F. M.  et al. Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population. Clin. Exp. Rheumatol. 27, 800\u2013806 (2009).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201241_CR25","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3899\/jrheum.090806","volume":"37","author":"B Paz\u00e1r","year":"2010","unstructured":"Paz\u00e1r, B.  et al. Association of ARTS1 gene polymorphisms with ankylosing spondylitis in the Hungarian population: the rs27044 variant is associated with HLA-B*2705 subtype in Hungarian patients with ankylosing spondylitis. J. Rheumatol. 37, 379\u2013384 (2010).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201241_CR26","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1002\/art.24933","volume":"60","author":"SI Davidson","year":"2009","unstructured":"Davidson, S. I.  et al. Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Arthritis Rheum. 60, 3263\u20133268 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3899\/jrheum.100652","volume":"38","author":"SY Bang","year":"2011","unstructured":"Bang, S. Y.  et al. Genetic studies of ankylosing spondylitis in Koreans confirm associations with ERAP1 and 2p15 reported in white patients. J. Rheumatol. 38, 322\u2013324 (2011).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201241_CR28","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1084\/jem.20052271","volume":"203","author":"J Yan","year":"2006","unstructured":"Yan, J.  et al. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J. Exp. Med. 203, 647\u2013659 (2006).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum201241_CR29","doi-asserted-by":"crossref","unstructured":"Genetic Analysis of Psoriasis Consortium and the Wellcome Trust Case Control Consortium 2. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat. Genet. 42, 985\u2013990 (2010).","DOI":"10.1038\/ng.694"},{"key":"BFnrrheum201241_CR30","doi-asserted-by":"publisher","first-page":"7745","DOI":"10.1073\/pnas.1101262108","volume":"108","author":"G Kochan","year":"2011","unstructured":"Kochan, G.  et al. Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc. Natl Acad. Sci. USA 108, 7745\u20137750 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum201241_CR31","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1172\/JCI0213847","volume":"110","author":"X Cui","year":"2002","unstructured":"Cui, X.  et al. Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding. J. Clin. Invest. 110, 515\u2013526 (2002).","journal-title":"J. Clin. Invest."},{"key":"BFnrrheum201241_CR32","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.3899\/jrheum.100019","volume":"37","author":"N Haroon","year":"2010","unstructured":"Haroon, N., Tsui, F. W., Chiu, B., Tsui, H. W. & Inman, R. D. Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms. J. Rheumatol. 37, 1907\u20131910 (2010).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201241_CR33","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1126\/science.1135245","volume":"314","author":"RH Duerr","year":"2006","unstructured":"Duerr, R. H.  et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461\u20131463 (2006).","journal-title":"Science"},{"key":"BFnrrheum201241_CR34","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1086\/511051","volume":"80","author":"M Cargill","year":"2007","unstructured":"Cargill, M.  et al. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. Am. J. Hum. Genet. 80, 273\u2013290 (2007).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR35","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/rheumatology\/ken501","volume":"48","author":"T Karaderi","year":"2009","unstructured":"Karaderi, T.  et al. Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case\u2013control study and meta-analysis of published series. Rheumatology (Oxford) 48, 386\u2013389 (2009).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201241_CR36","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/art.23389","volume":"58","author":"P Rahman","year":"2008","unstructured":"Rahman, P.  et al. Association of interleukin-23 receptor variants with ankylosing spondylitis. Arthritis Rheum. 58, 1020\u20131025 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR37","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1136\/ard.2007.080283","volume":"67","author":"B Rueda","year":"2008","unstructured":"Rueda, B.  et al. The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis. Ann. Rheum. Dis. 67, 1451\u20131454 (2008).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00011-009-0089-4","volume":"59","author":"E Safrany","year":"2010","unstructured":"Safrany, E.  et al. Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients. Inflamm. Res. 59, 159\u2013164 (2010).","journal-title":"Inflamm. Res."},{"key":"BFnrrheum201241_CR39","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3899\/jrheum.081121","volume":"236","author":"IH Sung","year":"2009","unstructured":"Sung, I. H.  et al. IL-23R polymorphisms in patients with ankylosing spondylitis in Korea. J. Rheum. 236, 1003\u20131005 (2009).","journal-title":"J. Rheum."},{"key":"BFnrrheum201241_CR40","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1136\/ard.2010.133322","volume":"70","author":"SI Davidson","year":"2011","unstructured":"Davidson, S. I.  et al.Association of STAT3 and TNFSF1A with ankylosing spondylitis in Han Chinese. Ann. Rheum. Dis. 70, 289\u2013292 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR41","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1038\/ng.203","volume":"40","author":"S Kugathasan","year":"2008","unstructured":"Kugathasan, S.  et al. Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat. Genet. 40, 1211\u20131215 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR42","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1093\/rheumatology\/40.12.1359","volume":"40","author":"F McGarry","year":"2001","unstructured":"McGarry, F., Neilly, J., Anderson, N., Sturrock, R. & Field, M. A polymorphism within the interleukin 1 receptor antagonist (IL-1Ra) gene is associated with ankylosing spondylitis. Rheumatology (Oxford) 40, 1359\u20131364 (2001).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201241_CR43","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1093\/rheumatology\/41.12.1419","volume":"41","author":"M van der Paardt","year":"2002","unstructured":"van der Paardt, M.  et al. Interleukin-1\u03b2 and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis. Rheumatology (Oxford) 41, 1419\u20131423 (2002).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201241_CR44","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1002\/art.11037","volume":"48","author":"WP Maksymowych","year":"2003","unstructured":"Maksymowych, W. P.  et al. High-throughput single-nucleotide polymorphism analysis of the IL1RN locus in patients with ankylosing spondylitis by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry. Arthritis Rheum. 48, 2011\u20132018 (2003).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR45","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1136\/ard.2005.046847","volume":"65","author":"C-T Chou","year":"2006","unstructured":"Chou, C.-T.  et al. Replication of association of IL-1 gene complex members with ankylosing spondylitis in Taiwanese Chinese. Ann. Rheum. Dis. 65, 1106\u20131109 (2006).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR46","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1086\/424695","volume":"75","author":"AE Timms","year":"2004","unstructured":"Timms, A. E.  et al. The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am. J. Hum. Genet. 75, 587\u2013595 (2004).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR47","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1136\/ard.2007.081364","volume":"67","author":"AM Sims","year":"2008","unstructured":"Sims, A. M.  et al. Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis. Ann. Rheum. Dis. 67, 1305\u20131309 (2008).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR48","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1136\/ard.2004.023176","volume":"64","author":"H Haibel","year":"2005","unstructured":"Haibel, H., Rudwaleit, M., Listing, J. & Sieper, J. Open label trial of anakinra in active ankylosing spondylitis over 24 weeks. Ann. Rheum. Dis. 64, 296\u2013298 (2005).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR49","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1086\/378781","volume":"73","author":"O Dowling","year":"2003","unstructured":"Dowling, O.  et al. Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am. J. Hum. Genet. 73, 957\u2013966 (2003).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/ni.1840","volume":"11","author":"JH Park","year":"2010","unstructured":"Park, J. H.  et al. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat. Immunol. 11, 257\u2013264 (2010).","journal-title":"Nat. Immunol."},{"key":"BFnrrheum201241_CR51","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/S0140-6736(09)60140-9","volume":"373","author":"A Gottlieb","year":"2009","unstructured":"Gottlieb, A.  et al. Ustekinumab, a human interleukin 12\/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 373, 633\u2013640 (2009).","journal-title":"Lancet"},{"key":"BFnrrheum201241_CR52","doi-asserted-by":"publisher","first-page":"e1001195","DOI":"10.1371\/journal.pgen.1001195","volume":"6","author":"P Danoy","year":"2010","unstructured":"Danoy, P.  et al. Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet. 6, e1001195 (2010).","journal-title":"PLoS Genet."},{"key":"BFnrrheum201241_CR53","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1084\/jem.20070906","volume":"205","author":"M Armaka","year":"2008","unstructured":"Armaka, M.  et al. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J. Exp. Med. 205, 331\u2013337 (2008).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum201241_CR54","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/ncb1086","volume":"6","author":"T Bouwmeester","year":"2004","unstructured":"Bouwmeester, T.  et al. A physical and functional map of the human TNF-\u03b1\/NF-\u03ba-B signal transduction pathway. Nat. Cell Biol. 6, 97\u2013105 (2004).","journal-title":"Nat. Cell Biol."},{"key":"BFnrrheum201241_CR55","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1136\/ard.2009.115147","volume":"69","author":"JJ Pointon","year":"2010","unstructured":"Pointon, J. J.  et al.The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD). Ann. Rheum. Dis. 69, 1243\u20131246 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR56","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/gene.2010.17","volume":"11","author":"JJ Pointon","year":"2010","unstructured":"Pointon, J. J.  et al. Elucidating the chromosome 9 association with AS; CARD9 is a candidate gene. Genes Immun. 11, 490\u2013496 (2010).","journal-title":"Genes Immun."},{"key":"BFnrrheum201241_CR57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1196\/annals.1443.024","volume":"1143","author":"J Ruland","year":"2008","unstructured":"Ruland, J. CARD9 signaling in the innate immune response. Ann. NY Acad. Sci. 1143, 35\u201344 (2008).","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnrrheum201241_CR58","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/ni1460","volume":"8","author":"S LeibundGut-Landmann","year":"2007","unstructured":"LeibundGut-Landmann, S.  et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat. Immunol. 8, 630\u2013638 (2007).","journal-title":"Nat. Immunol."},{"key":"BFnrrheum201241_CR59","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1189\/jlb.0310139","volume":"88","author":"MC Gagliardi","year":"2010","unstructured":"Gagliardi, M. C.  et al. Endogenous PGE2 promotes the induction of human TH17 responses by fungal \u03b2-glucan. J. Leukoc. Biol. 88, 947\u2013954 (2010).","journal-title":"J. Leukoc. Biol."},{"issue":"Suppl.","key":"BFnrrheum201241_CR60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3109\/03009749009097071","volume":"87","author":"AJ Dekker-Saeys","year":"1990","unstructured":"Dekker-Saeys, AJ, Keat, A. Follow-up study of ankylosing spondylitis over a period of 12 years (1977\u20131989). Scand. J. Rheumatol. 87 (Suppl.), 120\u2013121 (1990).","journal-title":"Scand. J. Rheumatol."},{"key":"BFnrrheum201241_CR61","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1046\/j.0022-202x.2001.01656.x","volume":"118","author":"J,E Gudj\u00f3nsson","year":"2002","unstructured":"Gudj\u00f3nsson J, E,  et al. HLA-Cw6-positive and HLA-Cw6-negative patients with psoriasis vulgaris have distinct clinical features. J. Invest. Dermatol. 118, 362\u2013365 (2002).","journal-title":"J. Invest. Dermatol."},{"key":"BFnrrheum201241_CR62","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1086\/302932","volume":"66","author":"RP Nair","year":"2000","unstructured":"Nair, R. P.  et al. Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am. J. Hum. Genet. 66, 1833\u20131844 (2000).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR63","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1086\/503821","volume":"78","author":"RP Nair","year":"2006","unstructured":"Nair, R. P.  et al. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am. J. Hum. Genet. 78, 827\u2013851 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR64","doi-asserted-by":"publisher","first-page":"e1000606","DOI":"10.1371\/journal.pgen.1000606","volume":"5","author":"BJ Feng","year":"2009","unstructured":"Feng, B. J.  et al. Multiple loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet. 5, e1000606 (2009).","journal-title":"PLoS Genet."},{"key":"BFnrrheum201241_CR65","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1126\/science.285.5428.727","volume":"285","author":"S Bauer","year":"1999","unstructured":"Bauer, S.  et al. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727\u2013729 (1999).","journal-title":"Science"},{"key":"BFnrrheum201241_CR66","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/sj.jid.5700488","volume":"127","author":"J Reischl","year":"2007","unstructured":"Reischl, J.  et al. Increased expression of Wnt5a in psoriatic plaques. J. Invest. Dermatol. 127, 163\u2013169 (2007).","journal-title":"J. Invest. Dermatol."},{"key":"BFnrrheum201241_CR67","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/gene.2009.11","volume":"10","author":"JT Elder","year":"2009","unstructured":"Elder, J. T. Genome-wide association scan yields new insights into the immuno-pathogenesis of psoriasis. Genes Immun. 10, 201\u2013209 (2009).","journal-title":"Genes Immun."},{"key":"BFnrrheum201241_CR68","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1038\/sj.jid.5701255","volume":"128","author":"RP Nair","year":"2008","unstructured":"Nair RP.  et al. Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J. Invest. Dermatol. 128, 1653\u20131661 (2008).","journal-title":"J. Invest. Dermatol."},{"key":"BFnrrheum201241_CR69","doi-asserted-by":"publisher","first-page":"e906","DOI":"10.1371\/journal.pone.0000906","volume":"2","author":"F Lesueur","year":"2007","unstructured":"Lesueur, F.  et al. ADAM33, a new candidate for psoriasis susceptibility. PLoS ONE 2, e906 (2007).","journal-title":"PLoS ONE"},{"key":"BFnrrheum201241_CR70","doi-asserted-by":"publisher","first-page":"e1000041","DOI":"10.1371\/journal.pgen.1000041","volume":"4","author":"Y Liu","year":"2008","unstructured":"Liu, Y.  et al. A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci. PLoS Genet. 4, e1000041 (2008).","journal-title":"PLoS Genet."},{"key":"BFnrrheum201241_CR71","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/ng.311","volume":"41","author":"RP Nair","year":"2009","unstructured":"Nair, R. P.  et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-\u03baB pathways. Nat. Genet. 41, 199\u2013204 (2009).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR72","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/ng.693","volume":"42","author":"PE Stuart","year":"2010","unstructured":"Stuart, P. E.  et al. Genome-wide association analysis identifies three psoriasis susceptibility loci. Nat. Genet. 42, 1000\u20131004 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR73","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/jid.2008.297","volume":"129","author":"Y Li","year":"2009","unstructured":"Li, Y.  et al. Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22. J. Invest Dermatol. 129, 629\u2013634 (2009).","journal-title":"J. Invest Dermatol."},{"key":"BFnrrheum201241_CR74","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1038\/ng.690","volume":"42","author":"LD Sun","year":"2010","unstructured":"Sun, L. D.  et al. Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat. Genet. 42, 1005\u20131009 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR75","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ng.689","volume":"242","author":"E Ellinghaus","year":"2010","unstructured":"Ellinghaus, E.  et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat. Genet. 242, 991\u2013995 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR76","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ng.688","volume":"42","author":"U H\u00fcffmeier","year":"2010","unstructured":"H\u00fcffmeier, U.  et al. Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis. Nat. Genet. 42, 996\u2013999 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR77","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/ni1439","volume":"8","author":"Y Qian","year":"2007","unstructured":"Qian, Y.  et al. The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat. Immunol. 8, 247\u2013256 (2007).","journal-title":"Nat. Immunol."},{"key":"BFnrrheum201241_CR78","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/ng.310","volume":"41","author":"XJ Zhang","year":"2009","unstructured":"Zhang, X. J.  et al. Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat. Genet. 41, 205\u2013210 (2009).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR79","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/ng.313","volume":"41","author":"R De Cid","year":"2009","unstructured":"De Cid, R.  et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat. Genet. 41, 211\u2013215 (2009).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR80","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1399-0039.2011.01670.x","volume":"77","author":"R Pollock","year":"2011","unstructured":"Pollock, R.  et al. Differential major histocompatibility complex class I chain-related A allele associations with skin and joint manifestations of psoriatic disease. Tissue Antigens 77, 554\u2013561 (2011).","journal-title":"Tissue Antigens"},{"key":"BFnrrheum201241_CR81","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1136\/ard.2010.133561","volume":"70","author":"P Rahman","year":"2011","unstructured":"Rahman, P.  et al. High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis. Ann. Rheum. Dis. 70, 690\u2013694 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR82","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1002\/art.21928","volume":"54","author":"P Rahman","year":"2006","unstructured":"Rahman, P.  et al. Association between the interleukin-1 family gene cluster and psoriatic arthritis. Arthritis Rheum. 54, 2321\u20132325 (2006).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201241_CR83","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1093\/rheumatology\/keg443","volume":"43","author":"JS Ravindran","year":"2004","unstructured":"Ravindran, J. S.  et al. Interleukin 1\u03b1, interleukin 1\u03b2 and interleukin 1 receptor gene polymorphisms in psoriatic arthritis. Rheumatology (Oxford) 43, 22\u201326 (2004).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201241_CR84","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1136\/ard.2011.150102","volume":"70","author":"J Bowes","year":"2011","unstructured":"Bowes, J.  et al. Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis. Ann. Rheum. Dis. 70, 1641\u20131644 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR85","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.1038\/jid.2009.169","volume":"129","author":"KC Duffin","year":"2009","unstructured":"Duffin, K. C.  et al. Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking. J. Invest. Dermatol. 129, 2777\u20132783 (2009).","journal-title":"J. Invest. Dermatol."},{"key":"BFnrrheum201241_CR86","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1136\/ard.2010.143123","volume":"70","author":"J Bowes","year":"2011","unstructured":"Bowes, J.  et al. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Ann. Rheum. Dis. 70, 1016\u20131019 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR87","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1136\/ard.2010.130575","volume":"69","author":"J Bowes","year":"2010","unstructured":"Bowes, J.  et al. Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. Ann. Rheum. Dis. 69, 2199\u20132203 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR88","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1136\/ard.2009.108951","volume":"69","author":"U Huffmeier","year":"2010","unstructured":"Huffmeier, U.  et al. Deletion of LCE3C and LCE3B genes at PSORS4 does not contribute to susceptibility to psoriatic arthritis in German patients. Ann. Rheum. Dis. 69, 876\u2013878 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201241_CR89","first-page":"1542","volume":"18","author":"H Mielants","year":"1991","unstructured":"Mielants, H.  et al. Gut inflammation in the spondyloarthropathies: clinical, radiologic, biologic and genetic features in relation to the type of histology. A prospective study. J. Rheumatol. 18, 1542\u20131551 (1991).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201241_CR90","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nm.2069","volume":"16","author":"R Cooney","year":"2010","unstructured":"Cooney, R.  et al. A. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16, 90\u201397, (2010).","journal-title":"Nat. Med."},{"key":"BFnrrheum201241_CR91","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/ng2032","volume":"39","author":"JD Rioux","year":"2007","unstructured":"Rioux, J. D.  et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 39, 596\u2013604 (2007).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR92","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/ng1954","volume":"39","author":"J Hampe","year":"2007","unstructured":"Hampe, J.  et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39, 207\u2013211 (2007).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR93","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ajhg.2009.01.026","volume":"84","author":"K Wang","year":"2009","unstructured":"Wang, K.  et al., Diverse genome-wide association studies associate the IL12\/IL23 pathway with Crohn disease. Am. J. Hum. Genet. 84, 399\u2013405 (2009).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR94","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1038\/ng.175","volume":"40","author":"JC Barrett","year":"2008","unstructured":"Barrett, J. C.  et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955\u2013962 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR95","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/ng.145","volume":"40","author":"SA Fisher","year":"2008","unstructured":"Fisher, S. A.  et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat. Genet. 40, 710\u2013712 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR96","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","volume":"42","author":"A Franke","year":"2010","unstructured":"Franke, A.  et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42, 1118\u20131125 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR97","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/ng.549","volume":"42","author":"DPB McGovern","year":"2010","unstructured":"McGovern, D. P. B.  et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat. Genet. 42, 332\u2013337 (2010).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR98","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/ng.764","volume":"43","author":"CA Anderson","year":"2011","unstructured":"Anderson, C. A.  et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat. Genet. 43, 246\u2013252 (2011).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR99","doi-asserted-by":"publisher","first-page":"e1001283","DOI":"10.1371\/journal.pgen.1001283","volume":"7","author":"EA Festen","year":"2011","unstructured":"Festen, E. A.  et al. A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease. PLoS Genet. 7, e1001283 (2011).","journal-title":"PLoS Genet."},{"key":"BFnrrheum201241_CR100","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/ng.762","volume":"43","author":"P Brest","year":"2011","unstructured":"Brest, P.  et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat. Genet. 43, 242\u2013245 (2011).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR101","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/ng.215","volume":"40","author":"SA McCarroll","year":"2008","unstructured":"McCarroll, S. A.  et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat. Genet. 40, 1107\u20131112 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR102","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1002\/ibd.21579","volume":"17","author":"M Waterman","year":"2010","unstructured":"Waterman, M.  et al. Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: Correlations with pathogenesis. Inflamm. Bowel Dis. 17, 1936\u20131942 (2010).","journal-title":"Inflamm. Bowel Dis."},{"key":"BFnrrheum201241_CR103","doi-asserted-by":"publisher","first-page":"e13795","DOI":"10.1371\/journal.pone.0013795","volume":"5","author":"D Laukens","year":"2010","unstructured":"Laukens, D.  et al. Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. PLoS ONE 5, e13795 (2010).","journal-title":"PLoS ONE"},{"key":"BFnrrheum201241_CR104","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/ng.733","volume":"43","author":"Y Momozawa","year":"2011","unstructured":"Momozawa, Y.  et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat. Genet. 43, 43\u201347 (2011).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR105","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1086\/505915","volume":"79","author":"K Fellermann","year":"2006","unstructured":"Fellermann, K.  et al. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am. J. Hum. Genet. 79, 439\u2013448 (2006).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrrheum201241_CR106","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/ng.2007.48","volume":"40","author":"EJ Hollox","year":"2008","unstructured":"Hollox, E. J.  et al. Psoriasis is associated with increased \u03b2-defensin genomic copy number. Nat. Genet. 40, 23\u201325 (2008).","journal-title":"Nat. Genet."},{"key":"BFnrrheum201241_CR107","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1093\/hmg\/ddr116","volume":"20","author":"J Kang","year":"2011","unstructured":"Kang, J.  et al. The NIDDK IBD Genetics Consortium. Improved risk prediction for Crohn's disease with a multi-locus approach. Hum. Mol. Genet. 20, 2435\u20132442 (2011).","journal-title":"Hum. Mol. Genet."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.41","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.41.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:31:27Z","timestamp":1684470687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2012.41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,10]]},"references-count":107,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["BFnrrheum201241"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2012.41","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,10]]}}}