{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:46:24Z","timestamp":1793720784661,"version":"4.6.1"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1038\/nrrheum.2012.80","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T08:10:34Z","timestamp":1338279034000},"page":"390-398","source":"Crossref","is-referenced-by-count":599,"title":["Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis"],"prefix":"10.1038","volume":"8","author":[{"given":"Paul I.","family":"Mapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"key":"BFnrrheum201280_CR1","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1136\/ard.47.11.881","volume":"47","author":"RA Brown","year":"1988","unstructured":"Brown, R. A. & Weiss, J. B. Neovascularisation and its role in the osteoarthritic process. Ann. Rheum. Dis. 47, 881\u2013885 (1988).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.joca.2009.11.015","volume":"18","author":"RE Frans\u00e8s","year":"2010","unstructured":"Frans\u00e8s, R. E., McWilliams, D. F., Mapp., P. I. & Walsh, D. A. Osteochondral angiogenesis and increased protease inhibitor expression in OA. Osteoarthritis Cartilage 18, 563\u2013571 (2010).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1093\/rheumatology\/keh344","volume":"44","author":"CS Bonnet","year":"2005","unstructured":"Bonnet, C. S. & Walsh, D. A. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 44, 7\u201316 (2005).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201280_CR4","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1136\/ard.2010.137844","volume":"70","author":"S Ashraf","year":"2011","unstructured":"Ashraf, S. et al. Increased vascular penetration and nerve growth in the meniscus: a potential source of pain in osteoarthritis. Ann. Rheum. Dis. 70, 523\u2013529 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR5","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1136\/ard.46.7.534","volume":"46","author":"JR Levick","year":"1987","unstructured":"Levick, J. R. & Knight, A. D. Osmotic flows across the blood-joint barrier. Ann. Rheum. Dis. 46, 534\u2013539 (1987).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR6","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1002\/art.1780341206","volume":"34","author":"CR Stevens","year":"1991","unstructured":"Stevens, C. R., Blake, D. R., Merry, P., Revell, P. A. & Levick, J. R. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthritis Rheum. 34, 1508\u20131513 (1991).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR7","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0140-6736(89)91305-6","volume":"1","author":"DR Blake","year":"1989","unstructured":"Blake, D. R. et al. Hypoxic-reperfusion injury in the inflamed human joint. Lancet 1, 289\u2013293 (1989).","journal-title":"Lancet"},{"key":"BFnrrheum201280_CR8","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1136\/ard.49.7.536","volume":"49","author":"BP O'Hara","year":"1990","unstructured":"O'Hara, B. P., Urban, J. P. & Maroudas, A. Influence of cyclic loading on the nutrition of articular cartilage. Ann. Rheum. Dis. 49, 536\u2013539 (1990).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR9","first-page":"1610","volume":"142","author":"DA Walsh","year":"1993","unstructured":"Walsh, D. A., Mapp., P. I., Wharton, J., Polak, J. M. & Blake, D. R. Neuropeptide degrading enzymes in normal and inflamed human synovium. Am. J. Pathol. 142, 1610\u20131621 (1993).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum201280_CR10","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1136\/ard.2006.063354","volume":"66","author":"S Suri","year":"2007","unstructured":"Suri, S. et al. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann. Rheum. Dis. 66, 1423\u20131428 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR11","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1002\/art.30422","volume":"63","author":"S Ashraf","year":"2011","unstructured":"Ashraf, S., Mapp., P. I. & Walsh, D. A. Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis. Arthritis Rheum. 63, 2700\u20132710 (2011).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.joca.2007.05.017","volume":"16","author":"PI Mapp.","year":"2008","unstructured":"Mapp., P. I. et al. Angiogenesis in two animal models of osteoarthritis. Osteoarthritis Cartilage 16, 61\u201369 (2008).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/joca.2002.0871","volume":"11","author":"A Shibakawa","year":"2003","unstructured":"Shibakawa, A. et al. Presence of pannus-like tissue on osteoarthritic cartilage and its histological character. Osteoarthritis Cartilage 11, 133\u2013140 (2003).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR14","first-page":"365","volume":"24","author":"MD Smith","year":"1997","unstructured":"Smith, M. D., Triantafillou, S., Parker, A., Youssef, P. P. & Coleman, M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J. Rheumatol. 24, 365\u2013371 (1997).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201280_CR15","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/art.27290","volume":"62","author":"J Bondeson","year":"2010","unstructured":"Bondeson, J. et al. The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum. 62, 647\u2013657 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR16","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1002\/art.11094","volume":"48","author":"L Haywood","year":"2003","unstructured":"Haywood, L. et al. Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum. 48, 2173\u20132177 (2003).","journal-title":"Arthritis Rheum."},{"issue":"Suppl. A","key":"BFnrrheum201280_CR17","doi-asserted-by":"publisher","first-page":"A87","DOI":"10.1016\/j.joca.2006.02.028","volume":"14","author":"PG Conaghan","year":"2006","unstructured":"Conaghan, P. G. et al. MRI and non-cartilaginous structures in knee osteoarthritis. Osteoarthritis Cartilage 14 (Suppl. A), A87\u2013A94 (2006).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1136\/ard.47.4.300","volume":"47","author":"PA Revell","year":"1988","unstructured":"Revell, P. A., Mayston, V., Lalor, P. & Mapp., P. The synovial membrane in osteoarthritis: a histological study including the characterisation of the cellular infiltrate present in inflammatory osteoarthritis using monoclonal antibodies. Ann. Rheum. Dis. 47, 300\u2013307 (1988).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR19","first-page":"691","volume":"152","author":"DA Walsh","year":"1998","unstructured":"Walsh, D. A., Wade, M., Mapp., P. I. & Blake, D. R. Focally regulated endothelial proliferation and cell death in human synovium. Am. J. Pathol. 152, 691\u2013702 (1998).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum201280_CR20","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","volume":"49","author":"DA Walsh","year":"2010","unstructured":"Walsh, D. A. et al. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology (Oxford) 49, 1852\u20131861 (2010).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201280_CR21","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s004290050141","volume":"197","author":"W Petersen","year":"1998","unstructured":"Petersen, W. & Tillmann, B. Collagenous fibril texture of the human knee joint menisci. Anat. Embryol. (Berl.) 197, 317\u2013324 (1998).","journal-title":"Anat. Embryol. (Berl.)"},{"key":"BFnrrheum201280_CR22","first-page":"236","volume":"73","author":"T Aigner","year":"1995","unstructured":"Aigner, T., Dietz, U., St\u00f6ss, H. & von der Mark, K. Differential expression of collagen types I, II, III, and X in human osteophytes. Lab. Invest. 73, 236\u2013243 (1995).","journal-title":"Lab. Invest."},{"key":"BFnrrheum201280_CR23","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1053\/joca.2001.0505","volume":"10","author":"S Hashimoto","year":"2002","unstructured":"Hashimoto, S. et al. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 10, 180\u2013187 (2002).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/ncprheum0559","volume":"3","author":"D Lainer-Carr","year":"2007","unstructured":"Lainer-Carr, D. & Brahn, E. Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis. Nat. Clin. Pract. Rheumatol. 3, 434\u2013442 (2007).","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"BFnrrheum201280_CR25","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","volume":"15","author":"DA Walsh","year":"2007","unstructured":"Walsh, D. A. et al. Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis Cartilage 15, 743\u2013751 (2007).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR26","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.immuni.2005.10.001","volume":"23","author":"A Mantovani","year":"2005","unstructured":"Mantovani, A., Sica, A. & Locati, M. Macrophage polarization comes of age. Immunity 23, 344\u2013346 (2005).","journal-title":"Immunity"},{"key":"BFnrrheum201280_CR27","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1210\/jc.2009-0925","volume":"94","author":"J Aron-Wisnewsky","year":"2009","unstructured":"Aron-Wisnewsky, J. et al. Human adipose tissue macrophages: m1 and m2 cell surface markers in subcutaneous and omental depots and after weight loss. J. Clin. Endocrinol. Metab. 94, 4619\u20134623 (2009).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"BFnrrheum201280_CR28","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1002\/art.24505","volume":"60","author":"JA Hamilton","year":"2009","unstructured":"Hamilton, J. A. & Tak, P. P. The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum. 60, 1210\u20131221 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR29","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1084\/jem.184.4.1519","volume":"184","author":"IB McInnes","year":"1996","unstructured":"McInnes, I. B. et al. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J. Exp. Med. 184, 1519\u20131524 (1996).","journal-title":"J. Exp. Med."},{"key":"BFnrrheum201280_CR30","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.imbio.2010.05.025","volume":"215","author":"WK Wu","year":"2010","unstructured":"Wu, W. K., Llewellyn, O. P., Bates, D. O., Nicholson, L. B. & Dick, A. D. IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia. Immunobiology 215, 796\u2013803 (2010).","journal-title":"Immunobiology"},{"key":"BFnrrheum201280_CR31","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1002\/1529-0131(200105)44:5<1082::AID-ANR188>3.0.CO;2-X","volume":"44","author":"T Pufe","year":"2001","unstructured":"Pufe, T., Petersen, W., Tillmann, B. & Mentlein, R. The splice variants VEGF121 and VEGF189 of the angiogenic peptide vascular endothelial growth factor are expressed in osteoarthritic cartilage. Arthritis Rheum. 44, 1082\u20131088 (2001).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR32","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/ard.59.6.448","volume":"59","author":"D Pfander","year":"2000","unstructured":"Pfander, D., Cramer, T., Deuerling, D., Weseloh, G. & Swoboda, B. Expression of thrombospondin-1 and its receptor CD36 in human osteoarthritic cartilage. Ann. Rheum. Dis. 59, 448\u2013454 (2000).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR33","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1073\/pnas.96.6.2645","volume":"96","author":"MA Moses","year":"1999","unstructured":"Moses, M. A. et al. Troponin I is present in human cartilage and inhibits angiogenesis. Proc. Natl Acad. Sci. USA 96, 2645\u20132650 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum201280_CR34","first-page":"765","volume":"73","author":"R Eisenstein","year":"1973","unstructured":"Eisenstein, R., Sorgente, N., Soble, L. W., Miller, A. & Kuettner, K. E. The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme. Am. J. Pathol. 73, 765\u2013774 (1973).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum201280_CR35","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1053\/joca.1998.0238","volume":"7","author":"SA Fenwick","year":"1999","unstructured":"Fenwick, S. A., Gregg, P. J. & Rooney, P. Osteoarthritic cartilage loses its ability to remain avascular. Osteoarthritis Cartilage 7, 441\u2013452 (1999).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR36","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/jor.1100130104","volume":"13","author":"GD Walker","year":"1995","unstructured":"Walker, G. D., Fischer, M., Gannon, J., Thompson, R. C. Jr & Oegema, T. R. Jr. Expression of type-X collagen in osteoarthritis. J. Orthop. Res. 13, 4\u201312 (1995).","journal-title":"J. Orthop. Res."},{"key":"BFnrrheum201280_CR37","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/ar.1091650404","volume":"165","author":"AS Wilson","year":"1969","unstructured":"Wilson, A. S., Legg, P. G. & McNeur, J. C. Studies on the innervation of the medial meniscus in the human knee joint. Anat. Rec. 165, 485\u2013491 (1969).","journal-title":"Anat. Rec."},{"key":"BFnrrheum201280_CR38","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0749-8063(85)80080-3","volume":"1","author":"B Day","year":"1985","unstructured":"Day, B., Mackenzie, W. G., Shim, S. S. & Leung, G. The vascular and nerve supply of the human meniscus. Arthroscopy 1, 58\u201362 (1985).","journal-title":"Arthroscopy"},{"key":"BFnrrheum201280_CR39","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1136\/ard.54.5.398","volume":"54","author":"PI Mapp.","year":"1995","unstructured":"Mapp., P. I. Innervation of the synovium. Ann. Rheum. Dis. 54, 398\u2013403 (1995).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201280_CR40","first-page":"167","volume":"109","author":"A Lanzetta","year":"2004","unstructured":"Lanzetta, A. et al. The nervous structures of anterior cruciate ligament of human knee, healthy and lesioned, studied with confocal scanning laser microscopy. Ital. J. Anat. Embryol. 109, 167\u2013176 (2004).","journal-title":"Ital. J. Anat. Embryol."},{"key":"BFnrrheum201280_CR41","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3109\/17453677708992006","volume":"48","author":"I Reimann","year":"1977","unstructured":"Reimann, I. & Christensen, S. B. A histological demonstration of nerves in subchondral bone. Acta Orthop. Scand. 48, 345\u2013352 (1977).","journal-title":"Acta Orthop. Scand."},{"key":"BFnrrheum201280_CR42","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/0306-4522(90)90199-E","volume":"37","author":"PI Mapp.","year":"1990","unstructured":"Mapp., P. I. et al. Substance P-, calcitonin gene-related peptide- and C-flanking peptide of neuropeptide Y-immunoreactive fibres are present in normal synovium but depleted in patients with rheumatoid arthritis. Neuroscience 37, 143\u2013153 (1990).","journal-title":"Neuroscience"},{"key":"BFnrrheum201280_CR43","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/BF02272149","volume":"28","author":"DA Walsh","year":"1996","unstructured":"Walsh, D. A. et al. Innervation and neurokinin receptors during angiogenesis in the rat sponge granuloma. Histochem. J. 28, 759\u2013769 (1996).","journal-title":"Histochem. J."},{"key":"BFnrrheum201280_CR44","doi-asserted-by":"publisher","first-page":"2564","DOI":"10.1016\/j.pain.2011.07.020","volume":"152","author":"JM Jimenez-Andrade","year":"2011","unstructured":"Jimenez-Andrade, J. M., Ghilardi, J. R., Casta\u00f1eda-Corral, G., Kuskowski, M. A. & Mantyh, P. W. Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation, and cancer pain. Pain 152, 2564\u20132574 (2011).","journal-title":"Pain"},{"key":"BFnrrheum201280_CR45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1476-5381.1993.tb13769.x","volume":"110","author":"TP Fan","year":"1993","unstructured":"Fan, T. P., Hu, D. E., Guard, S., Gresham, G. A. & Watling, K. J. Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br. J. Pharmacol. 110, 43\u201349 (1993).","journal-title":"Br. J. Pharmacol."},{"key":"BFnrrheum201280_CR46","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1096\/fj.05-4770fje","volume":"20","author":"S Movafagh","year":"2006","unstructured":"Movafagh, S., Hobson, J. P., Spiegel, S., Kleinman, H. K. & Zukowska, Z. Neuropeptide Y induces migration, proliferation, and tube formation of endothelial cells bimodally via Y1, Y2, and Y5 receptors. FASEB J. 20, 1924\u20131926 (2006).","journal-title":"FASEB J."},{"key":"BFnrrheum201280_CR47","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1124\/jpet.103.050013","volume":"306","author":"HC Seegers","year":"2003","unstructured":"Seegers, H. C., Hood, V. C., Kidd, B. L., Cruwys, S. C. & Walsh, D. A. Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J. Pharmacol. Exp. Ther. 306, 8\u201312 (2003).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"BFnrrheum201280_CR48","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1096\/fj.03-0727fje","volume":"18","author":"HC Seegers","year":"2004","unstructured":"Seegers, H. C., Avery, P. S., McWilliams, D. F., Haywood, L. & Walsh, D. A. Combined effect of bradykinin B2 and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis. FASEB J. 18, 762\u2013764 (2004).","journal-title":"FASEB J."},{"key":"BFnrrheum201280_CR49","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/j.1476-5381.2012.01848.x","volume":"166","author":"PI Mapp.","year":"2012","unstructured":"Mapp., P. I., McWilliams, D. F., Turley, M. J., Hargin, E. & Walsh, D. A. A role for the sensory neuropeptide calcitonin gene-related peptide in endothelial cell proliferation in vivo. Br. J. Pharmacol. 166, 1261\u20131271 (2012).","journal-title":"Br. J. Pharmacol."},{"key":"BFnrrheum201280_CR50","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/art.27462","volume":"62","author":"S Ashraf","year":"2010","unstructured":"Ashraf, S., Mapp., P. I. & Walsh, D. A. Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis. Arthritis Rheum. 62, 1890\u20131898 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR51","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/nature03875","volume":"436","author":"P Carmeliet","year":"2005","unstructured":"Carmeliet, P. & Tessier-Lavigne, M. Common mechanisms of nerve and blood vessel wiring. Nature 436, 193\u2013200 (2005).","journal-title":"Nature"},{"key":"BFnrrheum201280_CR52","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neures.2005.01.007","volume":"51","author":"T Masuda","year":"2005","unstructured":"Masuda, T. & Shiga, T. Chemorepulsion and cell adhesion molecules in patterning initial trajectories of sensory axons. Neurosci. Res. 51, 337\u2013347 (2005).","journal-title":"Neurosci. Res."},{"key":"BFnrrheum201280_CR53","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1002\/art.20110","volume":"50","author":"LE Miller","year":"2004","unstructured":"Miller, L. E. et al. Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 50, 1156\u20131163 (2004).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR54","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/art.24860","volume":"60","author":"A Fassold","year":"2009","unstructured":"Fassold, A. et al. Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis. Arthritis Rheum. 60, 2892\u20132901 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR55","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1002\/1529-0131(199808)41:8<1356::AID-ART4>3.0.CO;2-X","volume":"41","author":"T Seki","year":"1998","unstructured":"Seki, T., Selby, J., Haupl, T. & Winchester, R. Use of differential subtraction method to identify genes that characterize the phenotype of cultured rheumatoid arthritis synoviocytes. Arthritis Rheum. 41, 1356\u20131364 (1998).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR56","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH649>3.0.CO;2-E","volume":"191","author":"M Ikeda","year":"2000","unstructured":"Ikeda, M., Hosoda, Y., Hirose, S., Okada, Y. & Ikeda, E. Expression of vascular endothelial growth factor isoforms and their receptors Flt-1, KDR, and neuropilin-1 in synovial tissues of rheumatoid arthritis. J. Pathol. 191, 426\u2013433 (2000).","journal-title":"J. Pathol."},{"key":"BFnrrheum201280_CR57","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0002-9440(10)64372-6","volume":"160","author":"AM Matthies","year":"2002","unstructured":"Matthies, A. M., Low, Q. E., Lingen, M. W. & DiPietro, L. A. Neuropilin-1 participates in wound angiogenesis. Am. J. Pathol. 160, 289\u2013296 (2002).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum201280_CR58","doi-asserted-by":"publisher","first-page":"e3287","DOI":"10.1371\/journal.pone.0003287","volume":"3","author":"B Kigel","year":"2008","unstructured":"Kigel, B., Varshavsky, A., Kessler, O. & Neufeld, G. Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. PLoS ONE 3, e3287 (2008).","journal-title":"PLoS ONE"},{"key":"BFnrrheum201280_CR59","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1002\/art.27243","volume":"62","author":"JS Kong","year":"2010","unstructured":"Kong, J. S. et al. Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis. Arthritis Rheum. 62, 179\u2013190 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR60","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0002-9440(10)63808-4","volume":"162","author":"H Enomoto","year":"2003","unstructured":"Enomoto, H. et al. Vascular endothelial growth factor isoforms and their receptors are expressed in human osteoarthritic cartilage. Am. J. Pathol. 162, 171\u2013181 (2003).","journal-title":"Am. J. Pathol."},{"key":"BFnrrheum201280_CR61","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/dvdy.20512","volume":"234","author":"C Gomez","year":"2005","unstructured":"Gomez, C. et al. Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation. Dev. Dyn. 234, 393\u2013403 (2005).","journal-title":"Dev. Dyn."},{"key":"BFnrrheum201280_CR62","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.4049\/jimmunol.0903527","volume":"185","author":"A Catalano","year":"2010","unstructured":"Catalano, A. The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis. J. Immunol. 185, 6373\u20136383 (2010).","journal-title":"J. Immunol."},{"key":"BFnrrheum201280_CR63","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.mvr.2007.07.004","volume":"75","author":"B Nico","year":"2008","unstructured":"Nico, B., Mangieri, D., Benagiano, V., Crivellato, E. & Ribatti, D. Nerve growth factor as an angiogenic factor. Microvasc. Res. 75, 135\u2013141 (2008).","journal-title":"Microvasc. Res."},{"key":"BFnrrheum201280_CR64","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s004030100224","volume":"293","author":"SK Raychaudhuri","year":"2001","unstructured":"Raychaudhuri, S. K., Raychaudhuri, S. P., Weltman, H. & Farber, E. M. Effect of nerve growth factor on endothelial cell biology: proliferation and adherence molecule expression on human dermal microvascular endothelial cells. Arch. Dermatol. Res. 293, 291\u2013295 (2001).","journal-title":"Arch. Dermatol. Res."},{"key":"BFnrrheum201280_CR65","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1096\/fj.01-1000fje","volume":"16","author":"G Cantarella","year":"2002","unstructured":"Cantarella, G. et al. Nerve growth factor-endothelial cell interaction leads to angiogenesis in vitro and in vivo. FASEB J. 16, 1307\u20131309 (2002).","journal-title":"FASEB J."},{"key":"BFnrrheum201280_CR66","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.brainres.2004.05.013","volume":"1017","author":"KV Moser","year":"2004","unstructured":"Moser, K. V., Reindl, M., Blasig, I. & Humpel, C. Brain capillary endothelial cells proliferate in response to NGF, express NGF receptors and secrete NGF after inflammation. Brain Res. 1017, 53\u201360 (2004).","journal-title":"Brain Res."},{"key":"BFnrrheum201280_CR67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S1566-0702(03)00151-6","volume":"108","author":"JJ Steinle","year":"2003","unstructured":"Steinle, J. J. & Granger, H. J. Nerve growth factor regulates human choroidal, but not retinal, endothelial cell migration and proliferation. Auton. Neurosci. 108, 57\u201362 (2003).","journal-title":"Auton. Neurosci."},{"key":"BFnrrheum201280_CR68","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.bbrc.2003.12.036","volume":"313","author":"A Tanaka","year":"2004","unstructured":"Tanaka, A., Wakita, U., Kambe, N., Iwasaki, T. & Matsuda, H. An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells. Biochem. Biophys. Res. Commun. 313, 1009\u20131014 (2004).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnrrheum201280_CR69","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00424-005-1436-0","volume":"450","author":"UL Rahbek","year":"2005","unstructured":"Rahbek, U. L., Dissing, S., Thomassen, C., Hansen, A. J. & Tritsaris, K. Nerve growth factor activates aorta endothelial cells causing PI3K\/Akt- and ERK-dependent migration. Pflugers Arch. 450, 355\u2013361 (2005).","journal-title":"Pflugers Arch."},{"key":"BFnrrheum201280_CR70","doi-asserted-by":"publisher","first-page":"30485","DOI":"10.1074\/jbc.M701081200","volume":"282","author":"MJ Park","year":"2007","unstructured":"Park, M. J. et al. Nerve growth factor induces endothelial cell invasion and cord formation by promoting matrix metalloproteinase-2 expression through the phosphatidylinositol 3-kinase\/Akt signaling pathway and AP-2 transcription factor. J. Biol. Chem. 282, 30485\u201330496 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnrrheum201280_CR71","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1080\/10623320600669053","volume":"13","author":"P Lazarovici","year":"2006","unstructured":"Lazarovici, P., Gazit, A., Staniszewska, I., Marcinkiewicz, C. & Lelkes, P. I. Nerve growth factor (NGF) promotes angiogenesis in the quail chorioallantoic membrane. Endothelium 13, 51\u201359 (2006).","journal-title":"Endothelium"},{"key":"BFnrrheum201280_CR72","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.2174\/138161206777698738","volume":"12","author":"P Lazarovici","year":"2006","unstructured":"Lazarovici, P., Marcinkiewicz, C. & Lelkes, P. I. Cross talk between the cardiovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)-implications in drug development. Curr. Pharm. Des. 12, 2609\u20132622 (2006).","journal-title":"Curr. Pharm. Des."},{"key":"BFnrrheum201280_CR73","doi-asserted-by":"publisher","first-page":"125","DOI":"10.4142\/jvs.2001.2.2.125","volume":"2","author":"K Seo","year":"2001","unstructured":"Seo, K., Choi, J., Park, M. & Rhee, C. Angiogenesis effects of nerve growth factor (NGF) on rat corneas. J. Vet. Sci. 2, 125\u2013130 (2001).","journal-title":"J. Vet. Sci."},{"key":"BFnrrheum201280_CR74","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1073\/pnas.051626998","volume":"98","author":"L Calza","year":"2001","unstructured":"Calza, L., Giardino, L., Giuliani, A., Aloe, L. & Levi-Montalcini, R. Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors. Proc. Natl Acad. Sci. USA 98, 4160\u20134165 (2001).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum201280_CR75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1177\/019459989110500103","volume":"105","author":"PM Santos","year":"1991","unstructured":"Santos, P. M., Winterowd, J. G., Allen, G. G., Bothwell, M. A. & Rubel, E. W. Nerve growth factor: increased angiogenesis without improved nerve regeneration. Otolaryngol. Head Neck Surg. 105, 12\u201325 (1991).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"BFnrrheum201280_CR76","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s00125-004-1414-7","volume":"47","author":"G Graiani","year":"2004","unstructured":"Graiani, G. et al. Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of type 1 diabetic mice. Diabetologia 47, 1047\u20131054 (2004).","journal-title":"Diabetologia"},{"key":"BFnrrheum201280_CR77","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.1167\/iovs.09-4226","volume":"51","author":"X Liu","year":"2010","unstructured":"Liu, X. et al. Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model. Invest. Ophthalmol. Vis. Sci. 51, 3749\u20133757 (2010).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"BFnrrheum201280_CR78","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1161\/01.CIR.0000033971.56802.C5","volume":"106","author":"C Emanueli","year":"2002","unstructured":"Emanueli, C. et al. Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs. Circulation 106, 2257\u20132262 (2002).","journal-title":"Circulation"},{"key":"BFnrrheum201280_CR79","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1158\/0008-5472.CAN-07-1183","volume":"68","author":"E Adriaenssens","year":"2008","unstructured":"Adriaenssens, E. et al. Nerve growth factor is a potential therapeutic target in breast cancer. Cancer Res. 68, 346\u2013351 (2008).","journal-title":"Cancer Res."},{"key":"BFnrrheum201280_CR80","unstructured":"US National Library of Medicine. Phase III Study of docetaxel and ramucirumab or placebo in breast cancer. ClinicalTrials.gov [online] , (2012)."},{"key":"BFnrrheum201280_CR81","unstructured":"US National Library of Medicine. A study of paclitaxel with or without ramucirumab in metastatic gastric adenocarcinoma (RAINBOW). ClinicalTrials.gov [online] (2011)."},{"key":"BFnrrheum201280_CR82","unstructured":"US National Library of Medicine. A study of chemotherapy and ramucirumab vs. chemotherapy alone in second line non-small cell lung cancer patients who received prior first line platinum based chemotherapy ClinicalTrials.gov [online] (2012)."},{"key":"BFnrrheum201280_CR83","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1016\/j.joca.2010.06.007","volume":"18","author":"BW Strassle","year":"2010","unstructured":"Strassle, B. W. et al. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis Cartilage 18, 1319\u20131328 (2010).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR84","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/j.joca.2009.12.006","volume":"18","author":"PI Mapp.","year":"2010","unstructured":"Mapp., P. I., Walsh, D. A., Bowyer, J. & Maciewicz, R. A. Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis. Osteoarthritis Cartilage 18, 593\u2013600 (2010).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201280_CR85","doi-asserted-by":"publisher","first-page":"R98","DOI":"10.1186\/ar3373","volume":"13","author":"M Moreau","year":"2011","unstructured":"Moreau, M. et al. Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res. Ther. 13, R98 (2011).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum201280_CR86","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2460\/ajvr.2005.66.1487","volume":"66","author":"KA Agnello","year":"2005","unstructured":"Agnello, K. A., Trumble, T. N., Chambers, J. N., Seewald, W. & Budsberg, S. C. Effects of zoledronate on markers of bone metabolism and subchondral bone mineral density in dogs with experimentally induced cruciate-deficient osteoarthritis. Am. J. Vet. Res. 66, 1487\u20131495 (2005).","journal-title":"Am. J. Vet. Res."},{"key":"BFnrrheum201280_CR87","doi-asserted-by":"publisher","first-page":"2726","DOI":"10.1002\/art.27595","volume":"62","author":"MD Jones","year":"2010","unstructured":"Jones, M. D. et al. In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat. Arthritis Rheum. 62, 2726\u20132735 (2010).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR88","doi-asserted-by":"publisher","first-page":"R625","DOI":"10.1186\/ar1716","volume":"7","author":"TD Spector","year":"2005","unstructured":"Spector, T. D. et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res. Ther. 7, R625\u2013R633 (2005).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum201280_CR89","doi-asserted-by":"publisher","first-page":"3494","DOI":"10.1002\/art.22160","volume":"54","author":"CO Bingham 3rd","year":"2006","unstructured":"Bingham, C. O. 3rd et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum. 54, 3494\u20133507 (2006).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201280_CR90","doi-asserted-by":"publisher","unstructured":"Laslett, L. et al. Zoledronic acid reduces knee pain and bone marrow lesions over 1 year: a randomised controlled trial. Ann. Rheum. Dis. http:\/\/dx.doi.org\/10.1136\/annrheumdis-2011-200970","DOI":"10.1136\/annrheumdis-2011-200970"},{"key":"BFnrrheum201280_CR91","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","volume":"363","author":"NE Lane","year":"2010","unstructured":"Lane, N. E. et al. Tanezumab for the treatment of pain from osteoarthritis of the knee. N. Engl. J. Med. 363, 1521\u20131531 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFnrrheum201280_CR92","doi-asserted-by":"publisher","first-page":"2380","DOI":"10.1001\/jama.2011.1705","volume":"306","author":"W Dixon","year":"2011","unstructured":"Dixon, W. & Felson, D. T. Is anti-TNF therapy safer than previously thought? JAMA 306, 2380\u20132381 (2011).","journal-title":"JAMA"},{"key":"BFnrrheum201280_CR93","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1089\/ten.tea.2009.0771","volume":"16","author":"L Jeng","year":"2010","unstructured":"Jeng, L., Olsen, B. R. & Spector, M. Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds. Tissue Eng. Part A 16, 3011\u20133021 (2010).","journal-title":"Tissue Eng. Part A"}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.80.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.80","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2012.80.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T17:16:39Z","timestamp":1713978999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2012.80"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":93,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["BFnrrheum201280"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2012.80","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]}}}