{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:15:40Z","timestamp":1791087340083,"version":"4.1.0"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1038\/nrrheum.2013.95","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T13:36:12Z","timestamp":1372772172000},"page":"532-543","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Vaccinations in juvenile chronic inflammatory diseases: an update"],"prefix":"10.1038","volume":"9","author":[{"given":"Clovis A.","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia E.","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Bonfa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"BFnrrheum201395_CR1","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1136\/ard.2011.150193","volume":"70","author":"MW Heijstek","year":"2011","unstructured":"Heijstek, M. W.  et al. EULAR recommendations for vaccination in paediatric patients with rheumatic diseases. Ann. Rheum. Dis. 70, 1704\u20131712 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/nrrheum.2012.13","volume":"8","author":"G Janow","year":"2012","unstructured":"Janow, G. & Ilowite, N. T. Pediatric rheumatic disease: vaccination in pediatric rheumatic disease\u2014risks and benefits. Nat. Rev. Rheumatol. 8, 188\u2013190 (2012).","journal-title":"Nat. Rev. Rheumatol."},{"key":"BFnrrheum201395_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","volume":"36","author":"Y Shoenfeld","year":"2011","unstructured":"Shoenfeld, Y. & Agmon-Levin, N. 'ASIA'\u2014autoimmune\/inflammatory syndrome induced by adjuvants. J. Autoimmun. 36, 4\u20138 (2011).","journal-title":"J. Autoimmun."},{"key":"BFnrrheum201395_CR4","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1093\/rheumatology\/ker102","volume":"50","author":"L Dell'Era","year":"2011","unstructured":"Dell'Era, L., Esposito, S., Corona, F. & Principi, N. Vaccination of children and adolescents with rheumatic diseases. Rheumatology (Oxford) 50, 1358\u20131365 (2011).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201395_CR5","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/acr.20234","volume":"62","author":"RW Frenck","year":"2010","unstructured":"Frenck, R. W. & Seward, J. F. Varicella vaccine safety and immunogenicity in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids. Arthritis Care Res. (Hoboken) 62, 903\u2013906 (2010).","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"BFnrrheum201395_CR6","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1590\/S0482-50042010000400002","volume":"50","author":"CA Silva","year":"2010","unstructured":"Silva, C. A.  et al. Vaccination practice in children with rheumatic disease. Rev. Bras. Reumatol. 50, 351\u2013361 (2010).","journal-title":"Rev. Bras. Reumatol."},{"key":"BFnrrheum201395_CR7","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/rheumatology\/41.8.937","volume":"41","author":"K Davies","year":"2002","unstructured":"Davies, K. & Woo, P. British Paediatric Rheumatology Group. Immunization in rheumatic diseases of childhood: an audit of the clinical practice of British Paediatric Rheumatology Group members and a review of the evidence. Rheumatology (Oxford) 41, 937\u2013941 (2002).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201395_CR8","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1093\/rheumatology\/kes175","volume":"51","author":"MP Morin","year":"2012","unstructured":"Morin, M. P., Quach, C., Fortin, E. & Ch\u00e9deville G. Vaccination coverage in children with juvenile idiopathic arthritis followed at a paediatric tertiary care centre. Rheumatology (Oxford) 51, 2046\u20132050 (2012).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201395_CR9","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1136\/adc.2006.112805","volume":"92","author":"LJ McCann","year":"2007","unstructured":"McCann, L. J. Should children under treatment for juvenile idiopathic arthritis receive flu vaccination? Arch. Dis. Child. 92, 366\u2013368 (2007).","journal-title":"Arch. Dis. Child."},{"key":"BFnrrheum201395_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.autrev.2011.08.010","volume":"11","author":"MW Heijstek","year":"2011","unstructured":"Heijstek, M. W.  et al. Vaccination in paediatric patients with auto-immune rheumatic diseases: a systemic literature review for the European League against Rheumatism evidence-based recommendations. Autoimmun. Rev. 11, 112\u2013122 (2011).","journal-title":"Autoimmun. Rev."},{"key":"BFnrrheum201395_CR11","unstructured":"American Academy of Pediatrics. Red Book: 2003 Report of the Committee of Infectious Diseases 26th edn 672\u2013686 (American Academy of Pediatrics, 2003)."},{"key":"BFnrrheum201395_CR12","volume-title":"American College of Rheumatology: Hotline","author":"JJ Cush","year":"2008","unstructured":"Cush, J. J. & Kavanaugh, A. Herpes zoster (shingles) vaccine guidelines for immunosuppressed patients. American College of Rheumatology: Hotline [online] (2008)."},{"key":"BFnrrheum201395_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3899\/jrheum.110721","volume":"39","author":"NE Aikawa","year":"2012","unstructured":"Aikawa, N. E.  et al. Corticosteroid: major factor for reduced immunogenicity of 2009 influenza A (H1N1) vaccine in patients with juvenile autoimmune rheumatic disease. J. Rheumatol. 39, 167\u2013173 (2012).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201395_CR14","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3109\/03009742.2012.709272","volume":"42","author":"N Aikawa","year":"2013","unstructured":"Aikawa N.  et al. Effective seroconversion and safety following the pandemic influenza vaccination (anti-H1N1) in patients with juvenile idiopathic arthritis. Scand. J. Rheumatol. 42, 34\u201340 (2013).","journal-title":"Scand. J. Rheumatol."},{"key":"BFnrrheum201395_CR15","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/INF.0b013e3181f7ce44","volume":"30","author":"C Ogimi","year":"2011","unstructured":"Ogimi, C., Tanaka, R., Saitoh, A. & Oh-Ishi, T. Immunogenicity of influenza vaccine in children with pediatric rheumatic diseases receiving immunosuppressive agents. Pediatr. Infect. Dis. J. 30, 208\u2013211 (2011).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR16","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.vaccine.2011.11.083","volume":"30","author":"L Dell'Era","year":"2012","unstructured":"Dell'Era, L.  et al. Immunogenicity, safety and tolerability of MF59-adjuvanted seasonal influenza vaccine in children with juvenile idiopathic arthritis. Vaccine 30, 936\u2013940 (2012).","journal-title":"Vaccine"},{"key":"BFnrrheum201395_CR17","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1136\/ard.2010.145151","volume":"70","author":"A Ronaghy","year":"2011","unstructured":"Ronaghy, A.  et al. Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis. Ann. Rheum. Dis. 70, 2037\u20132043 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR18","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1177\/0961203310397409","volume":"20","author":"M Miyamoto","year":"2011","unstructured":"Miyamoto, M.  et al. Vaccine antibodies and T- and B-cell interaction in juvenile systemic lupus erythematosus. Lupus 20, 736\u2013744 (2011).","journal-title":"Lupus"},{"key":"BFnrrheum201395_CR19","first-page":"791","volume":"30","author":"CM Barbosa","year":"2012","unstructured":"Barbosa, C. M.  et al. Immune response and tolerability of varicella vaccine in children and adolescents with systemic lupus erythematosus previously exposed to varicella-zoster virus. Clin. Exp. Rheumatol. 30, 791\u2013798 (2012).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201395_CR20","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1136\/annrheumdis-2011-200637","volume":"71","author":"MW Heijstek","year":"2012","unstructured":"Heijstek, M. W., van Gageldonk, P. G., Berbers, G. A. & Wulffraat, N. M. Differences in persistence of measles, mumps, rubella, diphtheria and tetanus antibodies between children with rheumatic disease and healthy controls: a retrospective cross-sectional study. Ann. Rheum. Dis. 71, 948\u2013954 (2012).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR21","first-page":"436","volume":"30","author":"N Toplak","year":"2012","unstructured":"Toplak, N.  et al. Safety and efficacy of influenza vaccination in a prospective longitudinal study of 31 children with juvenile idiopathic arthritis. Clin. Exp. Rheumatol. 30, 436\u2013444 (2012).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201395_CR22","doi-asserted-by":"publisher","first-page":"27214","DOI":"10.1371\/journal.pone.0027214","volume":"6","author":"JL Miraglia","year":"2011","unstructured":"Miraglia, J. L.  et al. Immunogenicity and reactogenicity of 2009 influenza A (H1N1) inactivated monovalent non-adjuvanted vaccine in elderly and immunocompromised patients. PLoS ONE 6, 27214 (2011).","journal-title":"PLoS ONE"},{"key":"BFnrrheum201395_CR23","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.1128\/CVI.00309-12","volume":"19","author":"M Shimizu","year":"2012","unstructured":"Shimizu, M., Ueno, K. & Yachie, A. Relapse of systemic juvenile idiopathic arthritis after influenza vaccination in a patient receiving tocilizumab. Clin. Vaccine Immunol. 19, 1700\u20131702 (2012).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFnrrheum201395_CR24","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3109\/s10165-012-0595-z","volume":"22","author":"T Shinoki","year":"2012","unstructured":"Shinoki, T.  et al. Safety and response to influenza vaccine in patients with systemic-onset juvenile idiopathic arthritis receiving tocilizumab. Mod. Rheumatol. 22, 871\u2013876 (2012).","journal-title":"Mod. Rheumatol."},{"key":"BFnrrheum201395_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.jcma.2011.03.004","volume":"74","author":"M Erguven","year":"2011","unstructured":"Erguven, M., Kaya, B., Hamzah, O. Y. & Tufan, F. Evaluation of immune response to hepatitis A vaccination and vaccine safety in juvenile idiopathic arthritis. J. Chin. Med. Assoc. 74, 205\u2013208 (2011).","journal-title":"J. Chin. Med. Assoc."},{"key":"BFnrrheum201395_CR26","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1136\/ard.2010.134254","volume":"70","author":"P Quartier","year":"2011","unstructured":"Quartier, P.  et al. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial). Ann. Rheum. Dis. 70, 747\u2013754 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR27","unstructured":"Campos, L. M.  et al. High disease activity: an independent factor for reduced immunogenicity of pandemic influenza a vaccine in patients with juvenile SLE. Arthritis Care Res. (in press)."},{"key":"BFnrrheum201395_CR28","first-page":"882","volume":"29","author":"MB Aytac","year":"2011","unstructured":"Aytac, M. B.  et al. Hepatitis B vaccination in juvenile systemic lupus erythematosus. Clin. Exp. Rheumatol. 29, 882\u2013886 (2011).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201395_CR29","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpeds.2011.06.045","volume":"160","author":"CB Long","year":"2012","unstructured":"Long, C. B.  et al. Humoral and cell-mediated immune responses to monovalent 2009 influenza A\/H1N1 and seasonal trivalent influenza vaccines in high-risk children. J. Pediatr. 160, 74\u201381 (2012).","journal-title":"J. Pediatr."},{"key":"BFnrrheum201395_CR30","first-page":"583","volume":"30","author":"VR Guissa","year":"2012","unstructured":"Guissa, V. R.  et al. Influenza A H1N1\/2009 vaccine in juvenile dermatomyositis: reduced immunogenicity in patients under immunosuppressive therapy. Clin. Exp. Rheumatol. 30, 583\u2013588 (2012).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201395_CR31","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00467-010-1722-8","volume":"26","author":"T Watanabe","year":"2011","unstructured":"Watanabe, T. Henoch\u2013Sch\u00f6nlein purpura following influenza vaccinations during the pandemic of influenza A (H1N1). Pediatr. Nephrol. 26, 795\u2013798 (2011).","journal-title":"Pediatr. Nephrol."},{"key":"BFnrrheum201395_CR32","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1136\/ard.2011.149922","volume":"70","author":"EJ Bodar","year":"2011","unstructured":"Bodar, E. J.  et al. On-demand anakinra treatment is effective in mevalonate kinase deficiency. Ann. Rheum. Dis. 70, 2155\u20132158 (2011).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR33","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1586\/erv.12.69","volume":"11","author":"R Bodewes","year":"2012","unstructured":"Bodewes, R., Fraaij, P. L., Osterhaus, A. D. & Rimmelzwaan, G. F. Pediatric influenza vaccination: understanding the T-cell response. Expert Rev. Vaccines 11, 963\u2013971 (2012).","journal-title":"Expert Rev. Vaccines"},{"key":"BFnrrheum201395_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.yapd.2012.04.017","volume":"59","author":"MA Miller","year":"2012","unstructured":"Miller, M. A. & Rathore, M. H. Immunization in special populations. Adv. Pediatr. 59, 95\u2013136 (2012).","journal-title":"Adv. Pediatr."},{"key":"BFnrrheum201395_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/ni0311-189","volume":"12","author":"M PrabhuDas","year":"2011","unstructured":"PrabhuDas, M.  et al. Challenges in infant immunity: implications for responses to infection and vaccines. Nat. Immunol. 12, 189\u2013194 (2011).","journal-title":"Nat. Immunol."},{"key":"BFnrrheum201395_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0065-2776(07)95002-6","volume":"95","author":"M Carneiro-Sampaio","year":"2007","unstructured":"Carneiro-Sampaio, M. & Coutinho, A. Tolerance and autoimmunity: lessons at the bedside of primary immunodeficiencies. Adv. Immunol. 95, 51\u201382 (2007).","journal-title":"Adv. Immunol."},{"key":"BFnrrheum201395_CR37","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.jaci.2009.10.022","volume":"124","author":"LM Griffith","year":"2009","unstructured":"Griffith, L. M.  et al. Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management. J. Allergy Clin. Immunol. 124, 1152\u20131160 (2009).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnrrheum201395_CR38","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1136\/ard.34.4.354","volume":"34","author":"CC Linnemann","year":"1975","unstructured":"Linnemann, C. C., Levinson, J. E., Buncher, C. R. & Schiff, G. M. Rubella antibody levels in juvenile rheumatoid arthritis. Ann. Rheum. Dis. 34, 354\u2013358 (1975).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR39","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1136\/ard.2006.063586","volume":"66","author":"MW Heijstek","year":"2007","unstructured":"Heijstek, M. W.  et al. Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritis. Ann. Rheum. Dis. 66, 1384\u20131387 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR40","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/rheumatology\/ken436","volume":"48","author":"S Borte","year":"2009","unstructured":"Borte, S., Liebert, U. G., Borte, M. & Sack, U. Efficacy of measles, mumps and rubella revaccination in children with juvenile idiopathic arthritis treated with methotrexate and etanercept. Rheumatology (Oxford) 48, 144\u2013148 (2009).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201395_CR41","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1016\/j.vaccine.2009.06.052","volume":"27","author":"S Korematsu","year":"2009","unstructured":"Korematsu, S.  et al. A relapse of systemic type juvenile idiopathic arthritis after a rubella vaccination in a patient during a long-term remission period. Vaccine 27, 5041\u20135042 (2009).","journal-title":"Vaccine"},{"key":"BFnrrheum201395_CR42","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.3899\/jrheum.090173","volume":"36","author":"E Kiray","year":"2009","unstructured":"Kiray, E.  et al. Purified protein derivative response in juvenile idiopathic arthritis. J. Rheumatol. 36, 2029\u20132032 (2009).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201395_CR43","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1002\/acr.20183","volume":"62","author":"GS Pileggi","year":"2010","unstructured":"Pileggi, G. S., de Souza, C. B. & Ferriani, V. P. Safety and immunogenicity of varicella vaccine in patients with juvenile rheumatic diseases receiving methotrexate and corticosteroids. Arthritis Care Res. (Hoboken) 62, 1034\u20131039 (2010).","journal-title":"Arthritis Care Res. (Hoboken)"},{"key":"BFnrrheum201395_CR44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2249.2005.02931.x","volume":"142","author":"N Dhiman","year":"2005","unstructured":"Dhiman, N.  et al. Correlations among measles virus-specific antibody, lymphoproliferation and TH1\/TH2 cytokine responses following measles-mumps-rubella-II (MMR-II) vaccination. Clin. Exp. Immunol. 142, 498\u2013504 (2005).","journal-title":"Clin. Exp. Immunol."},{"key":"BFnrrheum201395_CR45","first-page":"1769","volume":"20","author":"PN Malleson","year":"1993","unstructured":"Malleson, P. N., Tekano, J. L., Scheifele, D. W. & Weber, J. M. Influenza immunization in children with chronic arthritis: a prospective study. J. Rheumatol. 20, 1769\u20131773 (1993).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201395_CR46","first-page":"1581","volume":"21","author":"NY Olson","year":"1994","unstructured":"Olson, N. Y. & Lindsley, C. B. Influenza immunization in children with chronic arthritis. J. Rheumatol. 21, 1581\u20131582 (1994).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201395_CR47","first-page":"589","volume":"19","author":"F Kanakoudi-Tsakalidou","year":"2001","unstructured":"Kanakoudi-Tsakalidou, F., Trachana, M., Pratsidou-Gertsi, P., Tsitsami, E. & Kyriazopoulou-Dalaina, V. Influenza vaccination in children with chronic rheumatic diseases and long-term immunosuppressive therapy. Clin. Exp. Rheumatol. 19, 589\u2013594 (2001).","journal-title":"Clin. Exp. Rheumatol."},{"key":"BFnrrheum201395_CR48","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1136\/ard.2003.013201","volume":"63","author":"O Kasap\u00e7opur","year":"2004","unstructured":"Kasap\u00e7opur, O.  et al. Hepatitis B vaccination in children with juvenile idiopathic arthritis. Ann. Rheum. Dis. 63, 1128\u20131130 (2004).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201395_CR49","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1016\/j.vaccine.2010.03.080","volume":"28","author":"E Farmaki","year":"2010","unstructured":"Farmaki, E.  et al. The effect of anti-TNF treatment on the immunogenicity and safety of the 7-valent conjugate pneumococcal vaccine in children with juvenile idiopathic arthritis. Vaccine 28, 5109\u20135113 (2010).","journal-title":"Vaccine"},{"key":"BFnrrheum201395_CR50","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/art.22399","volume":"56","author":"E Zonneveld-Huijssoon","year":"2007","unstructured":"Zonneveld-Huijssoon, E.  et al. Safety and efficacy of meningococcal C vaccination in juvenile idiopathic arthritis. Arthritis Rheum. 56, 639\u2013646 (2007).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201395_CR51","unstructured":"EMA. European Committee for Proprietary Medicinal Products. Guideline on dossier structure and content for pandemic influenza vaccine marketing authorisation application [online], (2004)."},{"key":"BFnrrheum201395_CR52","unstructured":"EMA. Committee for Proprietary Medicinal Products. Note for guidance on harmonisation of requirements for influenza vaccines [online], (1997)."},{"key":"BFnrrheum201395_CR53","unstructured":"US Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research. Guidance for industry: clinical data needed to support the licensure of pandemic influenza vaccines [online], (2007)."},{"key":"BFnrrheum201395_CR54","first-page":"181","volume":"5","author":"S Kashef","year":"2008","unstructured":"Kashef, S., Ghazizadeh, F., Derakhshan, A., Farjadian, S. & Alyasin, S. Antigen-specific antibody response in juvenile-onset SLE patients following routine immunization with tetanus toxoid. Iran. J. Immunol. 5, 181\u2013184 (2008).","journal-title":"Iran. J. Immunol."},{"key":"BFnrrheum201395_CR55","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/S0140-6736(78)90761-4","volume":"1","author":"W Ehrengut","year":"1978","unstructured":"Ehrengut, W. Dermatomyositis and vaccination. Lancet 1, 1040\u20131041 (1978).","journal-title":"Lancet"},{"key":"BFnrrheum201395_CR56","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3109\/03009747909114454","volume":"8","author":"E K\u00e5ss","year":"1979","unstructured":"K\u00e5ss, E., Straume, S., Mellbye, O. J., Munthe, E. & Solheim, B. G. Dermatomyositis associated with BCG vaccination. Scand. J. Rheumatol. 8, 187\u2013191 (1979).","journal-title":"Scand. J. Rheumatol."},{"key":"BFnrrheum201395_CR57","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/S0140-6736(78)92325-5","volume":"2","author":"JA Cotterill","year":"1978","unstructured":"Cotterill, J. A. & Shapiro, H. Dermatomyositis after immunisation. Lancet 2, 1158\u20131159 (1978).","journal-title":"Lancet"},{"key":"BFnrrheum201395_CR58","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00296-007-0485-4","volume":"28","author":"A Altman","year":"2008","unstructured":"Altman, A., Szyper-Kravitz, M. & Shoenfeld, Y. HBV vaccine and dermatomyositis: is there an association? Rheumatol. Int. 28, 609\u2013612 (2008).","journal-title":"Rheumatol. Int."},{"key":"BFnrrheum201395_CR59","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1525-1470.2011.01548.x","volume":"29","author":"A Khaled","year":"2012","unstructured":"Khaled, A.  et al. Postvaccination morphea profunda in a child. Pediatr. Dermatol. 29, 525\u2013527 (2012).","journal-title":"Pediatr. Dermatol."},{"key":"BFnrrheum201395_CR60","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.jaad.2009.02.047","volume":"63","author":"R Benmously Mlika","year":"2010","unstructured":"Benmously Mlika, R.  et al. Morphea profunda in a young infant after hepatitis B vaccination. J. Am. Acad. Dermatol. 63, 1111\u20131112 (2010).","journal-title":"J. Am. Acad. Dermatol."},{"key":"BFnrrheum201395_CR61","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1525-1470.2006.00289.x","volume":"23","author":"A Torrelo","year":"2006","unstructured":"Torrelo, A.  et al. Deep morphea after vaccination in two young children. Pediatr. Dermatol. 23, 484\u20137 (2006).","journal-title":"Pediatr. Dermatol."},{"key":"BFnrrheum201395_CR62","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1542\/peds.2009-3195","volume":"126","author":"MJ Goodman","year":"2010","unstructured":"Goodman, M. J., Nordin, J. D., Belongia, E. A., Mullooly, J. P. & Baggs, J. Henoch\u2013Sch\u00f6lein purpura and polysaccharide meningococcal vaccine. Pediatrics 126, 325\u2013329 (2010).","journal-title":"Pediatrics"},{"key":"BFnrrheum201395_CR63","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1007\/s004670100569","volume":"16","author":"T Watanabe","year":"2001","unstructured":"Watanabe, T. & Onda, H. Henoch\u2013Sch\u00f6nlein purpura with antiphospholipid antibodies following an influenza vaccination. Pediatr. Nephrol. 16, 458\u2013459 (2001).","journal-title":"Pediatr. Nephrol."},{"key":"BFnrrheum201395_CR64","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1442-200X.1989.tb01337.x","volume":"31","author":"T Ozaki","year":"1989","unstructured":"Ozaki, T., Miwata, H., Kodama, H., Matsui, Y. & Asano, Y. Henoch\u2013Sch\u00f6nlein purpura after measles immunization. Acta. Paediatr. Jpn. 31, 484\u2013486 (1989).","journal-title":"Acta. Paediatr. Jpn."},{"key":"BFnrrheum201395_CR65","doi-asserted-by":"publisher","first-page":"e491","DOI":"10.1542\/peds.112.6.e491","volume":"112","author":"EM Lambert","year":"2003","unstructured":"Lambert, E. M., Liebling, A., Glusac, E. & Antaya, R. J. Henoch\u2013Sch\u00f6nlein purpura following a meningococcal vaccine. Pediatrics 112, e491 (2003).","journal-title":"Pediatrics"},{"key":"BFnrrheum201395_CR66","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/rheumatology\/40.3.345","volume":"40","author":"PA Courtney","year":"2001","unstructured":"Courtney, P. A., Patterson, R. N. & Lee, R. J. Henoch\u2013Sch\u00f6nlein purpura following meningitis C vaccination. Rheumatology (Oxford) 40, 345\u2013346 (2001).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201395_CR67","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.vaccine.2004.07.029","volume":"23","author":"R Mormile","year":"2004","unstructured":"Mormile, R., D'Alterio, V., Treccagnoli, G. & Sorrentino, P. Henoch\u2013Sch\u00f6nlein purpura with antiphospholipid antibodies after influenza vaccination: how fearful is it in children? Vaccine 23, 567\u2013568 (2004).","journal-title":"Vaccine"},{"key":"BFnrrheum201395_CR68","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/INF.0b013e3181bbc571","volume":"28","author":"D Schm\u00f6eller","year":"2009","unstructured":"Schm\u00f6eller, D., Keiserman, M. W., Staub, H. L., Velho, F. P. & de F\u00e1tima Grohe, M. Yellow fever vaccination and Kawasaki disease. Pediatr. Infect. Dis. J. 28, 1037\u20131038 (2009).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR69","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s10067-003-0785-3","volume":"22","author":"D Miron","year":"2003","unstructured":"Miron, D., Fink, D. & Hashkes, P. J. Kawasaki disease in an infant following immunisation with hepatitis B vaccine. Clin. Rheumatol. 22, 461\u2013463 (2003).","journal-title":"Clin. Rheumatol."},{"key":"BFnrrheum201395_CR70","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/adc.2007.125195","volume":"94","author":"K Sexton","year":"2009","unstructured":"Sexton, K.  et al. Henoch\u2013Sch\u00f6nlein purpura and meningococcal B vaccination. Arch. Dis. Child. 94, 224\u2013226 (2009).","journal-title":"Arch. Dis. Child."},{"key":"BFnrrheum201395_CR71","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/INF.0b013e318196934a","volume":"28","author":"KJ Center","year":"2009","unstructured":"Center, K. J., Hansen, J. R., Lewis, E., Fireman, B. H. & Hilton B. Lack of association of Kawasaki disease after immunization in a cohort of infants followed for multiple autoimmune diagnoses in a large, phase-4 observational database safety study of 7-valent pneumococcal conjugate vaccine: lack of association between Kawasaki disease and seven-valent pneumococcal conjugate vaccine. Pediatr. Infect. Dis. J. 28, 438\u2013440 (2009).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR72","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1097\/INF.0b013e3181a66471","volume":"28","author":"W Hua","year":"2009","unstructured":"Hua, W.  et al. Kawasaki disease after vaccination: reports to the vaccine adverse event reporting system 1990\u20132007. Pediatr. Infect. Dis. J. 28, 943\u2013947 (2009).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR73","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1440-1754.2008.01364.x","volume":"44","author":"D Chalmers","year":"2008","unstructured":"Chalmers, D., Corban, J. G. & Moore, P. P. BCG site inflammation: a useful diagnostic sign in incomplete Kawasaki disease. J. Paediatr. Child Health 44, 525\u2013526 (2008).","journal-title":"J. Paediatr. Child Health"},{"key":"BFnrrheum201395_CR74","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0190-9622(97)80376-3","volume":"37","author":"S Kuniyuki","year":"1997","unstructured":"Kuniyuki, S. & Asada, M. An ulcerated lesion at the BCG vaccination site during the course of Kawasaki disease. J. Am. Acad. Dermatol. 37, 303\u2013304 (1997).","journal-title":"J. Am. Acad. Dermatol."},{"key":"BFnrrheum201395_CR75","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1503\/cmaj.051211","volume":"174","author":"M Weinstein","year":"2006","unstructured":"Weinstein, M. Inflammation at a previous inoculation site: an unusual presentation of Kawasaki disease. CMAJ 174, 459\u2013460 (2006).","journal-title":"CMAJ"},{"key":"BFnrrheum201395_CR76","first-page":"83","volume":"42","author":"D Antony","year":"2005","unstructured":"Antony, D. & Jessy, P. L. Involvement of BCG scar in Kawasaki disease. Indian Pediatr. 42, 83\u201384 (2005).","journal-title":"Indian Pediatr."},{"key":"BFnrrheum201395_CR77","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1097\/00006454-198706000-00020","volume":"6","author":"YH Hsu","year":"1987","unstructured":"Hsu, Y. H., Wang, Y. H., Hsu, W. Y. & Lee, Y. P. Kawasaki disease characterized by erythema and induration at the Bacillus Calmette\u2013Gu\u00e9rin and purified protein derivative inoculation sites. Pediatr. Infect. Dis. J. 6, 576\u2013578 (1987).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR78","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/adc.2004.071332","volume":"90","author":"R Sinha","year":"2005","unstructured":"Sinha, R. & Balakumar, T. BCG reactivation: a useful diagnostic tool even for incomplete Kawasaki disease. Arch. Dis. Child. 90, 891 (2005).","journal-title":"Arch. Dis. Child."},{"key":"BFnrrheum201395_CR79","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/INF.0b013e3181cacede","volume":"29","author":"R Uehara","year":"2010","unstructured":"Uehara, R., Igarashi, H., Yashiro, M., Nakamura, Y. & Yanagawa, H. Kawasaki disease patients with redness or crust formation at the Bacille Calmette\u2013Gu\u00e9rin inoculation site. Pediatr. Infect. Dis. J. 29, 430\u2013433 (2010).","journal-title":"Pediatr. Infect. Dis. J."},{"key":"BFnrrheum201395_CR80","first-page":"260","volume":"63","author":"EJ Bodar","year":"2005","unstructured":"Bodar, E. J., van der Hilst, J. C., Drenth, J. P., van der Meer, J. W. & Simon, A. Effect of etanercept and anakinra on inflammatory attacks in the hyper-IgD syndrome: introducing a vaccination provocation model. Neth. J. Med. 63, 260\u2013264 (2005).","journal-title":"Neth. J. Med."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2013.95.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2013.95","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2013.95.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T11:37:26Z","timestamp":1744285046000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2013.95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":80,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["BFnrrheum201395"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2013.95","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]},"assertion":[{"value":"2 July 2013","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}