{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:31:50Z","timestamp":1792445510171,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Rheumatol"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1038\/nrrheum.2014.47","type":"journal-article","created":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T05:30:59Z","timestamp":1396330259000},"page":"374-380","source":"Crossref","is-referenced-by-count":221,"title":["Osteoarthritis pain: nociceptive or neuropathic?"],"prefix":"10.1038","volume":"10","author":[{"given":"Matthew","family":"Thakur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Dickenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,1]]},"reference":[{"key":"BFnrrheum201447_CR1","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1212\/01.wnl.0000282763.29778.59","volume":"70","author":"RD Treede","year":"2008","unstructured":"Treede, R. D.  et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70, 1630\u20131635 (2008).","journal-title":"Neurology"},{"key":"BFnrrheum201447_CR2","doi-asserted-by":"publisher","first-page":"e33730","DOI":"10.1371\/journal.pone.0033730","volume":"7","author":"M Thakur","year":"2012","unstructured":"Thakur, M., Rahman, W., Hobbs, C., Dickenson, A. & Bennett, D. Characterisation of a peripheral neuropathic component of the rat monoiodoacetate model of osteoarthritis. PLoS ONE 7, e33730 (2012).","journal-title":"PLoS ONE"},{"key":"BFnrrheum201447_CR3","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1136\/ard.2006.063354","volume":"66","author":"S Suri","year":"2007","unstructured":"Suri, S.  et al. Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis. Ann. Rheum. Dis. 66, 1423\u20131428 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201447_CR4","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","volume":"42","author":"DA Walsh","year":"2010","unstructured":"Walsh, D. A.  et al. Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology (Oxford) 42, 1852\u20131861 (2010).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201447_CR5","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1136\/ard.2009.121426","volume":"69","author":"K Baker","year":"2010","unstructured":"Baker, K.  et al. Relation of synovitis to knee pain using contrast-enhanced MRIs. Ann. Rheum. Dis. 69, 1779\u20131783 (2010).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201447_CR6","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1136\/ard.2006.067470","volume":"66","author":"CL Hill","year":"2007","unstructured":"Hill, C. L.  et al. Synovitis detected on magnetic resonance imaging and its relation to pain and cartilage loss in knee osteoarthritis. Ann. Rheum. Dis. 66, 1599\u20131603 (2007).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201447_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar1376","volume":"6","author":"H Schaible","year":"2004","unstructured":"Schaible, H. Mechanisms of pain in arthritis. Arthritis Res. Ther. 6, 1\u20132 (2004).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum201447_CR8","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.joca.2013.06.018","volume":"21","author":"A Eitner","year":"2013","unstructured":"Eitner, A., Pester, J., Nietzsche, S., Hofmann, G. O. & Schaible, H. G. The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium. Osteoarthritis Cartilage 21, 1383\u20131391 (2013).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR9","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1136\/ard.56.11.641","volume":"56","author":"MV Hurley","year":"1997","unstructured":"Hurley, M. V., Scott, D. L., Rees, J. & Newham, D. J. Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann. Rheum. Dis. 56, 641\u2013648 (1997).","journal-title":"Ann. Rheum. Dis."},{"key":"BFnrrheum201447_CR10","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1002\/art.1780400821","volume":"40","author":"L Sharma","year":"1997","unstructured":"Sharma, L., Pai, Y. C., Holtkamp, K. & Rymer, W. Z. Is knee joint proprioception worse in the arthritic knee versus the unaffected knee in unilateral knee osteoarthritis? Arthritis Rheum. 40, 1518\u20131525 (1997).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR11","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/art.24606","volume":"61","author":"DT Felson","year":"2009","unstructured":"Felson, D. T.  et al. The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis. Arthritis Rheum. 61, 1070\u20131076 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR12","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/rheumatology\/ker343","volume":"51","author":"V Wylde","year":"2012","unstructured":"Wylde, V., Palmer, S., Learmonth, I. D. & Dieppe, P. Somatosensory abnormalities in knee OA. Rheumatology (Oxford) 51, 535\u2013543 (2012).","journal-title":"Rheumatology (Oxford)"},{"key":"BFnrrheum201447_CR13","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/art.30657","volume":"64","author":"N Shakoor","year":"2011","unstructured":"Shakoor, N.  et al. The relationship of vibratory perception with dynamic joint loading, radiographic severity, and pain in knee osteoarthritis. Arthritis Rheum. 64, 181\u2013186 (2011).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.jpain.2012.11.009","volume":"14","author":"RN Harden","year":"2013","unstructured":"Harden, R. N.  et al. The osteoarthritis knee model: psychophysical characteristics and putative outcomes. J. Pain 14, 281\u2013289 (2013).","journal-title":"J. Pain"},{"key":"BFnrrheum201447_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S1526-5900(03)00557-1","volume":"4","author":"JA Hendiani","year":"2003","unstructured":"Hendiani, J. A.  et al. Mechanical sensation and pain thresholds in patients with chronic arthropathies. J. Pain 4, 203\u2013211 (2003).","journal-title":"J. Pain"},{"key":"BFnrrheum201447_CR16","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1016\/j.joca.2013.06.023","volume":"21","author":"JR Hochman","year":"2013","unstructured":"Hochman, J. R., Davis, A. M., Elkayam, J., Gagliese, L. & Hawker, G. A. Neuropathic pain symptoms on the modified painDETECT correlate with signs of central sensitization in knee osteoarthritis. Osteoarthritis Cartilage 21, 1236\u20131242 (2013).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR17","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.joca.2013.06.010","volume":"21","author":"M Thakur","year":"2013","unstructured":"Thakur, M., Dawes, J. M. & McMahon, S. B. Genomics of pain in osteoarthritis. Osteoarthritis Cartilage 21, 1374\u20131382 (2013).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR18","first-page":"540","volume":"71","author":"J Street","year":"2005","unstructured":"Street, J., Lenehan, B., Flavin, R., Beale, E. & Murray, P. Do pain referral patterns determine patient outcome after total hip arthroplasty? Acta Orthop. Belg. 71, 540\u2013547 (2005).","journal-title":"Acta Orthop. Belg."},{"key":"BFnrrheum201447_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1526-4637.2006.00153.x","volume":"9","author":"JM Lesher","year":"2008","unstructured":"Lesher, J. M., Dreyfuss, P., Hager, N., Kaplan, M. & Furman, M. Hip joint pain referral patterns: a descriptive study. Pain Med. 9, 22\u201325 (2008).","journal-title":"Pain Med."},{"key":"BFnrrheum201447_CR20","first-page":"441","volume":"27","author":"M Farrell","year":"2000","unstructured":"Farrell, M., Gibson, S., McMeeken, J. & Helme, R. Pain and hyperalgesia in osteoarthritis of the hands. J. Rheumatol. 27, 441\u2013447 (2000).","journal-title":"J. Rheumatol."},{"key":"BFnrrheum201447_CR21","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1002\/art.24837","volume":"61","author":"SE Gwilym","year":"2009","unstructured":"Gwilym, S. E.  et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum. 61, 1226\u20131234 (2009).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR22","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1744-8069-5-45","volume":"5","author":"W Rahman","year":"2009","unstructured":"Rahman, W.  et al. Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Mol. Pain 5, 45 (2009).","journal-title":"Mol. Pain"},{"key":"BFnrrheum201447_CR23","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1124\/pr.112.006163","volume":"64","author":"J O'Neill","year":"2012","unstructured":"O'Neill, J.  et al. Unravelling the mystery of capsaicin: a tool to understand and treat pain. Pharmacol. Rev. 64, 939\u2013971 (2012).","journal-title":"Pharmacol. Rev."},{"key":"BFnrrheum201447_CR24","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/ana.24017","volume":"74","author":"R Baron","year":"2013","unstructured":"Baron, R., Hans, G. & Dickenson, A. Peripheral input and its importance for central sensitization. Ann. Neurol. 74, 630\u2013636 (2013).","journal-title":"Ann. Neurol."},{"issue":"Suppl. 2","key":"BFnrrheum201447_CR25","first-page":"S34","volume":"18","author":"T Neogi","year":"2010","unstructured":"Neogi, T.  et al. Central sensitization in knee OA: preliminary results from the MOST study. Osteoarthritis and Cartilage 18 (Suppl. 2), S34 (2010).","journal-title":"Osteoarthritis and Cartilage"},{"key":"BFnrrheum201447_CR26","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.pain.2010.04.003","volume":"149","author":"L Arendt-Nielsen","year":"2010","unstructured":"Arendt-Nielsen, L.  et al. Sensitization in patients with painful knee osteoarthritis. Pain 149, 573\u2013581 (2010).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR27","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1002\/art.24120","volume":"59","author":"M Imamura","year":"2008","unstructured":"Imamura, M.  et al. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis. Arthritis Rheum. 59, 1424\u20131431 (2008).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR28","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1002\/art.34466","volume":"64","author":"T Graven-Nielsen","year":"2012","unstructured":"Graven-Nielsen, T., Wodehouse, T., Langford, R. M., Arendt-Nielsen, L. & Kidd, B. L. Normalisation of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 64, 2907\u20132916 (2012).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1053\/eujp.2000.0175","volume":"4","author":"E Kosek","year":"2000","unstructured":"Kosek, E. & Ordeberg, G. Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment. Eur. J. Pain 4, 229\u2013238 (2000).","journal-title":"Eur. J. Pain"},{"key":"BFnrrheum201447_CR30","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.pain.2010.11.023","volume":"152","author":"V Wylde","year":"2011","unstructured":"Wylde, V., Hewlett, S., Learmonth, I. D. & Dieppe, P. Persistent pain after joint replacement: Prevalence, sensory qualities, and postoperative determinants. Pain 152, 566\u2013572 (2011).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR31","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.joca.2013.05.008","volume":"21","author":"V Wylde","year":"2013","unstructured":"Wylde, V., Palmer, S., Learmonth, I. D. & Dieppe, P. The association between pre-operative pain sensitisation and chronic pain after knee replacement: an exploratory study. Osteoarthritis Cartilage 21, 1253\u20131256 (2013).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR32","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1016\/j.joca.2013.05.011","volume":"21","author":"CR Scanzello","year":"2013","unstructured":"Scanzello, C. R.  et al. The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21, 1392\u20131399 (2013).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR33","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1185\/030079906X132488","volume":"22","author":"R Freynhagen","year":"2006","unstructured":"Freynhagen, R., Baron, R., Gockel, U. & T\u00f6lle, T. R. painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr. Res. Med. Opin. 22, 1911\u20131920 (2006).","journal-title":"Curr. Res. Med. Opin."},{"key":"BFnrrheum201447_CR34","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.pain.2007.08.013","volume":"136","author":"D Bouhassira","year":"2008","unstructured":"Bouhassira, D., Lanteri-Minet, M., Attal, N., Laurent, B. & Touboul, C. Prevalence of chronic pain with neuropathic characteristics in the general population. Pain 136, 380\u2013387 (2008).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR35","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3349\/ymj.2012.53.4.801","volume":"53","author":"S Ohtori","year":"2012","unstructured":"Ohtori, S.  et al. Existence of a neuropathic pain component in patients with osteoarthritis of the knee. Yonsei Med. J. 53, 801 (2012).","journal-title":"Yonsei Med. J."},{"key":"BFnrrheum201447_CR36","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1002\/art.37962","volume":"65","author":"A Soni","year":"2013","unstructured":"Soni, A.  et al. Neuropathic features of joint pain: a community-based study. Arthritis Rheum. 65, 1942\u20131949 (2013).","journal-title":"Arthritis Rheum."},{"key":"BFnrrheum201447_CR37","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.joca.2012.06.009","volume":"20","author":"AK Suokas","year":"2012","unstructured":"Suokas, A. K.  et al. Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage 20, 1075\u20131085 (2012).","journal-title":"Osteoarthritis Cartilage"},{"key":"BFnrrheum201447_CR38","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.pain.2010.05.002","volume":"150","author":"C Maier","year":"2010","unstructured":"Maier, C.  et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): somatosensory abnormalities in 1236 patients with different neuropathic pain syndromes. Pain 150, 439\u2013450 (2010).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR39","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","volume":"123","author":"R Rolke","year":"2006","unstructured":"Rolke, R.  et al. Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): standardized protocol and reference values. Pain 123, 231\u2013243 (2006).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR40","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.pain.2010.06.019","volume":"150","author":"NB Finnerup","year":"2010","unstructured":"Finnerup, N. B., Sindrup, S. H. & Jensen, T. S. The evidence for pharmacological treatment of neuropathic pain. Pain 150, 573\u2013581 (2010).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR41","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.ejpain.2008.09.008","volume":"13","author":"J Vonsy","year":"2009","unstructured":"Vonsy, J., Ghandehari, J. & Dickenson, A. Differential analgesic effects of morphine and gabapentin on behavioural measures of pain and disability in a model of osteoarthritis pain in rats. Eur. J. Pain 13, 786\u2013793 (2009).","journal-title":"Eur. J. Pain"},{"key":"BFnrrheum201447_CR42","doi-asserted-by":"publisher","first-page":"R14","DOI":"10.1186\/ar2121","volume":"9","author":"B Beyreuther","year":"2007","unstructured":"Beyreuther, B., Callizot, N. & Stohr, T. Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain. Arthritis Res. Ther. 9, R14 (2007).","journal-title":"Arthritis Res. Ther."},{"key":"BFnrrheum201447_CR43","doi-asserted-by":"publisher","first-page":"18195","DOI":"10.1073\/pnas.0506624102","volume":"102","author":"GD Iannetti","year":"2005","unstructured":"Iannetti, G. D.  et al. Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc. Natl Acad. Sci. USA 102, 18195\u201318200 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnrrheum201447_CR44","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1056\/NEJMsa0906126","volume":"361","author":"SS Vedula","year":"2009","unstructured":"Vedula, S. S., Bero, L., Scherer, R. W. & Dickersin, K. Outcome reporting in industry-sponsored trials of gabapentin for off-label use. N. Engl. J. Med. 361, 1963\u20131971 (2009).","journal-title":"N. Engl. J. Med."},{"key":"BFnrrheum201447_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.pain.2009.06.024","volume":"146","author":"AS Chappell","year":"2009","unstructured":"Chappell, A. S.  et al. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebo-controlled trial. Pain 146, 253\u2013260 (2009).","journal-title":"Pain"},{"key":"BFnrrheum201447_CR46","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.3349\/ymj.2013.54.5.1253","volume":"54","author":"S Ohtori","year":"2013","unstructured":"Ohtori, S.  et al. Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis. Yonsei Med. J. 54, 1253\u20131258 (2013).","journal-title":"Yonsei Med. J."},{"key":"BFnrrheum201447_CR47","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1213\/ANE.0b013e3181c4273a","volume":"110","author":"A Buvanendran","year":"2010","unstructured":"Buvanendran, A.  et al. Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth. Analg. 110, 199\u2013207 (2010).","journal-title":"Anesth. Analg."},{"key":"BFnrrheum201447_CR48","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s40261-013-0102-0","volume":"33","author":"I Steigerwald","year":"2013","unstructured":"Steigerwald, I.  et al. Effectiveness and tolerability of tapentadol prolonged release compared with prior opioid therapy for the management of severe, chronic osteoarthritis pain. Clin. Drug Investig. 33, 607\u2013619 (2013).","journal-title":"Clin. Drug Investig."},{"key":"BFnrrheum201447_CR49","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.clinthera.2009.02.009","volume":"31","author":"C Hartrick","year":"2009","unstructured":"Hartrick, C., Van Hove, I., Stegmann, J. U., Oh, C. & Upmalis, D. Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: a 10-day, phase III, randomized, double-blind, active-and placebo-controlled study. Clin. Ther. 31, 260\u2013271 (2009).","journal-title":"Clin. Ther."},{"key":"BFnrrheum201447_CR50","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1185\/03007995.2012.679254","volume":"28","author":"I Steigerwald","year":"2012","unstructured":"Steigerwald, I.  et al. Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: results of an open-label, phase 3b study. Curr. Med. Res. Opin. 28, 911\u2013936 (2012)","journal-title":"Curr. Med. Res. Opin."},{"key":"BFnrrheum201447_CR51","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1185\/03007995.2010.534446","volume":"27","author":"B Morlion","year":"2011","unstructured":"Morlion, B. Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components. Curr. Med. Res. Opin. 27, 11\u201333 (2011).","journal-title":"Curr. Med. Res. Opin."}],"container-title":["Nature Reviews Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2014.47.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2014.47","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrrheum.2014.47.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:35:44Z","timestamp":1684470944000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrrheum.2014.47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,1]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["BFnrrheum201447"],"URL":"https:\/\/doi.org\/10.1038\/nrrheum.2014.47","relation":{},"ISSN":["1759-4790","1759-4804"],"issn-type":[{"value":"1759-4790","type":"print"},{"value":"1759-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,1]]}}}