{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:48:50Z","timestamp":1790135330781,"version":"4.0.1"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T00:00:00Z","timestamp":1323129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Rev Urol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1038\/nrurol.2011.192","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T07:24:39Z","timestamp":1323156279000},"page":"85-93","source":"Crossref","is-referenced-by-count":70,"title":["Asymptomatic bacteriuria: when the treatment is worse than the disease"],"prefix":"10.1038","volume":"9","author":[{"given":"Barbara W.","family":"Trautner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,12,6]]},"reference":[{"key":"BFnrurol2011192_CR1","doi-asserted-by":"publisher","first-page":"W20","DOI":"10.7326\/0003-4819-149-1-200807010-00009-w1","volume":"149","author":"K Lin","year":"2008","unstructured":"Lin, K. & Fajardo, K. Screening for asymptomatic bacteriuria in adults: evidence for the U. S. Preventive Services Task Force reaffirmation recommendation statement. Ann. Intern. Med. 149, W20\u2013W24 (2008).","journal-title":"Ann. Intern. Med."},{"key":"BFnrurol2011192_CR2","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1086\/650482","volume":"50","author":"TM Hooton","year":"2010","unstructured":"Hooton, T. M.  et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin. Infect. Dis. 50, 625\u2013663 (2010).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.ajic.2008.03.002","volume":"36","author":"T Horan","year":"2009","unstructured":"Horan, T., Andrus, M. & Dudeck, M. CDC\/NHSN surveillance definition of healthcare-associated infection and criteria for specific types of infections in the acute care setting. Am. J. Infect. Control 36, 309\u2013332 (2009).","journal-title":"Am. J. Infect. Control"},{"key":"BFnrurol2011192_CR4","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1086\/427507","volume":"40","author":"LE Nicolle","year":"2005","unstructured":"Nicolle, L. E.  et al. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin. Infect. Dis. 40, 643\u2013654 (2005).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1086\/604719","volume":"49","author":"J Brown","year":"2009","unstructured":"Brown, J., Doloresco Iii, F. & Mylotte, J. M. \u201cNever events\u201d: not every hospital-acquired infection is preventable. Clin. Infect. Dis. 49, 743\u2013746 (2009).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR6","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1086\/604720","volume":"49","author":"J Carlet","year":"2009","unstructured":"Carlet, J., Fabry, J., Amalberti, R. & Degos, L. The \u201czero risk\u201d concept for hospital-acquired infections: a risky business! Clin. Infect. Dis. 49, 747\u2013749 (2009).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR7","doi-asserted-by":"publisher","first-page":"877","DOI":"10.7326\/0003-4819-150-12-200906160-00013","volume":"150","author":"S Saint","year":"2009","unstructured":"Saint, S., Meddings, J. A., Calfee, D., Kowalski, C. P. & Krein, S. L. Catheter-associated urinary tract infection and the Medicare rule changes. Ann. Intern. Med. 150, 877\u2013884 (2009).","journal-title":"Ann. Intern. Med."},{"key":"BFnrurol2011192_CR8","volume-title":"An APIC Guide","author":"L Greene","year":"2008","unstructured":"Greene, L., Marx, J. & Oriola, S. Guide to the Elimination of Catheter-Associated Urinary Tract Infections (CAUTIs) in An APIC Guide (APIC, Washington, 2008)."},{"issue":"Suppl. 1","key":"BFnrurol2011192_CR9","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1086\/591066","volume":"29","author":"E Lo","year":"2008","unstructured":"Lo, E.  et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect. Control Hosp. Epidemiol. 29 (Suppl. 1), S41\u2013S50 (2008).","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"Suppl. 1","key":"BFnrurol2011192_CR10","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1016\/j.ijantimicag.2007.07.033","volume":"31","author":"P Tenke","year":"2008","unstructured":"Tenke, P.  et al. European and Asian guidelines on management and prevention of catheter-associated urinary tract infections. Int. J. Antimicrob. Agents 31 (Suppl. 1), S68\u2013S78 (2008).","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"Suppl. 1","key":"BFnrurol2011192_CR11","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1086\/591060","volume":"29","author":"DS Yokoe","year":"2008","unstructured":"Yokoe, D. S.  et al. A compendium of strategies to prevent healthcare-associated infections in acute care hospitals. Infect. Control Hosp. Epidemiol. 29 (Suppl. 1), S12\u2013S21 (2008).","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"BFnrurol2011192_CR12","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1086\/597403","volume":"48","author":"M Cope","year":"2009","unstructured":"Cope, M.  et al. Inappropriate treatment of catheter-associated asymptomatic bacteriuria in a tertiary care hospital. Clin. Infect. Dis. 48, 1182\u20131188 (2009).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR13","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1155\/2005\/868179","volume":"16","author":"DM Dalen","year":"2005","unstructured":"Dalen, D. M., Zvonar, R. K. & Jessamine, P. G. An evaluation of the management of asymptomatic catheter-associated bacteriuria and candiduria at The Ottawa Hospital. Can. J. Infect. Dis. Med. Microbiol. 16, 166\u2013170 (2005).","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"BFnrurol2011192_CR14","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1086\/593951","volume":"30","author":"T Gandhi","year":"2009","unstructured":"Gandhi, T., Flanders, S. A., Markovitz, E., Saint, S. & Kaul, D. R. Importance of urinary tract infection to antibiotic use among hospitalized patients. Infect. Control Hosp. Epidemiol. 30, 193\u2013195 (2009).","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"BFnrurol2011192_CR15","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.ajem.2011.04.007","volume":"29","author":"T Khawcharoenporn","year":"2011","unstructured":"Khawcharoenporn, T., Vasoo, S., Ward, E. & Singh, K. Abnormal urinalysis finding triggered antibiotic prescription for asymptomatic bacteriuria in the ED. Am. J. Emerg. Med. 29, 828\u2013830 (2011).","journal-title":"Am. J. Emerg. Med."},{"key":"BFnrurol2011192_CR16","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1086\/522183","volume":"45","author":"PA Gross","year":"2007","unstructured":"Gross, P. A. & Patel, B. Reducing antibiotic overuse: a call for a national performance measure for not treating asymptomatic bacteriuria. Clin. Infect. Dis. 45, 1335\u20131337 (2007).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR17","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"K Gupta","year":"2011","unstructured":"Gupta, K.  et al. International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin. Infect. Dis. 52, e103\u2013e120 (2011).","journal-title":"Clin. Infect. Dis."},{"issue":"Suppl. 4","key":"BFnrurol2011192_CR18","doi-asserted-by":"publisher","first-page":"S341","DOI":"10.1086\/382690","volume":"38","author":"DL Paterson","year":"2004","unstructured":"Paterson, D. L. \u201cCollateral damage\u201d from cephalosporin or quinolone antibiotic therapy. Clin. Infect. Dis. 38 (Suppl. 4), S341\u2013S345 (2004).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR19","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/cid\/cir301","volume":"53","author":"V Stevens","year":"2011","unstructured":"Stevens, V., Dumyati, G., Fine, L. S., Fisher, S. G. & van Wijngaarden, E. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin. Infect. Dis. 53, 42\u201348 (2011).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1056\/NEJMra1007755","volume":"365","author":"G Montini","year":"2011","unstructured":"Montini, G., Tullus, K. & Hewitt, I. Febrile urinary tract infections in children. N. Engl. J. Med. 365, 239\u2013250 (2011).","journal-title":"N. Engl. J. Med."},{"key":"BFnrurol2011192_CR21","doi-asserted-by":"publisher","first-page":"c199","DOI":"10.1136\/bmj.c199","volume":"340","author":"P Little","year":"2010","unstructured":"Little, P.  et al. Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ 340, c199 (2010).","journal-title":"BMJ"},{"key":"BFnrurol2011192_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jinf.2008.12.009","volume":"58","author":"ME Falagas","year":"2009","unstructured":"Falagas, M. E., Kotsantis, I. K., Vouloumanou, E. K. & Rafailidis, P. I. Antibiotics versus placebo in the treatment of women with uncomplicated cystitis: a meta-analysis of randomized controlled trials. J. Infect. 58, 91\u2013102 (2009).","journal-title":"J. Infect."},{"issue":"Suppl. 6","key":"BFnrurol2011192_CR23","first-page":"NP","volume":"52","author":"R Duma","year":"2011","unstructured":"Duma, R. & Edwards, J. E. Candida urinary tract infections. Clin. Infect. Dis. 52 (Suppl. 6), NP (2011).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR24","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1086\/323130","volume":"33","author":"R Darouiche","year":"2001","unstructured":"Darouiche, R. Device-associated infections: a macroproblem that starts with microadherence. Clin. Infect. Dis. 33, 1567\u20131572 (2001).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.femsle.2005.08.028","volume":"252","author":"CF Marrs","year":"2005","unstructured":"Marrs, C. F., Zhang, L. & Foxman, B. Escherichia coli mediated urinary tract infections: are there distinct uropathogenic E. coli (UPEC) pathotypes? FEMS Microbiol. Lett. 252, 183\u2013190 (2005).","journal-title":"FEMS Microbiol. Lett."},{"key":"BFnrurol2011192_CR26","doi-asserted-by":"publisher","first-page":"4589","DOI":"10.1128\/JCM.02070-06","volume":"44","author":"A Takahashi","year":"2006","unstructured":"Takahashi, A.  et al. Escherichia coli isolates associated with uncomplicated and complicated cystitis and asymptomatic bacteriuria possess similar phylogenies, virulence genes, and O-serogroup profiles. J. Clin. Microbiol. 44, 4589\u20134592 (2006).","journal-title":"J. Clin. Microbiol."},{"key":"BFnrurol2011192_CR27","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1128\/IAI.05621-11","volume":"79","author":"RR Spurbeck","year":"2011","unstructured":"Spurbeck, R. R.  et al. Fimbrial profiles predict virulence of uropathogenic E. coli strains: contribution of Ygi and Yad Fimbriae. Infect. Immun. 79, 4753\u20134763 (2011).","journal-title":"Infect. Immun."},{"key":"BFnrurol2011192_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ijmm.2008.06.003","volume":"299","author":"AN Mabbett","year":"2009","unstructured":"Mabbett, A. N.  et al. Virulence properties of asymptomatic bacteriuria Escherichia coli. Int. J. Med. Microbiol. 299, 53\u201363 (2009).","journal-title":"Int. J. Med. Microbiol."},{"key":"BFnrurol2011192_CR29","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1574-6968.2006.00355.x","volume":"262","author":"V Roos","year":"2006","unstructured":"Roos, V., Nielsen, E. M. & Klemm, P. Asymptomatic bacteriuria Escherichia coli strains: adhesins, growth and competition. FEMS Microbiol. Lett. 262, 22\u201330 (2006).","journal-title":"FEMS Microbiol. Lett."},{"key":"BFnrurol2011192_CR30","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1128\/IAI.01215-07","volume":"76","author":"J Zdziarski","year":"2008","unstructured":"Zdziarski, J., Svanborg, C., Wullt, B., Hacker, J. & Dobrindt, U. Molecular basis of commensalism in the urinary tract: low virulence or virulence attenuation? Infect. Immun. 76, 695\u2013703 (2008).","journal-title":"Infect. Immun."},{"key":"BFnrurol2011192_CR31","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1128\/JCM.01611-09","volume":"48","author":"RE Watts","year":"2010","unstructured":"Watts, R. E.  et al. Escherichia coli isolates causing asymptomatic bacteriuria in catheterized and noncatheterized individuals possess similar virulence properties. J. Clin. Microbiol. 48, 2449\u20132458 (2010).","journal-title":"J. Clin. Microbiol."},{"key":"BFnrurol2011192_CR32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/sc.2008.60","volume":"46","author":"TA Schlager","year":"2008","unstructured":"Schlager, T. A., Johnson, J. R., Ouellette, L. M. & Whittam, T. S. Escherichia coli colonizing the neurogenic bladder are similar to widespread clones causing disease in patients with normal bladder function. Spinal Cord 46, 633\u2013638 (2008).","journal-title":"Spinal Cord"},{"key":"BFnrurol2011192_CR33","doi-asserted-by":"publisher","first-page":"e1001078","DOI":"10.1371\/journal.ppat.1001078","volume":"6","author":"J Zdziarski","year":"2010","unstructured":"Zdziarski, J.  et al. Host imprints on bacterial genomes--rapid, divergent evolution in individual patients. PLoS Pathog. 6, e1001078 (2010).","journal-title":"PLoS Pathog."},{"key":"BFnrurol2011192_CR34","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/sc.2008.166","volume":"47","author":"A Prasad","year":"2009","unstructured":"Prasad, A., Cevallos, M. E., Riosa, S., Darouiche, R. O. & Trautner, B. W. A bacterial interference strategy for prevention of UTI in persons practicing intermittent catheterization. Spinal Cord 47, 565\u2013569 (2009).","journal-title":"Spinal Cord"},{"key":"BFnrurol2011192_CR35","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1086\/497272","volume":"41","author":"R Darouiche","year":"2005","unstructured":"Darouiche, R., Thornby, J., Cerra-Stewart, C., Donovan, W. & Hull, R. Bacterial interference for preventing urinary tract infection: a prospective, randomized, placebo-controlled, double-blind pilot trial. Clin. Infect. Dis. 41, 1531\u20131540 (2005).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR36","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.juro.2010.03.024","volume":"184","author":"F Sunden","year":"2010","unstructured":"Sunden, F., Hakansson, L., Ljunggren, E. & Wullt, B. Escherichia coli 83972 bacteriuria protects against recurrent lower urinary tract infections in patients with incomplete bladder emptying. J. Urol. 184, 179\u2013185 (2010).","journal-title":"J. Urol."},{"key":"BFnrurol2011192_CR37","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00438-010-0532-9","volume":"283","author":"RM Vejborg","year":"2010","unstructured":"Vejborg, R. M., Friis, C., Hancock, V., Schembri, M. A. & Klemm, P. A virulent parent with probiotic progeny: comparative genomics of Escherichia coli strains CFT073, Nissle 1917 and ABU 83972. Mol. Genet. Genomics 283, 469\u2013484 (2010).","journal-title":"Mol. Genet. Genomics"},{"key":"BFnrurol2011192_CR38","doi-asserted-by":"publisher","first-page":"3688","DOI":"10.1128\/IAI.01730-06","volume":"75","author":"P Klemm","year":"2007","unstructured":"Klemm, P., Hancock, V. & Schembri, M. A. Mellowing out: adaptation to commensalism by Escherichia coli asymptomatic bacteriuria strain 83972. Infect. Immun. 75, 3688\u20133695 (2007).","journal-title":"Infect. Immun."},{"key":"BFnrurol2011192_CR39","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1128\/IAI.74.1.781-785.2006","volume":"74","author":"P Klemm","year":"2006","unstructured":"Klemm, P., Roos, V., Ulett, G. C., Svanborg, C. & Schembri, M. A. Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: the taming of a pathogen. Infect. Immun. 74, 781\u2013785 (2006).","journal-title":"Infect. Immun."},{"key":"BFnrurol2011192_CR40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1007\/s00438-010-0578-8","volume":"284","author":"V Hancock","year":"2010","unstructured":"Hancock, V., Vejborg, R. M. & Klemm, P. Functional genomics of probiotic Escherichia coli Nissle 1917 and 83972, and UPEC strain CFT073: comparison of transcriptomes, growth and biofilm formation. Mol. Genet. Genomics 284, 437\u2013454 (2010).","journal-title":"Mol. Genet. Genomics"},{"key":"BFnrurol2011192_CR41","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s00438-008-0330-9","volume":"279","author":"V Hancock","year":"2008","unstructured":"Hancock, V., Seshasayee, A. S., Ussery, D. W., Luscombe, N. M. & Klemm, P. Transcriptomics and adaptive genomics of the asymptomatic bacteriuria Escherichia coli strain 83972. Mol. Genet. Genomics 279, 523\u2013534 (2008).","journal-title":"Mol. Genet. Genomics"},{"key":"BFnrurol2011192_CR42","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1128\/IAI.74.1.615-624.2006","volume":"74","author":"V Roos","year":"2006","unstructured":"Roos, V., Ulett, G. C., Schembri, M. A. & Klemm, P. The asymptomatic bacteriuria Escherichia coli strain 83972 outcompetes uropathogenic E. coli strains in human urine. Infect. Immun. 74, 615\u2013624 (2006).","journal-title":"Infect. Immun."},{"key":"BFnrurol2011192_CR43","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.ijmm.2010.04.010","volume":"300","author":"U Dobrindt","year":"2010","unstructured":"Dobrindt, U., Zdziarski, J., Salvador, E. & Hacker, J. Bacterial genome plasticity and its impact on adaptation during persistent infection. Int. J. Med. Microbiol. 300, 363\u2013366 (2010).","journal-title":"Int. J. Med. Microbiol."},{"key":"BFnrurol2011192_CR44","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nrurol.2010.101","volume":"7","author":"GR Nielubowicz","year":"2010","unstructured":"Nielubowicz, G. R. & Mobley, H. L. Host-pathogen interactions in urinary tract infection. Nat. Rev. Urol. 7, 430\u2013441 (2010).","journal-title":"Nat. Rev. Urol."},{"issue":"Suppl. 2","key":"BFnrurol2011192_CR45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1365-2362.2008.02004.x","volume":"38","author":"B Ragnarsdottir","year":"2008","unstructured":"Ragnarsdottir, B.  et al. TLR- and CXCR1-dependent innate immunity: insights into the genetics of urinary tract infections. Eur. J. Clin. Invest. 38 (Suppl. 2), 12\u201320 (2008).","journal-title":"Eur. J. Clin. Invest."},{"key":"BFnrurol2011192_CR46","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1086\/518893","volume":"196","author":"B Ragnarsdottir","year":"2007","unstructured":"Ragnarsdottir, B.  et al. Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria. J. Infect. Dis. 196, 475\u2013484 (2007).","journal-title":"J. Infect. Dis."},{"key":"BFnrurol2011192_CR47","doi-asserted-by":"publisher","first-page":"e10734","DOI":"10.1371\/journal.pone.0010734","volume":"5","author":"B Ragnarsdottir","year":"2010","unstructured":"Ragnarsdottir, B.  et al. Toll-like receptor 4 promoter polymorphisms: common TLR4 variants may protect against severe urinary tract infection. PLoS ONE 5, e10734 (2010).","journal-title":"PLoS ONE"},{"key":"BFnrurol2011192_CR48","doi-asserted-by":"publisher","first-page":"e8300","DOI":"10.1371\/journal.pone.0008300","volume":"4","author":"TR Hawn","year":"2009","unstructured":"Hawn, T. R.  et al. Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women. PLoS ONE 4, e8300 (2009).","journal-title":"PLoS ONE"},{"key":"BFnrurol2011192_CR49","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1086\/512620","volume":"195","author":"AC Lundstedt","year":"2007","unstructured":"Lundstedt, A. C.  et al. Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. J. Infect. Dis. 195, 1227\u20131234 (2007).","journal-title":"J. Infect. Dis."},{"key":"BFnrurol2011192_CR50","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1172\/JCI116650","volume":"92","author":"W Agace","year":"1993","unstructured":"Agace, W., Hedges, S., Ceska, M. & Svanborg, C. Interleukin-8 and the neutrophil response to mucosal gram-negative infection. J. Clin. Invest. 92, 780\u2013785 (1993).","journal-title":"J. Clin. Invest."},{"key":"BFnrurol2011192_CR51","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1016\/j.juro.2009.01.103","volume":"181","author":"M May","year":"2009","unstructured":"May, M.  et al. Post-void residual urine as a predictor of urinary tract infection--is there a cutoff value in asymptomatic men? J. Urol. 181, 2540\u20132544 (2009).","journal-title":"J. Urol."},{"key":"BFnrurol2011192_CR52","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.juro.2008.03.044","volume":"180","author":"JC Truzzi","year":"2008","unstructured":"Truzzi, J. C., Almeida, F. M., Nunes, E. C. & Sadi, M. V. Residual urinary volume and urinary tract infection-when are they linked? J. Urol. 180, 182\u2013185 (2008).","journal-title":"J. Urol."},{"key":"BFnrurol2011192_CR53","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.ajic.2009.12.009","volume":"38","author":"L Tsan","year":"2010","unstructured":"Tsan, L.  et al. Nursing home-associated infections in Department of Veterans Affairs community living centers. Am. J. Infect. Control 38, 461\u2013466 (2010).","journal-title":"Am. J. Infect. Control"},{"key":"BFnrurol2011192_CR54","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1001\/archinte.163.8.972","volume":"163","author":"MT Hecker","year":"2003","unstructured":"Hecker, M. T., Aron, D. C., Patel, N. P., Lehmann, M. K. & Donskey, C. J. Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity. Arch. Intern. Med. 163, 972\u2013978 (2003).","journal-title":"Arch. Intern. Med."},{"key":"BFnrurol2011192_CR55","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/1471-2334-11-187","volume":"11","author":"NL Werner","year":"2011","unstructured":"Werner, N. L., Hecker, M. T., Sethi, A. K. & Donskey, C. J. Unnecessary use of fluoroquinolone antibiotics in hospitalized patients. BMC Infect. Dis. 11, 187 (2011).","journal-title":"BMC Infect. Dis."},{"key":"BFnrurol2011192_CR56","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nrurol.2010.190","volume":"7","author":"B Foxman","year":"2010","unstructured":"Foxman, B. The epidemiology of urinary tract infection. Nat. Rev. Urol. 7, 653\u2013660 (2010).","journal-title":"Nat. Rev. Urol."},{"key":"BFnrurol2011192_CR57","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1086\/598184","volume":"48","author":"JH Powers","year":"2009","unstructured":"Powers, J. H. Risk perception and inappropriate antimicrobial use: yes, it can hurt. Clin. Infect. Dis. 48, 1350\u20131353 (2009).","journal-title":"Clin. Infect. Dis."},{"key":"BFnrurol2011192_CR58","doi-asserted-by":"publisher","first-page":"46","DOI":"10.7326\/0003-4819-56-1-46","volume":"56","author":"EH Kass","year":"1962","unstructured":"Kass, E. H. Pyelonephritis and bacteriuria. A major problem in preventive medicine. Ann. Intern. Med. 56, 46\u201353 (1962).","journal-title":"Ann. Intern. Med."},{"key":"BFnrurol2011192_CR59","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1056\/NEJM198605013141804","volume":"314","author":"GR Nordenstam","year":"1986","unstructured":"Nordenstam, G. R., Brandberg, C. A., Oden, A. S., Svanborg Eden, C. M. & Svanborg, A. Bacteriuria and mortality in an elderly population. N. Engl. J. Med. 314, 1152\u20131156 (1986).","journal-title":"N. Engl. J. Med."},{"key":"BFnrurol2011192_CR60","first-page":"673","volume":"160","author":"PA Tambyah","year":"2000","unstructured":"Tambyah, P. A. & Maki, D. G. The relationship between pyuria and infection in patients with indwelling urinary catheters: a prospective study of 761 patients. Arch. Intern. Med. 160, 673\u2013677 (2000).","journal-title":"Arch. Intern. Med."},{"key":"BFnrurol2011192_CR61","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1155\/2009\/702545","volume":"20","author":"SA Silver","year":"2009","unstructured":"Silver, S. A., Baillie, L. & Simor, A. E. Positive urine cultures: A major cause of inappropriate antimicrobial use in hospitals? Can. J. Infect. Dis. Med. Microbiol. 20, 107\u2013111 (2009).","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"BFnrurol2011192_CR62","first-page":"273","volume":"163","author":"S Walker","year":"2000","unstructured":"Walker, S., McGeer, A., Simor, A. E., Armstrong-Evans, M. & Loeb, M. Why are antibiotics prescribed for asymptomatic bacteriuria in institutionalized elderly people? A qualitative study of physicians' and nurses' perceptions. CMAJ 163, 273\u2013277 (2000).","journal-title":"CMAJ"},{"key":"BFnrurol2011192_CR63","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1532-5415.2007.01533.x","volume":"56","author":"PJ Drinka","year":"2008","unstructured":"Drinka, P. J. & Crnich, C. J. Diagnostic accuracy of criteria for urinary tract infection in a cohort of nursing home residents. J. Am. Geriatr. Soc. 56, 376\u2013378 (2008).","journal-title":"J. Am. Geriatr. Soc."},{"key":"BFnrurol2011192_CR64","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1093\/infdis\/146.6.719","volume":"146","author":"JW Warren","year":"1982","unstructured":"Warren, J. W., Tenney, J. H., Hoopes, J. M., Muncie, H. L. & Anthony, W. C. A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J. Infect. Dis. 146, 719\u2013723 (1982).","journal-title":"J. Infect. Dis."},{"key":"BFnrurol2011192_CR65","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/S0891-5520(05)70378-0","volume":"11","author":"L Nicolle","year":"1997","unstructured":"Nicolle, L. Asymptomatic bacteriuria in the elderly. Infect. Dis. Clin. N. Am. 11, 647\u2013662 (1997).","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"BFnrurol2011192_CR66","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0002-9343(96)90014-5","volume":"100","author":"P Orr","year":"1996","unstructured":"Orr, P.  et al. Febrile urinary tract infection in the institutionalized elderly. Am. J. Med. 100, 71\u201377 (1996).","journal-title":"Am. J. Med."},{"key":"BFnrurol2011192_CR67","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/infdis\/155.6.1151","volume":"155","author":"J Warren","year":"1987","unstructured":"Warren, J.  et al. Fever, bacteremia, and death as complications of bacteriuria in women with long-term urethral catheters. J. Infect. Dis. 155, 1151\u20131158 (1987).","journal-title":"J. Infect. Dis."},{"key":"BFnrurol2011192_CR68","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.jamda.2008.04.004","volume":"9","author":"C Bonnal","year":"2008","unstructured":"Bonnal, C.  et al. Bacteriuria in a geriatric hospital: impact of an antibiotic improvement program. J. Am. Med. Dir. Assoc. 9, 605\u2013609 (2008).","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"BFnrurol2011192_CR69","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1086\/660764","volume":"32","author":"LA Linares","year":"2011","unstructured":"Linares, L. A., Thornton, D. J., Strymish, J., Baker, E. & Gupta, K. Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria. Infect. Control Hosp. Epidemiol. 32, 644\u2013648 (2011).","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"BFnrurol2011192_CR70","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/bmj.38602.586343.55","volume":"331","author":"M Loeb","year":"2005","unstructured":"Loeb, M.  et al. Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomised controlled trial. BMJ 331, 669 (2005).","journal-title":"BMJ"},{"key":"BFnrurol2011192_CR71","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1086\/597514","volume":"30","author":"P Pavese","year":"2009","unstructured":"Pavese, P.  et al. Does an educational session with an infectious diseases physician reduce the use of inappropriate antibiotic therapy for inpatients with positive urine culture results? A controlled before-and-after study. Infect. Control Hosp. Epidemiol. 30, 596\u2013599 (2009).","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"BFnrurol2011192_CR72","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ajic.2007.11.007","volume":"36","author":"TF Zabarsky","year":"2008","unstructured":"Zabarsky, T. F., Sethi, A. K. & Donskey, C. J. Sustained reduction in inappropriate treatment of asymptomatic bacteriuria in a long-term care facility through an educational intervention. Am. J. Infect. Control 36, 476\u2013480 (2008).","journal-title":"Am. J. Infect. Control"},{"key":"BFnrurol2011192_CR73","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1532-5415.2004.52019.x","volume":"52","author":"M Lutters","year":"2004","unstructured":"Lutters, M.  et al. Effect of a comprehensive, multidisciplinary, educational program on the use of antibiotics in a geriatric university hospital. J. Am. Geriatr. Soc. 52, 112\u2013116 (2004).","journal-title":"J. Am. Geriatr. Soc."},{"key":"BFnrurol2011192_CR74","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1111\/j.1532-5415.2007.01250.x","volume":"55","author":"J Monette","year":"2007","unstructured":"Monette, J.  et al. Effect of an educational intervention on optimizing antibiotic prescribing in long-term care facilities. J. Am. Geriatr. Soc. 55, 1231\u20131235 (2007).","journal-title":"J. Am. Geriatr. Soc."},{"key":"BFnrurol2011192_CR75","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1111\/j.1532-5415.2007.01251.x","volume":"55","author":"DN Schwartz","year":"2007","unstructured":"Schwartz, D. N.  et al. An educational intervention to improve antimicrobial use in a hospital-based long-term care facility. J. Am. Geriatr. Soc. 55, 1236\u20131242 (2007).","journal-title":"J. Am. Geriatr. Soc."},{"issue":"Suppl. 1","key":"BFnrurol2011192_CR76","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1016\/j.ijantimicag.2006.05.010","volume":"28","author":"LE Nicolle","year":"2006","unstructured":"Nicolle, L. E. Asymptomatic bacteriuria: review and discussion of the IDSA guidelines. Int. J. Antimicrob. Agents 28 (Suppl. 1), S42\u2013S48 (2006).","journal-title":"Int. J. Antimicrob. Agents"},{"key":"BFnrurol2011192_CR77","doi-asserted-by":"crossref","unstructured":"Smaill, F. & Vazquez, J. C. Antibiotics for asymptomatic bacteriuria in pregnancy. Cochrane Database of Systematic Reviews, Issue 2. Art. No.: CD000490. doi:10.1002\/14651858.CD000490.pub2 (2007).","DOI":"10.1002\/14651858.CD000490.pub2"},{"key":"BFnrurol2011192_CR78","doi-asserted-by":"crossref","unstructured":"Guinto, V. T., De Guia, B., Festin, M. R. & Dowswell, T. Different antibiotic regimens for treating asymptomatic bacteriuria in pregnancy. Cochrane Database of Systematic Reviews, Issue 9. Art. No.: CD007855. doi:10.1002\/14651858.CD007855.pub2 (2010).","DOI":"10.1002\/14651858.CD007855.pub2"},{"key":"BFnrurol2011192_CR79","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/AOG.0b013e318195c2a2","volume":"113","author":"P Lumbiganon","year":"2009","unstructured":"Lumbiganon, P.  et al. One-day compared with 7-day nitrofurantoin for asymptomatic bacteriuria in pregnancy: a randomized controlled trial. Obstet. Gynecol. 113, 339\u2013345 (2009).","journal-title":"Obstet. Gynecol."},{"key":"BFnrurol2011192_CR80","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF02097183","volume":"6","author":"M Grabe","year":"1987","unstructured":"Grabe, M., Forsgren, A., Bjork, T. & Hellsten, S. Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery. Eur. J. Clin. Microbiol. 6, 11\u201317 (1987).","journal-title":"Eur. J. Clin. Microbiol."},{"key":"BFnrurol2011192_CR81","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.eururo.2008.03.033","volume":"54","author":"AM Bootsma","year":"2008","unstructured":"Bootsma, A. M., Laguna Pes, M. P., Geerlings, S. E. & Goossens, A. Antibiotic prophylaxis in urologic procedures: a systematic review. Eur. Urol. 54, 1270\u20131286 (2008).","journal-title":"Eur. Urol."},{"key":"BFnrurol2011192_CR82","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.juro.2008.01.068","volume":"179","author":"JS Wolf Jr","year":"2008","unstructured":"Wolf, J. S. Jr  et al. Best practice policy statement on urologic surgery antimicrobial prophylaxis. J. Urol. 179, 1379\u20131390 (2008).","journal-title":"J. Urol."},{"key":"BFnrurol2011192_CR83","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.micinf.2004.05.016","volume":"6","author":"M Leone","year":"2004","unstructured":"Leone, M., Garnier, F., Avidan, M. & Martin, C. Catheter-associated urinary tract infections in intensive care units. Microbes Infect. 6, 1026\u20131032 (2004).","journal-title":"Microbes Infect."},{"key":"BFnrurol2011192_CR84","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/sur.2007.023","volume":"9","author":"JF Golob Jr","year":"2008","unstructured":"Golob, J. F. Jr  et al. Fever and leukocytosis in critically ill trauma patients: it's not the urine. Surg. Infect. (Larchmt.) 9, 49\u201356 (2008).","journal-title":"Surg. Infect. (Larchmt.)"},{"key":"BFnrurol2011192_CR85","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1097\/CCM.0b013e31820a8581","volume":"39","author":"C Chant","year":"2011","unstructured":"Chant, C., Smith, O. M., Marshall, J. C. & Friedrich, J. O. Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies. Crit. Care Med. 39, 1167\u20131173 (2011).","journal-title":"Crit. Care Med."},{"key":"BFnrurol2011192_CR86","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1007\/s00134-007-0534-1","volume":"33","author":"M Leone","year":"2007","unstructured":"Leone, M.  et al. A randomized trial of catheter change and short course of antibiotics for asymptomatic bacteriuria in catheterized ICU patients. Intensive Care Med. 33, 726\u2013729 (2007).","journal-title":"Intensive Care Med."},{"key":"BFnrurol2011192_CR87","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1097\/CCM.0b013e3181692af9","volume":"36","author":"C Chant","year":"2008","unstructured":"Chant, C.  et al. Discordance between perception and treatment practices associated with intensive care unit-acquired bacteriuria and funguria: a Canadian physician survey. Crit. Care Med. 36, 1158\u20131167 (2008).","journal-title":"Crit. Care Med."},{"key":"BFnrurol2011192_CR88","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1093\/ndt\/gfq531","volume":"26","author":"S Fiorante","year":"2011","unstructured":"Fiorante, S.  et al. Acute graft pyelonephritis in renal transplant recipients: incidence, risk factors and long-term outcome. Nephrol. Dial. Transplant. 26, 1065\u20131073 (2011).","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnrurol2011192_CR89","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/ki.2010.286","volume":"78","author":"S Fiorante","year":"2010","unstructured":"Fiorante, S.  et al. Systematic screening and treatment of asymptomatic bacteriuria in renal transplant recipients. Kidney Int. 78, 774\u2013781 (2010).","journal-title":"Kidney Int."},{"key":"BFnrurol2011192_CR90","doi-asserted-by":"crossref","unstructured":"Ei Amari, E. B.  et al. Outcome of treated and untreated asymptomatic bacteriuria in renal transplant recipients. Nephrol. Dial. Transplant doi:10.1093\/ndt\/gfr198 (2011).","DOI":"10.1093\/ndt\/gfr198"},{"key":"BFnrurol2011192_CR91","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1399-3062.2011.00644.x","volume":"13","author":"H Green","year":"2011","unstructured":"Green, H., Rahamimov, R., Gafter, U., Leibovitci, L. & Paul, M. Antibiotic prophylaxis for urinary tract infections in renal transplant recipients: a systematic review and meta-analysis. Transpl. Infect. Dis. 13, 441\u2013447 (2011).","journal-title":"Transpl. Infect. Dis."},{"key":"BFnrurol2011192_CR92","unstructured":"US National Library of Medicine Clinicaltrials.gov \n                    [online]\n                    \n                  , (2011)."},{"key":"BFnrurol2011192_CR93","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1111\/j.1464-410X.2007.07366.x","volume":"101","author":"F Suriano","year":"2008","unstructured":"Suriano, F.  et al. Bacteriuria in patients with an orthotopic ileal neobladder: urinary tract infection or asymptomatic bacteriuria? BJU Int. 101, 1576\u20131579 (2008).","journal-title":"BJU Int."},{"key":"BFnrurol2011192_CR94","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.eururo.2006.02.012","volume":"50","author":"B Wullt","year":"2006","unstructured":"Wullt, B.  et al. Mucosal host responses to bacteriuria in colonic and ileal neobladders. Eur. Urol. 50, 1065\u20131072 (2006).","journal-title":"Eur. Urol."},{"issue":"Suppl. 1","key":"BFnrurol2011192_CR95","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.3949\/ccjm.74.Electronic_Suppl_1.S17","volume":"74","author":"A Rajamanickam","year":"2007","unstructured":"Rajamanickam, A., Noor, S. & Usmani, A. Should an asymptomatic patient with an abnormal urinalysis (bacteriuria or pyuria) be treated with antibiotics prior to major joint replacement surgery? Cleve. Clin. J. Med. 74 (Suppl. 1), S17\u2013S18 (2007).","journal-title":"Cleve. Clin. J. Med."},{"key":"BFnrurol2011192_CR96","first-page":"665","volume":"63","author":"AB Wymenga","year":"1992","unstructured":"Wymenga, A. B., van Horn, J. R., Theeuwes, A., Muytjens, H. L. & Slooff, T. J. Perioperative factors associated with septic arthritis after arthroplasty. Prospective multicenter study of 362 knee and 2651 hip operations. Acta Orthop. Scand. 63, 665\u2013671 (1992).","journal-title":"Acta Orthop. Scand."},{"key":"BFnrurol2011192_CR97","unstructured":"Lin, E., Bhusal, Y., Horwitz, D., Shelburne, S. & Trautner, B. Enterococcal bacteriuria is often overtreated and rarely leads to infectious complications. Arch. Intern. Med. (in press)."}],"container-title":["Nature Reviews Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2011.192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2011.192","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2011.192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:48:42Z","timestamp":1684457322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrurol.2011.192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,6]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["BFnrurol2011192"],"URL":"https:\/\/doi.org\/10.1038\/nrurol.2011.192","relation":{},"ISSN":["1759-4812","1759-4820"],"issn-type":[{"value":"1759-4812","type":"print"},{"value":"1759-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,6]]}}}