{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:46:55Z","timestamp":1781740015034,"version":"3.54.5"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T00:00:00Z","timestamp":1402963200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Urol"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1038\/nrurol.2014.132","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T10:49:20Z","timestamp":1403002160000},"page":"412-419","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fetal therapy for the treatment of congenital bladder neck obstruction"],"prefix":"10.1038","volume":"11","author":[{"given":"Mark D.","family":"Kilby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Katie","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,17]]},"reference":[{"key":"BFnrurol2014132_CR1","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.siny.2007.09.011","volume":"13","author":"MA Lewis","year":"2008","unstructured":"Lewis, M. A. Demography of renal disease in childhood. Semin. Fetal Neonatal Med. 13, 118\u2013124 (2008).","journal-title":"Semin. Fetal Neonatal Med."},{"key":"BFnrurol2014132_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.juro.2007.08.160","volume":"179","author":"O Sarhan","year":"2008","unstructured":"Sarhan, O. et al. Long-term outcome of prenatally detected posterior urethral valves: single center study of 65 cases managed by primary valve ablation. J. Urol. 179, 307\u2013312 (2008).","journal-title":"J. Urol."},{"key":"BFnrurol2014132_CR3","first-page":"874","volume":"19","author":"E Ylinen","year":"2004","unstructured":"Ylinen, E., Ala-Houhala, M. & Wikstr\u00f6m, S. Prognostic factors of posterior urethral valves and the role of antenatal detection. Pediatr. Nephrol. 19, 874\u2013879 (2004).","journal-title":"Pediatr. Nephrol."},{"key":"BFnrurol2014132_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1464-410X.1988.tb04267.x","volume":"62","author":"HF Parkhouse","year":"1988","unstructured":"Parkhouse, H. F. et al. Long-term outcome of boys with posterior urethral valves. Br. J. Urol. 62, 59\u201362 (1988).","journal-title":"Br. J. Urol."},{"key":"BFnrurol2014132_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/pd.1074","volume":"25","author":"DO Anumba","year":"2005","unstructured":"Anumba, D. O., Scott J. E., Plant, N. D. & Robson S. C. Diagnosis and outcome of fetal lower urinary tract obstruction in the northern region of England. Prenat. Diagn. 25, 7\u201313 (2005).","journal-title":"Prenat. Diagn."},{"key":"BFnrurol2014132_CR6","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1111\/j.1471-0528.2012.03476.x","volume":"119","author":"G Malin","year":"2012","unstructured":"Malin G., Tonks, A. M., Morris R. K., Gardosi J. & Kilby, M. D. Congenital lower urinary tract obstruction: a population-based epidemiological study. BJOG 119, 1455\u20131464 (2012).","journal-title":"BJOG"},{"key":"BFnrurol2014132_CR7","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0378-3782(86)90167-2","volume":"14","author":"WF Knox","year":"1986","unstructured":"Knox, W. F. & Barson, A. J. Pulmonary hypoplasia in a regional perinatal unit. Early Hum. Dev. 14, 33\u201342 (1986).","journal-title":"Early Hum. Dev."},{"key":"BFnrurol2014132_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/uog.81","volume":"21","author":"AW Liao","year":"2003","unstructured":"Liao, A. W., Sebire, N. J., Geerts, L., Cicero, S. & Nicolaides, K. H. Megacystis at 10\u201314 weeks of gestation: chromosomal defects and outcome according to bladder length. Ultrasound Obstet. Gynecol. 21, 338\u2013341 (2003).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"BFnrurol2014132_CR9","doi-asserted-by":"publisher","first-page":"743","DOI":"10.7863\/jum.1998.17.12.743","volume":"17","author":"H Montemarano","year":"1998","unstructured":"Montemarano, H., Bulas, D. I., Rushton, H. G. & Selby, D. Bladder distension and pyelectasis in the male fetus: causes, comparisons, and contrasts. J. Ultrasound Med. 17, 743\u2013749 (1998).","journal-title":"J. Ultrasound Med."},{"key":"BFnrurol2014132_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.siny.2007.10.002","volume":"13","author":"J Yiee","year":"2008","unstructured":"Yiee, J. & Wilcox, D. Abnormalities of the fetal bladder. Semin. Fetal Neonatal Med. 13, 164\u2013170 (2008).","journal-title":"Semin. Fetal Neonatal Med."},{"key":"BFnrurol2014132_CR11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0029-7844(96)00211-6","volume":"88","author":"EA Wickstrom","year":"1996","unstructured":"Wickstrom, E. A., Thangavelu, M., Parilla, B. V., Tamura, R. K. & Sabbagha, R. E. A prospective study of the association between isolated fetal pyelectasis and chromosome abnormality. Obstet. Gynecol. 88, 379\u2013382 (1996).","journal-title":"Obstet. Gynecol."},{"key":"BFnrurol2014132_CR12","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1046\/j.1469-0705.1999.14060402.x","volume":"14","author":"R Favre","year":"1999","unstructured":"Favre R., Kohler, M., Gasser, B., Muller, F. & Nisand, I. Early fetal megacystis between 11 and 15 weeks of gestation. Ultrasound Obstet. Gynecol. 14, 402\u2013406 (1999).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"BFnrurol2014132_CR13","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ajhg.2011.10.007","volume":"89","author":"S Weber","year":"2011","unstructured":"Weber, S. et al. Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome. Am. J. Hum. Genet. 89, 668\u2013674 (2011).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnrurol2014132_CR14","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1111\/j.1471-0528.2009.02194.x","volume":"116","author":"RK Morris","year":"2009","unstructured":"Morris, R. K., Malin G. L., Khan, K. S. & Kilby, M. D. Antenatal ultrasound to predict postnatal renal function in congenital lower urinary tract obstruction: systematic review of test accuracy. BJOG 116, 1290\u20131299 (2009).","journal-title":"BJOG"},{"key":"BFnrurol2014132_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.siny.2007.10.003","volume":"13","author":"DF Thomas","year":"2008","unstructured":"Thomas, D. F. Prenatally diagnosed urinary tract abnormalities: long-term outcome. Semin. Fetal Neonatal Med. 13, 189\u2013195 (2008).","journal-title":"Semin. Fetal Neonatal Med."},{"key":"BFnrurol2014132_CR16","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.jpedsurg.2010.12.010","volume":"46","author":"LS Bernardes","year":"2011","unstructured":"Bernardes, L. S., Salomon, R., Aksnes, G., Lortat-Jacob, S. & Benachi, A. Ultrasound evaluation of prognosis in fetuses with posterior urethral valves. J. Pediatr. Surg. 46, 1412\u20131418 (2011).","journal-title":"J. Pediatr. Surg."},{"key":"BFnrurol2014132_CR17","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0002-9378(12)91847-5","volume":"170","author":"MP Johnson","year":"1994","unstructured":"Johnson, M. P. et al. In utero surgical treatment of fetal obstructive uropathy: a new comprehensive approach to identify appropriate candidates for vesicoamniotic shunt therapy. Am. J. Obstet. Gynecol. 170, 1770\u20131776 (1994).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrurol2014132_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0002-9378(95)90170-1","volume":"173","author":"MP Johnson","year":"1995","unstructured":"Johnson, M. P. et al. Sequential urinalysis improves evaluation of fetal renal function in obstructive uropathy. Am. J. Obstet. Gynecol. 173, 59\u201365 (1995).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrurol2014132_CR19","first-page":"813","volume":"82","author":"F Muller","year":"1993","unstructured":"Muller, F. et al. Fetal urinary biochemistry predicts postnatal renal function in children with bilateral obstructive uropathies. Obstet. Gynecol. 82, 813\u2013820 (1993).","journal-title":"Obstet. Gynecol."},{"key":"BFnrurol2014132_CR20","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1046\/j.1523-1755.2000.00167.x","volume":"58","author":"M Dommergues","year":"2000","unstructured":"Dommergues, M. et al. Fetal serum \u03b22-microglobulin predicts postnatal renal function in bilateral uropathies. Kidney Int. 58, 312\u2013316 (2000).","journal-title":"Kidney Int."},{"key":"BFnrurol2014132_CR21","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1002\/pd.1810","volume":"27","author":"RK Morris","year":"2007","unstructured":"Morris R. K., Quinlan-Jones, E., Kilby, M. D. & Khan, K. S. Systematic review of accuracy of fetal urine analysis to predict poor postnatal renal function in cases of congenital urinary tract obstruction. Prenat. Diagn. 27, 900\u2013911 (2007).","journal-title":"Prenat. Diagn."},{"key":"BFnrurol2014132_CR22","doi-asserted-by":"publisher","first-page":"198ra106","DOI":"10.1126\/scitranslmed.3005807","volume":"5","author":"J Klein","year":"2013","unstructured":"Klein, J. et al. Fetal urinary peptides to predict postnatal outcome of renal disease in fetuses with posterior urethral valves (PUV). Sci. Transl. Med. 5, 198ra106 (2013).","journal-title":"Sci. Transl. Med."},{"key":"BFnrurol2014132_CR23","first-page":"328","volume-title":"The Unborn Patient: Prenatal diagnosis and treatment","author":"MR Harrison","year":"1990","unstructured":"Harrison, M. R. & Filly, R. A. in The Unborn Patient: Prenatal diagnosis and treatment 2nd edn (eds Harrison, M. R., Goldbus, M. & Filly, R. A.) 328\u2013402 (Saunders, 1990)."},{"key":"BFnrurol2014132_CR24","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/S0022-3468(82)80476-4","volume":"17","author":"MR Harrison","year":"1982","unstructured":"Harrison, M. R., Nakayama, D. K., Noall, R. & de Lorimier, A. A. Correction of congenital hydronephrosis in utero II. Decompression reverses the effects of obstruction of the fetal lung and urinary tract. J. Pediatr. Surg. 17, 965\u2013974 (1982).","journal-title":"J. Pediatr. Surg."},{"key":"BFnrurol2014132_CR25","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0022-3468(83)80003-7","volume":"18","author":"PL Glick","year":"1983","unstructured":"Glick, P. L., Harrison, M. R., Noall, R. A. & Villa, R. L. Correction of congenital hydronephrosis in utero III. Early mid-trimester ureteral obstruction produces renal dysplasia. J. Pediatr. Surg. 18, 681\u2013687 (1983).","journal-title":"J. Pediatr. Surg."},{"key":"BFnrurol2014132_CR26","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0022-3468(83)80094-3","volume":"18","author":"MR Harrison","year":"1983","unstructured":"Harrison, M. R., Ross, N., Noall, R. & de Lorimier, A. A. Correction of congenital hydronephrosis in utero I. The model: fetal urethral obstruction produces hydronephrosis and pulmonary hypoplasia in fetal lambs. J. Pediatr. Surg. 18, 247\u2013256 (1983).","journal-title":"J. Pediatr. Surg."},{"key":"BFnrurol2014132_CR27","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1016\/S0022-3468(88)80325-7","volume":"23","author":"TM Crombleholme","year":"1988","unstructured":"Crombleholme, T. M. et al. Early experience with open fetal surgery for congenital hydronephrosis. J. Pediatr. Surg. 23, 1114\u20131121 (1988).","journal-title":"J. Pediatr. Surg."},{"key":"BFnrurol2014132_CR28","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1159\/000111585","volume":"23","author":"MS Clifton","year":"2008","unstructured":"Clifton, M. S., Harrison, M. R., Ball, R. & Lee, H. Fetoscopic transuterine release of posterior urethral valves: a new technique. Fetal Diagn. Ther. 23, 89\u201394 (2008).","journal-title":"Fetal Diagn. Ther."},{"key":"BFnrurol2014132_CR29","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1056\/NEJM198607313150532","volume":"315","author":"FA Manning","year":"1986","unstructured":"Manning, F. A., Harrison, M. R. & Rodeck, C. Catheter shunts for fetal hydronephrosis and hydrocephalus. Report of the International Fetal Surgery Registry. N. Engl. J. Med. 315, 336\u2013340 (1986).","journal-title":"N. Engl. J. Med."},{"key":"BFnrurol2014132_CR30","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1471-0528.2010.02500.x","volume":"117","author":"RK Morris","year":"2010","unstructured":"Morris, R. K., Malin G. L., Khan, K. S. & Kilby, M. D. Systematic review of the effectiveness of antenatal intervention for the treatment of congenital lower urinary tract obstruction. BJOG 117, 382\u2013390 (2010).","journal-title":"BJOG"},{"key":"BFnrurol2014132_CR31","first-page":"367","volume":"102","author":"TJ Clark","year":"2003","unstructured":"Clark, T. J. et al. Prenatal bladder drainage in the management of fetal lower urinary tract obstruction: a systematic review and meta-analysis. Obstet. Gynecol. 102, 367\u2013382 (2003).","journal-title":"Obstet. Gynecol."},{"key":"BFnrurol2014132_CR32","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nrurol.2012.9","volume":"9","author":"DB Clayton","year":"2012","unstructured":"Clayton, D. B. & Brock, J. W. 3rd. In utero intervention for urologic diseases. Nat. Rev. Urol. 9, 207\u2013217 (2012).","journal-title":"Nat. Rev. Urol."},{"key":"BFnrurol2014132_CR33","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/S0140-6736(95)91381-5","volume":"346","author":"RA Quintero","year":"1995","unstructured":"Quintero, R. A. et al. In-utero percutaneous cystoscopy in the management of fetal lower obstructive uropathy. Lancet 346, 537\u2013540 (1995).","journal-title":"Lancet"},{"key":"BFnrurol2014132_CR34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/pd.2418","volume":"30","author":"R Ruano","year":"2010","unstructured":"Ruano, R. et al. Fetal cystoscopy for severe lower urinary tract obstruction\u2014initial experience of a single center. Prenat. Diagn. 30, 30\u201339 (2010).","journal-title":"Prenat. Diagn."},{"key":"BFnrurol2014132_CR35","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/0002-9378(95)90115-9","volume":"172","author":"RA Quintero","year":"1995","unstructured":"Quintero, R. A. et al. Percutaneous fetal cystoscopy and endoscopic fulguration of posterior urethral valves. Am. J. Obstet. Gynecol. 172, 206\u2013209 (1995).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"BFnrurol2014132_CR36","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1002\/pd.717","volume":"23","author":"A Welsh","year":"2003","unstructured":"Welsh, A., Agarwal, S., Kumar, S., Smith, R. P. & Fisk, N. M. Fetal cystoscopy in the management of fetal obstructive uropathy: experience in a single European centre. Prenat. Diagn. 23, 1033\u20131041 (2003).","journal-title":"Prenat. Diagn."},{"key":"BFnrurol2014132_CR37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/uog.8981","volume":"37","author":"RK Morris","year":"2011","unstructured":"Morris, R. K., Ruano, R. & Kilby, M. D. Effectiveness of fetal cystoscopy as a diagnostic and therapeutic intervention for lower urinary tract obstruction: a systematic review. Ultrasound Obstet. Gynecol. 37, 629\u2013637 (2011).","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"BFnrurol2014132_CR38","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1016\/S0140-6736(13)60992-7","volume":"382","author":"RK Morris","year":"2013","unstructured":"Morris, R. K. et al. Percutaneous vesicoamniotic shunting versus conservative management for lower urinary tract obstruction (PLUTO): a randomised trial. Lancet 382, 1496\u20131506 (2013).","journal-title":"Lancet"},{"key":"BFnrurol2014132_CR39","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.ejogrb.2010.04.019","volume":"152","author":"C Brown","year":"2010","unstructured":"Brown, C. et al. Effectiveness of percutaneous vesico-amniotic shunting in congenital lower urinary tract obstruction: divergence in prior beliefs among specialist groups. Eur. J. Obstet. Gynecol. Reprod. Biol. 152, 25\u201329 (2010).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"BFnrurol2014132_CR40","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/S0140-6736(85)91775-1","volume":"325","author":"KI Pritchard","year":"1985","unstructured":"Pritchard, K. I. et al. Clinical uses of Bayesian probability. Lancet 325, 993\u2013994 (1985).","journal-title":"Lancet"},{"key":"BFnrurol2014132_CR41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1023\/A:1008929526011","volume":"10","author":"DJ Lunn","year":"2000","unstructured":"Lunn, D. J., Thomas, A., Best, N. & Spiegelhalter, D. WinBUGS\u2014A Bayesian modelling framework: Concepts, structure, and extensibility. Statistics Computing 10, 325\u2013337 (2000).","journal-title":"Statistics Computing"},{"key":"BFnrurol2014132_CR42","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/01.AOG.0000171117.38929.eb","volume":"106","author":"JM Biard","year":"2005","unstructured":"Biard, J. M. et al. Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction. Obstet. Gynecol. 106, 503\u2013508 (2005).","journal-title":"Obstet. Gynecol."},{"key":"BFnrurol2014132_CR43","doi-asserted-by":"publisher","unstructured":"Denny, E., Quinlan-Jones, E., Bibila, S. & Kilby, M. D. The experience of pregnant women with a diagnosis of fetal lower urinary tract obstruction (LUTO). Midwifery http:\/\/dx.doi.org\/10.1016\/j.midw.2013.10.023 .","DOI":"10.1016\/j.midw.2013.10.023"}],"container-title":["Nature Reviews Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2014.132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2014.132","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2014.132.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T05:00:16Z","timestamp":1684472416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrurol.2014.132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,17]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["BFnrurol2014132"],"URL":"https:\/\/doi.org\/10.1038\/nrurol.2014.132","relation":{},"ISSN":["1759-4812","1759-4820"],"issn-type":[{"value":"1759-4812","type":"print"},{"value":"1759-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,17]]},"assertion":[{"value":"17 June 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}