{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:18:38Z","timestamp":1770229118272,"version":"3.49.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Urol"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1038\/nrurol.2016.249","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T15:51:52Z","timestamp":1480434712000},"page":"69-70","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New insights into interstitial cystitis and chronic pelvic pain syndromes"],"prefix":"10.1038","volume":"14","author":[{"given":"Jia-Fong","family":"Jhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,29]]},"reference":[{"key":"BFnrurol2016249_CR1","doi-asserted-by":"publisher","first-page":"e0143316","DOI":"10.1371\/journal.pone.0143316","volume":"10","author":"D Maeda","year":"2015","unstructured":"Maeda, D.  et al. Hunner-type (classic) interstitial cystitis: a distinct inflammatory disorder characterized by pancystitis, with frequent expansion of clonal B-cells and epithelial denudation. PLoS ONE 10, e0143316 (2015).","journal-title":"PLoS ONE"},{"key":"BFnrurol2016249_CR2","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.eururo.2016.02.058","volume":"70","author":"I Offiah","year":"2016","unstructured":"Offiah, I.  et al. The expression of inflammatory mediators in bladder pain syndrome. Eur. Urol. 70, 283\u2013290 (2016).","journal-title":"Eur. Urol."},{"key":"BFnrurol2016249_CR3","doi-asserted-by":"publisher","unstructured":"Doggweiler, R.  et al. A standard for terminology in chronic pelvic pain syndromes: a report from the chronic pelvic pain working group of the International Continence Society. Neurourol. Urodyn. \n                    http:\/\/dx.doi.org\/10.1002\/nau.23072\n                    \n                   (2016).","DOI":"10.1002\/nau.23072"},{"key":"BFnrurol2016249_CR4","doi-asserted-by":"publisher","first-page":"e91609","DOI":"10.1371\/journal.pone.0091609","volume":"9","author":"YH Jiang","year":"2014","unstructured":"Jiang, Y. H.  et al. Decrease of urinary nerve growth factor but not brain-derived neurotrophic factor in patients with interstitial cystitis\/bladder pain syndrome treated with hyaluronic acid. PLoS ONE 9, e91609 (2014).","journal-title":"PLoS ONE"},{"key":"BFnrurol2016249_CR5","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ebiom.2016.03.040","volume":"7","author":"KS Parker","year":"2016","unstructured":"Parker, K. S.  et al. Urinary metabolomics identifies a molecular correlate of interstitial cystitis\/bladder pain syndrome in a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network cohort. EBioMedicine 7, 167\u2013174 (2016).","journal-title":"EBioMedicine"},{"key":"BFnrurol2016249_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0165-6147(03)00023-3","volume":"24","author":"DS Reddy","year":"2003","unstructured":"Reddy, D. S. Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions? Trends Pharmacol. Sci. 24, 103\u2013106 (2003).","journal-title":"Trends Pharmacol. Sci."},{"key":"BFnrurol2016249_CR7","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/nau.22760","volume":"35","author":"HC Kuo","year":"2016","unstructured":"Kuo, H. C.  et al. Intravesical botulinum toxin-A injections reduce bladder pain of interstitial cystitis\/bladder pain syndrome refractory to conventional treatment \u2014 a prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial. Neurourol. Urodyn. 35, 609\u2013614 (2016).","journal-title":"Neurourol. Urodyn."},{"key":"BFnrurol2016249_CR8","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1464-410X.2012.11466.x","volume":"111","author":"JH Shie","year":"2013","unstructured":"Shie, J. H.  et al. Immunohistochemical evidence suggests repeated intravesical application of botulinum toxin A injections may improve treatment efficacy of interstitial cystitis\/bladder pain syndrome. BJU. Int. 111, 638\u2013646 (2013).","journal-title":"BJU. Int."},{"key":"BFnrurol2016249_CR9","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.juro.2016.03.003","volume":"196","author":"JC Nickel","year":"2016","unstructured":"Nickel, J. C.  et al. A phase II study of the efficacy and safety of the novel oral SHIP1 activator AQX-1125 in subjects with moderate to severe interstitial cystitis\/bladder pain syndrome. J. Urol. 196, 747\u2013754 (2016).","journal-title":"J. Urol."},{"key":"BFnrurol2016249_CR10","doi-asserted-by":"publisher","first-page":"e0153037","DOI":"10.1371\/journal.pone.0153037","volume":"12","author":"SC Lewis","year":"2016","unstructured":"Lewis, S. C.  et al. Gabapentin for the management of chronic pelvic pain in women (GaPP1): a pilot randomised controlled trial. PLoS ONE 12, e0153037 (2016).","journal-title":"PLoS ONE"}],"container-title":["Nature Reviews Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2016.249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2016.249","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2016.249.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:16:30Z","timestamp":1684469790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrurol.2016.249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,29]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["BFnrurol2016249"],"URL":"https:\/\/doi.org\/10.1038\/nrurol.2016.249","relation":{},"ISSN":["1759-4812","1759-4820"],"issn-type":[{"value":"1759-4812","type":"print"},{"value":"1759-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,29]]},"assertion":[{"value":"29 November 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}