{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:36:29Z","timestamp":1792805789341,"version":"4.5.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:00:00Z","timestamp":1500940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Rev Urol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1038\/nrurol.2017.119","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T10:51:03Z","timestamp":1500979863000},"page":"593-606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Low-intensity shockwave therapy for erectile dysfunction: is the evidence strong enough?"],"prefix":"10.1038","volume":"14","author":[{"name":"Young Academic Urologists Men's Health Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"BFnrurol2017119_CR1","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","volume":"57","author":"K Hatzimouratidis","year":"2010","unstructured":"Hatzimouratidis, K.  et al. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. Eur. Urol. 57, 804\u2013814 (2010).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR2","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/S0022-5347(05)64302-9","volume":"168","author":"DM Latini","year":"2002","unstructured":"Latini, D. M.  et al. Psychological impact of erectile dysfunction: validation of a new health related quality of life measure for patients with erectile dysfunction. J. Urol. 168, 2086\u20132091 (2002).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR3","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1097\/00005392-199805000-00037","volume":"159","author":"C Hanson-Divers","year":"1998","unstructured":"Hanson-Divers, C., Jackson, S. E., Lue, T. F., Crawford, S. Y. & Rosen, R. C. Health outcomes variables important to patients in the treatment of erectile dysfunction. J. Urol. 159, 1541\u20131547 (1998).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR4","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.eururo.2010.04.004","volume":"58","author":"Y Vardi","year":"2010","unstructured":"Vardi, Y., Appel, B., Jacob, G., Massarwi, O. & Gruenwald, I. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur. Urol. 58, 243\u2013248 (2010).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR5","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/smrj.9","volume":"1","author":"I Gruenwald","year":"2013","unstructured":"Gruenwald, I., Kitrey, N. D., Appel, B. & Vardi, Y. Low-intensity extracorporeal shock wave therapy in vascular disease and erectile dysfunction: theory and outcomes. Sexual Med. Rev. 1, 83\u201390 (2013).","journal-title":"Sexual Med. Rev."},{"key":"BFnrurol2017119_CR6","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/j.juro.2016.03.147","volume":"196","author":"R Assaly-Kaddoum","year":"2016","unstructured":"Assaly-Kaddoum, R.  et al. Low intensity extracorporeal shock wave therapy improves erectile function in a model of type II diabetes independently of NO\/cGMP pathway. J. Urol. 196, 950\u2013956 (2016).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR7","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1743-6109.2011.02498.x","volume":"9","author":"I Gruenwald","year":"2012","unstructured":"Gruenwald, I., Appel, B. & Vardi, Y. Low-intensity extracorporeal shock wave therapy \u2014 a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J. Sex. Med. 9, 259\u2013264 (2012).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR8","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.juro.2015.12.049","volume":"195","author":"ND Kitrey","year":"2016","unstructured":"Kitrey, N. D.  et al. Penile low intensity shock wave treatment is able to shift PDE5i nonresponders to responders: a double-blind, sham controlled study. J. Urol. 195, 1550\u20131555 (2016).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR9","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/9781444345148.ch49","volume-title":"Smith's Textbook of Endourology","author":"RO Cleveland","year":"2012","unstructured":"Cleveland, R. O. & McAteer, J. A. in Smith's Textbook of Endourology (eds Smith A. D., Preminger G., Badlani G. & Kavoussi L. R.) 527\u2013558 (Wiley-Blackwell, 2012)"},{"key":"BFnrurol2017119_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1177\/205873920601900104","volume":"19","author":"M Bongrazio","year":"2006","unstructured":"Bongrazio, M.  et al. Shear stress modulates the expression of thrombospondin-1 and CD36 in endothelial cells in vitro and during shear stress-induced angiogenesis in vivo. Int. J. Immunopathol. Pharmacol. 19, 35\u201348 (2006).","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"BFnrurol2017119_CR11","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1186\/s12929-016-0224-9","volume":"23","author":"D Belik","year":"2016","unstructured":"Belik, D.  et al. Endothelium-derived microparticles from chronically thromboembolic pulmonary hypertensive patients facilitate endothelial angiogenesis. J. Biomed. Sci. 23, 462 (2016).","journal-title":"J. Biomed. Sci."},{"key":"BFnrurol2017119_CR12","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/0301-5629(90)90005-W","volume":"16","author":"SR Young","year":"1990","unstructured":"Young, S. R. & Dyson, M. The effect of therapeutic ultrasound on angiogenesis. Ultrasound Med. Biol. 16, 261\u2013269 (1990).","journal-title":"Ultrasound Med. Biol."},{"key":"BFnrurol2017119_CR13","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.burns.2012.02.018","volume":"38","author":"O Goertz","year":"2012","unstructured":"Goertz, O.  et al. Extracorporeal shock waves improve angiogenesis after full thickness burn. Burns 38, 1010\u20131018 (2012).","journal-title":"Burns"},{"key":"BFnrurol2017119_CR14","doi-asserted-by":"publisher","first-page":"3055","DOI":"10.1161\/01.CIR.0000148849.51177.97","volume":"110","author":"T Nishida","year":"2004","unstructured":"Nishida, T.  et al. Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. Circulation 110, 3055\u20133061 (2004).","journal-title":"Circulation"},{"key":"BFnrurol2017119_CR15","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1161\/CIRCULATIONAHA.106.628623","volume":"114","author":"A Aicher","year":"2006","unstructured":"Aicher, A.  et al. Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia. Circulation 114, 2823\u20132830 (2006).","journal-title":"Circulation"},{"key":"BFnrurol2017119_CR16","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/S0736-0266(03)00104-9","volume":"21","author":"C-J Wang","year":"2003","unstructured":"Wang, C.-J.  et al. Shock wave therapy induces neovascularization at the tendon-bone junction. A study in rabbits. J. Orthop. Res. 21, 984\u2013989 (2003).","journal-title":"J. Orthop. Res."},{"key":"BFnrurol2017119_CR17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.orthres.2003.10.005","volume":"22","author":"Y-J Chen","year":"2004","unstructured":"Chen, Y.-J.  et al. Recruitment of mesenchymal stem cells and expression of TGF-\u03b21 and VEGF in the early stage of shock wave-promoted bone regeneration of segmental defect in rats. J. Orthop. Res. 22, 526\u2013534 (2004).","journal-title":"J. Orthop. Res."},{"key":"BFnrurol2017119_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1023\/B:HIJO.0000032355.66152.b8","volume":"35","author":"M Kucia","year":"2004","unstructured":"Kucia, M.  et al. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J. Mol. Histol. 35, 233\u2013245 (2004).","journal-title":"J. Mol. Histol."},{"key":"BFnrurol2017119_CR19","first-page":"201","volume":"123","author":"S Fuchs","year":"2010","unstructured":"Fuchs, S., Dohle, E., Kolbe, M. & Kirkpatrick, C. J. Outgrowth endothelial cells: sources, characteristics and potential applications in tissue engineering and regenerative medicine. Adv. Biochem. Eng. Biotechnol. 123, 201\u2013217 (2010).","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"BFnrurol2017119_CR20","first-page":"172","volume":"5","author":"O Seemann","year":"1993","unstructured":"Seemann, O., Rassweiler, J., Chvapil, M., Alken, P. & Drach, G. W. The effect of single shock waves on the vascular system of artificially perfused rabbit kidneys. J. Stone Dis. 5, 172\u2013178 (1993).","journal-title":"J. Stone Dis."},{"key":"BFnrurol2017119_CR21","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0014-5793(02)02807-7","volume":"520","author":"G Gotte","year":"2002","unstructured":"Gotte, G.  et al. Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment. FEBS Lett. 520, 153\u2013155 (2002).","journal-title":"FEBS Lett."},{"key":"BFnrurol2017119_CR22","first-page":"1106","volume":"7","author":"J-J Huang","year":"2015","unstructured":"Huang, J.-J.  et al. Angiogenesis effect of therapeutic ultrasound on HUVECs through activation of the PI3K-Akt-eNOS signal pathway. Am. J. Transl Res. 7, 1106\u20131115 (2015).","journal-title":"Am. J. Transl Res."},{"key":"BFnrurol2017119_CR23","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.1016\/j.febslet.2005.11.023","volume":"579","author":"AR Ciampa","year":"2005","unstructured":"Ciampa, A. R.  et al. Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves. FEBS Lett. 579, 6839\u20136845 (2005).","journal-title":"FEBS Lett."},{"key":"BFnrurol2017119_CR24","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.expneurol.2012.04.019","volume":"236","author":"T Hausner","year":"2012","unstructured":"Hausner, T.  et al. Improved rate of peripheral nerve regeneration induced by extracorporeal shock wave treatment in the rat. Exp. Neurol. 236, 363\u2013370 (2012).","journal-title":"Exp. Neurol."},{"key":"BFnrurol2017119_CR25","doi-asserted-by":"publisher","first-page":"138","DOI":"10.4103\/2394-8108.192520","volume":"2","author":"C Schuh","year":"2016","unstructured":"Schuh, C., Hausner T. & Redl H. R. A therapeutic shock propels Schwann cells to proliferate in peripheral nerve injury. Brain Circul. 2, 138 (2016).","journal-title":"Brain Circul."},{"key":"BFnrurol2017119_CR26","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/nrurol.2016.23","volume":"13","author":"A Castela","year":"2016","unstructured":"Castela, A. & Costa, C. Molecular mechanisms associated with diabetic endothelial\u2013erectile dysfunction. Nat. Rev. Urol. 13, 266\u2013274 (2016).","journal-title":"Nat. Rev. Urol."},{"key":"BFnrurol2017119_CR27","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1111\/jsm.12024","volume":"10","author":"X Qiu","year":"2013","unstructured":"Qiu, X.  et al. Effects of low-energy shockwave therapy on the erectile function and tissue of a diabetic rat model. J. Sex. Med. 10, 738\u2013746 (2013).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR28","doi-asserted-by":"publisher","first-page":"10661","DOI":"10.3390\/ijms140510661","volume":"14","author":"J Liu","year":"2013","unstructured":"Liu, J.  et al. Evaluation of the effect of different doses of low energy shock wave therapy on the erectile function of streptozotocin (STZ)-induced diabetic rats. IJMS 14, 10661\u201310673 (2013).","journal-title":"IJMS"},{"key":"BFnrurol2017119_CR29","doi-asserted-by":"publisher","first-page":"1241.e11","DOI":"10.1016\/j.urology.2015.07.026","volume":"86","author":"H Lei","year":"2015","unstructured":"Lei, H.  et al. Low-intensity pulsed ultrasound improves erectile function in streptozotocin-induced type I diabetic rats. Urology 86, 1241.e11 (2015).","journal-title":"Urology"},{"key":"BFnrurol2017119_CR30","doi-asserted-by":"publisher","first-page":"e0144734","DOI":"10.1371\/journal.pone.0144734","volume":"10","author":"J Wang","year":"2015","unstructured":"Wang, J.  et al. Kinetics of label retaining cells in the developing rat kidneys. PLoS ONE 10, e0144734 (2015).","journal-title":"PLoS ONE"},{"key":"BFnrurol2017119_CR31","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1177\/002203458106000311011","volume":"60","author":"JR Bickenbach","year":"1981","unstructured":"Bickenbach, J. R. Identification and behavior of label-retaining cells in oral mucosa and skin. J. Dent. Res. 60, 1611\u20131620 (1981).","journal-title":"J. Dent. Res."},{"key":"BFnrurol2017119_CR32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jsxm.2015.11.008","volume":"13","author":"H Li","year":"2016","unstructured":"Li, H.  et al. Low-energy shock wave therapy ameliorates erectile dysfunction in a pelvic neurovascular injuries rat model. J. Sex. Med. 13, 22\u201332 (2016).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR33","doi-asserted-by":"publisher","first-page":"F29","DOI":"10.1152\/ajprenal.00538.2014","volume":"308","author":"BD Humphreys","year":"2015","unstructured":"Humphreys, B. D. Cutting to the chase: taking the pulse of label-retaining cells in kidney. Am. J. Physiol. Renal Physiol. 308, F29\u2013F30 (2015)","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"BFnrurol2017119_CR34","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1089\/scd.2014.0360","volume":"24","author":"G Lin","year":"2015","unstructured":"Lin, G.  et al. Presence of stem\/progenitor cells in the rat penis. Stem Cells Dev. 24, 264\u2013270 (2015).","journal-title":"Stem Cells Dev."},{"key":"BFnrurol2017119_CR35","first-page":"1109","volume":"28","author":"C-S Lin","year":"2013","unstructured":"Lin, C.-S., Xin, Z.-C., Dai, J. & Lue, T. F. Commonly used mesenchymal stem cell markers and tracking labels: limitations and challenges. Histol. Histopathol. 28, 1109\u20131116 (2013).","journal-title":"Histol. Histopathol."},{"key":"BFnrurol2017119_CR36","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1111\/j.1743-6109.2007.00600.x","volume":"4","author":"JP Mulhall","year":"2007","unstructured":"Mulhall, J. P., Goldstein, I., Bushmakin, A. G., Cappelleri, J. C. & Hvidsten, K. Validation of the erection hardness score. J. Sex. Med. 4, 1626\u20131634 (2007).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR37","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","volume":"11","author":"RC Rosen","year":"1999","unstructured":"Rosen R. C., Cappelleri J. C., Smith M. D., Lipsky J. & Pe\u00f1a B. M. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot. Res. 11, 319\u2013326 (1999).","journal-title":"Int J Impot. Res."},{"key":"BFnrurol2017119_CR38","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","volume":"49","author":"RC Rosen","year":"1997","unstructured":"Rosen, R. C.  et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49, 822\u2013830 (1997).","journal-title":"Urology"},{"key":"BFnrurol2017119_CR39","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1016\/j.juro.2011.12.117","volume":"187","author":"Y Vardi","year":"2012","unstructured":"Vardi, Y., Appel, B., Kilchevsky, A. & Gruenwald, I. Does low intensity extracorporeal shock wave therapy have a physiological effect on erectile function? Short-term results of a randomized, double-blind, sham controlled study. J. Urol. 187, 1769\u20131775 (2012).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR40","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3109\/21681805.2014.984326","volume":"49","author":"AB Olsen","year":"2015","unstructured":"Olsen, A. B., Persiani, M., Boie, S., Hanna, M. & Lund, L. Can low-intensity extracorporeal shockwave therapy improve erectile dysfunction? A prospective, randomized, double-blind, placebo-controlled study. Scand. J. Urol. 49, 329\u2013333 (2015).","journal-title":"Scand. J. Urol."},{"key":"BFnrurol2017119_CR41","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1111\/iju.12506","volume":"21","author":"C-H Yee","year":"2014","unstructured":"Yee, C.-H., Chan, E. S., Hou, S. S.-M. & Ng, C.-F. Extracorporeal shockwave therapy in the treatment of erectile dysfunction: a prospective, randomized, double-blinded, placebo controlled study. Int. J. Urol. 21, 1041\u20131045 (2014).","journal-title":"Int. J. Urol."},{"key":"BFnrurol2017119_CR42","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/ijir.2014.41","volume":"27","author":"Y Reisman","year":"2015","unstructured":"Reisman, Y., Hind, A., Varaneckas, A. & Motil, I. Initial experience with linear focused shockwave treatment for erectile dysfunction: a 6-month follow-up pilot study. Int. J. Impot. Res. 27, 108\u2013112 (2015).","journal-title":"Int. J. Impot. Res."},{"issue":"Suppl. 5","key":"BFnrurol2017119_CR43","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/bju.13035","volume":"115","author":"E Chung","year":"2015","unstructured":"Chung, E. & Cartmill, R. Evaluation of clinical efficacy, safety and patient satisfaction rate after low-intensity extracorporeal shockwave therapy for the treatment of male erectile dysfunction: an Australian first open-label single-arm prospective clinical trial. BJU Int. 115 (Suppl. 5), 46\u201349 (2015).","journal-title":"BJU Int."},{"key":"BFnrurol2017119_CR44","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.acuro.2014.09.010","volume":"39","author":"M Pelayo-Nieto","year":"2015","unstructured":"Pelayo-Nieto, M.  et al. Linear shock wave therapy in the treatment of erectile dysfunction. Actas Urol. Esp. 39, 456\u2013459 (2015).","journal-title":"Actas Urol. Esp."},{"key":"BFnrurol2017119_CR45","first-page":"7614","volume":"22","author":"VS Srini","year":"2015","unstructured":"Srini, V. S., Reddy, R. K., Shultz, T. & Denes, B. Low intensity extracorporeal shockwave therapy for erectile dysfunction: a study in an Indian population. Can. J. Urol. 22, 7614\u20137622 (2015).","journal-title":"Can. J. Urol."},{"key":"BFnrurol2017119_CR46","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1590\/S1677-5538.IBJU.2014.0386","volume":"41","author":"A Ruffo","year":"2015","unstructured":"Ruffo, A.  et al. Safety and efficacy of low intensity shockwave (LISW) treatment in patients with erectile dysfunction. Int. Braz. J. Urol. 41, 967\u2013974 (2015).","journal-title":"Int. Braz. J. Urol."},{"key":"BFnrurol2017119_CR47","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3109\/21681805.2015.1100675","volume":"50","author":"A Frey","year":"2015","unstructured":"Frey, A., S\u00f8nksen, J. & Fode, M. Low-intensity extracorporeal shockwave therapy in the treatment of postprostatectomy erectile dysfunction: a pilot study. Scand. J. Urol. 50, 123\u2013127 (2015).","journal-title":"Scand. J. Urol."},{"key":"BFnrurol2017119_CR48","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1016\/j.esxm.2016.06.001","volume":"4","author":"A Bechara","year":"2016","unstructured":"Bechara, A., Casab\u00e9, A., De Bonis, W. & Ciciclia, P. G. Twelve-month efficacy and safety of low-intensity shockwave therapy for erectile dysfunction in patients who do not respond to phosphodiesterase type 5 inhibitors. Sex. Med. 4, e225\u2013e232 (2016).","journal-title":"Sex. Med."},{"key":"BFnrurol2017119_CR49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/iju.12955","volume":"23","author":"S-I Hisasue","year":"2015","unstructured":"Hisasue, S.-I.  et al. Impact of aging and comorbidity on the efficacy of low-intensity shock wave therapy for erectile dysfunction. Int. J. Urol. 23, 80\u201384 (2015).","journal-title":"Int. J. Urol."},{"key":"BFnrurol2017119_CR50","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jsxm.2016.11.307","volume":"14","author":"GL Fojecki","year":"2017","unstructured":"Fojecki, G. L., Tiessen, S. & Osther, P. J. S. Effect of low-energy linear shockwave therapy on erectile dysfunction\u2014A double-blinded, sham-controlled, randomized clinical trial. J. Sex. Med. 14, 106\u2013112 (2017).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR51","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4236\/asm.2016.62002","volume":"6","author":"I Motil","year":"2016","unstructured":"Motil, I., Kubis, I. & Sramkova, T. Treatment of vasculogenic erectile dysfunction with Piezowave2 device. Application of low intensity shockwaves using novel linear shockwave tissue coverage (LSTC-ED\u00ae) technique. A prospective, multicentric, placebo-controlled study. Adv. Sexual Med. 6, 15\u201318 (2016).","journal-title":"Adv. Sexual Med."},{"key":"BFnrurol2017119_CR52","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.eururo.2016.05.050","volume":"71","author":"Z Lu","year":"2017","unstructured":"Lu, Z.  et al. Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis. Eur. Urol. 71, 223\u2013233 (2017).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00345-016-1834-2","volume":"35","author":"GL Fojecki","year":"2016","unstructured":"Fojecki, G. L., Tiessen, S. & Osther, P. J. S. Extracorporeal shock wave therapy (ESWT) in urology: a systematic review of outcome in Peyronie's disease, erectile dysfunction and chronic pelvic pain. World J. Urol. 35, 1\u20139 (2016).","journal-title":"World J. Urol."},{"issue":"8","key":"BFnrurol2017119_CR54","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.acuro.2016.07.005","volume":"41","author":"J.C. Angulo","year":"2017","unstructured":"Angulo, J. C.  et al. Efficacy of low-intensity shock wave therapy for erectile dysfunction: a systematic review and meta-analysis. Actas Urol. Esp. \n                    https:\/\/doi.org\/10.1016\/j.acuro.2016.07.005\n                    \n                   (2016).","journal-title":"Actas Urol\u00f3gicas Espa\u00f1olas"},{"key":"BFnrurol2017119_CR55","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jsxm.2016.11.001","volume":"14","author":"RI Clavijo","year":"2017","unstructured":"Clavijo, R. I., Kohn, T. P., Kohn, J. R. & Ramasamy, R. Effects of low-intensity extracorporeal shockwave therapy on erectile dysfunction: A systematic review and meta-analysis. J. Sex. Med. 14, 27\u201335 (2017).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jsxm.2016.08.016","volume":"14","author":"WA Fisher","year":"2017","unstructured":"Fisher, W. A.  et al. Standards for clinical trials in male and female sexual dysfunction: III. Unique aspects of clinical trials in male sexual dysfunction. J. Sex. Med. 14, 3\u201318 (2017).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR57","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1111\/j.1464-410X.2008.07511.x","volume":"101","author":"TA Masterson","year":"2008","unstructured":"Masterson, T. A., Serio, A. M., Mulhall, J. P., Vickers, A. J. & Eastham, J. A. Modified technique for neurovascular bundle preservation during radical prostatectomy: association between technique and recovery of erectile function. BJU Int. 101, 1217\u20131222 (2008).","journal-title":"BJU Int."},{"key":"BFnrurol2017119_CR58","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/nrurol.2015.72","volume":"12","author":"E Weyne","year":"2015","unstructured":"Weyne, E., Castiglione, F., Van der Aa, F., Bivalacqua, T. J. & Albersen, M. Landmarks in erectile function recovery after radical prostatectomy. Nat. Rev. Urol. 12, 289\u2013297 (2015).","journal-title":"Nat. Rev. Urol."},{"key":"BFnrurol2017119_CR59","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1097\/01.ju.0000154356.76027.4f","volume":"173","author":"F Iacono","year":"2005","unstructured":"Iacono, F.  et al. Histological alterations in cavernous tissue after radical prostatectomy. J. Urol. 173, 1673\u20131676 (2005).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR60","doi-asserted-by":"publisher","unstructured":"Miles, C.  et al. Interventions for sexual dysfunction following treatments for cancer. Cochrane Database Syst Rev. \n                    https:\/\/doi.org\/10.1002\/14651858.CD005540.pub2\n                    \n                   (2007).","DOI":"10.1002\/14651858.CD005540.pub2"},{"key":"BFnrurol2017119_CR61","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.eururo.2008.10.028","volume":"55","author":"K Hatzimouratidis","year":"2009","unstructured":"Hatzimouratidis, K.  et al. Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction: a critical analysis of the basic science rationale and clinical application. Eur. Urol. 55, 334\u2013347 (2009).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR62","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1464-410X.2011.10757.x","volume":"110","author":"S Kilminster","year":"2011","unstructured":"Kilminster, S.  et al. Predicting erectile function outcome in men after radical prostatectomy for prostate cancer. BJU Int. 110, 422\u2013426 (2011).","journal-title":"BJU Int."},{"key":"BFnrurol2017119_CR63","first-page":"417","volume":"61","author":"C Bellorofonte","year":"1989","unstructured":"Bellorofonte, C.  et al. [Possibility of using the piezoelectric lithotriptor in the treatment of severe cavernous fibrosis]. Arch. Ital. Urol. Nefrol Androl 61, 417\u2013422 (1989).","journal-title":"Arch. Ital. Urol. Nefrol Androl"},{"key":"BFnrurol2017119_CR64","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1745-7262.2006.00138.x","volume":"8","author":"V Poulakis","year":"2006","unstructured":"Poulakis, V.  et al. Extracorporeal shockwave therapy for Peyronie's disease: an alternative treatment? Asian J. Androl. 8, 361\u2013366 (2006).","journal-title":"Asian J. Androl."},{"key":"BFnrurol2017119_CR65","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1590\/S1677-55382004000300004","volume":"30","author":"JA Claro","year":"2004","unstructured":"Claro, J. A.  et al. An alternative non-invasive treatment for Peyronie's disease. Int. Braz. J. Urol. 30, 199\u2013204 (2004).","journal-title":"Int. Braz. J. Urol."},{"key":"BFnrurol2017119_CR66","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/sj.ijir.3901192","volume":"16","author":"RT Strebel","year":"2004","unstructured":"Strebel, R. T., Suter, S., Sautter, T. & Hauri, D. Extracorporeal shockwave therapy for Peyronie's disease does not correct penile deformity. Int. J. Impot. Res. 16, 448\u2013451 (2004).","journal-title":"Int. J. Impot. Res."},{"key":"BFnrurol2017119_CR67","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S0090-4295(02)01970-2","volume":"60","author":"R Manikandan","year":"2002","unstructured":"Manikandan, R., Islam, W., Srinivasan, V. & Evans, C. M. Evaluation of extracorporeal shock wave therapy in Peyronie's disease. Urology 60, 795\u2013800 (2002).","journal-title":"Urology"},{"key":"BFnrurol2017119_CR68","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S0090-4295(02)01527-3","volume":"59","author":"T Lebret","year":"2002","unstructured":"Lebret, T.  et al. Extracorporeal shock wave therapy in the treatment of Peyronie's disease: experience with standard lithotriptor (siemens-multiline). Urology 59, 657\u2013661 (2002).","journal-title":"Urology"},{"key":"BFnrurol2017119_CR69","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.eururo.2009.05.012","volume":"56","author":"A Palmieri","year":"2009","unstructured":"Palmieri, A.  et al. A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy for the treatment of Peyronie's disease. Eur. Urol. 56, 363\u2013369 (2009).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR70","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1111\/jsm.12275","volume":"10","author":"G Hatzichristodoulou","year":"2013","unstructured":"Hatzichristodoulou, G., Meisner, C., Gschwend, J. E., Stenzl, A. & Lahme, S. Extracorporeal shock wave therapy in Peyronie's disease: results of a placebo-controlled, prospective, randomized, single-blind study. J. Sex. Med. 10, 2815\u20132821 (2013).","journal-title":"J. Sex. Med."},{"key":"BFnrurol2017119_CR71","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1111\/j.1464-410X.2010.09331.x","volume":"106","author":"S Chitale","year":"2010","unstructured":"Chitale, S., Morsey, M., Swift, L. & Sethia, K. Limited shock wave therapy versus sham treatment in men with Peyronie's disease: results of a prospective randomized controlled double-blind trial. - PubMed - NCBI. BJU Int. 106, 1352\u20131356 (2010).","journal-title":"BJU Int."},{"key":"BFnrurol2017119_CR72","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1016\/S0022-5347(06)00270-9","volume":"175","author":"JP Mulhall","year":"2006","unstructured":"Mulhall, J. P., Schiff, J. & Guhring, P. An analysis of the natural history of peyronie's disease. J. Urol. 175, 2115\u20132118 (2006).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR73","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.ucl.2011.02.006","volume":"38","author":"SM Larsen","year":"2011","unstructured":"Larsen, S. M. & Levine, L. A. Peyronie's disease: review of nonsurgical treatment options. Urol. Clin. North Amer. 38, 195\u2013205 (2011).","journal-title":"Urol. Clin. North Amer."},{"key":"BFnrurol2017119_CR74","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1016\/j.juro.2012.01.032","volume":"187","author":"M Gelbard","year":"2012","unstructured":"Gelbard, M.  et al. Phase 2b study of the clinical efficacy and safety of collagenase clostridium histolyticum in patients with peyronie disease. J. Urol. 187, 2268\u20132274 (2012).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR75","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1365-2605.2011.01226.x","volume":"35","author":"A Palmieri","year":"2011","unstructured":"Palmieri, A.  et al. Tadalafil once daily and extracorporeal shock wave therapy in the management of patients with Peyronie's disease and erectile dysfunction: results from a prospective randomized trial. Int. J. Androl. 35, 190\u2013195 (2011).","journal-title":"Int. J. Androl."},{"key":"BFnrurol2017119_CR76","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1097\/01.ju.0000108060.30363.8d","volume":"171","author":"EW Hauck","year":"2004","unstructured":"Hauck, E. W.  et al. Extracorporeal shock wave therapy for Peyronie's disease: exploratory meta-analysis of clinical trials. J. Urol. 171, 740\u2013745 (2004).","journal-title":"J. Urol."},{"key":"BFnrurol2017119_CR77","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1097\/BRS.0b013e3181b1c99f","volume":"34","author":"AD Furlan","year":"2009","unstructured":"Furlan, A. D., Pennick, V., Bombardier, C. & van Tulder, M. 2009 updated method guidelines for systematic reviews in the cochrane back review group. Spine 34, 1929\u20131941 (2009).","journal-title":"Spine"},{"key":"BFnrurol2017119_CR78","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.eururo.2011.07.053","volume":"60","author":"RC Rosen","year":"2011","unstructured":"Rosen, R. C., Allen, K. R., Ni, X. & Araujo, A. B. Minimal clinically important differences in the erectile function domain of the international index of erectile function scale. Eur. Urol. 60, 1010\u20131016 (2011).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR79","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/nrurol.2011.154","volume":"8","author":"M Albersen","year":"2011","unstructured":"Albersen, M. & Lue, T. F. Sexual dysfunction: MCID provides new perspective on erectile function research. Nat. Rev. Urol. 8, 591\u2013592 (2011).","journal-title":"Nat. Rev. Urol."},{"key":"BFnrurol2017119_CR80","doi-asserted-by":"publisher","first-page":"e76","DOI":"10.1016\/j.eururo.2016.08.042","volume":"71","author":"M Fode","year":"2017","unstructured":"Fode, M. & Albersen, M. Re: Zhihua Lu, Guiting Lin, Amanda Reed-Maldonado, Chunxi Wang, Yung-Chin Lee, Tom F. Lue. Low-intensity extracorporeal shock wave treatment improves erectile function: a systematic review and meta-analysis. Eur Urol 2017;71:223\u201333. Eur. Urol. 71, e76\u2013e77 (2017).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR81","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/S1569-9056(15)60126-9","volume":"14","author":"DG Hatzichristou","year":"2015","unstructured":"Hatzichristou, D. G. & Kalyvianakis D. E. Erectile dysfunction shock wave therapy (EDSWT) improves hemodynamic parameters in patients with vasculogenic erectile dysfunction (ED): a triplex-based sham-controlled trial. Eur. Urol. 14, e124 (2015).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR82","volume-title":"Medispec.com","author":"RA Feldman","year":"2015","unstructured":"Feldman, R. A.,  et al. The safety and efficacy of li-ESWT in 604 patients for erectile dysfunction: summary of current and evolving evidence. Medispec.com \n                    http:\/\/medispec.com\/general\/the-safety-and-efficacy-of-li-eswt-in-604-patients-for-erectile-dysfunction-summary-of-current-and-evolving-evidence\/\n                    \n                   (2015)."},{"key":"BFnrurol2017119_CR83","unstructured":"US National Library of Medicine. ClinicalTrials.gov \n                    https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02063061\n                    \n                   (2016)."},{"key":"BFnrurol2017119_CR84","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.eururo.2016.06.037","volume":"71","author":"D Hatzichristou","year":"2017","unstructured":"Hatzichristou, D. Low-intensity extracorporeal shock waves therapy (LI-ESWT) for the treatment of erectile dysfunction: where do we stand? Eur. Urol. 71, 234\u2013236 (2017).","journal-title":"Eur. Urol."},{"key":"BFnrurol2017119_CR85","unstructured":"Hamilton M. Cricket legend Sir Ian Botham bravely reveals impotence treatment after having privates zapped. \n                    www.thesun.co.uk\n                    \n                  \n                    https:\/\/www.thesun.co.uk\/sport\/1606663\/sir-ian-botham-has-privates-zapped-in-bid-to-cure-impotence1606663\/\n                    \n                   (2016)."},{"key":"BFnrurol2017119_CR86","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0090-4295(99)00099-0","volume":"54","author":"JC Cappelleri","year":"1999","unstructured":"Cappelleri, J. C., Rosen, R. C., Smith, M. D., Mishra, A. & Osterloh, I. H. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 54, 346\u2013351 (1999).","journal-title":"Urology"},{"key":"BFnrurol2017119_CR87","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.eururo.2009.03.043","volume":"56","author":"R Zimmermann","year":"2009","unstructured":"Zimmermann, R., Cumpanas, A., Miclea, F. & Janetschek, G. Extracorporeal shock wave therapy for the treatment of chronic pelvic pain syndrome in males: a randomised, double-blind, placebo-controlled study. Eur. Urol. 56, 418\u2013424 (2009).","journal-title":"Eur. Urol."}],"container-title":["Nature Reviews Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2017.119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2017.119","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nrurol.2017.119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nrurol.2017.119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T04:17:58Z","timestamp":1684469878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nrurol.2017.119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,25]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["BFnrurol2017119"],"URL":"https:\/\/doi.org\/10.1038\/nrurol.2017.119","relation":{},"ISSN":["1759-4812","1759-4820"],"issn-type":[{"value":"1759-4812","type":"print"},{"value":"1759-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,25]]},"assertion":[{"value":"25 July 2017","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}