{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:15:47Z","timestamp":1791422147928,"version":"4.3.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,12,2]],"date-time":"2012-12-02T00:00:00Z","timestamp":1354406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2012,12,2]],"date-time":"2012-12-02T00:00:00Z","timestamp":1354406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Struct Mol Biol"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1038\/nsmb.2432","type":"journal-article","created":{"date-parts":[[2012,12,2]],"date-time":"2012-12-02T21:52:44Z","timestamp":1354485164000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4"],"prefix":"10.1038","volume":"20","author":[{"given":"Xiaoai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine W-H","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,12,2]]},"reference":[{"issue":"suppl. 1","key":"BFnsmb2432_CR1","doi-asserted-by":"publisher","first-page":"S335","DOI":"10.1093\/infdis\/jir101","volume":"204","author":"A Mankertz","year":"2011","unstructured":"Mankertz, A. et al. Molecular genotyping and epidemiology of measles virus transmission in the World Health Organization European Region, 2007\u20132009. J. Infect. Dis. 204 (suppl. 1), S335\u2013S342 (2011).","journal-title":"J. Infect. Dis."},{"key":"BFnsmb2432_CR2","first-page":"129","volume":"330","author":"PA Rota","year":"2009","unstructured":"Rota, P.A., Featherstone, D.A. & Bellini, W.J. Molecular epidemiology of measles virus. Curr. Top. Microbiol. Immunol. 330, 129\u2013150 (2009).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFnsmb2432_CR3","unstructured":"Anonymous. Increased transmission and outbreaks of measles, European Region, 2011. Wkly. Epidemiol. Rec. 86, 559\u2013564 (2011)."},{"key":"BFnsmb2432_CR4","unstructured":"Griggin, D.E. Measles virus. in Fields Virology (Fields, B.N. et al.) 1551\u20131585 (Lippincott, Williams & Wilkins, Philadelphia, 2007)."},{"key":"BFnsmb2432_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00430-010-0153-2","volume":"199","author":"D Reuter","year":"2010","unstructured":"Reuter, D. & Schneider-Schaulies, J. Measles virus infection of the CNS: human disease, animal models, and approaches to therapy. Med. Microbiol. Immunol. (Berl.) 199, 261\u2013271 (2010).","journal-title":"Med. Microbiol. Immunol. (Berl.)"},{"key":"BFnsmb2432_CR6","doi-asserted-by":"publisher","first-page":"e1002240","DOI":"10.1371\/journal.ppat.1002240","volume":"7","author":"RS Noyce","year":"2011","unstructured":"Noyce, R.S. et al. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog. 7, e1002240 (2011).","journal-title":"PLoS Pathog."},{"key":"BFnsmb2432_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0092-8674(93)80071-L","volume":"75","author":"RE D\u00f6rig","year":"1993","unstructured":"D\u00f6rig, R.E., Marcil, A., Chopra, A. & Richardson, C.D. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75, 295\u2013305 (1993).","journal-title":"Cell"},{"key":"BFnsmb2432_CR8","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1128\/jvi.67.10.6025-6032.1993","volume":"67","author":"D Naniche","year":"1993","unstructured":"Naniche, D. et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J. Virol. 67, 6025\u20136032 (1993).","journal-title":"J. Virol."},{"key":"BFnsmb2432_CR9","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/35022579","volume":"406","author":"H Tatsuo","year":"2000","unstructured":"Tatsuo, H., Ono, N., Tanaka, K. & Yanagi, Y. SLAM (CDw150) is a cellular receptor for measles virus. Nature 406, 893\u2013897 (2000).","journal-title":"Nature"},{"key":"BFnsmb2432_CR10","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nature10639","volume":"480","author":"MD M\u00fchlebach","year":"2011","unstructured":"M\u00fchlebach, M.D. et al. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature 480, 530\u2013533 (2011).","journal-title":"Nature"},{"key":"BFnsmb2432_CR11","first-page":"13","volume":"329","author":"Y Yanagi","year":"2009","unstructured":"Yanagi, Y., Takeda, M., Ohno, S. & Hashiguchi, T. Measles virus receptors. Curr. Top. Microbiol. Immunol. 329, 13\u201330 (2009).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"BFnsmb2432_CR12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1002\/rmv.430","volume":"14","author":"N Dhiman","year":"2004","unstructured":"Dhiman, N., Jacobson, R.M. & Poland, G.A. Measles virus receptors: SLAM and CD46. Rev. Med. Virol. 14, 217\u2013229 (2004).","journal-title":"Rev. Med. Virol."},{"key":"BFnsmb2432_CR13","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.iy.09.040191.002243","volume":"9","author":"MK Liszewski","year":"1991","unstructured":"Liszewski, M.K., Post, T.W. & Atkinson, J.P. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9, 431\u2013455 (1991).","journal-title":"Annu. Rev. Immunol."},{"key":"BFnsmb2432_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nri2456","volume":"9","author":"PL Schwartzberg","year":"2009","unstructured":"Schwartzberg, P.L., Mueller, K.L., Qi, H. & Cannons, J.L. SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat. Rev. Immunol. 9, 39\u201346 (2009).","journal-title":"Nat. Rev. Immunol."},{"key":"BFnsmb2432_CR15","doi-asserted-by":"publisher","first-page":"43205","DOI":"10.1074\/jbc.M103810200","volume":"276","author":"N Reymond","year":"2001","unstructured":"Reymond, N. et al. Nectin4\/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1\/PRR1 through V domain interaction. J. Biol. Chem. 276, 43205\u201343215 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb2432_CR16","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ajhg.2010.07.003","volume":"87","author":"F Brancati","year":"2010","unstructured":"Brancati, F. et al. Mutations in PVRL4, encoding cell adhesion molecule nectin-4, cause ectodermal dysplasia-syndactyly syndrome. Am. J. Hum. Genet. 87, 265\u2013273 (2010).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnsmb2432_CR17","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/nsmb1342","volume":"14","author":"LA Colf","year":"2007","unstructured":"Colf, L.A., Juo, Z.S. & Garcia, K.C. Structure of the measles virus hemagglutinin. Nat. Struct. Mol. Biol. 14, 1227\u20131228 (2007).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb2432_CR18","doi-asserted-by":"publisher","first-page":"19535","DOI":"10.1073\/pnas.0707830104","volume":"104","author":"T Hashiguchi","year":"2007","unstructured":"Hashiguchi, T. et al. Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proc. Natl. Acad. Sci. USA 104, 19535\u201319540 (2007).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb2432_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/nsmb.1726","volume":"17","author":"C Santiago","year":"2010","unstructured":"Santiago, C., Celma, M.L., Stehle, T. & Casasnovas, J.M. Structure of the measles virus hemagglutinin bound to the CD46 receptor. Nat. Struct. Mol. Biol. 17, 124\u2013129 (2010).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb2432_CR20","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nsmb.1969","volume":"18","author":"T Hashiguchi","year":"2011","unstructured":"Hashiguchi, T. et al. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat. Struct. Mol. Biol. 18, 135\u2013141 (2011).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb2432_CR21","doi-asserted-by":"publisher","first-page":"4630","DOI":"10.1128\/JVI.02691-07","volume":"82","author":"M Tahara","year":"2008","unstructured":"Tahara, M. et al. Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin. J. Virol. 82, 4630\u20134637 (2008).","journal-title":"J. Virol."},{"key":"BFnsmb2432_CR22","first-page":"2448","volume":"118","author":"VH Leonard","year":"2008","unstructured":"Leonard, V.H. et al. Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J. Clin. Invest. 118, 2448\u20132458 (2008).","journal-title":"J. Clin. Invest."},{"key":"BFnsmb2432_CR23","doi-asserted-by":"publisher","first-page":"9051","DOI":"10.1128\/JVI.78.17.9051-9063.2004","volume":"78","author":"N Mass\u00e9","year":"2004","unstructured":"Mass\u00e9, N. et al. Measles virus (MV) hemagglutinin: evidence that attachment sites for MV receptors SLAM and CD46 overlap on the globular head. J. Virol. 78, 9051\u20139063 (2004).","journal-title":"J. Virol."},{"key":"BFnsmb2432_CR24","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1128\/JVI.78.1.302-313.2004","volume":"78","author":"S Vongpunsawad","year":"2004","unstructured":"Vongpunsawad, S., Oezgun, N., Braun, W. & Cattaneo, R. Selectively receptor-blind measles viruses: identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model. J. Virol. 78, 302\u2013313 (2004).","journal-title":"J. Virol."},{"key":"BFnsmb2432_CR25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nrm2457","volume":"9","author":"Y Takai","year":"2008","unstructured":"Takai, Y., Miyoshi, J., Ikeda, W. & Ogita, H. Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferation. Nat. Rev. Mol. Cell Biol. 9, 603\u2013615 (2008).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFnsmb2432_CR26","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1242\/jcs.00167","volume":"116","author":"Y Takai","year":"2003","unstructured":"Takai, Y. & Nakanishi, H. Nectin and afadin: novel organizers of intercellular junctions. J. Cell Sci. 116, 17\u201327 (2003).","journal-title":"J. Cell Sci."},{"key":"BFnsmb2432_CR27","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1080\/15216540600719622","volume":"58","author":"H Ogita","year":"2006","unstructured":"Ogita, H. & Takai, Y. Nectins and nectin-like molecules: roles in cell adhesion, polarization, movement, and proliferation. IUBMB Life 58, 334\u2013343 (2006).","journal-title":"IUBMB Life"},{"key":"BFnsmb2432_CR28","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1146\/annurev.cellbio.24.110707.175339","volume":"24","author":"Y Takai","year":"2008","unstructured":"Takai, Y., Ikeda, W., Ogita, H. & Rikitake, Y. The immunoglobulin-like cell adhesion molecule nectin and its associated protein afadin. Annu. Rev. Cell Dev. Biol. 24, 309\u2013342 (2008).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"BFnsmb2432_CR29","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1099\/0022-1317-75-5-1043","volume":"75","author":"A Hu","year":"1994","unstructured":"Hu, A., Cattaneo, R., Schwartz, S. & Norrby, E. Role of N-linked oligosaccharide chains in the processing and antigenicity of measles virus hemagglutinin protein. J. Gen. Virol. 75, 1043\u20131052 (1994).","journal-title":"J. Gen. Virol."},{"key":"BFnsmb2432_CR30","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1146\/annurev.biochem.66.1.823","volume":"66","author":"C Chothia","year":"1997","unstructured":"Chothia, C. & Jones, E.Y. The molecular structure of cell adhesion molecules. Annu. Rev. Biochem. 66, 823\u2013862 (1997).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnsmb2432_CR31","first-page":"309","volume":"242","author":"P Bork","year":"1994","unstructured":"Bork, P., Holm, L. & Sander, C. The immunoglobulin fold. Structural classification, sequence patterns and common core. J. Mol. Biol. 242, 309\u2013320 (1994).","journal-title":"J. Mol. Biol."},{"key":"BFnsmb2432_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/viro.2000.0529","volume":"275","author":"PG Spear","year":"2000","unstructured":"Spear, P.G., Eisenberg, R.J. & Cohen, G.H. Three classes of cell surface receptors for alphaherpesvirus entry. Virology 275, 1\u20138 (2000).","journal-title":"Virology"},{"key":"BFnsmb2432_CR33","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(89)90690-9","volume":"56","author":"CL Mendelsohn","year":"1989","unstructured":"Mendelsohn, C.L., Wimmer, E. & Racaniello, V.R. Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56, 855\u2013865 (1989).","journal-title":"Cell"},{"key":"BFnsmb2432_CR34","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1038\/ncomms1571","volume":"2","author":"N Zhang","year":"2011","unstructured":"Zhang, N. et al. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nat. Commun. 2, 577 (2011).","journal-title":"Nat. Commun."},{"key":"BFnsmb2432_CR35","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1107\/S1744309112027236","volume":"F68","author":"X Xu","year":"2012","unstructured":"Xu, X., Zhang, X., Lu, G. & Cai, Y. Purification, crystallization and preliminary X-ray analysis of the first IgV domain of human nectin-4. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. F68, 942\u2013945 (2012).","journal-title":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun."},{"key":"BFnsmb2432_CR36","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s13238-010-0059-1","volume":"1","author":"W Zhang","year":"2010","unstructured":"Zhang, W. et al. Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell 1, 459\u2013467 (2010).","journal-title":"Protein Cell"},{"key":"BFnsmb2432_CR37","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s13238-011-1009-2","volume":"2","author":"G Lu","year":"2011","unstructured":"Lu, G. et al. hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA. Protein Cell 2, 64\u201373 (2011).","journal-title":"Protein Cell"},{"key":"BFnsmb2432_CR38","doi-asserted-by":"publisher","first-page":"5511","DOI":"10.4049\/jimmunol.1200324","volume":"188","author":"J Liu","year":"2012","unstructured":"Liu, J. et al. Crystal structure of cell adhesion molecule nectin-2\/CD112 and its binding to immune receptor DNAM-1\/CD226. J. Immunol. 188, 5511\u20135520 (2012).","journal-title":"J. Immunol."},{"key":"BFnsmb2432_CR39","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307\u2013326 (1997).","journal-title":"Methods Enzymol."},{"key":"BFnsmb2432_CR40","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1107\/S0907444901012471","volume":"57","author":"RJ Read","year":"2001","unstructured":"Read, R.J. Pushing the boundaries of molecular replacement with maximum likelihood. Acta Crystallogr. D Biol. Crystallogr. 57, 1373\u20131382 (2001).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFnsmb2432_CR41","doi-asserted-by":"crossref","unstructured":"Collaborative Computing Project Number 4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50, 760\u2013763 (1994).","DOI":"10.1107\/S0907444994003112"},{"key":"BFnsmb2432_CR42","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"GN Murshudov","year":"1997","unstructured":"Murshudov, G.N., Vagin, A.A. & Dodson, E.J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240\u2013255 (1997).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFnsmb2432_CR43","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D Biol. Crystallogr. 60, 2126\u20132132 (2004).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFnsmb2432_CR44","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"PD Adams","year":"2010","unstructured":"Adams, P.D. et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213\u2013221 (2010).","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"BFnsmb2432_CR45","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"RA Laskowski","year":"1993","unstructured":"Laskowski, R.A., MacArthur, M.W., Moss, D.S. & Thornton, J.M. PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 26, 283\u2013291 (1993).","journal-title":"J. Appl. Crystallogr."}],"container-title":["Nature Structural & Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nsmb.2432.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nsmb.2432","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nsmb.2432.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T07:09:44Z","timestamp":1659078584000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nsmb.2432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["BFnsmb2432"],"URL":"https:\/\/doi.org\/10.1038\/nsmb.2432","relation":{},"ISSN":["1545-9993","1545-9985"],"issn-type":[{"value":"1545-9993","type":"print"},{"value":"1545-9985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,2]]},"assertion":[{"value":"15 June 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}