{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:54:44Z","timestamp":1792144484664,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Struct Mol Biol"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/nsmb.3228","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T12:01:48Z","timestamp":1462795308000},"page":"540-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":359,"title":["BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin"],"prefix":"10.1038","volume":"23","author":[{"given":"Ballachanda N","family":"Devaiah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanelle","family":"Case-Borden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Gegonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih Hao","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Meerzaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ozato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinah S","family":"Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"BFnsmb3228_CR1","doi-asserted-by":"publisher","first-page":"13141","DOI":"10.1074\/jbc.R700001200","volume":"282","author":"SY Wu","year":"2007","unstructured":"Wu, S.Y. & Chiang, C.M. The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J. Biol. Chem. 282, 13141\u201313145 (2007).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR2","doi-asserted-by":"publisher","first-page":"6537","DOI":"10.1128\/MCB.20.17.6537-6549.2000","volume":"20","author":"A Dey","year":"2000","unstructured":"Dey, A. et al. A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G2-to-M transition. Mol. Cell. Biol. 20, 6537\u20136549 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb3228_CR3","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/nature12147","volume":"498","author":"SR Floyd","year":"2013","unstructured":"Floyd, S.R. et al. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature 498, 246\u2013250 (2013).","journal-title":"Nature"},{"key":"BFnsmb3228_CR4","doi-asserted-by":"publisher","first-page":"4899","DOI":"10.1091\/mbc.e09-05-0380","volume":"20","author":"A Dey","year":"2009","unstructured":"Dey, A., Nishiyama, A., Karpova, T., McNally, J. & Ozato, K. Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription. Mol. Biol. Cell 20, 4899\u20134909 (2009).","journal-title":"Mol. Biol. Cell"},{"key":"BFnsmb3228_CR5","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1756-8935-6-6","volume":"6","author":"S Kadauke","year":"2013","unstructured":"Kadauke, S. & Blobel, G.A. Mitotic bookmarking by transcription factors. Epigenetics Chromatin 6, 6 (2013).","journal-title":"Epigenetics Chromatin"},{"key":"BFnsmb3228_CR6","doi-asserted-by":"publisher","first-page":"9040","DOI":"10.1074\/jbc.M707603200","volume":"283","author":"K Mochizuki","year":"2008","unstructured":"Mochizuki, K. et al. The bromodomain protein Brd4 stimulates G1 gene transcription and promotes progression to S phase. J. Biol. Chem. 283, 9040\u20139048 (2008).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR7","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/j.molcel.2012.12.006","volume":"49","author":"SY Wu","year":"2013","unstructured":"Wu, S.Y., Lee, A.Y., Lai, H.T., Zhang, H. & Chiang, C.M. Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting. Mol. Cell 49, 843\u2013857 (2013).","journal-title":"Mol. Cell"},{"key":"BFnsmb3228_CR8","doi-asserted-by":"publisher","first-page":"5094","DOI":"10.1128\/MCB.00299-09","volume":"29","author":"J You","year":"2009","unstructured":"You, J. et al. Regulation of aurora B expression by the bromodomain protein Brd4. Mol. Cell. Biol. 29, 5094\u20135103 (2009).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb3228_CR9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","volume":"153","author":"J Lov\u00e9n","year":"2013","unstructured":"Lov\u00e9n, J. et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153, 320\u2013334 (2013).","journal-title":"Cell"},{"key":"BFnsmb3228_CR10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3410\/B1-98","volume":"1","author":"CM Chiang","year":"2009","unstructured":"Chiang, C.M. Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4. F1000 Biol. Rep. 1, 98 (2009).","journal-title":"F1000 Biol. Rep."},{"key":"BFnsmb3228_CR11","doi-asserted-by":"publisher","first-page":"6927","DOI":"10.1073\/pnas.1120422109","volume":"109","author":"BN Devaiah","year":"2012","unstructured":"Devaiah, B.N. et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc. Natl. Acad. Sci. USA 109, 6927\u20136932 (2012).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb3228_CR12","doi-asserted-by":"publisher","first-page":"38755","DOI":"10.1074\/jbc.M112.412015","volume":"287","author":"BN Devaiah","year":"2012","unstructured":"Devaiah, B.N. & Singer, D.S. Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation. J. Biol. Chem. 287, 38755\u201338766 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR13","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1101\/gad.12.5.599","volume":"12","author":"K Struhl","year":"1998","unstructured":"Struhl, K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12, 599\u2013606 (1998).","journal-title":"Genes Dev."},{"key":"BFnsmb3228_CR14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1093\/bfgp\/ell032","volume":"5","author":"H Fukuda","year":"2006","unstructured":"Fukuda, H., Sano, N., Muto, S. & Horikoshi, M. Simple histone acetylation plays a complex role in the regulation of gene expression. Brief Funct. Genomic. Proteomic. 5, 190\u2013208 (2006).","journal-title":"Brief Funct. Genomic. Proteomic."},{"key":"BFnsmb3228_CR15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1128\/MMBR.64.2.435-459.2000","volume":"64","author":"DE Sterner","year":"2000","unstructured":"Sterner, D.E. & Berger, S.L. Acetylation of histones and transcription-related factors. Microbiol. Mol. Biol. Rev. 64, 435\u2013459 (2000).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"BFnsmb3228_CR16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides, T. Chromatin modifications and their function. Cell 128, 693\u2013705 (2007).","journal-title":"Cell"},{"key":"BFnsmb3228_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/47412","volume":"403","author":"BD Strahl","year":"2000","unstructured":"Strahl, B.D. & Allis, C.D. The language of covalent histone modifications. Nature 403, 41\u201345 (2000).","journal-title":"Nature"},{"key":"BFnsmb3228_CR18","doi-asserted-by":"publisher","first-page":"8758","DOI":"10.1073\/pnas.1433065100","volume":"100","author":"A Dey","year":"2003","unstructured":"Dey, A., Chitsaz, F., Abbasi, A., Misteli, T. & Ozato, K. The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis. Proc. Natl. Acad. Sci. USA 100, 8758\u20138763 (2003).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnsmb3228_CR19","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/nsmb.2581","volume":"20","author":"P Tropberger","year":"2013","unstructured":"Tropberger, P. & Schneider, R. Scratching the (lateral) surface of chromatin regulation by histone modifications. Nat. Struct. Mol. Biol. 20, 657\u2013661 (2013).","journal-title":"Nat. Struct. Mol. Biol."},{"key":"BFnsmb3228_CR20","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.cell.2013.01.032","volume":"152","author":"P Tropberger","year":"2013","unstructured":"Tropberger, P. et al. Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell 152, 859\u2013872 (2013).","journal-title":"Cell"},{"key":"BFnsmb3228_CR21","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1038\/nature09589","volume":"468","author":"E Nicodeme","year":"2010","unstructured":"Nicodeme, E. et al. Suppression of inflammation by a synthetic histone mimic. Nature 468, 1119\u20131123 (2010).","journal-title":"Nature"},{"key":"BFnsmb3228_CR22","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1091\/mbc.e05-08-0729","volume":"17","author":"A Nishiyama","year":"2006","unstructured":"Nishiyama, A., Dey, A., Miyazaki, J. & Ozato, K. Brd4 is required for recovery from antimicrotubule drug-induced mitotic arrest: preservation of acetylated chromatin. Mol. Biol. Cell 17, 814\u2013823 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFnsmb3228_CR23","doi-asserted-by":"crossref","first-page":"38307","DOI":"10.1074\/jbc.M100290200","volume":"276","author":"MJ Kruhlak","year":"2001","unstructured":"Kruhlak, M.J. et al. Regulation of global acetylation in mitosis through loss of histone acetyltransferases and deacetylases from chromatin. J. Biol. Chem. 276, 38307\u201338319 (2001).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR24","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ncb2341","volume":"13","author":"R Zhao","year":"2011","unstructured":"Zhao, R., Nakamura, T., Fu, Y., Lazar, Z. & Spector, D.L. Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nat. Cell Biol. 13, 1295\u20131304 (2011).","journal-title":"Nat. Cell Biol."},{"key":"BFnsmb3228_CR25","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1074\/jbc.M114.600759","volume":"290","author":"R Wang","year":"2015","unstructured":"Wang, R. & You, J. Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation. J. Biol. Chem. 290, 2744\u20132758 (2015).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR26","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/S0092-8674(00)81584-6","volume":"94","author":"RN Dutnall","year":"1998","unstructured":"Dutnall, R.N., Tafrov, S.T., Sternglanz, R. & Ramakrishnan, V. Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell 94, 427\u2013438 (1998).","journal-title":"Cell"},{"key":"BFnsmb3228_CR27","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature09504","volume":"468","author":"P Filippakopoulos","year":"2010","unstructured":"Filippakopoulos, P. et al. Selective inhibition of BET bromodomains. Nature 468, 1067\u20131073 (2010).","journal-title":"Nature"},{"key":"BFnsmb3228_CR28","doi-asserted-by":"publisher","first-page":"105","DOI":"10.4161\/epi.5.2.10942","volume":"5","author":"S Vernarecci","year":"2010","unstructured":"Vernarecci, S., Tosi, F. & Filetici, P. Tuning acetylated chromatin with HAT inhibitors: a novel tool for therapy. Epigenetics 5, 105\u2013111 (2010).","journal-title":"Epigenetics"},{"key":"BFnsmb3228_CR29","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.molcel.2012.10.025","volume":"49","author":"MA McBrian","year":"2013","unstructured":"McBrian, M.A. et al. Histone acetylation regulates intracellular pH. Mol. Cell 49, 310\u2013321 (2013).","journal-title":"Mol. Cell"},{"key":"BFnsmb3228_CR30","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1038\/ncomms3203","volume":"4","author":"Y Zheng","year":"2013","unstructured":"Zheng, Y., Thomas, P.M. & Kelleher, N.L. Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nat. Commun. 4, 2203 (2013).","journal-title":"Nat. Commun."},{"key":"BFnsmb3228_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.4161\/trns.22542","volume":"4","author":"BN Devaiah","year":"2013","unstructured":"Devaiah, B.N. & Singer, D.S. Two faces of brd4: mitotic bookmark and transcriptional lynchpin. Transcription 4, 13\u201317 (2013).","journal-title":"Transcription"},{"key":"BFnsmb3228_CR32","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.cell.2016.02.036","volume":"165","author":"L Baranello","year":"2016","unstructured":"Baranello, L. et al. RNA Polymerase II regulates Topoisomerase 1 activity to favor efficient transcription. Cell 165, 357\u2013371 (2016).","journal-title":"Cell"},{"key":"BFnsmb3228_CR33","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1016\/j.cell.2011.08.017","volume":"146","author":"JE Delmore","year":"2011","unstructured":"Delmore, J.E. et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146, 904\u2013917 (2011).","journal-title":"Cell"},{"key":"BFnsmb3228_CR34","doi-asserted-by":"publisher","first-page":"43137","DOI":"10.1074\/jbc.M112.413047","volume":"287","author":"W Zhang","year":"2012","unstructured":"Zhang, W. et al. Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J. Biol. Chem. 287, 43137\u201343155 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR35","doi-asserted-by":"publisher","first-page":"10738","DOI":"10.1074\/jbc.M111.323493","volume":"287","author":"R Wang","year":"2012","unstructured":"Wang, R., Li, Q., Helfer, C.M., Jiao, J. & You, J. Bromodomain protein Brd4 associated with acetylated chromatin is important for maintenance of higher-order chromatin structure. J. Biol. Chem. 287, 10738\u201310752 (2012).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR36","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.devcel.2012.10.010","volume":"23","author":"MJ Jones","year":"2012","unstructured":"Jones, M.J. & Jallepalli, P.V. Chromothripsis: chromosomes in crisis. Dev. Cell 23, 908\u2013917 (2012).","journal-title":"Dev. Cell"},{"key":"BFnsmb3228_CR37","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1016\/j.cell.2013.10.056","volume":"155","author":"W Liu","year":"2013","unstructured":"Liu, W. et al. Brd4 and JMJD6-associated anti-pause enhancers in regulation of transcriptional pause release. Cell 155, 1581\u20131595 (2013).","journal-title":"Cell"},{"key":"BFnsmb3228_CR38","doi-asserted-by":"publisher","first-page":"38772","DOI":"10.1074\/jbc.M110.173864","volume":"285","author":"BN Devaiah","year":"2010","unstructured":"Devaiah, B.N. et al. Novel functions for TAF7, a regulator of TAF1-independent transcription. J. Biol. Chem. 285, 38772\u201338780 (2010).","journal-title":"J. Biol. Chem."},{"key":"BFnsmb3228_CR39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ymeth.2005.03.002","volume":"36","author":"CE Berndsen","year":"2005","unstructured":"Berndsen, C.E. & Denu, J.M. Assays for mechanistic investigations of protein\/histone acetyltransferases. Methods 36, 321\u2013331 (2005).","journal-title":"Methods"},{"key":"BFnsmb3228_CR40","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S0092-8674(00)81821-8","volume":"87","author":"CA Mizzen","year":"1996","unstructured":"Mizzen, C.A. et al. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell 87, 1261\u20131270 (1996).","journal-title":"Cell"},{"key":"BFnsmb3228_CR41","doi-asserted-by":"publisher","first-page":"7323","DOI":"10.1128\/MCB.00889-08","volume":"28","author":"AS Kotekar","year":"2008","unstructured":"Kotekar, A.S., Weissman, J.D., Gegonne, A., Cohen, H. & Singer, D.S. Histone modifications, but not nucleosomal positioning, correlate with major histocompatibility complex class I promoter activity in different tissues in vivo . Mol. Cell. Biol. 28, 7323\u20137336 (2008).","journal-title":"Mol. Cell. Biol."},{"key":"BFnsmb3228_CR42","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.celrep.2014.06.016","volume":"8","author":"S Nagarajan","year":"2014","unstructured":"Nagarajan, S. et al. Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription. Cell Rep. 8, 460\u2013469 (2014).","journal-title":"Cell Rep."},{"key":"BFnsmb3228_CR43","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.ccr.2013.11.003","volume":"24","author":"B Chapuy","year":"2013","unstructured":"Chapuy, B. et al. Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. Cancer Cell 24, 777\u2013790 (2013).","journal-title":"Cancer Cell"},{"key":"BFnsmb3228_CR44","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead, B. & Salzberg, S.L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357\u2013359 (2012).","journal-title":"Nat. Methods"},{"key":"BFnsmb3228_CR45","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/978-1-61779-477-3_24","volume":"833","author":"K Cui","year":"2012","unstructured":"Cui, K. & Zhao, K. Genome-wide approaches to determining nucleosome occupancy in metazoans using MNase-Seq. Methods Mol. Biol. 833, 413\u2013419 (2012).","journal-title":"Methods Mol. Biol."},{"key":"BFnsmb3228_CR46","unstructured":"Li, H. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM. Preprint at http:\/\/arxiv.org\/abs\/1303.3997 (2013)."},{"key":"BFnsmb3228_CR47","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1101\/gr.142067.112","volume":"23","author":"K Chen","year":"2013","unstructured":"Chen, K. et al. DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing. Genome Res. 23, 341\u2013351 (2013).","journal-title":"Genome Res."},{"key":"BFnsmb3228_CR48","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/B978-0-12-391938-0.00013-6","volume":"513","author":"G Wei","year":"2012","unstructured":"Wei, G., Hu, G., Cui, K. & Zhao, K. Genome-wide mapping of nucleosome occupancy, histone modifications, and gene expression using next-generation sequencing technology. Methods Enzymol. 513, 297\u2013313 (2012).","journal-title":"Methods Enzymol."},{"key":"BFnsmb3228_CR49","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell, C., Pachter, L. & Salzberg, S.L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105\u20131111 (2009).","journal-title":"Bioinformatics"},{"key":"BFnsmb3228_CR50","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/1471-2105-12-267","volume":"12","author":"X Deng","year":"2011","unstructured":"Deng, X. SeqGene: a comprehensive software solution for mining exome- and transcriptome- sequencing data. BMC Bioinformatics 12, 267 (2011).","journal-title":"BMC Bioinformatics"}],"updated-by":[{"DOI":"10.1038\/nsmb0217-194c","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000}}],"container-title":["Nature Structural &amp; Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nsmb.3228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb.3228","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nsmb.3228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:39:52Z","timestamp":1684456792000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nsmb.3228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFnsmb3228"],"URL":"https:\/\/doi.org\/10.1038\/nsmb.3228","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726342631.793518686","asserted-by":"object"}]},"ISSN":["1545-9993","1545-9985"],"issn-type":[{"value":"1545-9993","type":"print"},{"value":"1545-9985","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,9]]},"assertion":[{"value":"3 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2016","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Erratum","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the version of this article initially published, the blots in Figure 2c were inadvertently replaced with a duplicate of the blots in Figure 2b. The error has been corrected in the HTML and PDF versions of the article.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}