{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:03:18Z","timestamp":1789232598405,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T00:00:00Z","timestamp":1463961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr &amp; Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes and has a key role in protecting the liver. An elevated gamma-glutamyl transferase (GGT) level is related to oxidative stress and nonalcoholic fatty liver disease (NAFLD). We herein investigated the association between inactive <jats:italic>ALDH2*2<\/jats:italic> allele (rs671) and the risk of NAFLD, including the relationship to the GGT level. A retrospective follow-up study (mean 5.4\u00b11.1 years) was conducted among 341 Japanese health screening program participants. The receiver operating characteristic curve indicated that the GGT level predicted the development of NAFLD (area under the curve: 0.65, <jats:italic>P<\/jats:italic>&lt;0.05) with a cutoff value of 25.5\u2009IUl<jats:sup>\u22121<\/jats:sup>. The longitudinal risk of NAFLD was higher in the <jats:italic>ALDH2*2<\/jats:italic> allele carriers than in the noncarriers (odds ratio (OR): 2.30, 95% confidence interval (CI): 1.21\u20134.40), and the risk was further increased among the <jats:italic>*2<\/jats:italic> allele carriers with GGT values \u2a7e25.5\u2009IUl<jats:sup>\u22121<\/jats:sup> (OR: 4.28, 95% CI: 1.80\u201310.19). On the other hand, there were no significant changes in the subjects\u2019 body weight and body mass index during observation period. The <jats:italic>ALDH2*2<\/jats:italic> allele, in relation to the GGT level, may potentially be a novel risk factor for NAFLD.<\/jats:p>","DOI":"10.1038\/nutd.2016.17","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T08:53:21Z","timestamp":1464080001000},"page":"e210-e210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease"],"prefix":"10.1038","volume":"6","author":[{"given":"K","family":"Oniki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kajiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Otake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Saruwatari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,23]]},"reference":[{"key":"BFnutd201617_CR1","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2015.01.001","volume":"239","author":"NN Than","year":"2015","unstructured":"Than NN, Newsome PN . 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