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Given the advanced-stage CKD with nephrotic proteinuria, we supplemented low-protein diet with high doses of a tailored essential amino acid mixture (AAs: 44\u2009g per day) to improve weight reduction in the patient. After 20 months of conservative therapy, the patient lost 43\u2009kg; despite two episodes of infection, albumin plasma levels increased up to 3.7\u2009g per day. After a further 20 months of dialysis, the patient maintained a diet of 1800 kcal supplemented with 32\u2009g of AAs and lost 47\u2009kg, whereas both albumin (3.89\u00b10.12\u2009g\u2009dl<jats:sup>\u22121<\/jats:sup>) and C reactive protein returned to normal. During the follow-up period, anemia improved, erythropoietin was thus discontinued and insulin requirement decreased to 105 IU. This therapeutic option may be beneficial in advanced CKD patients with obesity and diabetes resulting from malnutrition.<\/jats:p>","DOI":"10.1038\/nutd.2016.4","type":"journal-article","created":{"date-parts":[[2016,2,29]],"date-time":"2016-02-29T15:21:37Z","timestamp":1456759297000},"page":"e196-e196","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Morbid obesity in a young woman affected by advanced chronic kidney disease: an exceptional case report. Does a high dose of essential amino acids play a key role in therapeutic success?"],"prefix":"10.1038","volume":"6","author":[{"given":"S","family":"Caria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Murtas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Loria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F S","family":"Dioguardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Secci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bolasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,29]]},"reference":[{"key":"BFnutd20164_CR1","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1001\/jama.289.1.76","volume":"289","author":"AH Mokdad","year":"2003","unstructured":"Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS et al. 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