{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:01:30Z","timestamp":1769940090377,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr &amp; Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objective:<\/jats:title>\n                <jats:p>There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women, independent of other dietary and lifestyle factors. One unexplored hypothesis for this association is that fructose malabsorption, due to regular consumption of excess free fructose (EFF) and HFCS, contributes to fructose reactivity in the gastrointestinal tract and intestinal <jats:italic>in situ<\/jats:italic> formation of enFruAGEs, which once absorbed, travel beyond the intestinal boundaries to other tissues and promote inflammation. In separate studies, the accumulation of advanced glycation end-products has been associated with joint inflammation in RA. Objective of this study was to assess the association between EFF beverages intake and non-age, non-wear and tear-associated arthritis in US young adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods:<\/jats:title>\n                <jats:p>In this cross sectional study of 1209 adults aged 20\u201330y, (Nutrition and Health Examination Surveys 2003\u20132006) exposure variables were high EFF beverages, including HFCS sweetened soft drinks, and any combination of HFCS sweetened soft drinks, fruit drinks (FD) and apple juice, referred to as tEFF. Analyses of diet soda and diet FD were included for comparison. The outcome was self-reported arthritis. Rao Scott \u04b2<jats:sup>2<\/jats:sup> was used for prevalence differences and logistic regression for associations, adjusted for confounders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results:<\/jats:title>\n                <jats:p>Young adults consuming any combination of high EFF beverages (tEFF) \u2a7e5 times\/week (but not diet soda) were three times as likely to have arthritis as non\/low consumers (odds ratios=3.01; <jats:italic>p<\/jats:italic>\u2a7d0.021; 95% confidence intervals=1.20\u20137.59), independent of all covariates, including physical activity, other dietary factors, blood glucose and smoking.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion:<\/jats:title>\n                <jats:p>EFF beverage intake is significantly associated with arthritis in US adults aged 20\u201330 years, possibly due to the intestinal <jats:italic>in situ<\/jats:italic> formation of enFruAGEs.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1038\/nutd.2016.7","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T15:22:45Z","timestamp":1457364165000},"page":"e199-e199","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20\u201330 years"],"prefix":"10.1038","volume":"6","author":[{"given":"L R","family":"DeChristopher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Uribarri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K L","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"BFnutd20167_CR1","unstructured":"Arthritis Foundation. http:\/\/www.arthritis.org\/. Accessed 08\/15\/2015."},{"key":"BFnutd20167_CR2","unstructured":"Centers for Disease Control and Prevention (CDC). Prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation\u2014United States, 2003-2005. MMWR Morb Mortal Wkly Rep. 2006; 55: 1089-92. Erratum in: MMWR Morb Mortal Wkly Rep. 2007; 56: 55. MMWR Morb Mortal Wkly Rep. 2006; 55: 1129."},{"key":"BFnutd20167_CR3","doi-asserted-by":"publisher","first-page":"iii8","DOI":"10.1136\/ard.61.suppl_3.iii8","volume":"61","author":"J Sieper","year":"2002","unstructured":"Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A . Ankylosing spondylitis: an overview. Ann Rheum Dis 2002; 61: iii8\u201318.","journal-title":"Ann Rheum Dis"},{"key":"BFnutd20167_CR4","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3945\/ajcn.114.086918","volume":"100","author":"Y Hu","year":"2014","unstructured":"Hu Y, Costenbader KH, Gao X, Al-Daabil M, Sparks JA, Solomon DH et al. Sugar-sweetened soda consumption and risk of developing rheumatoid arthritis in women. Am J Clin Nutr 2014; 100: 959\u2013967.","journal-title":"Am J Clin Nutr"},{"key":"BFnutd20167_CR5","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1097\/AJP.0b013e31827da381","volume":"29","author":"S Evans","year":"2013","unstructured":"Evans S, Moieni M, Lung K, Tsao J, Sternlieb B, Taylor M et al. Impact of iyengar yoga on quality of life in young women with rheumatoid arthritis. Clin J Pain 2013; 29: 988\u2013997.","journal-title":"Clin J Pain"},{"key":"BFnutd20167_CR6","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1177\/0961203308093072","volume":"17","author":"J Ju\u00e1rez-Rojas","year":"2008","unstructured":"Ju\u00e1rez-Rojas J, Medina-Urrutia A, Posadas-S\u00e1nchez R, Jorge-Galarza E, Mendoza-P\u00e9rez E, Caracas-Portilla N et al. High-density lipoproteins are abnormal in young women with uncomplicated systemic lupus erythematosus. Lupus 2008; 17: 981\u2013987.","journal-title":"Lupus"},{"key":"BFnutd20167_CR7","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1002\/art.21115","volume":"52","author":"V Lilleby","year":"2005","unstructured":"Lilleby V, Lien G, Frey Fr\u00f8slie K, Haugen M, Flat\u00f8 B, F\u00f8rre \u00d8 . Frequency of osteopenia in children and young adults with childhood-onset systemic lupus erythematosus. Arthritis Rheum 2005; 52: 2051\u20132059.","journal-title":"Arthritis Rheum"},{"key":"BFnutd20167_CR8","first-page":"21","volume":"258","author":"M McLaughlin","year":"2014","unstructured":"McLaughlin M, Ost\u00f6r A . Early treatment of psoriatic arthritis improves prognosis. Practitioner 2014; 258: 21\u20134, 3.","journal-title":"Practitioner"},{"key":"BFnutd20167_CR9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/art.22380","volume":"56","author":"AH van der Helm-van Mil","year":"2007","unstructured":"van der Helm-van Mil AH, le Cessie S, van Dongen H, Breedveld FC, Toes RE, Huizinga TW . A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisions. Arthritis Rheum 2007; 56: 433\u2013440.","journal-title":"Arthritis Rheum"},{"key":"BFnutd20167_CR10","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1136\/ard.2005.043869","volume":"65","author":"G Haugeberg","year":"2006","unstructured":"Haugeberg G, Green MJ, Quinn MA, Marzo-Ortega H, Proudman S, Karim Z et al. Hand bone loss in early undifferentiated arthritis: evaluating bone mineral density loss before the development of rheumatoid arthritis. Ann Rheum Dis 2006; 65: 736\u2013740.","journal-title":"Ann Rheum Dis"},{"key":"BFnutd20167_CR11","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.3899\/jrheum.111311","volume":"39","author":"E Myasoedova","year":"2012","unstructured":"Myasoedova E, Matteson EL, Talley NJ, Crowson CS . Increased incidence and impact of upper and lower gastrointestinal events in patients with rheumatoid arthritis in Olmsted County, Minnesota: a longitudinal population-based study. J Rheumatol 2012; 39: 1355\u20131362.","journal-title":"J Rheumatol"},{"key":"BFnutd20167_CR12","first-page":"1373","volume":"27","author":"F Wolfe","year":"2000","unstructured":"Wolfe F, Kong SX, Watson DJ . Gastrointestinal symptoms and health related quality of life in patients with arthritis. J Rheumatol 2000; 27: 1373\u20131378.","journal-title":"J Rheumatol"},{"key":"BFnutd20167_CR13","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.3748\/wjg.v16.i24.2971","volume":"16","author":"XP Tian","year":"2010","unstructured":"Tian XP, Zhang X . Gastrointestinal involvement in systemic lupus erythematosus: insight into pathogenesis, diagnosis and treatment. World J Gastroenterol 2010; 16: 2971\u20132977.","journal-title":"World J Gastroenterol"},{"key":"BFnutd20167_CR14","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12178-011-9085-8","volume":"4","author":"SL Arvikar","year":"2011","unstructured":"Arvikar SL, Fisher MC . Inflammatory bowel disease associated arthropathy. Curr Rev Musculoskelet Med 2011; 4: 123\u2013131.","journal-title":"Curr Rev Musculoskelet Med"},{"key":"BFnutd20167_CR15","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1136\/gut.2005.076901","volume":"55","author":"M Hvatum","year":"2006","unstructured":"Hvatum M, Kanerud L, H\u00e4llgren R, Brandtzaeg P . The gut-joint axis: cross reactive food antibodies in rheumatoid arthritis. Gut 2006; 55: 1240\u20131247.","journal-title":"Gut"},{"key":"BFnutd20167_CR16","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1002\/art.20731","volume":"50","author":"DJ Pattison","year":"2004","unstructured":"Pattison DJ, Symmons DP, Lunt M, Welch A, Luben R, Bingham SA et al. Dietary risk factors for the development of inflammatory polyarthritis: evidence for a role of high level of red meat consumption. Arthritis Rheum 2004; 50: 3804\u20133812.","journal-title":"Arthritis Rheum"},{"key":"BFnutd20167_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0950-3579(89)80021-4","volume":"3","author":"KD Katz","year":"1989","unstructured":"Katz KD, Hollander D . Intestinal mucosal permeability and rheumatological diseases. Baillieres Clin Rheumatol 1989; 3: 271\u2013284.","journal-title":"Baillieres Clin Rheumatol"},{"key":"BFnutd20167_CR18","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/0140-6736(91)91770-U","volume":"338","author":"J Kjeldsen-Kragh","year":"1991","unstructured":"Kjeldsen-Kragh J, Haugen M, Borchgrevink CF, Laerum E, Eek M, Mowinkel P et al. Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet 1991; 338: 899\u2013902.","journal-title":"Lancet"},{"key":"BFnutd20167_CR19","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jada.2010.03.018","volume":"110","author":"J Uribarri","year":"2010","unstructured":"Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc 2010; 110: 911\u201316.e12.","journal-title":"J Am Diet Assoc"},{"key":"BFnutd20167_CR20","doi-asserted-by":"crossref","unstructured":"DeChristopher LR, Uribarri J, Tucker KL . Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years. Public Health Nutr 2015; 1\u20138.","DOI":"10.1017\/S1368980015000865"},{"key":"BFnutd20167_CR21","unstructured":"DeChristopher Luanne Robalo Consumption of Fructose and High Fructose Corn Syrup: Is Fructositis triggered bronchitis, arthritis, & auto-immune reactivity merely a side bar in the Etiology of Metabolic Syndrome II (to be defined)? \u2013 Evidence and a Hypothesis, New York Medical College Library, 2012, print. Online at http:\/\/www.amazon.com\/Consumption-Fructose-High-Syrup-ebook\/d\/B00DHV3WZO."},{"key":"BFnutd20167_CR22","doi-asserted-by":"publisher","first-page":"748S","DOI":"10.1093\/ajcn\/58.5.748S","volume":"58","author":"JE Riby","year":"1993","unstructured":"Riby JE, Fujisawa T, Kretchmer N . Fructose absorption. Am J Clin Nutr 1993; 58: 748S\u2013753S.","journal-title":"Am J Clin Nutr"},{"key":"BFnutd20167_CR23","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1016\/j.jada.2005.07.002","volume":"105","author":"PL Beyer","year":"2005","unstructured":"Beyer PL, Caviar EM, McCallum RW . Fructose intake at current levels in the united states may cause gastrointestinal distress in normal adults. J Am Diet Assoc 2005; 105: 1559\u20131566.","journal-title":"J Am Diet Assoc"},{"key":"BFnutd20167_CR24","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1365-2036.2006.03186.x","volume":"25","author":"PR Gibson","year":"2007","unstructured":"Gibson PR, Newnham E, Barrett JS, Shepherd SJ, Muir JG . Review article: Fructose malabsorption and the bigger picture. Aliment Pharmacol Ther 2007; 25: 349\u2013363.","journal-title":"Aliment Pharmacol Ther"},{"key":"BFnutd20167_CR25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1097\/MPG.0b013e318166cbe4","volume":"47","author":"RE Gomara","year":"2008","unstructured":"Gomara RE, Halata MS, Newman LJ, Bostwick HE, Berezin SH, Cukaj L et al. Fructose intolerance in children presenting with abdominal pain. J Pediatr Gastroenterol Nutr 2008; 47: 303\u2013308.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BFnutd20167_CR26","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/MPG.0b013e3181fd1315","volume":"52","author":"HF Jones","year":"2011","unstructured":"Jones HF, Burt E, Dowling K, Davidson G, Brooks DA, Butler RN . Effect of age on fructose malabsorption in children presenting with gastrointestinal symptoms. J Pediatr Gastroenterol Nutr 2011; 52: 581\u2013584.","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"BFnutd20167_CR27","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1136\/adc.68.1.136","volume":"68","author":"JH Hoekstra","year":"1993","unstructured":"Hoekstra JH, van Kempen AA, Bijl SB, Kneepkens CM . Fructose breath hydrogen tests. Arch Dis Child 1993; 68: 136\u2013138.","journal-title":"Arch Dis Child"},{"key":"BFnutd20167_CR28","doi-asserted-by":"publisher","first-page":"R205","DOI":"10.1186\/ar3538","volume":"13","author":"L de Groot","year":"2011","unstructured":"de Groot L, Hinkema H, Westra J, Smit AJ, Kallenberg CG, Bijl M et al. Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease. Arthritis Res Ther 2011; 13: R205.","journal-title":"Arthritis Res Ther"},{"key":"BFnutd20167_CR29","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1136\/ard.61.6.488","volume":"61","author":"S Drinda","year":"2002","unstructured":"Drinda S, Franke S, Canet CC, Petrow P, Br\u00e4uer R, H\u00fcttich C et al. Identification of the advanced glycation end products N(epsilon)-carboxymethyllysine in the synovial tissue of patients with rheumatoid arthritis. Ann Rheum Dis 2002; 61: 488\u2013492.","journal-title":"Ann Rheum Dis"},{"key":"BFnutd20167_CR30","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1042\/BST20140024","volume":"42","author":"U Ahmed","year":"2014","unstructured":"Ahmed U, Thornalley PJ, Rabbani N . Possible role of methylglyoxal and glyoxalase in arthritis. Biochem Soc Trans 2014; 42: 538\u2013542.","journal-title":"Biochem Soc Trans"},{"key":"BFnutd20167_CR31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1756-185X.2011.01679.x","volume":"15","author":"A Syngle","year":"2012","unstructured":"Syngle A, Vohra K, Garg N, Kaur L, Chand P . Advanced glycation end-products inhibition improves endothelial dysfunction in rheumatoid arthritis. Int J Rheum Dis 2012; 15: 45\u201355.","journal-title":"Int J Rheum Dis"},{"key":"BFnutd20167_CR32","doi-asserted-by":"publisher","first-page":"403460","DOI":"10.1155\/2013\/403460","volume":"2013","author":"YK Chuah","year":"2013","unstructured":"Chuah YK, Basir R, Talib H, Tie TH, Nordin N . Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases. Int J Inflam 2013; 2013: 403460.","journal-title":"Int J Inflam"},{"key":"BFnutd20167_CR33","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/17441692.2012.736257","volume":"8","author":"MI Goran","year":"2013","unstructured":"Goran MI, Ulijaszek SJ, Ventura EE . High fructose corn syrup and diabetes prevalence: a global perspective. Glob Public Health 2013; 8: 55\u201364.","journal-title":"Glob Public Health"},{"key":"BFnutd20167_CR34","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1016\/j.nut.2014.04.003","volume":"30","author":"RW Walker","year":"2014","unstructured":"Walker RW, Dumke KA, Goran MI . Fructose content in popular beverages made with and without high-fructose corn syrup. Nutrition 2014; 30: 928\u2013935.","journal-title":"Nutrition"},{"key":"BFnutd20167_CR35","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1038\/oby.2010.255","volume":"19","author":"EE Ventura","year":"2011","unstructured":"Ventura EE, Davis JN, Goran MI . Sugar content of popular sweetened beverages based on objective laboratory analysis: Focus on fructose content. Obesity (Silver Spring) 2011; 19: 868\u2013874.","journal-title":"Obesity (Silver Spring)"},{"key":"BFnutd20167_CR36","unstructured":"US Department of Agriculture, Agricultural Research Service. 2012. USDA National Nutrient Database for Standard Reference, Release 26. Nutrient Data Laboratory Home Page http:\/\/www.ars.usda.gov\/ba\/bhnrc\/ndl."},{"key":"BFnutd20167_CR37","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jand.2012.09.016","volume":"113","author":"E Han","year":"2013","unstructured":"Han E, Powell LM . Consumption patterns of sugar-sweetened beverages in the United States. J Acad Nutr Diet 2013; 113: 43\u201353.","journal-title":"J Acad Nutr Diet"},{"key":"BFnutd20167_CR38","unstructured":"US Centers for Disease Control, National Health and Nutrition Examination Survey. Page http:\/\/www.cdc.gov\/nchs\/nhanes.htm."},{"key":"BFnutd20167_CR39","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1016\/j.jada.2006.07.002","volume":"106","author":"AF Subar","year":"2006","unstructured":"Subar AF, Dodd KW, Guenther PM, Kipnis V, Midthune D, McDowell M et al. The food propensity questionnaire: concept, development, and validation for use as a covariate in a model to estimate usual food intake. J Am Diet Assoc 2006; 106: 1556\u20131563.","journal-title":"J Am Diet Assoc"},{"key":"BFnutd20167_CR40","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/art.23245","volume":"59","author":"JW Choi","year":"2008","unstructured":"Choi JW, Ford ES, Gao X, Choi HK . Sugar-sweetened soft drinks, diet soft drinks, and serum uric acid level: the Third National Health and Nutrition Examination Survey. Arthritis Rheum 2008; 59: 109\u2013116.","journal-title":"Arthritis Rheum"},{"key":"BFnutd20167_CR41","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jand.2012.09.020","volume":"113","author":"S Park","year":"2013","unstructured":"Park S, Blanck HM, Sherry B, Jones SE, Pan L . Regular-soda intake independent of weight status is associated with asthma among US high school students. J Acad Nutr Diet 2013; 113: 106\u2013111.","journal-title":"J Acad Nutr Diet"},{"key":"BFnutd20167_CR42","unstructured":"U.S. Centers for Disease Control, National Health and Nutrition Examination Survey. Analytic Note Regarding 2007-2010 Survey Design Changes and Combining Data Across other Survey Cycles Page http:\/\/www.cdc.gov\/nchs\/data\/nhanes\/analyticnote_2007-2010.pdf."},{"key":"BFnutd20167_CR43","unstructured":"US Department of Agriculture Food and Nutrition Service. May 22, 2003. Recommendation regarding pasteurized Juice. http:\/\/www.fns.usda.gov\/cnd\/governance\/Policy-Memos\/2003\/2003-5-22.pdf. Retrieved on 7 August 2013."},{"key":"BFnutd20167_CR44","unstructured":"US Department of Agriculture. National Agriculture Library. Juice and Produce HACCP (Hazard Analysis and Critical Control Points). http:\/\/fsrio.nal.usda.gov\/hacc\/juice-and-produce-haccp. Retrieved on 7 August 2013."},{"key":"BFnutd20167_CR45","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s10620-011-1951-0","volume":"57","author":"P Chen","year":"2012","unstructured":"Chen P, Zhao J, Gregersen H . Up-regulated expression of advanced glycation end-products and their receptor in the small intestine and colon of diabetic rats. Dig Dis Sci 2012; 57: 48\u201357.","journal-title":"Dig Dis Sci"},{"key":"BFnutd20167_CR46","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/j.jbiomech.2013.01.010","volume":"46","author":"J Zhao","year":"2013","unstructured":"Zhao J, Chen P, Gregersen H . Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats\u2014is it related to advanced glycation end product formation? J Biomech 2013; 46: 1128\u20131134.","journal-title":"J Biomech"},{"key":"BFnutd20167_CR47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1042\/bj3500149","volume":"350","author":"PA Helliwell","year":"2000","unstructured":"Helliwell PA, Richardson M, Affleck J, Kellett GL . Stimulation of fructose transport across the intestinal brush-border membrane by PMA is mediated by GLUT2 and dynamically regulated by protein kinase C. Biochem J 2000; 350: 149\u2013154.","journal-title":"Biochem J"},{"key":"BFnutd20167_CR48","unstructured":"US Department of Agriculture, Economic Research Service. 2012. The ERS Food Availability (Per Capita) Data System. Economic Research Service Home Page: http:\/\/www.ers.usda.gov\/data-products\/food-availability-(per-capita)-data-system.aspx#.UbdwxucthyJ."},{"key":"BFnutd20167_CR49","doi-asserted-by":"publisher","first-page":"667","DOI":"10.2105\/AJPH.2005.083782","volume":"97","author":"LR Vartanian","year":"2007","unstructured":"Vartanian LR, Schwartz MB, Brownell KD . Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am J Public Health 2007; 97: 667\u2013675.","journal-title":"Am J Public Health"},{"key":"BFnutd20167_CR50","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.3748\/wjg.v16.i21.2579","volume":"16","author":"W Nseir","year":"2010","unstructured":"Nseir W, Nassar F, Assy N . Soft drinks consumption and nonalcoholic fatty liver disease. World J Gastroenterol 2010; 16: 2579\u20132588.","journal-title":"World J Gastroenterol"},{"key":"BFnutd20167_CR51","doi-asserted-by":"publisher","first-page":"R82","DOI":"10.1186\/ar622","volume":"5","author":"MM Newkirk","year":"2003","unstructured":"Newkirk MM, Goldbach-Mansky R, Lee J, Hoxworth J, McCoy A, Yarboro C et al. Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis. Arthritis Res Ther 2003; 5: R82\u2013R90.","journal-title":"Arthritis Res Ther"},{"key":"BFnutd20167_CR52","doi-asserted-by":"publisher","first-page":"917108","DOI":"10.1155\/2010\/917108","volume":"2010","author":"ST Buckley","year":"2010","unstructured":"Buckley ST, Ehrhardt C . The receptor for advanced glycation end products (RAGE) and the lung. J Biomed Biotechnol 2010; 2010: 917108.","journal-title":"J Biomed Biotechnol"},{"key":"BFnutd20167_CR53","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1172\/JCI200114002","volume":"108","author":"AM Schmidt","year":"2001","unstructured":"Schmidt AM, Yan SD, Yan SF, Stern DM . The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest 2001; 108: 949\u2013955.","journal-title":"J Clin Invest"},{"key":"BFnutd20167_CR54","doi-asserted-by":"publisher","first-page":"R113","DOI":"10.1186\/ar3398","volume":"13","author":"YJ Heo","year":"2011","unstructured":"Heo YJ, Oh HJ, Jung YO, Cho ML, Lee SY, Yu JG et al. The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1. Arthritis Res Ther 2011; 13: R113.","journal-title":"Arthritis Res Ther"},{"key":"BFnutd20167_CR55","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.3899\/jrheum.110058","volume":"38","author":"A Myles","year":"2011","unstructured":"Myles A, Viswanath V, Singh YP, Aggarwal A . Soluble receptor for advanced glycation endproducts is decreased in patients with juvenile idiopathic arthritis (ERA category) and inversely correlates with disease activity and S100A12 levels. J Rheumatol 2011; 38: 1994\u20131999.","journal-title":"J Rheumatol"},{"key":"BFnutd20167_CR56","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/ar1764","volume":"7","author":"B Moser","year":"2005","unstructured":"Moser B, Hudson BI, Schmidt AM . Soluble RAGE: a hot new biomarker for the hot joint? Arthritis Res Ther 2005; 7: 142\u2013144.","journal-title":"Arthritis Res Ther"},{"key":"BFnutd20167_CR57","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1136\/gut.28.4.394","volume":"28","author":"C Cuvelier","year":"1987","unstructured":"Cuvelier C, Barbatis C, Mielants H, De Vos M, Roels H, Veys E . Histopathology of intestinal inflammation related to reactive arthritis. Gut 1987; 28: 394\u2013401.","journal-title":"Gut"},{"key":"BFnutd20167_CR58","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/ejcn.2015.101","volume":"69","author":"LR DeChristopher","year":"2015","unstructured":"DeChristopher LR . Excess free fructose and childhood asthma. Eur J Clin Nutr 2015; 69: 1371.","journal-title":"Eur J Clin Nutr"},{"issue":"2","key":"BFnutd20167_CR59","doi-asserted-by":"publisher","first-page":"AB228","DOI":"10.1016\/j.jaci.2014.12.1678","volume":"135","author":"Lakiea S. Wright","year":"2015","unstructured":"Wright LS, Rifas-Shiman S, Oken E, Gillman M, Litonjua AA, Gold DR . Maternal prenatal intake of fructose is associated with asthma in children. J Aller Clin Immunol 135, AB228.","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"BFnutd20167_CR60","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/ejcn.2014.153","volume":"69","author":"NE Berentzen","year":"2015","unstructured":"Berentzen NE, van Stokkom VL, Gehring U, Koppelman GH, Schaap LA, Smit HA et al. Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort. Eur J Clin Nutr 2015; 69: 303\u2013308.","journal-title":"Eur J Clin Nutr"},{"key":"BFnutd20167_CR61","doi-asserted-by":"crossref","unstructured":"DeChristopher LR, Uribarri J, Tucker KL . Intake of high fructose corn syrup sweetened soft drinks is associated with prevalent chronic bronchitis in US adults, aged 20\u201355 y. Nutr J 2015. e-pub ahead 16 October 2015 doi:10.1186\/s12937-015-0097-x.","DOI":"10.1186\/s12937-015-0097-x"},{"key":"BFnutd20167_CR62","unstructured":"Ogden CL, Kit BK, Carroll MD, Park S. Consumption of Sugar Drinks in the United States, 2005\u20132008. NCHS Data Brief, Number 71, August 2011. Home Page: http:\/\/www.cdc.gov\/nchs\/data\/databriefs\/db71.htm."},{"key":"BFnutd20167_CR63","doi-asserted-by":"publisher","first-page":"1722S","DOI":"10.3945\/ajcn.2008.25825C","volume":"88","author":"KJ Duffey","year":"2008","unstructured":"Duffey KJ, Popkin BM . High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr 2008; 88: 1722S\u20131732S.","journal-title":"Am J Clin Nutr"}],"container-title":["Nutrition &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nutd20167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nutd20167","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nutd20167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T08:42:29Z","timestamp":1672821749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nutd20167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,7]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,3]]}},"alternative-id":["BFnutd20167"],"URL":"https:\/\/doi.org\/10.1038\/nutd.2016.7","relation":{},"ISSN":["2044-4052"],"issn-type":[{"value":"2044-4052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,7]]},"assertion":[{"value":"24 September 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}