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We first examined whether SNS activity toward discrete adipose depots changes in response to a weight loss diet in mice. We found that SNS activity toward each adipose depot is unique in timing, pattern of activation, and habituation with the most dramatic contrast between visceral and subcutaneous adipose depots. Sympathetic drive toward visceral epididymal adipose is more than doubled early in weight loss and then suppressed later in the diet when weight loss plateaued. Coincident with the decline in SNS activity toward visceral adipose is an increase in activity toward subcutaneous depots indicating a switch in lipolytic sources. In response to calorie restriction, SNS activity toward retroperitoneal and brown adipose depots is unaffected. Finally, pharmacological blockage of sympathetic activity on adipose tissue using the \u03b23-adrenergic receptor antagonist, SR59230a, suppressed loss of visceral adipose mass in response to diet. 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This pattern of sympathetic activation is required for energy liberation and loss of adipose tissue in response to calorie-restricted diet.<\/jats:p>","DOI":"10.1038\/nutd.2017.13","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T14:27:50Z","timestamp":1491834470000},"page":"e260-e260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Differential sympathetic outflow to adipose depots is required for visceral fat loss in response to calorie restriction"],"prefix":"10.1038","volume":"7","author":[{"given":"L M","family":"Sipe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Ephrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Garren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Hirsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C D","family":"Deppmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"BFnutd201713_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2165\/00024677-200403010-00002","volume":"3","author":"KS Bell-Anderson","year":"2004","unstructured":"Bell-Anderson KS, Bryson JM . 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