{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:38:16Z","timestamp":1787002696178,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4511,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Objective:<\/jats:italic>\n                    Abdominal obesity has a key role in the pathogenesis of prevalent and serious diseases and has been shown to be associated with an altered hypothalamic\u2010pituitary\u2010adrenal (HPA) axis function, which is regulated by endocrine feedback mediated via hippocampal glucocorticoid receptors (GR).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Research Methods and Procedures:<\/jats:italic>\n                    We examined the HPA axis function by repeated salivary samples for the assessment of cortisol, as well as other endocrine, anthropometric, metabolic, and circulatory variables in middle\u2010aged Swedish men (\n                    <jats:italic>n<\/jats:italic>\n                    = 284). With the restriction enzyme\n                    <jats:italic>Bcl<\/jats:italic>\n                    I, variants of the GR gene (GRL) locus were identified and two alleles with fragment lengths of 4.5 and 2.3 kilobases (kb) were detected.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Results:<\/jats:italic>\n                    The observed frequencies were 40.1% for the 2.3\u2010 and 2.3\u2010kb, 46.2% for the 4.5\u2010 and 2.3\u2010kb, and 13.7% for the 4.5\u2010 and 4.5\u2010kb genotypes. The larger allele (4.5 and 4.5 kb) was associated with elevated body mass index (BMI;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), waist\u2010to\u2010hip circumference ratio (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015), abdominal sagittal diameter (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002), leptin (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001), and systolic blood pressure (borderline,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.058). The 4.5\u2010 and 4.5\u2010kb allele was associated with leptin after adjustment for BMI. Moreover, salivary cortisol values, particularly after stimulation by a standardized lunch (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.040 to 0.086), were elevated in the men with the larger allele.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Discussion:<\/jats:italic>\n                    These results indicate that there is an association between a deficient GR function, defined as a poor feedback regulation of the HPA axis activity, and a polymorphic restriction site at the GR gene locus. An abnormal control of HPA axis function due to genetic alterations may contribute to the pathogenesis of abdominal obesity.\n                  <\/jats:p>","DOI":"10.1038\/oby.2000.24","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T07:35:18Z","timestamp":1208244918000},"page":"211-218","source":"Crossref","is-referenced-by-count":176,"title":["A Glucocorticoid Receptor Gene Marker Is Associated with Abdominal Obesity, Leptin, and Dysregulation of the Hypothalamic\u2010Pituitary\u2010Adrenal Axis"],"prefix":"10.1002","volume":"8","author":[{"given":"Roland","family":"Rosmond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvon C.","family":"Chagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Chagnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"P\u00e9russe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajsa","family":"Lindell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Bj\u00f6rntorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1993.tb00614.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.1853"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00067.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-12-2-118"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(98)90321-3"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.2.E173"},{"key":"e_1_2_6_8_2","first-page":"157","volume-title":"Handbook of Obesity","author":"Bouchard C.","year":"1998"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0090295"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1997.tb00292.x"},{"key":"e_1_2_6_11_2","first-page":"599","article-title":"The influence of occupational and social factors on obesity and body fat distribution in middle\u2010aged men","volume":"20","author":"Rosmond R.","year":"1996","journal-title":"Int J Obes Relat Metab Disord"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1996.tb00542.x"},{"key":"e_1_2_6_13_2","first-page":"294","volume-title":"Obesity","author":"Bray G. A.","year":"1992"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90676-9"},{"key":"e_1_2_6_15_2","first-page":"309","volume-title":"Progress in Obesity Research: 7","author":"Sj\u00f6str\u00f6m L.","year":"1996"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)90013-2"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1996.tb00546.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(92)90171-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-51-4-781"},{"key":"e_1_2_6_20_2","first-page":"435","article-title":"European multicentre evaluation of the ESAT 6660","volume":"28","author":"R\u00f6mer M.","year":"1990","journal-title":"J Clin Chem Clin Biochem"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365518009095573"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.3.269"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/13.20.7207"},{"key":"e_1_2_6_24_2","first-page":"9.16","volume-title":"Molecular Cloning: A Laboratory Manual.","author":"Sambrook J.","year":"1989"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90381-6"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.2307\/2284534"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/75.2.383"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-2-343"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000118611"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800745"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2337\/diab.46.4.717","article-title":"Glucocorticoids as counterregulatory hormones of leptin: towards an understanding of leptin resistance","volume":"46","author":"Zakrzewska K. E.","year":"1997","journal-title":"Diabetes"}],"container-title":["Obesity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2000.24","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2000.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T20:45:02Z","timestamp":1698698702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2000.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["10.1038\/oby.2000.24"],"URL":"https:\/\/doi.org\/10.1038\/oby.2000.24","archive":["Portico"],"relation":{},"ISSN":["1071-7323","1550-8528"],"issn-type":[{"value":"1071-7323","type":"print"},{"value":"1550-8528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}