{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T21:19:43Z","timestamp":1771017583608,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4388,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2000,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> This study assessed whether adding orlistat to sibutramine would induce further weight loss in patients who previously had lost weight while taking sibutramine alone.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Patients were 34 women with a mean age of 44.1 \u00b1 10.4 years, weight of 89.4 \u00b1 13.8 kg, and body mass index (BMI) of 33.9 \u00b1 4.9 kg\/m<jats:sup>2<\/jats:sup> who had lost an average of 11.6 \u00b1 9.2% of initial weight during the prior 1 year of treatment by sibutramine combined with lifestyle modification. Patients were randomly assigned, in double\u2010blind fashion, to sibutramine plus orlistat or sibutramine plus placebo. In addition to medication, participants were provided five brief lifestyle modification visits during the 16\u2010week continuation trial.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Mean body weight did not change significantly in either treatment condition during the 16 weeks. The addition of orlistat to sibutramine did not induce further weight loss as compared with treatment by sibutramine alone (mean changes = +0.1 \u00b1 4.1 kg vs. +0.5 \u00b1 2.1 kg, respectively).<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> These results must be interpreted with caution because of the study's small sample size. The findings, however, suggest that the combination of sibutramine and orlistat is unlikely to have additive effects that will yield mean losses \u226515% of initial weight, as desired by many obese individuals.<\/jats:p>","DOI":"10.1038\/oby.2000.53","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T11:45:59Z","timestamp":1208259959000},"page":"431-437","source":"Crossref","is-referenced-by-count":99,"title":["Effects of Sibutramine Plus Orlistat in Obese Women Following 1 Year of Treatment by Sibutramine Alone: A Placebo\u2010Controlled Trial"],"prefix":"10.1002","volume":"8","author":[{"given":"Thomas A.","family":"Wadden","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert I.","family":"Berkowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie G.","family":"Womble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Sarwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie E.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie M.","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1509","volume-title":"Physician's Desk Reference","author":"Knoll Pharmaceutical Co.","year":"2000"},{"key":"e_1_2_6_3_2","first-page":"2693","volume-title":"Physician's Desk Reference","author":"Roche Laboratories.","year":"2000"},{"key":"e_1_2_6_4_2","first-page":"30S","article-title":"Sibutramine: a review of clinical efficacy","volume":"21","author":"Lean M. 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