{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:10:51Z","timestamp":1764173451231},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4176,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> African American women have a high prevalence of obesity, which partially may be explained by their lower rates of resting energy expenditure (REE). The aim of this study was to examine the influence of acute sibutramine administration on REE and post\u2010exercise energy expenditure in African American women.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> A total of 15 premenopausal, African American women (age, 29 \u00b1 5 years; body fat, 38 \u00b1 7%) completed a randomized, double\u2010blind cross\u2010over design with a 30\u2010mg ingestion of sibutramine or a placebo. Each trial was completed a month apart in the follicular phase and included a 30\u2010minute measurement of REE 2.5 hours after sibutramine or placebo administration. This was followed by 40 minutes of cycling at \u223c70% of peak aerobic capacity and a subsequent 2\u2010hour measurement of post\u2010cycling energy expenditure.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> There was no difference (<jats:italic>p<\/jats:italic> &gt; 0.05) in REE (23.70 \u00b1 2.81 vs. 23.69 \u00b1 2.95 kcal\/30 min), exercise oxygen consumption (1.22 \u00b1 0.15 vs. 1.25 \u00b1 0.15 liter\/min), and post\u2010cycling energy expenditure (104.2 \u00b1 12.7 vs. 104.9 \u00b1 11.4 kcal\/120 min) between the sibutramine and placebo trials, respectively. Cycling heart rate was significantly higher (<jats:italic>p<\/jats:italic> = 0.01) during the sibutramine (158 \u00b1 14 beats\/min) vs. placebo (150 \u00b1 12 beats\/min) trials.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> These data demonstrate that acute sibutramine ingestion does not increase REE or post\u2010exercise energy expenditures but does increase exercising heart rate in overweight African American women. Sibutramine may, therefore, impact weight loss through energy intake and not energy expenditure mechanisms.<\/jats:p>","DOI":"10.1038\/oby.2001.29","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T12:38:50Z","timestamp":1208263130000},"page":"251-256","source":"Crossref","is-referenced-by-count":12,"title":["Influence of Sibutramine on Energy Expenditure in African American Women"],"prefix":"10.1002","volume":"9","author":[{"given":"Raymond D.","family":"Starling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis H.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"243","article-title":"Obesity among African American women: prevalence, consequences, causes, and developing research","volume":"3","author":"Allison D. 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