{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:36:41Z","timestamp":1762144601059},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4085,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To determine whether altered central and\/or peripheral opioidergic mechanisms contribute to the altered ventilatory response to sustained hypoxia in obese Zucker rats.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Eight lean (176 \u00b1 8 [SEM] g) and eight obese (225 \u00b1 12 g) Zucker rats were studied at 6 weeks of age. Pulmonary ventilation (V\u0307<jats:sub>E<\/jats:sub>), tidal volume (V<jats:sub>T<\/jats:sub>), and breathing frequency (f) at rest and in response to sustained (30 minutes) hypoxic (10% O<jats:sub>2<\/jats:sub>) challenges were measured on three separate occasions by the barometric method after the randomized, blinded administration of equal volumes of saline (control), naloxone methiodide (N<jats:sub>M<\/jats:sub>; 5 mg\/kg, peripheral opioid antagonist), or naloxone hydrochloride (N<jats:sub>HCl<\/jats:sub>; 5 mg\/kg, peripheral and central opioid antagonist).<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Administration of N<jats:sub>M<\/jats:sub> and N<jats:sub>HCl<\/jats:sub> in lean animals had no effect on V\u0307<jats:sub>E<\/jats:sub> either at rest or during 30 minutes of sustained exposure to hypoxia. Similarly, N<jats:sub>M<\/jats:sub> failed to alter V\u0307<jats:sub>E<\/jats:sub> in obese rats. In contrast, N<jats:sub>HCl<\/jats:sub> significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) increased V\u0307<jats:sub>E<\/jats:sub> and V<jats:sub>T<\/jats:sub> both at rest and during 2 to 10 minutes of hypoxic exposure in obese rats. After 20 to 30 minutes of hypoxic exposure, V<jats:sub>T<\/jats:sub> remained elevated with N<jats:sub>HCl<\/jats:sub>, but the earlier elevation of V\u0307<jats:sub>E<\/jats:sub> seemed to be attenuated due to a decrease in f at 20 minutes of exposure to hypoxia.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> Thus, endogenous opioids modulate both resting V\u0307<jats:sub>E<\/jats:sub> and the ventilatory response to sustained hypoxia in obese, but not in lean, Zucker rats by acting specifically on opioid receptors located within the central nervous system.<\/jats:p>","DOI":"10.1038\/oby.2001.53","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T13:12:29Z","timestamp":1208265149000},"page":"407-413","source":"Crossref","is-referenced-by-count":13,"title":["Opioidergic Modulation of Ventilatory Response to Sustained Hypoxia in Obese Zucker Rats"],"prefix":"10.1002","volume":"9","author":[{"given":"Shin\u2010Da","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulysses J.","family":"Magalang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Krasney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaspar A.","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"387","article-title":"The obesity\u2010hypoventilation syndrome","volume":"129","author":"Morgan E. 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