{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:02:22Z","timestamp":1791252142464,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4054,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To gain insight into the in vivo modulation of the expression of the adipogenic transcription factors PPAR\u03b32, C\/EBP\u03b1, and ADD1\/SREBP1c by retinoids and its relationship with whole\u2010body adiposity.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Three\u2010week\u2010old mice were fed with standard chow or a vitamin A\u2010deficient diet for 10 weeks. During the 4 days immediately before they were killed, the animals were treated either with all\u2010<jats:italic>trans<\/jats:italic> retinoic acid (tRA; 100 mg\/kg per day, subcutaneously) or vehicle. The specific levels of the mRNAs for the three transcription factors were analyzed in epididymal white adipose tissue (eWAT) and inguinal white adipose tissue and in brown adipose tissue (BAT). Other parameters determined were leptin and UCP2 levels in white adipose tissue depots, total cholesterol and triglyceride serum levels, energy intake, body weight, and adiposity.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Vitamin A\u2010deficient diet feeding led to a marked increase of adiposity and to a small increase of body weight. Hypertrophy of white adipose tissue depots correlated with enhanced PPAR\u03b32 expression. Hypertrophy of BAT, in contrast, correlated with a decrease of PPAR\u03b32 expression that may contribute to the known reduced thermogenic potential of BAT under conditions of vitamin A restriction. Treatment with tRA triggered a reduction of adiposity and body weight that correlated with a down\u2010regulation of PPAR\u03b32 expression in all adipose tissues. The effects of tRA were more pronounced in eWAT, where C\/EBP\u03b1 and ADD1\/SREBP1c levels were also reduced. The response to tRA was impaired in the eWAT and BAT of animals fed the vitamin A\u2010deficient diet.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> The results emphasize the importance of retinoids as physiological regulators of adipose tissue development and function in intact animals.<\/jats:p>","DOI":"10.1038\/oby.2001.65","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T13:31:39Z","timestamp":1208266299000},"page":"500-509","source":"Crossref","is-referenced-by-count":136,"title":["Changes of Adiposity in Response to Vitamin A Status Correlate with Changes of PPAR\u03b32 Expression"],"prefix":"10.1002","volume":"9","author":[{"given":"Joan","family":"Ribot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Felipe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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