{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:52:49Z","timestamp":1790319169730,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":4023,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2001,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> This is a report of health\u2010related quality of life (HRQOL) changes in obese patients completing at least 1 year of outpatient treatment in a weight reduction program combining phentermine\u2010fenfluramine and dietary counseling.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Participants were 141 women (87.6%) and 20 men (12.4%) who had an average body mass index at intake of 41.1 kg\/m<jats:sup>2<\/jats:sup> (SD = 7.0, range = 29.5 to 67.0 kg\/m<jats:sup>2<\/jats:sup>) and an average age of 44.9 years (SD = 9.3, range = 23 to 65 years). HRQOL was assessed at intake and at 1\u2010year follow\u2010up using the Impact of Weight on Quality of Life (IWQOL)\u2010Lite questionnaire. The relationship between HRQOL changes and weight loss was examined using Pearson correlations. Clinically meaningful change in HRQOL was defined as a 1.96 SEM reduction in IWQOL\u2010Lite total score.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> On average, participants lost 20.2 kg or 17.6% of their weight over the 1\u2010year period. Of the participants, 15.5% lost &lt;10% of their weight, 24.2% lost 10% to 14.9%, 23.6% lost 15% to 19.9%, and 36.6% lost 20% or more. All five IWQOL\u2010Lite scales and total score showed statistically significant improvement over the 1\u2010year period. Changes in IWQOL\u2010Lite scores from intake to 1 year showed statistically significant correlations with percentage of weight loss for all subscales and total score. Subscale correlations with weight loss ranged from 0.166 (Public Distress) to 0.396 (Physical Function) and was 0.370 for the total score. Forty\u2010four percent of participants losing &lt;10% met the criterion of clinically meaningful change, compared with 51.3% losing 10% to 14.9%, 55.3% losing 15% to 19.95%, and 76.3% losing &gt;20%. For total score and for three of the five IWQOL\u2010Lite scales (Physical Function, Self\u2010Esteem, and Sexual Life), the relationship between weight loss and clinically meaningful change was linear and was significant at <jats:italic>p<\/jats:italic> &lt; 0.05. Physical Function and Self\u2010Esteem were most strongly affected by weight loss.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> HRQOL changes, as measured by an obesity\u2010specific instrument (IWQOL\u2010Lite), are strongly related to weight reduction.<\/jats:p>","DOI":"10.1038\/oby.2001.73","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T13:50:21Z","timestamp":1208267421000},"page":"564-571","source":"Crossref","is-referenced-by-count":204,"title":["The Relationship between Health\u2010Related Quality of Life and Weight Loss"],"prefix":"10.1002","volume":"9","author":[{"given":"Ronette L.","family":"Kolotkin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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