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The mean basal amylin concentration is higher in obese than in lean human subjects. The amylin response to oral glucose is also greater in obese subjects, whether or not they have impaired glucose tolerance. The elevated amylin levels in obesity may lead to down\u2010regulation of amylin receptors and lessen the impact of postprandial amylin secretion on satiety and gastric emptying. Amylin administration may overcome resistance at target tissues, delay gastric emptying, and have potential for inducing weight loss in obese individuals.<\/jats:p>","DOI":"10.1038\/oby.2002.147","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T13:07:32Z","timestamp":1208351252000},"page":"1087-1091","source":"Crossref","is-referenced-by-count":100,"title":["Amylin, Food Intake, and Obesity"],"prefix":"10.1002","volume":"10","author":[{"given":"Tarek K.","family":"Reda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Geliebter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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