{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:07:23Z","timestamp":1783555643120,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3567,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To compare the effectiveness of a conjugated linoleic acid (CLA) isomer mixture (mCLA) with each main isomer [trans\u201010,cis\u201012 CLA (CLA10,12) and cis\u20109,trans\u201011 CLA (CLA9,11)] in causing body lipid loss and adipose tissue apoptosis.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> Mice selected over 16 generations for high (MH) or low (ML) energy expenditure and a control group (MC) were fed diets containing either soy oil or soy oil plus mCLA, CLA10,12, or CLA9,11 for 5 days in one study and 14 days in a second study.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Mice fed mCLA or CLA10,12 had less body lipid (<jats:italic>p<\/jats:italic> &lt; 0.05), smaller retroperitoneal fat pads (<jats:italic>p<\/jats:italic> &lt; 0.05), and ate less (<jats:italic>p<\/jats:italic> &lt; 0.01) than mice fed no CLA or CLA9,11 for 5 days. Mice consuming 1% mCLA or 0.5% CLA10,12 gained less weight (<jats:italic>p<\/jats:italic> &lt; 0.01) and had less body lipid (<jats:italic>p<\/jats:italic> &lt; 0.05) and smaller epididymal (<jats:italic>p<\/jats:italic> &lt; 0.05) and retroperitoneal fat pads (<jats:italic>p<\/jats:italic> &lt; 0.01) than mice consuming either control or 0.5% CLA9,11\u2010containing diets for 14 days. Only mCLA and CLA10,12 increased apoptosis in retroperitoneal fat pads (<jats:italic>p<\/jats:italic> &lt; 0.01). The effects of mCLA and CLA10,12 were independent of genetic line except for the effect on adipocyte apoptosis. Mice of the MH line were slightly less sensitive than MC or ML mice to CLA\u2010induced adipose tissue apoptosis.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> CLA10,12, but not CLA9,11, can induce both body fat loss and adipose apoptosis. Although mice of a genotype with less body fat and greater metabolic rate and feed intake appear less sensitive, these CLA effects are robust for mice of varying metabolic background.<\/jats:p>","DOI":"10.1038\/oby.2002.174","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T14:00:08Z","timestamp":1208354408000},"page":"1284-1290","source":"Crossref","is-referenced-by-count":84,"title":["Adipose Depletion and Apoptosis Induced by Trans\u201010, Cis\u201012 Conjugated Linoleic Acid in Mice*"],"prefix":"10.1002","volume":"10","author":[{"given":"Kimberly M.","family":"Hargrave","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChangLong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett J.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Kachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane L.","family":"Hartzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Anne","family":"Della\u2010Fera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jess L.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton A.","family":"Baile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940801)74:3 <1050::AID-CNCR2820741512>3.0.CO;2-I"},{"key":"e_1_2_6_3_2","first-page":"1212","article-title":"Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat","volume":"54","author":"Ip C.","year":"1994","journal-title":"Cancer Res."},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0712-x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90034-5"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.1149"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8303"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.275.3.R667"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2527\/2001.7982187x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.10.2722"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/147323000102900503"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-999-0359-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/S11745-000-0599-6"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.9.1534"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.16"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-999-0358-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672397003017"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2527\/1997.7561461x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-998-0198-6"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-001-0836-z"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-2863(00)00155-8"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.8.1920"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.12.1939"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.1.92"},{"key":"e_1_2_6_25_2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/jn\/129.3.602","article-title":"Conjugated linoleic acid inhibits differentiation of pre\u2010 and post\u2010confluent 3T3\u2013L1 preadipocytes but inhibits cell proliferation only in preconfluent cells","volume":"129","author":"Brodie A. 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