{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:05:59Z","timestamp":1790863559857,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3750,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic>Recent studies in rats suggest an important effect of \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoreceptor stimulation on glucose uptake in white adipocytes. It is not known if \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoreceptor stimulation elicits similar metabolic effects in humans.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic>Three microdialysis catheters in abdominal subcutaneous adipose tissue were perfused with 0.00, 0.01, 0.10, 1.00, and 10.00 \u03bcM isoproterenol, phenylephrine, or phenylephrine plus 100 \u03bcM propranolol. Dialysate concentrations of ethanol, glycerol, glucose, and lactate were measured for estimating blood flow (ethanol\u2010dilution technique), lipolysis, and glycolysis, respectively.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Phenylephrine, with or without propranolol, did not elicit a change in ethanol ratio. In contrast, the ethanol ratio decreased markedly with isoproterenol. Dialysate glucose concentration decreased with phenylephrine with and without propranolol and increased with isoproterenol. Phenylephrine caused a dose\u2010dependent increase in dialysate glycerol concentration, with a maximal effect similar to that of isoproterenol. The effect was attenuated with propranolol.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic>Our findings suggest that \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoreceptor stimulation by phenylephrine increases glucose uptake and metabolism in human abdominal adipose tissue. Furthermore, phenylephrine elicits a marked increase in lipolytic activity in white adipose tissue through \u03b2\u2010adrenoreceptor activation.<\/jats:p>","DOI":"10.1038\/oby.2002.75","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T12:26:41Z","timestamp":1208348801000},"page":"555-558","source":"Crossref","is-referenced-by-count":39,"title":["In Vivo Response to \u03b1<sub>1<\/sub>\u2010Adrenoreceptor Stimulation in Human White Adipose Tissue"],"prefix":"10.1002","volume":"10","author":[{"given":"Michael","family":"Boschmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Krupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich C.","family":"Luft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Klaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"131","volume-title":"Adipose Tissue.","author":"Boschmann M.","year":"2001"},{"key":"e_1_2_6_3_2","first-page":"235","article-title":"\u03b1\u20101 Adrenergic regulation of lactate production by white adipocytes","volume":"277","author":"Faintrenie G.","year":"1996","journal-title":"J Pharm Exp Ther."},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3565(24)37629-3","article-title":"\u03b1\u20101 Adrenergic stimulation of glucose uptake in rat white adipocytes","volume":"286","author":"Faintrenie G.","year":"1998","journal-title":"J Pharm Exp Ther."},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00163.x"},{"key":"e_1_2_6_6_2","first-page":"435","article-title":"Techniques for the measurement of white adipose tissue metabolism: a practical guide","volume":"19","author":"Arner P.","year":"1995","journal-title":"Int J Obes."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.6.2803"},{"key":"e_1_2_6_8_2","first-page":"1499","volume-title":"Methods of Enzymatic Analysis.","author":"Bernt E.","year":"1974"},{"key":"e_1_2_6_9_2","first-page":"350","article-title":"Influence of local blood flow on glycerol levels in human adipose tissue","volume":"19","author":"Enoksson S.","year":"1995","journal-title":"Int J Obes."},{"key":"e_1_2_6_10_2","first-page":"220","article-title":"Evaluation of the microdialysis ethanol technique for monitoring of subcutaneous adipose tissue blood flow in humans","volume":"20","author":"Fellander G.","year":"1996","journal-title":"Int J Obes."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1855"},{"issue":"2","key":"e_1_2_6_12_2","first-page":"S83","article-title":"Reduction of smooth muscle contraction by perivascular adipose tissue","volume":"25","author":"Dubrovska G.","year":"2001","journal-title":"Int J Obes."},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000420361"}],"container-title":["Obesity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2002.75","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2002.75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T19:20:09Z","timestamp":1738178409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2002.75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1038\/oby.2002.75"],"URL":"https:\/\/doi.org\/10.1038\/oby.2002.75","archive":["Portico"],"relation":{},"ISSN":["1071-7323","1550-8528"],"issn-type":[{"value":"1071-7323","type":"print"},{"value":"1550-8528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}