{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:57:30Z","timestamp":1770040650920,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3720,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic>To study the safety, tolerability, and potential efficacy of orlistat in adolescents with obesity and its comorbid conditions.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic>We studied 20 adolescents (age, 14.6 \u00b1 2.0 years; body mass index, 44.1 \u00b1 12.6 kg\/m<jats:sup>2<\/jats:sup>). Subjects were evaluated before and after taking orlistat (120 mg three times daily) and a multivitamin for 3 months. Subjects were simultaneously enrolled in a 12\u2010week program emphasizing diet, exercise, and strategies for behavior change.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Participants who completed treatment (85%) reported taking 80% of prescribed medication. Adverse effects were generally mild, limited to gastrointestinal effects observed in adults, and decreased with time. Three subjects required additional vitamin D supplementation despite the prescription of a daily multivitamin containing vitamin D. Weight decreased significantly (\u22124.4 \u00b1 4.6 kg,<jats:italic>p<\/jats:italic>&lt; 0.001; \u22123.8 \u00b1 4.1% of initial weight), as did body mass index (\u22121.9 \u00b1 2.5 kg\/m<jats:sup>2<\/jats:sup>;<jats:italic>p<\/jats:italic>&lt; 0.0002). Total cholesterol (\u221221.3 \u00b1 24.7 mg\/dL;<jats:italic>p<\/jats:italic>&lt; 0.001), low\u2010density lipoprotein\u2010cholesterol (\u221217.3 \u00b1 15.8 mg\/dL;<jats:italic>p<\/jats:italic>&lt; 0.0001), fasting insulin (\u221213.7 \u00b1 19.0 \u03bcU\/mL;<jats:italic>p<\/jats:italic>&lt; 0.02), and fasting glucose (\u221215.4 \u00b1 7.4 mg\/dL;<jats:italic>p<\/jats:italic>&lt; 0.003) were also significantly lower after orlistat. Insulin sensitivity, assessed by a frequently sampled intravenous glucose\u2010tolerance test, improved significantly (<jats:italic>p<\/jats:italic>&lt; 0.02).<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic>We conclude that, in adolescents, short\u2010term treatment with orlistat, in the context of a behavioral program, is well\u2010tolerated and has a side\u2010effect profile similar to that observed in adults, but its true benefit versus conventional therapy remains to be determined in placebo\u2010controlled trials.<\/jats:p>","DOI":"10.1038\/oby.2002.87","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T12:39:59Z","timestamp":1208349599000},"page":"642-650","source":"Crossref","is-referenced-by-count":133,"title":["Three\u2010Month Tolerability of Orlistat in Adolescents with Obesity\u2010Related Comorbid Conditions"],"prefix":"10.1002","volume":"10","author":[{"given":"Jennifer R.","family":"McDuffie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim A.","family":"Calis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel I.","family":"Uwaifo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy G.","family":"Sebring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica M.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van S.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Health, United States, 2000","author":"National Center for Health Statistics","year":"2001"},{"key":"e_1_2_6_3_2","volume-title":"Prevalence of Overweight among Children and Adolescents: United States, 1999","author":"National Center for Health Statistics","year":"2001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800852"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014361"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.19.Suppl1.5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/abm\/16.3.235","article-title":"Treatments for childhood and adolescent obesity","volume":"16","author":"Haddock C.","year":"1994","journal-title":"Ann Behav Med"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1746-1561.1984.tb09747.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0002-8223(21)03117-5","article-title":"Adolescent obesity intervention: validation of the SHAPEDOWN program","volume":"87","author":"Mellin L. 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