{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:57Z","timestamp":1791267297176,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3536,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> Rats with ventromedial hypothalamic lesion (VMH) are massively obese with endogenous hyperinsulinemia, insulin resistance, low sympathetic activity, and high parasympathetic activity, which are likely to induce hypertension. The goal was to follow in this model the long\u2010term hemodynamic changes and to investigate the role of autonomic nervous system and insulin resistance in these changes.<\/jats:p><jats:p><jats:italic>Research Metho ds and Procedures:<\/jats:italic> Heart rate and blood pressure were monitored for 12 weeks after operation using a telemetric system in VMH and sham rats. Plasma catecholamines and heart \u03b2\u2010adrenoceptors were measured. Glucose tolerance was studied after an intravenous glucose injection and insulin sensitivity during a euglycemic hyperinsulinemic clamp test.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> A marked bradycardia and only a mild increase in blood pressure occurred in VMH rats compared with sham animals. Response to autonomic\u2010acting drugs showed an increase in heart vagal tone and responsiveness to a \u03b2\u2010agonist drug. Plasma catecholamine levels were markedly increased, and the density and affinity of heart \u03b2\u2010adrenoceptors were similar in VMH, sham, and control rats. Muscle glucose use was reduced by 1 week after operation in VMH animals.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> These results show the following in this model of massively obese rats with sympathetic impairment: 1) adrenal medulla secretion is increased, probably as a result of hyperinsulinemia and increased vagal activity; 2) cardiac responsiveness to \u03b2\u2010agonist stimulation is increased; and 3) despite these changes and suspected resistance to the vasodilative effect of insulin, blood pressure does not increase. We conclude that high vagal activity may be protective against hypertension associated with obesity.<\/jats:p>","DOI":"10.1038\/oby.2003.10","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:26:07Z","timestamp":1208525167000},"page":"54-64","source":"Crossref","is-referenced-by-count":26,"title":["Cardiovascular Vagosympathetic Activity in Rats with Ventromedial Hypothalamic Obesity"],"prefix":"10.1002","volume":"11","author":[{"given":"Paul","family":"Valensi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Doar\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Perret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Germack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pari\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Mesangeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602083340607"},{"key":"e_1_2_6_3_2","first-page":"1081","article-title":"Diet, obesity and hypertension: a hypothesis involving insulin, the sympathetic nervous system and adaptive thermogenesis","volume":"236","author":"Landsberg L.","year":"1986","journal-title":"QJM"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90028-V"},{"key":"e_1_2_6_5_2","first-page":"H1540","article-title":"Radiotelemetric characterization of overweight\u2010associated rises in blood pressure and heart rate","volume":"46","author":"Rupp H.","year":"1999","journal-title":"Am J Physiol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641968809075977"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.1_Suppl.I90"},{"key":"e_1_2_6_8_2","first-page":"R1418","article-title":"Heart rate variability as a measure of autonomic function during weight change in humans","volume":"261","author":"Hirsch J. 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