{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:29:49Z","timestamp":1791145789629,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3385,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: A randomized, double\u2010blind, placebo\u2010controlled, dose\u2010ranging trial was conducted. Three hundred eighty\u2010five subjects, 18 and 75 years of age, were randomized to receive either placebo or TPM at 64, 96, 192, or 384 mg daily. Dosing began at 16 mg once daily. In week 2, the dose was increased to 16 mg twice daily. Thereafter, the dose was raised every week by 32 mg\/d (16 mg twice daily) until subjects reached their target dose. Twenty\u2010four weeks after beginning treatment, all subjects were tapered off treatment by a dose reduction of 50% per week. All participants received the same lifestyle program.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Mean percent weight loss from baseline to week 24 was \u22122.6% in placebo\u2010treated patients vs. \u22125.0%, \u22124.8%, \u22126.3%, and \u22126.3% in the 64, 96, 192, and 384 mg\/d TPM groups, respectively. Greater percentages of TPM\u2010treated patients lost at least 5% or 10% of body weight compared with placebo. The most frequent adverse events were related to the central or peripheral nervous system, including paresthesia, somnolence, and difficulty with memory, concentration, and attention. Most events were dose\u2010related, occurred early in treatment, and usually resolved spontaneously; only 21% receiving TPM withdrew due to adverse events compared with 11% on placebo.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: TPM produced significantly greater weight loss than placebo at all doses.<\/jats:p>","DOI":"10.1038\/oby.2003.102","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T14:09:32Z","timestamp":1208527772000},"page":"722-733","source":"Crossref","is-referenced-by-count":304,"title":["A 6\u2010Month Randomized, Placebo\u2010Controlled, Dose\u2010Ranging Trial of Topiramate for Weight Loss in Obesity"],"prefix":"10.1002","volume":"11","author":[{"given":"George A.","family":"Bray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Hollander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kushner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Fitchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara H.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"WHO Technical Series Report 894","author":"World Health Organization","year":"2000"},{"issue":"2","key":"e_1_2_7_3_2","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2014the evidence report","volume":"9","author":"NHLBI Obesity Initiative Task Force","year":"1998","journal-title":"Obes Res"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00569.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)22029-0"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1037\/10510-000"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1999.tb00701.x"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11509-4"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00451-2"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801873"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb02175.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(97)80006-9"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00316-9"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v61n0508"},{"key":"e_1_2_7_16_2","author":"World Medical Association","year":"1996","journal-title":"Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780100614"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_7_19_2","first-page":"223","article-title":"Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds","volume":"42","author":"Rogawski M. 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