{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:09:28Z","timestamp":1788260968324,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3324,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Interleukin\u20106 (IL\u20106), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism. IL\u20106 exerts its actions through a heterodimeric receptor consisting of two membrane\u2010bound glycoproteins: an 80\u2010kDa IL\u20106 binding unit (IL6R\u2010\u03b1) and a 130\u2010kDa IL\u20106 signal transducer (gp130). Genetic variability at these loci might contribute to explain the development of obesity and hyperandrogenism.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: We have evaluated the possible association of several polymorphisms in the <jats:italic>IL6R<\/jats:italic>\u2010\u03b1 and <jats:italic>gp130<\/jats:italic> genes with obesity and\/or hyperandrogenism in a case\u2010control study involving 143 hyperandrogenic patients and 45 healthy women from Spain.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: A microsatellite CA\u2010repeat polymorphism in the IL6R\u2010\u03b1 locus was associated with obesity. The frequency of the common 149\u2010bp allele was markedly increased in obese women compared with controls when considering patients and controls as a whole (0.41 vs. 0.29, \u03c7<jats:sup>2<\/jats:sup> = 17.085, <jats:italic>p<\/jats:italic> &lt; 0.050). On the other hand, the uncommon Arg148 allele of the Gly148Arg polymorphism in the <jats:italic>gp130<\/jats:italic> gene was more frequent in controls compared with hyperandrogenic patients (0.17 vs. 0.08, \u03c7<jats:sup>2<\/jats:sup> = 5.605, <jats:italic>p<\/jats:italic> = 0.026). Controls carrying Arg148 alleles had lower 11\u2010deoxycortisol and 17\u2010hydroxyprogesterone concentrations, a lower response of androstenedione to 1\u201324 adrenocorticotropin, and an almost significant decrease in free testosterone levels, suggesting that Arg148 alleles in the <jats:italic>gp130<\/jats:italic> gene have a protective effect against androgen excess and adrenal hyperactivity.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: Polymorphisms in the gp130 and IL6R\u2010\u03b1 loci influence hyperandrogenism and obesity, respectively. Our present results further suggest that proinflammatory genotypes are involved in the pathogenesis of these common metabolic disorders.<\/jats:p>","DOI":"10.1038\/oby.2003.136","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T14:23:41Z","timestamp":1208528621000},"page":"987-996","source":"Crossref","is-referenced-by-count":79,"title":["Association of Polymorphisms in the Interleukin 6 Receptor Complex with Obesity and Hyperandrogenism"],"prefix":"10.1002","volume":"11","author":[{"given":"H\u00e9ctor F.","family":"Escobar\u2010Morreale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M.","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Villuendas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Sancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"San Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.6.5803"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.7.2434"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14956"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051451"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2097"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.7.3309"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025619510292"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.6.7580"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.8.3761"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.8.8715"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.3.1134"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801994"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(00)00272-1"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00463-3"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.3.847"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.9.3338"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3610105"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.4.810"},{"key":"e_1_2_7_20_2","first-page":"377","volume-title":"Polycystic Ovary Syndrome. 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