{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:41:57Z","timestamp":1790890917875,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3324,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Resistin is associated with insulin resistance in mice and may play a similar role in humans. The aim of our study was to examine the relationship of serum resistin level to body composition, insulin resistance, and related obesity phenotypes in humans.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Sixty\u2010four young (age 32 \u00b1 10 years), obese (BMI 32.9 \u00b1 5.6), nondiabetic subjects taking no medication, and 15 lean (BMI 21.1 \u00b1 1.3) volunteers were studied cross\u2010sectionally. Thirty\u2010five of the subjects were also reevaluated after 1.5 years on a weight reduction program entailing dieting and exercise; changes of serum resistin were compared with changes of BMI, body composition, fat distribution, and several indices of insulin sensitivity derived from plasma glucose and serum insulin levels measured during 75\u2010g oral glucose tolerance test.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: In a cross\u2010sectional analysis, serum resistin was significantly higher in obese subjects than in lean volunteers (24.58 \u00b1 12.93 ng\/mL; <jats:italic>n<\/jats:italic> = 64 vs. 12.83 \u00b1 8.30 ng\/mL; <jats:italic>n<\/jats:italic> = 15; <jats:italic>p<\/jats:italic> &lt; 0.01), and there was a correlation between resistin level and BMI, when the two groups were combined (\u03c1 = 0.35, <jats:italic>p<\/jats:italic> &lt; 0.01). Although cross\u2010sectional analysis in obese subjects revealed no correlation between serum resistin and parameters related to adiposity or insulin resistance, longitudinal analysis revealed change in serum resistin to be positively correlated with changes in BMI, body fat, fat mass, visceral fat area, and mean glucose and insulin (\u03c1 = 0.39, 0.40, 0.44, 0.50, 0.40, and 0.50; <jats:italic>p<\/jats:italic> = 0.02, 0.03, 0.02, &lt;0.01, 0.02, and &lt;0.01, respectively).<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: Resistin appears to be related to human adiposity and to be a possible candidate factor in human insulin resistance.<\/jats:p>","DOI":"10.1038\/oby.2003.137","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T14:23:41Z","timestamp":1208528621000},"page":"997-1001","source":"Crossref","is-referenced-by-count":265,"title":["Correlation between Serum Resistin Level and Adiposity in Obese Individuals"],"prefix":"10.1002","volume":"11","author":[{"given":"Koichiro","family":"Azuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuminori","family":"Katsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Oguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16521"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00457.2002"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.502"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5173"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.10.2199"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.1"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07281-1"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.5.8627"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02841-3"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02864-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8528"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020109"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.2.171"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_17_2","first-page":"1609","article-title":"The relationship between human serum resistin level and body fat content, plasma glucose as well as blood pressure","volume":"82","author":"Zhang J.","year":"2002","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021604"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115274"},{"key":"e_1_2_7_20_2","first-page":"175","article-title":"High fasting insulin levels associated with lower rates of weight gain in persons with normal glucose tolerance: The San Luis Valley Diabetes Study","volume":"19","author":"Hoag S.","year":"1995","journal-title":"Int J Obes"}],"container-title":["Obesity 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