{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:38:59Z","timestamp":1768685939788,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3293,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: Sibutramine causes weight loss by suppressing the appetite and by promoting energy expenditure, but it can also increase blood pressure through a norepinephrine effect. The aim of this study was to provide a comprehensive meta\u2010analysis of randomized, controlled trials on the effects of sibutramine on blood pressure and weight loss.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Twenty\u2010one placebo\u2010controlled, double\u2010blind, randomized trials of sibutramine were identified using MEDLINE, EMBASE, and a manual search. The effect sizes of sibutramine on weight and systolic (SBP) and diastolic (DBP) blood pressure changes were estimated. Subgroup analyses were undertaken to explore the relationship between effect sizes and the study characteristics.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: The effect size of sibutramine on weight change was \u22121.00 (\u22121.17 to \u22120.84), whereas the effect sizes on SBP and DBP changes were 0.16 (0.08 to 0.24) and 0.26 (0.18 to 0.33), respectively. By subgroup analysis, the effect sizes on weight loss were significantly larger when the dosage was \u226515 mg. The effect sizes on increased SBP were significantly larger when the initial body weight was \u226592 kg and the age was &lt;44 years; similarly, the effect sizes on increased DBP were significantly larger when the initial weight was \u226592 kg.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: Sibutramine showed a large effect on weight loss. Because blood pressure was found to be increased slightly, but significantly, sibutramine should be used cautiously in patients with borderline or high blood pressure. Additional studies on its effect on blood pressure are needed.<\/jats:p>","DOI":"10.1038\/oby.2003.152","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T14:27:20Z","timestamp":1208528840000},"page":"1116-1123","source":"Crossref","is-referenced-by-count":83,"title":["Effect of Sibutramine on Weight Loss and Blood Pressure: A Meta\u2010analysis of Controlled Trials"],"prefix":"10.1002","volume":"11","author":[{"given":"Su Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Ha","family":"Jee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung Mo","family":"Nam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00569.x"},{"key":"e_1_2_6_3_2","volume-title":"Korean National Health Examination Survey","author":"Korea Institute of Health and Society Affairs","year":"1999"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00006"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-6047.11.s8.6.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856060-00019"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01423-1"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2001.117510"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1326.2000.00081.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.11.1957"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1999.tb00701.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.14.2185"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001298"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801059"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00411-2"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.17.1855"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047310"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0066-782X2002000200006"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.124403"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801889"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta6060"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(01)00261-6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800540"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1998.tb00324.x"},{"key":"e_1_2_6_25_2","first-page":"505","article-title":"Randomized placebo\u2010controlled trial of long\u2010term treatment with sibutramine in mild to moderate obesity","volume":"50","author":"Smith I. 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