{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T22:26:55Z","timestamp":1768084015765,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3477,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To understand the impact of the phenylethanolamine <jats:italic>N<\/jats:italic>\u2010methyltransferase (<jats:italic>PNMT<\/jats:italic>) <jats:italic>G\u2010148A<\/jats:italic> gene and nutritional variables on weight loss in obese women.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: One hundred forty\u2010nine women, ages 45 to 65 with a body mass index of &gt;30 kg\/m<jats:sup>2<\/jats:sup>, participated in a 6\u2010month, open\u2010label intervention that included sibutramine (15 mg\/d) and a monthly health\u2010education class. Anthropometric measurements, vital signs, food frequency, exercise log, medication compliance, and psychological and sociological questionnaires were completed each month. Genetic polymorphisms of <jats:italic>PNMT<\/jats:italic> were determined.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Univariate analysis of G\/G, G\/A, and A\/A genotypes against tertiles of percentage of weight loss were significant at 3 but not at 6 months (Pearson \u03c7<jats:sup>2<\/jats:sup>: <jats:italic>p<\/jats:italic> &lt; 0.006; homozygous\/heterozygosity: <jats:italic>p<\/jats:italic> &lt; 0.002, <jats:italic>p<\/jats:italic> &lt; 0.253, and <jats:italic>p<\/jats:italic> &lt; 0.122, respectively). A regression model that included the <jats:italic>PNMT<\/jats:italic> genetic variation and certain nutrition and exercise variables demonstrated that only the <jats:italic>PNMT<\/jats:italic> gene (\u03b2 = 0.360, SE 0.585, and <jats:italic>p<\/jats:italic> = 0.003) was statistically significant at 6 months, and the total calories (\u03b2 = \u22120.925, SE = 0.004, and <jats:italic>p<\/jats:italic> = 0.009), fiber intake (\u03b2 = 0.621, SE = 0.124, and <jats:italic>p<\/jats:italic> = 0.000), and <jats:italic>PNMT<\/jats:italic> (\u03b2 = 0.262, SE = 1.415, and <jats:italic>p<\/jats:italic> = 0.024) were significant.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: The homozygosity\/heterozygosity of the <jats:italic>PNMT<\/jats:italic> gene was highly predictive of significant weight loss with sibutramine during the first 3 months, which highlights the need for specific pharmacotherapy. The early weight\u2010loss success of those subjects who were homozygous for <jats:italic>PNMT<\/jats:italic> may have motivated and selected those that would make further dietary changes, which then augmented their final weight loss.<\/jats:p>","DOI":"10.1038\/oby.2003.56","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:42:12Z","timestamp":1208526132000},"page":"415-419","source":"Crossref","is-referenced-by-count":28,"title":["Phenylethanolamine <i>N<\/i>\u2010Methyltransferase <i>G\u2010148A<\/i> Genetic Variant and Weight Loss in Obese Women"],"prefix":"10.1002","volume":"11","author":[{"given":"Warren R.","family":"Peters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"MacMurry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Russell J.","family":"Giese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Comings","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.2"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(01)00098-1"},{"issue":"1","key":"e_1_2_7_4_2","first-page":"S41","article-title":"Promising new approaches","volume":"1","author":"Reasoner C. A.","year":"1999","journal-title":"Diab Obes Metab"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/68.6.1180"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2000.26"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/1.3.175"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.141.11.4239"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199912000-00004"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3015"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1363"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.4.513"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.10"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2222"}],"container-title":["Obesity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2003.56","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2003.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:38:28Z","timestamp":1697535508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2003.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["10.1038\/oby.2003.56"],"URL":"https:\/\/doi.org\/10.1038\/oby.2003.56","archive":["Portico"],"relation":{},"ISSN":["1071-7323","1550-8528"],"issn-type":[{"value":"1071-7323","type":"print"},{"value":"1550-8528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}