{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:04:52Z","timestamp":1791216292695,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3477,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: The aim of this study was to compare the relative importance of computed tomography\u2010measured abdominal fat compartment areas, including adipose tissue located posterior to the subcutaneous Fascia, in predicting plasma lipid\u2010lipoprotein alterations.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Areas of visceral as well as subcutaneous deep and superficial abdominal adipose tissue were measured by computed tomography in a sample of 66 healthy women, ages 37 to 60 years, for whom a detailed lipid\u2010lipoprotein profile was available.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Strong significant associations were observed between visceral adipose tissue area and most variables of the lipid\u2010lipoprotein profile (<jats:italic>r<\/jats:italic> = \u22120.25, <jats:italic>p<\/jats:italic> &lt; 0.05 to 0.62, <jats:italic>p<\/jats:italic> &lt; 0.0001). Measures of hepatic lipoprotein synthesis such as very\u2010low\u2010density lipoprotein\u2010triglyceride and cholesterol content as well as total and very\u2010low\u2010density lipoprotein\u2010apolipoprotein B levels were also strongly associated with visceral adipose tissue area (<jats:italic>r<\/jats:italic> = 0.57, 0.57, 0.61, and 0.62, respectively, <jats:italic>p<\/jats:italic> &lt; 0.0001). Significant associations were found between these variables and the deep subcutaneous adipose tissue area or DXA\u2010measured total body fat mass. However, the correlation coefficients were of lower magnitude compared to those with visceral adipose tissue area. Multivariate regression analyses demonstrated that visceral adipose tissue area was the strongest predictor of lipid\u2010lipoprotein profile variables (7% to 48% explained variance, 0.02 \u2265 <jats:italic>p<\/jats:italic> \u2264 0.0001).<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: Although previous studies have generated controversial data as to which abdominal adipose tissue compartment was more closely associated with insulin resistance, our results suggest that visceral adipose tissue area is a stronger correlate of other obesity\u2010related outcomes such as lipid\u2010lipoprotein alterations.<\/jats:p>","DOI":"10.1038\/oby.2003.64","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:42:12Z","timestamp":1208526132000},"page":"469-476","source":"Crossref","is-referenced-by-count":72,"title":["Subdivision of the Subcutaneous Adipose Tissue Compartment and Lipid\u2010Lipoprotein Levels in Women"],"prefix":"10.1002","volume":"11","author":[{"given":"Daniel","family":"Desch\u00eanes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Couture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Tchernof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.761"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.6.0415"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.2.203"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.41.7.826"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.6.629"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.3.855"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00469.2001"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118083"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.46.10.1579"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90033-1"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198708000-00015"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2353(1996)9:1<19::AID-CA4>3.0.CO;2-V"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1997.tb00648.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.5.E941"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.1.E113"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.21693"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2001.2"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.7.1425"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(87)90183-1"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38059-7"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(66)90246-6"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.2.0461"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199706000-00004"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(99)00098-4"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.10.4.493"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.5.E1110"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.36"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-978681"}],"container-title":["Obesity 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