{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:40:37Z","timestamp":1779914437782,"version":"3.53.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:italic>Objective<\/jats:italic><\/jats:bold>: The purpose of this study was to evaluate the effects of sibutramine vs. placebo on binge\u2010eating behavior, hunger, and satiety in patients who had problems with binge eating.<\/jats:p><jats:p><jats:bold><jats:italic>Research Methods and Procedures<\/jats:italic><\/jats:bold>: Seven adult subjects who had problems with binge eating (mean age, 42 years) were randomly assigned to receive alternating sibutramine and placebo in a double\u2010blind placebo\u2010controlled crossover study. This involved two 4\u2010week dosing periods separated by a 2\u2010week washout.<\/jats:p><jats:p><jats:bold><jats:italic>Results<\/jats:italic><\/jats:bold>: Subjects lost weight on sibutramine but not on placebo. There was a significant difference in the number of kilocalories consumed between the sibutramine and placebo conditions, with a significant reduction of intake during binge\u2010eating episodes on sibutramine.<\/jats:p><jats:p><jats:bold><jats:italic>Discussion<\/jats:italic><\/jats:bold>: Sibutramine suppresses intake during binge\u2010eating episodes. This effect is demonstrable in a human feeding laboratory paradigm.<\/jats:p>","DOI":"10.1038\/oby.2003.85","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:59:59Z","timestamp":1208527199000},"page":"599-602","source":"Crossref","is-referenced-by-count":22,"title":["Effects of Sibutramine on Binge Eating, Hunger, and Fullness in a Laboratory Human Feeding Paradigm"],"prefix":"10.1002","volume":"11","author":[{"given":"James E.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake A.","family":"Gosnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Roerig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"de Zwaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Wonderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross D.","family":"Crosby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A.","family":"Burgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth N.","family":"Wambach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01423-1"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1467-789x.2000.00020.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801949"},{"key":"e_1_2_7_5_2","volume-title":"Biological Psychiatry","author":"Mitchell J. 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