{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T15:23:53Z","timestamp":1698765833278},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated <jats:italic>POMC<\/jats:italic> sequence variants in 242 overweight and nonoverweight African\u2010American and white children and examined the associations between body composition and <jats:italic>POMC<\/jats:italic> polymorphisms. Three novel polymorphisms and two previously identified sequence variants were found: A7301G, A7429G, and C8246T were all in untranslated regions. A 9\u2010bp (AGC AGC GGC) duplication\/insertion was found between positions 7677 and 7678, and one normal\u2010weight African\u2010American girl had a 45\u2010bp triple duplication\/insertion at this location. Compared with whites, African\u2010American children were significantly more likely to have polymorphisms A7301G, A7429G, and the 9\u2010bp insertion. However, there were no significant associations between any of the polymorphisms and body composition. Five African\u2010American subjects who were homozygous for A7429G had a trend (<jats:italic>p<\/jats:italic> = 0.08) for a greater BMI\u2010SD score (5.3 \u00b1 5.3 kg\/m<jats:sup>2<\/jats:sup>) compared with wild\u2010type children (BMI\u2010SD score, 2.4 \u00b1 3.2 kg\/m<jats:sup>2<\/jats:sup>) or heterozygotes (BMI\u2010SD score, 2.7 \u00b1 3.7 kg\/m<jats:sup>2<\/jats:sup>). However, there were no differences in BMI\u2010SD score for A7429G when African American subjects were studied separately and both gender and height were taken into account. The contribution of the <jats:italic>POMC<\/jats:italic> gene variants we studied to pediatric\u2010onset obesity seems to be limited.<\/jats:p>","DOI":"10.1038\/oby.2003.89","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:59:59Z","timestamp":1208527199000},"page":"619-624","source":"Crossref","is-referenced-by-count":9,"title":["Sequence Variants of the <i>POMC<\/i> Gene and Their Associations with Body Composition in Children"],"prefix":"10.1002","volume":"11","author":[{"given":"Ningping","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Adler\u2010Wailes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Elberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff Y.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Carr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Frazer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack A.","family":"Yanovski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.30"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1641"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(81)80952-0"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/11.19.6847"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81865-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/12506"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/509"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-303"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.10.3737"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800814"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801485"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-273"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70199-3"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.9.3307"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2660"},{"key":"e_1_2_5_17_2","first-page":"203","article-title":"Slipped\u2010strand mispairing: a major mechanism for DNA sequence evolution","volume":"4","author":"Levinson G.","year":"1987","journal-title":"Mol Biol Evol"},{"key":"e_1_2_5_18_2","first-page":"178","volume-title":"Anthropometric Standards for the Assessment of Growth and Nutritional Status","author":"Frisancho A.","year":"1999"},{"key":"e_1_2_5_19_2","first-page":"1","volume-title":"Anthropometric Standardization Reference Manual","author":"Lohman T. 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