{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:04:03Z","timestamp":1770509043647,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold><jats:italic>Objective<\/jats:italic><\/jats:bold>: We describe associations among the heart\u2010rate\u2010corrected QT (QTc) interval, QTc dispersion (QTc\u2010d), circadian BP variation, and autonomic function in obese normotensive women and the effect of sustained weight loss.<\/jats:p><jats:p><jats:bold><jats:italic>Research Methods and Procedures<\/jats:italic><\/jats:bold>: In 71 obese (BMI = 37.14 \u00b1 2.6 kg\/m<jats:sup>2<\/jats:sup>) women, 25 to 44 years of age, circadian BP variations (24\u2010hour ambulatory BP monitoring), autonomic function (power spectral analysis of RR interval oscillations), and cardiac repolarization times (QTc\u2010d and QTc interval) were recorded at baseline and after 1 year of a multidisciplinary program of weight reduction.<\/jats:p><jats:p><jats:bold><jats:italic>Results<\/jats:italic><\/jats:bold>: Compared with nonobese age\u2010matched women (<jats:italic>n<\/jats:italic> = 28, BMI = 23 \u00b1 2.0 kg\/m<jats:sup>2<\/jats:sup>), obese women had higher values of QTc\u2010d (<jats:italic>p<\/jats:italic> &lt; 0.05) and QTc (<jats:italic>p<\/jats:italic> &lt; 0.05), an altered sympathovagal balance (ratio of low\u2010frequency\/high\u2010frequency power, <jats:italic>p<\/jats:italic> &lt; 0.01), and a blunted nocturnal drop in BP (<jats:italic>p<\/jats:italic> &lt; 0.01). In obese women, QTc\u2010d and the QTc interval correlated with diastolic nighttime BP (<jats:italic>p<\/jats:italic> &lt; 0.01) and sympathovagal balance (<jats:italic>p<\/jats:italic> &lt; 0.01). Waist\u2010to\u2010hip ratio, free fatty acids, and plasma insulin levels correlated with QT intervals and reduced nocturnal drops in both systolic and diastolic BP and sympathovagal balance (<jats:italic>p<\/jats:italic> &lt; 0.01). After 1 year, obese women lost at least 10% of their original weight, which was associated with decrements of QTc\u2010d (<jats:italic>p<\/jats:italic> &lt; 0.02), the QTc interval (<jats:italic>p<\/jats:italic> &lt; 0.05), nighttime BP (<jats:italic>p<\/jats:italic> &lt; 0.01), and sympathovagal balance (<jats:italic>p<\/jats:italic> &lt; 0.02).<\/jats:p><jats:p><jats:bold><jats:italic>Discussion<\/jats:italic><\/jats:bold>: Sustained weight loss is a safe method to ameliorate diastolic nighttime BP drop and sympathetic overactivity, which may reduce the cardiovascular risk in obese women.<\/jats:p>","DOI":"10.1038\/oby.2003.93","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T13:59:59Z","timestamp":1208527199000},"page":"653-659","source":"Crossref","is-referenced-by-count":37,"title":["Sympathovagal Balance, Nighttime Blood Pressure, and QT Intervals in Normotensive Obese Women"],"prefix":"10.1002","volume":"11","author":[{"given":"Katherine","family":"Esposito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Marfella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Gualdiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Carusone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pontillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Giugliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Giugliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00045415-200107000-00005"},{"key":"e_1_2_7_3_2","first-page":"329","article-title":"Dippers and non\u2010dippers among overweight hypertensive men","volume":"1","author":"Chamontin B.","year":"1996","journal-title":"Blood Press Monit"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126097-199900460-00004"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641969909061002"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.3.986"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00087-9"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.63.6.342"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.779"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800521"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1640059"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1990.tb01301.x"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(96)80036-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000515"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.87.5.2080"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.13.1821"},{"key":"e_1_2_7_17_2","first-page":"353","article-title":"An analysis of the time relations of electrocardiograms","volume":"7","author":"Bazzett H. 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