{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:16:58Z","timestamp":1751469418031},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":2989,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To characterize the effects of dietary fat on the diurnal variation in serum and cerebrospinal fluid (CSF) leptin levels in Osborne\u2010Mendel (OM) and S5B\/Pl rats and quantitate the dose response to lower doses of leptin administered into the third cerebral ventricle.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Rats were fitted with implanted vascular ports or third ventricular cannulas and fed either laboratory chow or one of two semipurified high\u2010fat or low\u2010fat diets. Leptin and insulin were measured by immunoassay.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Serum leptin and insulin levels were positively correlated and had similar patterns of diurnal change. CSF leptin and insulin also had diurnal rhythms, with a peak at 7:00 am, but the diurnal oscillations of leptin and insulin were significantly lower in the S5B\/Pl rats than the OM rats. Thus, the ratio of CSF to serum leptin was significantly higher in the S5B\/Pl rats than in the OM rats. Dietary fat had no effect on these diurnal patterns. There was a right shift in the dose response to leptin in the OM rats compared with the S5B\/P1 rats. S5B\/P1 rats treated with leptin had higher signal transduction and translation (STAT\u20103) mRNA levels compared with pair\u2010fed or saline injected S5B\/P1 rats. Hypothalamic suppressors of cytokine signaling mRNA levels were not statistically different between the groups.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: The higher CSF\u2010to\u2010serum leptin ratio in the S5B\/P1 rats, the enhanced suppression of food intake and body weight with leptin injections, and the higher STAT\u20103 activity in these animals suggest that S5B\/P1 rats are more sensitive to leptin than OM rats.<\/jats:p>","DOI":"10.1038\/oby.2004.134","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T09:16:40Z","timestamp":1208769400000},"page":"1067-1076","source":"Crossref","is-referenced-by-count":18,"title":["Effects of Diet and Time of the Day on Serum and CSF Leptin Levels in Osborne\u2010Mendel and S5B\/Pl Rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Yuri","family":"Ishihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy L.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruaki","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Kageyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"York","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Bray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03173-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-589"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(99)00139-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.7.1219"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(99)00156-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.6.R2048"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.10.1606"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(89)90075-9"},{"key":"e_1_2_7_10_2","first-page":"R290","article-title":"Catecholamine turnover in S 5B\/P1 and Osborne\u2010Mendel rats: response to a high\u2010fat diet","volume":"247","author":"Fisler J. 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