{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:12:01Z","timestamp":1760645521227},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":2958,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To determine the effect of acute and chronic administration of a new food intake\u2010reducing compound (HMR1426) with novel mode of action (retardation of gastric emptying) on body weight development, food intake, and energy metabolism in rats.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Adult male Shoe\u2010Wistar rats were implanted with transponders allowing registration of body temperature (T<jats:sub>b<\/jats:sub>) and locomotor activity. HMR1426 (10 or 50 mg\/kg) was given orally, and acute (8 hours) and chronic (15 days) effects were measured on food intake, T<jats:sub>b<\/jats:sub>, activity, total energy expenditure (indirect calorimetry), and epididymal adipose tissue mass. The effect of chronic treatment was compared with the effect of sibutramine (10 mg\/kg).<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: HMR1426 (50 mg\/kg) caused an acute and chronic decrease of food intake. There was no effect on the level and daily pattern of total energy expenditure, T<jats:sub>b<\/jats:sub>, and locomotor activity. Respiratory quotient was acutely decreased by HMR1426 due to reduced food intake. Chronic treatment with HMR1426 decreased weight gain by 31% and epididymal white fat by 24%. Sibutramine caused a respective reduction of 48% and 35%. Energy efficiency was not affected by HMR1426 in contrast to sibutramine, which reduced energy efficiency and transiently increased activity.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: HMR1426 showed an anorectic potential in rats and decreased body weight and fat mass. This was achieved solely by reducing food intake without influencing overall energy expenditure or behavior suggesting a peripheral mode of action. Thus, HMR1426 can be considered a potential new drug for obesity treatment.<\/jats:p>","DOI":"10.1038\/oby.2004.163","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T09:21:54Z","timestamp":1208769714000},"page":"1290-1297","source":"Crossref","is-referenced-by-count":13,"title":["The Novel Antiobesic HMR1426 Reduces Food Intake without Affecting Energy Expenditure in Rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Sylvia","family":"Ortmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliane","family":"Kampe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Gossel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bickel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Geisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"J\u00e4hne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Jochen","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Klaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.15.1814"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011808701117"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:13:2:201"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:13:2:193"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801931"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802216"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00105-4"},{"issue":"1","key":"e_1_2_7_9_2","first-page":"S5","article-title":"The beneficial effects of modest weight loss on cardiovascular risk factors","volume":"21","author":"Gaal L. 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