{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:26:28Z","timestamp":1790475988440,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3171,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic>To examine bone mass and metabolism in women who had previously undergone Roux\u2010en\u2010Y gastric bypass (RYGB) and determine the effect of supplementation with calcium (Ca) and vitamin D.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Bone mineral density and bone mineral content (BMC) were examined in 44 RYGB women (\u22653 years post\u2010surgery; 31% weight loss; BMI, 34 kg\/m<jats:sup>2<\/jats:sup>) and compared with age\u2010 and weight\u2010matched control (CNT) women (<jats:italic>n<\/jats:italic> = 65). In a separate analysis, RYGB women who presented with low bone mass (<jats:italic>n<\/jats:italic> = 13) were supplemented to a total 1.2 g Ca\/d and 8 \u03bcg vitamin D\/d over 6 months and compared with an unsupplemented CNT group (<jats:italic>n<\/jats:italic> = 13). Bone mass and turnover and serum parathyroid hormone (PTH) and 25\u2010hydroxyvitamin D were measured.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic>Bone mass did not differ between premenopausal RYGB and CNT women (42 \u00b1 5 years), whereas postmenopausal RYGB women (55 \u00b1 7 years) had higher bone mineral density and BMC at the lumbar spine and lower BMC at the femoral neck. Before and after dietary supplementation, bone mass was similar, and serum PTH and markers of bone resorption were higher (<jats:italic>p<\/jats:italic> &lt; 0.001) in RYGB compared with CNT women and did not change significantly after supplementation.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: Postmenopausal RYGB women show evidence of secondary hyperparathyroidism, elevated bone resorption, and patterns of bone loss (reduced femoral neck and higher lumbar spine) similar to other subjects with hyperparathyroidism. Although a modest increase in Ca or vitamin D does not suppress PTH or bone resorption, it is possible that greater dietary supplementation may be beneficial.<\/jats:p>","DOI":"10.1038\/oby.2004.7","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T08:57:23Z","timestamp":1208768243000},"page":"40-47","source":"Crossref","is-referenced-by-count":192,"title":["Bone and Gastric Bypass Surgery: Effects of Dietary Calcium and Vitamin D"],"prefix":"10.1002","volume":"12","author":[{"given":"Lisa R.","family":"Goode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Brolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasina A.","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue A.","family":"Shapses","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"311","volume-title":"Nutritional Aspects of Osteoporosis","author":"Shapses SA.","year":"2001"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170053"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800827"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(85)90003-1"},{"key":"e_1_2_7_6_2","first-page":"850","article-title":"Late effects of gastric bypass for obesity","volume":"79","author":"Crowley L. V.","year":"1984","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(84)90712-1"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.8.669"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02411201"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1381\/096089292765559936"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1381\/096089202321019693"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.21.7.624"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430220042009"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709007681"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1991.tb07591.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-6009(08)80250-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.6.1045"},{"key":"e_1_2_7_18_2","volume-title":"Assessment of Fracture Risk and Application to Screening for Postmenopausal Osteoporosis","author":"World Health Organization","year":"1994"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170130"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1329"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.4.1305"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90070-6"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050093"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040302"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.5.1562"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00192633"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-002-1324-9"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01625450"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302502"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111971"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"e_1_2_7_32_2","first-page":"1031","article-title":"Treatment with high\u2010dose oral vitamin D2 in patients with jejunoileal bypass for morbid obesity. Effects on calcium and magnesium metabolism, vitamin D metabolites, and faecal lag time","volume":"19","author":"Charles P.","year":"1984","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_7_33_2","first-page":"635","article-title":"Problems with direct 25\u2010hydroxyvitamin D assays, and the target amount of vitamin D nutrition desirable for patients with osteoporosis","volume":"11","author":"Vieth R.","year":"2000","journal-title":"Osteoporos Int"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100711"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709043371003"},{"key":"e_1_2_7_36_2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/00365521.1975.12097032","article-title":"The influence of calcium and calcium + vitamin D2 treatment on bone mineral after partial gastrectomy","volume":"10","author":"Alhava E. M.","year":"1975","journal-title":"Scand J Gastroenterol"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-67-793-71"},{"key":"e_1_2_7_38_2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ajcn\/67.4.734","article-title":"Effect of weight loss on bone mineral content and bone mineral density in obese women","volume":"67","author":"Loan M. D.","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_7_39_2","first-page":"51S","article-title":"Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults\u2014the evidence report","volume":"6","author":"National Institutes of Health","year":"1998","journal-title":"Obes Res"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.1.141"}],"container-title":["Obesity Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2004.7","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2004.7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T20:35:27Z","timestamp":1698784527000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2004.7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1038\/oby.2004.7"],"URL":"https:\/\/doi.org\/10.1038\/oby.2004.7","archive":["Portico"],"relation":{},"ISSN":["1071-7323","1550-8528"],"issn-type":[{"value":"1071-7323","type":"print"},{"value":"1550-8528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}