{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:35:38Z","timestamp":1769549738122,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":3080,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obesity Research"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective<\/jats:italic>: To investigate the involvement of \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptors in the sympathetic regulation of glucose uptake in human adipocytes.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures<\/jats:italic>: Twenty\u2010four severely obese subjects participated in this study. The microdialysis technique was used to determine interstitial glucose concentration after stimulation of abdominal subcutaneous adipose tissue with the \u03b1<jats:sub>1<\/jats:sub>\u2010agonist norfenefrine, the \u03b1<jats:sub>1, 2<\/jats:sub>\u03b2\u2010agonist norepinephrine, and both agents in combination with the \u03b1<jats:sub>1<\/jats:sub>\u2010antagonist urapidil. The effect of \u03b2\u2010adrenoceptor stimulation was assessed by orciprenaline. Changes in local blood flow were determined using the ethanol escape technique.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Both norfenefrine and norepinephrine induced a concentration\u2010dependent decrease of interstitial glucose concentration, with a greater decrease observed with norepinephrine. Preperfusion of adipose tissue with urapidil inhibited glucose decrease. The inhibition was overcome with high concentrations of norfenefrine and norepinephrine, respectively. Both adrenergic agents induced tachyphylaxia. Urapidil enhanced extracellular glucose level at high concentration. Blood flow decreased in the presence of norfenefrine and norepinephrine but increased in response to urapidil. The accelerated blood flow due to urapidil was counteracted by norepinephrine and norfenefrine. Orciprenaline decreased interstitial glucose concentration and increased nutritive blood flow. The observed changes in blood flow induced by adrenergic agents were not related to glucose uptake.<\/jats:p><jats:p><jats:italic>Discussion<\/jats:italic>: The stimulatory effect of the sympathetic nerves on glucose uptake in subcutaneous adipose tissue appears to be mediated by the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor. Norepinephrine enhances glucose entry into adipocytes independently of insulin action. In obese subjects with insulin resistance, the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenergic receptor may provide an important alternative pathway for glucose uptake.<\/jats:p>","DOI":"10.1038\/oby.2004.70","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T09:07:37Z","timestamp":1208768857000},"page":"612-620","source":"Crossref","is-referenced-by-count":28,"title":["Sympathetic Regulation of Glucose Uptake by the \u03b1<sub>1<\/sub>\u2010Adrenoceptor in Human Obesity"],"prefix":"10.1002","volume":"12","author":[{"given":"Marion","family":"Flechtner\u2010Mors","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher P.","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Alt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans K.","family":"Biesalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Adler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herwig H.","family":"Ditschuneit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/sj.ijo.0802028","article-title":"Impaired (\u201cdiabetic\u201d) insulin signaling and action occur in fat cells long before glucose intolerance: is insulin resistance initiated in the adipose tissue?","volume":"6","author":"Smith U.","year":"2002","journal-title":"Int J Obes."},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051341"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-106-3-786"},{"key":"e_1_2_6_5_2","first-page":"R914","article-title":"Chronic norepinephrine infusion stimulates glucose uptake in white and brown adipose tissues","volume":"266","author":"Liu X.","year":"1994","journal-title":"Am J Physiol."},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00896-1"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-3565(24)29397-6","article-title":"\u03b11\u2010Adrenergic receptors: new insights and directions","volume":"298","author":"Piaschik M. 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