{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T00:40:24Z","timestamp":1699922424493},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":2259,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Objective:<\/jats:italic> To identify the genetic determinants of obesity using univariate and bivariate models in a genome scan.<\/jats:p><jats:p><jats:italic>Research Methods and Procedures:<\/jats:italic> We evaluated the genetic and environmental effects and performed a genome\u2010wide linkage analysis of obesity\u2010related traits in 478 subjects from 105 Mexican\u2010American nuclear families ascertained through a proband with documented coronary artery disease. The available obesity traits include BMI, body surface area (BSA), waist\u2010to\u2010hip ratio (WHR), and trunk fat mass as percentage of body weight. Heritability estimates and multipoint linkage analysis were performed using a variance components procedure implemented in SOLAR software.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> The heritability estimates were 0.62 for BMI, 0.73 for BSA, 0.40 for WHR, and 0.38 for trunk fat mass as percentage of body weight. Using a bivariate genetic model, we observed significant genetic correlations between BMI and other obesity\u2010related traits (all <jats:italic>p<\/jats:italic> &lt; 0.01). Evidence for univariate linkage was observed at 252 to approximately 267 cM on chromosome 2 for three obesity\u2010related traits (except for WHR) and at 163 to approximately 167 cM on chromosome 5 for BMI and BSA, with the maximum logarithm of the odds ratio score of 3.12 (empirical <jats:italic>p<\/jats:italic> value, 0.002) for BSA on chromosome 2. Use of the bivariate linkage model yielded an additional peak (logarithm of the odds ratio = 3.25, empirical <jats:italic>p<\/jats:italic> value, 0.002) at 25 cM on chromosome 7 for the pair of BMI and BSA.<\/jats:p><jats:p><jats:italic>Discussion:<\/jats:italic> The evidence for linkage on chromosomes 2q36\u201037 and 5q36 is supported both by univariate and bivariate analysis, and an additional linkage peak at 7p15 was identified by the bivariate model. This suggests that use of the bivariate model provides additional information to identify linkage of genes responsible for obesity\u2010related traits.<\/jats:p>","DOI":"10.1038\/oby.2006.136","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T14:15:14Z","timestamp":1208960114000},"page":"1192-1200","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic Effects on Obesity Assessed by Bivariate Genome Scan: The Mexican\u2010American Coronary Artery Disease Study"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiaohui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel J.","family":"Qui\u00f1ones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Bulnes\u2010Enriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xochitl","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"De, La Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Aurea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent D.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willa A.","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_7_2_2","volume-title":"Handbook of Obesity","author":"Bray G.","year":"2004"},{"key":"e_1_2_7_3_2","first-page":"481","volume-title":"The Genetics Basis of Common Diseases","author":"Bray G.","year":"2002"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.12.9337146"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/381717"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1999)16:4<397::AID-GEPI6>3.0.CO;2-X"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801257"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/320100"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-4-S1-S52"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.12.4239"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000076971.55421.AD"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.1.214"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-9-200405040-00009"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1916.00080130010002"},{"key":"e_1_2_7_15_2","first-page":"475","article-title":"Human body surface area: validation of formulae based on cadaver study","volume":"56","author":"Martin A. 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