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In this context, several authors have recently debated the different \u201cweight\u201d of BMI as an index of general adiposity vs. the importance of the epicardial fat depot as a marker of local visceral adiposity in obesity\u2010related LV changes. Studies in uncomplicated obesity suggest that the role of BMI in predicting LV abnormalities remains rather doubtful. In contrast, several lines of evidence suggest that cardiac adiposity could play an important part in the development of cardiac modifications. Epicardial fat as an index of cardiac adiposity could have a functional and mechanical role in obesity\u2010related LV abnormalities. Epicardial fat is clinically correlated with LV mass, atrial dimensions, and diastolic function, but a causal effect of epicardial adipose tissue on cardiac chamber modifications remains to be demonstrated. Nevertheless, the close anatomical and functional relationship of epicardial adipose tissue to the adjacent myocardium should readily allow local, paracrine interactions between these tissues.<\/jats:p>","DOI":"10.1038\/oby.2006.192","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T14:29:17Z","timestamp":1208960957000},"page":"1679-1684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Different \u201cWeight\u201d of Cardiac and General Adiposity in Predicting Left Ventricle Morphology"],"prefix":"10.1002","volume":"14","author":[{"given":"Gianluca","family":"Iacobellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline M.","family":"Pond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arya M.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2005.130"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.10.1127"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.10.1152"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.10.062"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00519-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.02.073"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.012"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2002.104"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.201"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0742-2822.2005.03138.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.73"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800596"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.7.1396"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.07.009"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio0319"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.06.075"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90537-7"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1997.0731"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000137993.70745.82"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.05.028"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.45"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030698"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1087"},{"key":"e_1_2_5_25_2","first-page":"369","article-title":"Statistical analysis of the epicardial fat weight in human hearts","volume":"60","author":"Reiner L.","year":"1955","journal-title":"AMA Arch Pathol"},{"key":"e_1_2_5_26_2","first-page":"58","article-title":"The weight of the human heart: I. 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