{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T14:44:42Z","timestamp":1694616282210},"reference-count":33,"publisher":"Wiley","issue":"S6","license":[{"start":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T00:00:00Z","timestamp":1346889600000},"content-version":"vor","delay-in-days":2289,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The serotonin, norepinephrine, dopamine, and endocannabinoid systems, as well as a host of other systems, mediate hunger and satiety signals. Weight loss agents that modulate appetite through pure central nervous system pathways (e.g., APD356, a selective serotonin receptor agonist) and peripheral signals to central nervous system pathways (e.g., cholecystokinin receptor agonists and ghrelin receptor antagonists) are in preclinical or early phase studies. Both devices and pharmacological compounds that facilitate weight loss and\/or target multiple components of metabolic risk also are in development. One of the medications that has completed extensive phase III clinical trials and may become available in the foreseeable future is rimonabant, a selective cannabinoid 1\u2010receptor antagonist. Drugs that improve adipose tissue function or fatty acid metabolism (e.g., AOD9604) also are in clinical trials. Some currently available medications may reduce metabolic complications without treating obesity per se (e.g., acipimox, pioglitazone). Surgically implanted gastric pacemaker systems that modulate vagus nerve activity and delay gastric emptying are under study.<\/jats:p>","DOI":"10.1038\/oby.2006.294","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T15:34:28Z","timestamp":1208964868000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Potential Role of New Therapies in Modifying Cardiovascular Risk in Overweight Patients with Metabolic Risk Factors"],"prefix":"10.1002","volume":"14","author":[{"given":"Michael D.","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,6]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2003.01839.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450053174550"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1109951"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.195"},{"issue":"1","key":"e_1_2_9_6_2","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1007\/BF03342137","article-title":"\u201cWhat are the Yanks doing?\u201d The U.S. experience with implantable gastric stimulation (IGS) for the treatment of obesity\u2014update on the ongoing clinical trials","volume":"14","author":"Shikora SA","year":"2004","journal-title":"Obes Surg."},{"key":"e_1_2_9_7_2","unstructured":"Smith S. Anderson J. Frank A. For the APD356 Study Groupet al(October 18 2005)Effect of APD356 a selective 5\u2010HT2cagonist on weight loss in a 4\u2010week study of healthy obese patients2005 Annual Scientific Meeting of the North American Association for the Study of Obesity Vancouver British Columbia Canada."},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1997.tb00305.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026033452258"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/380403a0"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8111"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.09.001"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702190"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.4.908"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.07.030"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1495"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17725"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19376"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66374-X"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044537"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.7.761"},{"key":"e_1_2_9_22_2","unstructured":"Scheen AJ(June 12 2005)Rimonabant in patients with type 2 diabetes: results from the RIO\u2010Diabetes trial 65th Annual Scientific Sessions of the American Diabetes AssociationSan Diego CA."},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_9_24_2","author":"Jensen MD","journal-title":"Rimonabant in the treatment of metabolic syndrome: pooled data from the RIO-Lipids, RIO-Europe and RIO-North America studies 1st International Congress on \u201cPrediabetes\u201d and the Metabolic Syndrome: Epidemiology, Management and Prevention of Diabetes and Cardiovascular Disease, April 14, 2005, Berlin, Germany"},{"key":"e_1_2_9_25_2","first-page":"11","article-title":"Development of beta 3\u2010adrenoceptor agonists for the treatment of obesity and diabetes\u2014an update","volume":"25","author":"Weyer C.","year":"1999","journal-title":"Diabetes Metab."},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.10.1555"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.12.5182"},{"key":"e_1_2_9_28_2","unstructured":"Herd C. 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Caterson I. et alThe effect of AOD9604 on weight loss in obese adults: results of a randomized double\u2010blind placebo\u2010controlled multicenter study2005 Annual Scientific Meeting of the North American Association for the Study of Obesity October 18 2005 Vancouver British Columbia Canada."},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.11.3148"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.3.667"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.11.3148"},{"key":"e_1_2_9_32_2","article-title":"Summary minutes of the Endocrinologic and Metabolic Drugs Advisory Committee meeting for September 9, 2005","author":"Endocrinologic and Metabolic Drugs Advisory Committee Meeting","journal-title":"U.S. Food and Drug Administration Center for Drug Evaluation and Research"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.20.joc50147"},{"key":"e_1_2_9_34_2","article-title":"Treatment of obesity with diet\/exercise versus pioglitazone has distinct effects on lipoprotein particle size","author":"Shadid S.","journal-title":"Atherosclerosis"}],"container-title":["Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Foby.2006.294","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/oby.2006.294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T17:39:14Z","timestamp":1694540354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/oby.2006.294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":33,"journal-issue":{"issue":"S6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1038\/oby.2006.294"],"URL":"https:\/\/doi.org\/10.1038\/oby.2006.294","archive":["Portico"],"relation":{},"ISSN":["1930-7381","1930-739X"],"issn-type":[{"value":"1930-7381","type":"print"},{"value":"1930-739X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"2012-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}